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In a genome-wide association study of vertigo (<jats:italic>N<\/jats:italic><jats:sub>cases<\/jats:sub>\u2009=\u200948,072, <jats:italic>N<\/jats:italic><jats:sub>controls<\/jats:sub>\u2009=\u2009894,541), we uncovered an association with six common sequence variants in individuals of European ancestry, including missense variants in <jats:italic>ZNF91, OTOG, OTOGL<\/jats:italic>, and <jats:italic>TECTA<\/jats:italic>, and a <jats:italic>cis<\/jats:italic>-eQTL for <jats:italic>ARMC9<\/jats:italic>. The association of variants in <jats:italic>ZNF91<\/jats:italic>, <jats:italic>OTOGL<\/jats:italic>, and <jats:italic>OTOP1<\/jats:italic> was driven by an association with benign paroxysmal positional vertigo. Using previous reports of sequence variants associating with age-related hearing impairment and motion sickness, we found eight additional variants that associate with vertigo. Although disorders of the auditory and the vestibular system may co-occur, none of the six genome-wide significant vertigo variants were associated with hearing loss and only one was associated with age-related hearing impairment. Our results uncovered sequence variants associating with vertigo in a genome-wide association study and implicated genes with known roles in inner ear development, maintenance, and disease.<\/jats:p>","DOI":"10.1038\/s42003-021-02673-2","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T16:04:41Z","timestamp":1633622681000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["A genome-wide meta-analysis uncovers six sequence variants conferring risk of vertigo"],"prefix":"10.1038","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5048-0933","authenticated-orcid":false,"given":"Astros Th.","family":"Skuladottir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyda","family":"Bjornsdottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5576-9007","authenticated-orcid":false,"given":"Muhammad Sulaman","family":"Nawaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4376-3361","authenticated-orcid":false,"given":"Solvi","family":"Rognvaldsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9579-4362","authenticated-orcid":false,"given":"Kristjan Helgi Swerford","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pall I.","family":"Olafsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6669-3071","authenticated-orcid":false,"given":"Sigur\u00f0ur H.","family":"Magnusson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Bjornsdottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olafur A.","family":"Sveinsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudrun R.","family":"Sigurdardottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9392-6184","authenticated-orcid":false,"given":"Saedis","family":"Saevarsdottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2069-0681","authenticated-orcid":false,"given":"Erna V.","family":"Ivarsdottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilja","family":"Stefansdottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjarni","family":"Gunnarsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph B.","family":"Muhlestein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk U.","family":"Knowlton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lincoln D.","family":"Nadauld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette M.","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Rujescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Strupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5415-6487","authenticated-orcid":false,"given":"G. 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M.S. is a joint chief editor of the <i>Journal of Neurology<\/i>, chief editor of <i>Frontiers of Neuro-otology<\/i> and section editor of <i>F1000<\/i>. He has received speaker\u2019s honoraria from Abbott, Auris Medical, Biogen, Eisai, Gr\u00fcnenthal, GSK, Henning Pharma, Interacoustics, J&J, MSD, Otometrics, Pierre-Fabre, TEVA, and UCB. He is a shareholder and investor of IntraBio. He distributes \u201cM-glasses\u201d and the \u201cPositional vertigo App\u201d. He acts as a consultant for Abbott, Auris Medical, Heel, IntraBio and Sensorion. The remaining authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1148"}}