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However, to our knowledge, this mechanism has never been observed in non-clinical cohorts exhibiting high anxiety. Moreover, empirical support regarding said association is mixed, potentially because of publication bias with a relatively small sample size. Hence, how the <jats:italic>5-HTTLPR<\/jats:italic> modulates neural correlates remains controversial. Here we show that <jats:italic>5-HTTLPR<\/jats:italic> short-allele carriers had significantly increased baseline ERPs and reduced fearful MMN, phenomena which can nevertheless be reversed by acute anxiolytic treatment. This provides evidence that the <jats:italic>5-HTT<\/jats:italic> affects the automatic processing of threatening and non-threatening voices, impacts broadly on social cognition, and conclusively asserts the heightened baseline arousal level as the universal underlying neural mechanism for anxiety-related susceptibilities, functioning as a spectrum-like distribution from high trait anxiety non-patients to anxiety patients.<\/jats:p>","DOI":"10.1038\/s42003-020-0850-3","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T11:03:11Z","timestamp":1583838191000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["An integrative analysis of 5HTT-mediated mechanism of hyperactivity to non-threatening voices"],"prefix":"10.1038","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8050-6754","authenticated-orcid":false,"given":"Chenyi","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5536-5897","authenticated-orcid":false,"given":"R\u00f3ger M.","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsai-Tsen","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin-Yau","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Yung","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yawei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,3,10]]},"reference":[{"key":"850_CR1","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1176\/appi.ajp.2008.07101682","volume":"166","author":"JB Nitschke","year":"2009","unstructured":"Nitschke, J. 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