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Here, we show that an environmental strain of\n                    <jats:italic>Bacillus subtilis<\/jats:italic>\n                    undergoes heritable phenotypic variation upon interaction with the soil fungal pathogen\n                    <jats:italic>Setophoma terrestris<\/jats:italic>\n                    (ST). Metabolomics analysis revealed differential profiles in\n                    <jats:italic>B. subtilis<\/jats:italic>\n                    before (pre-ST) and after (post-ST) interacting with the fungus, which paradoxically involved the absence of lipopeptides surfactin and plipastatin and yet acquisition of antifungal activity in post-ST variants. The profile of volatile compounds showed that 2-heptanone and 2-octanone were the most discriminating metabolites present at higher concentrations in post-ST during the interaction process. Both ketones showed strong antifungal activity, which was lost with the addition of exogenous surfactin. Whole-genome analyses indicate that mutations in ComQPXA quorum-sensing system, constituted the genetic bases of post-ST conversion, which rewired\n                    <jats:italic>B. subtilis<\/jats:italic>\n                    metabolism towards the depletion of surfactins and the production of antifungal compounds during its antagonistic interaction with\n                    <jats:italic>S. terrestris<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1038\/s42003-020-01342-0","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T06:02:41Z","timestamp":1605160961000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Fungal\u2013bacterial interaction selects for quorum sensing mutants with increased production of natural antifungal compounds"],"prefix":"10.1038","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4722-1439","authenticated-orcid":false,"given":"Andrea G.","family":"Albarrac\u00edn Orio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6561-3022","authenticated-orcid":false,"given":"Daniel","family":"Petras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9259-5392","authenticated-orcid":false,"given":"Romina A.","family":"Tobares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander A.","family":"Aksenov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5916-8858","authenticated-orcid":false,"given":"Florencia","family":"Juncosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6682-9514","authenticated-orcid":false,"given":"Pamela","family":"Sayago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4976-7611","authenticated-orcid":false,"given":"Alejandro J.","family":"Moyano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter C.","family":"Dorrestein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6527-7719","authenticated-orcid":false,"given":"Andrea M.","family":"Smania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,12]]},"reference":[{"key":"1342_CR1","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1038\/441300a","volume":"441","author":"R Kolter","year":"2006","unstructured":"Kolter, R. & Greenberg, P. 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