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Nine H3K4me enzymes are associated with neurodevelopmental disorders to date, indicating their important roles in the brain. However, interplay among H3K4me enzymes during brain development remains largely unknown. Here, we show functional interactions of a writer-eraser duo,\n                    <jats:italic>KMT2A<\/jats:italic>\n                    and\n                    <jats:italic>KDM5C<\/jats:italic>\n                    , which are responsible for Wiedemann-Steiner Syndrome (WDSTS), and mental retardation X-linked syndromic Claes-Jensen type (MRXSCJ), respectively. Despite opposite enzymatic activities, the two mouse models deficient for either\n                    <jats:italic>Kmt2a<\/jats:italic>\n                    or\n                    <jats:italic>Kdm5c<\/jats:italic>\n                    shared reduced dendritic spines and increased aggression. Double mutation of\n                    <jats:italic>Kmt2a<\/jats:italic>\n                    and\n                    <jats:italic>Kdm5c<\/jats:italic>\n                    clearly reversed dendritic morphology, key behavioral traits including aggression, and partially corrected altered transcriptomes and H3K4me landscapes. Thus, our study uncovers common yet mutually suppressive aspects of the WDSTS and MRXSCJ models and provides a proof of principle for balancing a single writer-eraser pair to ameliorate their associated disorders.\n                  <\/jats:p>","DOI":"10.1038\/s42003-020-1001-6","type":"journal-article","created":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T06:03:14Z","timestamp":1590991394000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Mutually suppressive roles of KMT2A and KDM5C in behaviour, neuronal structure, and histone H3K4 methylation"],"prefix":"10.1038","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3159-3200","authenticated-orcid":false,"given":"Christina N.","family":"Vallianatos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0877-8266","authenticated-orcid":false,"given":"Brynne","family":"Raines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1627-4877","authenticated-orcid":false,"given":"Robert S.","family":"Porter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine M.","family":"Bonefas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3829-8039","authenticated-orcid":false,"given":"Michael C.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1659-8126","authenticated-orcid":false,"given":"Patricia M.","family":"Garay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie M.","family":"Collette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Ah","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7780-6542","authenticated-orcid":false,"given":"Catherine E.","family":"Keegan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5676-1579","authenticated-orcid":false,"given":"Natalie C.","family":"Tronson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2280-7422","authenticated-orcid":false,"given":"Shigeki","family":"Iwase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,1]]},"reference":[{"key":"1001_CR1","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.ajhg.2017.11.013","volume":"102","author":"V Faundes","year":"2018","unstructured":"Faundes, V. et al. 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