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We seek to uncover the intrinsic relationship among brain regions fundamental to their functional activity by constructing a pairwise maximum entropy model (MEM) of the inter-ictal activation patterns of five patients with medically refractory epilepsy over an average of ~14 hours of band-passed intracranial EEG (iEEG) recordings per patient. We find that the pairwise MEM accurately predicts iEEG electrodes\u2019 activation patterns\u2019 probability and their pairwise correlations. We demonstrate that the estimated pairwise MEM\u2019s interaction weights predict structural connectivity and its strength over several frequencies significantly beyond what is expected based solely on sampled regions\u2019 distance in most patients. Together, the pairwise MEM offers a framework for explaining iEEG functional connectivity and provides insight into how the brain\u2019s structural connectome gives rise to large-scale activation patterns by promoting co-activation between connected structures.<\/jats:p>","DOI":"10.1038\/s42003-021-01700-6","type":"journal-article","created":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T18:37:58Z","timestamp":1613587078000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Pairwise maximum entropy model explains the role of white matter structure in shaping emergent co-activation states"],"prefix":"10.1038","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1529-7041","authenticated-orcid":false,"given":"Arian","family":"Ashourvan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preya","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Pines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2303-6770","authenticated-orcid":false,"given":"Shi","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W.","family":"Lynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6183-4493","authenticated-orcid":false,"given":"Danielle S.","family":"Bassett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn A.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Litt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,16]]},"reference":[{"key":"1700_CR1","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/s41583-018-0038-8","volume":"19","author":"DS Bassett","year":"2018","unstructured":"Bassett, D. 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