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We performed a genome-wide association study of POP using data from Iceland and the UK Biobank, a total of 15,010 cases with hospital-based diagnosis code and 340,734 female controls, and found eight sequence variants at seven loci associating with POP (<jats:italic>P<\/jats:italic>\u2009&lt;\u20095 \u00d7 10<jats:sup>\u22128<\/jats:sup>); seven common (minor allele frequency &gt;5%) and one with minor allele frequency of 4.87%. Some of the variants associating with POP also associated with traits of similar pathophysiology. Of these, rs3820282, which may alter the estrogen-based regulation of <jats:italic>WNT4<\/jats:italic>, also associates with leiomyoma of uterus, gestational duration and endometriosis. Rs3791675 at <jats:italic>EFEMP1<\/jats:italic>, a gene involved in connective tissue homeostasis, also associates with hernias and carpal tunnel syndrome. Our results highlight the role of connective tissue metabolism and estrogen exposure in the etiology of POP.<\/jats:p>","DOI":"10.1038\/s42003-020-0857-9","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T11:02:44Z","timestamp":1584442964000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK 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