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We present a GWAS of a Japanese cohort (700 sarcoidosis cases and 886 controls) with replication in independent samples from Japan (931 cases and 1,042 controls) and the Czech Republic (265 cases and 264 controls). We identified three loci outside the<jats:italic>HLA<\/jats:italic>complex,<jats:italic>CCL24<\/jats:italic>,<jats:italic>STYXL1-SRRM3<\/jats:italic>, and<jats:italic>C1orf141<\/jats:italic>-<jats:italic>IL23R<\/jats:italic>, which showed genome-wide significant associations (<jats:italic>P<\/jats:italic>\u2009&lt;\u20095.0\u2009\u00d7\u200910<jats:sup>\u22128<\/jats:sup>) with sarcoidosis;<jats:italic>CCL24<\/jats:italic>and<jats:italic>STYXL1-SRRM3<\/jats:italic>were novel. The disease-risk alleles in<jats:italic>CCL24<\/jats:italic>and<jats:italic>IL23R<\/jats:italic>were associated with reduced<jats:italic>CCL24<\/jats:italic>and<jats:italic>IL23R<\/jats:italic>expression, respectively. The disease-risk allele in<jats:italic>STYXL1-SRRM3<\/jats:italic>was associated with elevated<jats:italic>POR<\/jats:italic>expression. These results suggest that genetic control of<jats:italic>CCL24<\/jats:italic>,<jats:italic>POR<\/jats:italic>, and<jats:italic>IL23R<\/jats:italic>expression contribute to the pathogenesis of sarcoidosis. We speculate that the<jats:italic>CCL24<\/jats:italic>risk allele might be involved in a polarized Th1 response in sarcoidosis, and that<jats:italic>POR<\/jats:italic>and<jats:italic>IL23R<\/jats:italic>risk alleles may lead to diminished host defense against sarcoidosis pathogens.<\/jats:p>","DOI":"10.1038\/s42003-020-01185-9","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T10:44:26Z","timestamp":1598006666000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Genetic control of CCL24, POR, and IL23R contributes to the pathogenesis of 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