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Tumor heterogeneity, which hampers development of targeted therapies, was herein deconvoluted via single cell RNA sequencing in aggressive human adenocarcinomas (carrying\n                    <jats:italic>Kras<\/jats:italic>\n                    -mutations) and comparable murine model. We identified a tumor-specific,\n                    <jats:italic>mutant-KRAS-associated<\/jats:italic>\n                    subpopulation which is conserved in both human and murine lung cancer. We previously reported a key role for the oncogene BMI-1 in adenocarcinomas. We therefore investigated the effects of in vivo PTC596 treatment, which affects BMI-1 activity, in our murine model. Post-treatment, MRI analysis showed decreased tumor size, while single cell transcriptomics concomitantly detected near complete ablation of the\n                    <jats:italic>mutant-KRAS-associated<\/jats:italic>\n                    subpopulation, signifying the presence of a pharmacologically targetable, tumor-associated subpopulation. Our findings therefore hold promise for the development of a targeted therapy for\n                    <jats:italic>KRAS-mutant<\/jats:italic>\n                    adenocarcinomas.\n                  <\/jats:p>","DOI":"10.1038\/s42003-021-01897-6","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T06:05:44Z","timestamp":1618380344000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer"],"prefix":"10.1038","volume":"4","author":[{"given":"Giorgia","family":"Maroni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4322-2968","authenticated-orcid":false,"given":"Mahmoud 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