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The onset and progression of cognitive decline in individuals with Parkinson\u2019s disease is variable, and the neurobiological mechanisms that contribute to, or protect against, cognitive decline in Parkinson\u2019s disease are poorly understood. Using resting-state functional magnetic resonance imaging data collected from individuals with Parkinson\u2019s disease with and without cognitive decline, we examined the relationship between topological brain-network resilience and cognition in Parkinson\u2019s disease. By leveraging network attack analyses, we demonstrate that relative to individuals with Parkinson\u2019s disease experiencing cognitive decline, the frontoparietal network in cognitively stable individuals with Parkinson\u2019s disease is significantly more resilient to network perturbation. Our findings suggest that the topological robustness of the frontoparietal network is associated with the absence of cognitive decline in individuals with Parkinson\u2019s disease.<\/jats:p>","DOI":"10.1038\/s42003-021-02478-3","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T10:04:51Z","timestamp":1630490691000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Frontoparietal network resilience is associated with protection against cognitive decline in Parkinson\u2019s disease"],"prefix":"10.1038","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5948-2831","authenticated-orcid":false,"given":"Arianna D.","family":"Cascone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Langella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6031-4763","authenticated-orcid":false,"given":"Miriam","family":"Sklerov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9710-9210","authenticated-orcid":false,"given":"Eran","family":"Dayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,1]]},"reference":[{"key":"2478_CR1","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1136\/jnnp.2007.131045","volume":"79","author":"J Jankovic","year":"2008","unstructured":"Jankovic, J. 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