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Here, we show that\n                    <jats:italic>Lrig<\/jats:italic>\n                    -null mouse embryonic fibroblasts (MEFs) are deficient in adipogenesis and bone morphogenetic protein (BMP) signaling. In contrast, transforming growth factor-beta (TGF-\u03b2) and receptor tyrosine kinase (RTK) signaling appeared unaltered in\n                    <jats:italic>Lrig<\/jats:italic>\n                    -null cells. The BMP signaling defect was rescued by ectopic expression of LRIG1 or LRIG3 but not by expression of LRIG2.\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    with mutant\n                    <jats:italic>LRIG<\/jats:italic>\n                    \/\n                    <jats:italic>sma-10<\/jats:italic>\n                    variants also exhibited a lipid storage defect. Human\n                    <jats:italic>LRIG1<\/jats:italic>\n                    variants were strongly associated with increased body mass index (BMI) yet protected against type 2 diabetes; these effects were likely mediated by altered adipocyte morphology. These results demonstrate that LRIG proteins function as evolutionarily conserved regulators of lipid metabolism and BMP signaling and have implications for human disease.\n                  <\/jats:p>","DOI":"10.1038\/s42003-020-01613-w","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T06:02:54Z","timestamp":1611036174000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes"],"prefix":"10.1038","volume":"4","author":[{"given":"Carl","family":"Herdenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal M.","family":"Mutie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5824-6263","authenticated-orcid":false,"given":"Ola","family":"Billing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3502-5948","authenticated-orcid":false,"given":"Ahmad","family":"Abdullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8506-3585","authenticated-orcid":false,"given":"Rona J.","family":"Strawbridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Dahlman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Tuck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Holmlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6208-6220","authenticated-orcid":false,"given":"Peter","family":"Arner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Henriksson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0520-7604","authenticated-orcid":false,"given":"Paul W.","family":"Franks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6891-6996","authenticated-orcid":false,"given":"H\u00e5kan","family":"Hedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,19]]},"reference":[{"key":"1613_CR1","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.ygeno.2004.01.013","volume":"84","author":"D Guo","year":"2004","unstructured":"Guo, D., Holmlund, C., Henriksson, R. & Hedman, H. 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