{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T10:57:35Z","timestamp":1780657055614,"version":"3.54.1"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000265","name":"RCUK | Medical Research Council","doi-asserted-by":"publisher","award":["MR\/R004625\/1"],"award-info":[{"award-number":["MR\/R004625\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000703","name":"Action on Hearing Loss","doi-asserted-by":"publisher","award":["S39"],"award-info":[{"award-number":["S39"]}],"id":[{"id":"10.13039\/501100000703","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Neurons and sensory cells are particularly vulnerable to oxidative stress due to their high oxygen demand during stimulus perception and transmission. The mechanisms that protect them from stress-induced death and degeneration remain elusive. Here we show that embryonic deletion of the chromodomain helicase DNA-binding protein 7 (CHD7) in auditory neurons or hair cells leads to sensorineural hearing loss due to postnatal degeneration of both cell types. Mechanistically, we demonstrate that\n                    <jats:italic>CHD7<\/jats:italic>\n                    controls the expression of major stress pathway components. In its absence, hair cells are hypersensitive, dying rapidly after brief exposure to stress inducers, suggesting that sound at the onset of hearing triggers their degeneration. In humans,\n                    <jats:italic>CHD7<\/jats:italic>\n                    haploinsufficiency causes CHARGE syndrome, a disorder affecting multiple organs including the ear. Our findings suggest that\n                    <jats:italic>CHD7<\/jats:italic>\n                    mutations cause developmentally silent phenotypes that predispose cells to postnatal degeneration due to a failure of protective mechanisms.\n                  <\/jats:p>","DOI":"10.1038\/s42003-021-02788-6","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T07:04:18Z","timestamp":1635923058000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration"],"prefix":"10.1038","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2028-6475","authenticated-orcid":false,"given":"Mohi","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra Singh","family":"Prajapati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elysia","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9834-7528","authenticated-orcid":false,"given":"M. Albert","family":"Basson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7664-7917","authenticated-orcid":false,"given":"Andrea","family":"Streit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,3]]},"reference":[{"key":"2788_CR1","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1038\/ng1407","volume":"36","author":"LE Vissers","year":"2004","unstructured":"Vissers, L. E. et al. Mutations in a new member of the chromodomain gene family cause CHARGE syndrome. Nat. Genet. 36, 955\u2013957 (2004).","journal-title":"Nat. Genet."},{"key":"2788_CR2","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1002\/ajmg.a.33323","volume":"152A","author":"GE Zentner","year":"2010","unstructured":"Zentner, G. E., Layman, W. S., Martin, D. M. & Scacheri, P. C. Molecular and phenotypic aspects of CHD7 mutation in CHARGE syndrome. Am. J. Med. Genet. A. 152A, 674\u2013686 (2010).","journal-title":"J. Med. Genet. A."},{"key":"2788_CR3","doi-asserted-by":"publisher","first-page":"3463","DOI":"10.1093\/hmg\/ddi375","volume":"14","author":"EA Bosman","year":"2005","unstructured":"Bosman, E. A. et al. Multiple mutations in mouse Chd7 provide models for CHARGE syndrome. Hum. Mol. Genet 14, 3463\u20133476 (2005).","journal-title":"Hum. Mol. Genet"},{"key":"2788_CR4","first-page":"3301","volume":"119","author":"V Randall","year":"2009","unstructured":"Randall, V. et L. Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in mice. J. Clin. Invest 119, 3301\u20133310 (2009).","journal-title":"J. Clin. Invest"},{"key":"2788_CR5","doi-asserted-by":"publisher","first-page":"3139","DOI":"10.1242\/dev.047894","volume":"137","author":"EA Hurd","year":"2010","unstructured":"Hurd, E. A. et al. The ATP-dependent chromatin remodeling enzyme CHD7 regulates pro-neural gene expression and neurogenesis in the inner ear. Development 137, 3139\u20133150 (2010).","journal-title":"Development"},{"key":"2788_CR6","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.heares.2011.08.005","volume":"282","author":"EA Hurd","year":"2011","unstructured":"Hurd, E. A. et al. Mature middle and inner ears express Chd7 and exhibit distinctive pathologies in a mouse model of CHARGE syndrome. Hear Res 282, 184\u2013195 (2011).","journal-title":"Hear Res"},{"key":"2788_CR7","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1038\/ng.825","volume":"43","author":"Engelen","year":"2011","unstructured":"Engelen et al. Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes. Nat. Genet. 43, 607\u2013611 (2011).","journal-title":"Nat. Genet."},{"key":"2788_CR8","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1002\/stem.1822","volume":"33","author":"KM Jones","year":"2015","unstructured":"Jones, K. M. et al. CHD7 Maintains neural stem cell quiescence and prevents premature stem cell depletion in the adult hippocampus. Stem Cells 33, 196\u2013210 (2015).","journal-title":"Stem Cells"},{"key":"2788_CR9","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14758","volume":"8","author":"W Feng","year":"2017","unstructured":"Feng, W. et al. Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme. Nat. Commun. 8, 14758 (2017).","journal-title":"Nat. Commun."},{"key":"2788_CR10","doi-asserted-by":"publisher","first-page":"86","DOI":"10.3389\/fnana.2017.00086","volume":"11","author":"APA Donovan","year":"2017","unstructured":"Donovan, A. P. A. et al. Cerebellar vermis and midbrain hypoplasia upon conditional deletion of Chd7 from the embryonic mid-hindbrain region. Front Neuroanat. 11, 86 (2017).","journal-title":"Front Neuroanat."},{"key":"2788_CR11","first-page":"465","volume":"175C","author":"DE Whittaker","year":"2017","unstructured":"Whittaker, D. E. et al. Distinct cerebellar foliation anomalies in a CHD7 haploinsufficient mouse model of CHARGE syndrome. Am. J. Med Genet C. Semin. Med. Genet. 175C, 465\u2013477 (2017).","journal-title":"Am. J. Med Genet C. Semin. Med. Genet."},{"key":"2788_CR12","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1172\/JCI83408","volume":"127","author":"DE Whittaker","year":"2017","unstructured":"Whittaker, D. E. et al. The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression. J. Clin. Invest 127, 874\u2013887 (2017).","journal-title":"J. Clin. Invest"},{"key":"2788_CR13","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.neuron.2008.02.028","volume":"58","author":"P Dallos","year":"2008","unstructured":"Dallos, P. et al. Prestin-based outer hair cell motility is necessary for mammalian cochlear amplification. Neuron 58, 333\u2013339 (2008).","journal-title":"Neuron"},{"key":"2788_CR14","doi-asserted-by":"publisher","first-page":"14078","DOI":"10.1523\/JNEUROSCI.3765-07.2007","volume":"27","author":"EJ Koundakjian","year":"2007","unstructured":"Koundakjian, E. J., Appler, J. L. & Goodrich, L. V. Auditory neurons make stereotyped wiring decisions before maturation of their targets. J. Neurosci. 27, 14078\u201314088 (2007).","journal-title":"J. Neurosci."},{"key":"2788_CR15","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1097\/00005537-200107000-00005","volume":"111","author":"JG Feghali","year":"2001","unstructured":"Feghali, J. G., Liu, W. & Van De Water, T. R. L-n-acetyl-cysteine protection against cisplatin-induced auditory neuronal and hair cell toxicity. Laryngoscope 111, 1147\u20131155 (2001).","journal-title":"Laryngoscope"},{"key":"2788_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/01.aud.0000191942.36672.f3","volume":"27","author":"D Henderson","year":"2006","unstructured":"Henderson, D., Bielefeld, E. C., Harris, K. C. & Hu, B. H. The role of oxidative stress in noise-induced hearing loss. Ear Hear 27, 1\u201319 (2006).","journal-title":"Ear Hear"},{"key":"2788_CR17","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1016\/j.neurobiolaging.2006.06.025","volume":"28","author":"H Jiang","year":"2007","unstructured":"Jiang, H., Talaska, A. E., Schacht, J. & Sha, S. H. Oxidative imbalance in the aging inner ear. Neurobiol. Aging 28, 1605\u20131612 (2007).","journal-title":"Neurobiol. Aging"},{"key":"2788_CR18","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/j.physbeh.2011.06.018","volume":"104","author":"L Cheng","year":"2011","unstructured":"Cheng, L. et al. Moderate noise induced cognition impairment of mice and its underlying mechanisms. Physiol. Behav. 104, 981\u2013988 (2011).","journal-title":"Physiol. Behav."},{"key":"2788_CR19","doi-asserted-by":"publisher","first-page":"582849","DOI":"10.1155\/2014\/582849","volume":"2014","author":"C Fujimoto","year":"2014","unstructured":"Fujimoto, C. & Yamasoba, T. Oxidative stresses and mitochondrial dysfunction in age- related hearing loss. Oxid. Med Cell Longev. 2014, 582849 (2014).","journal-title":"Oxid. Med Cell Longev."},{"key":"2788_CR20","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1242\/dev.129.10.2495","volume":"129","author":"P Chen","year":"2002","unstructured":"Chen, P. et al. The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination. Development 129, 2495\u20132505 (2002).","journal-title":"Development"},{"key":"2788_CR21","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.devcel.2011.12.006","volume":"22","author":"M Ahmed","year":"2012","unstructured":"Ahmed, M. et al. Eya1-Six1 interaction is sufficient to induce hair cell fate in the cochlea by activating Atoh1 expression in cooperation with Sox2. Dev. Cell 22, 377\u2013390 (2012).","journal-title":"Dev. Cell"},{"key":"2788_CR22","doi-asserted-by":"publisher","first-page":"451","DOI":"10.3109\/00016486509124579","volume":"59","author":"D Mikaelian","year":"1965","unstructured":"Mikaelian, D. & Ruben, R. J. Development of hearing in the normal Cba-J mouse: correlation of physiological observations with behavioral responses and with cochlear anatomy. Acta Otolaryngol. 59, 451\u2013461 (1965).","journal-title":"Acta Otolaryngol."},{"key":"2788_CR23","doi-asserted-by":"publisher","first-page":"10992","DOI":"10.1523\/JNEUROSCI.2188-06.2006","volume":"26","author":"M Beurg","year":"2006","unstructured":"Beurg, M., Evans, M. G., Hackney, C. M. & Fettiplace, R. A large-conductance calcium-selective mechanotransducer channel in mammalian cochlear hair cells. J. Neurosci. 26, 10992\u201311000 (2006).","journal-title":"J. Neurosci."},{"key":"2788_CR24","doi-asserted-by":"publisher","first-page":"2639","DOI":"10.1529\/biophysj.107.123257","volume":"94","author":"M Beurg","year":"2008","unstructured":"Beurg, M., Nam, J. H., Crawford, A. & Fettiplace, R. The actions of calcium on hair bundle mechanics in mammalian cochlear hair cells. Biophys. J. 94, 2639\u20132653 (2008).","journal-title":"Biophys. J."},{"key":"2788_CR25","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1242\/dev.128.3.417","volume":"128","author":"WY Kim","year":"2001","unstructured":"Kim, W. Y. et al. NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development. Development 128, 417\u2013426 (2001).","journal-title":"Development"},{"key":"2788_CR26","doi-asserted-by":"publisher","first-page":"3879","DOI":"10.1523\/JNEUROSCI.4030-12.2013","volume":"33","author":"L Evsen","year":"2013","unstructured":"Evsen, L. et al. Progression of neurogenesis in the inner ear requires inhibition of Sox2 transcription by Neurogenin1 and Neurod1. J. Neurosci. 33, 3879\u20133890 (2013).","journal-title":"J. Neurosci."},{"key":"2788_CR27","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s004410051244","volume":"295","author":"B Fritzsch","year":"1999","unstructured":"Fritzsch, B., Pirvola, U. & Ylikoski, J. Making and breaking the innervation of the ear: neurotrophic support during ear development and its clinical implications. Cell Tissue Res. 295, 369\u2013382 (1999).","journal-title":"Cell Tissue Res"},{"key":"2788_CR28","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1387\/ijdb.072373hs","volume":"51","author":"H Sanchez-Calderon","year":"2007","unstructured":"Sanchez-Calderon, H., Milo, M., Leon, Y. & Varela-Nieto, I. A network of growth and transcription factors controls neuronal differentation and survival in the developing ear. Int. J. Dev. Biol. 51, 557\u2013570 (2007).","journal-title":"Int. J. Dev. Biol."},{"key":"2788_CR29","doi-asserted-by":"crossref","unstructured":"Huang L. C. et al. Synaptic profiles during neurite extension, refinement and retraction in the developing cochlea. Neural Dev. B, 7:38 (2012).","DOI":"10.1186\/1749-8104-7-38"},{"key":"2788_CR30","doi-asserted-by":"publisher","first-page":"6415","DOI":"10.1073\/pnas.1812029116","volume":"116","author":"S Michanski","year":"2019","unstructured":"Michanski, S. et al. Mapping developmental maturation of inner hair cell ribbon synapses in the apical mouse cochlea. Proc. Natl Acad. Sci. 116, 6415\u20136424 (2019).","journal-title":"Proc. Natl Acad. Sci."},{"key":"2788_CR31","doi-asserted-by":"publisher","first-page":"5383","DOI":"10.1091\/mbc.e04-08-0715","volume":"15","author":"N Gilks","year":"2004","unstructured":"Gilks, N. et al. Stress granule assembly is mediated by prion-like aggregation of TIA-1. Mol. Biol. Cell 15, 5383\u20135398 (2004).","journal-title":"Mol. Biol. Cell"},{"key":"2788_CR32","doi-asserted-by":"crossref","first-page":"e13136","DOI":"10.1111\/acel.13136","volume":"19","author":"FD Leeuw","year":"2020","unstructured":"Leeuw, F. D. et al. The cold-inducible RNA-binding protein migrates from the nucleus to cytoplasmic stress granules by a methylation-dependent mechanism and acts as a translational repressor. Aging Cell 19, e13136 (2020).","journal-title":"Aging Cell"},{"key":"2788_CR33","doi-asserted-by":"publisher","first-page":"2466","DOI":"10.1073\/pnas.1614462114","volume":"114","author":"PP Gopal","year":"2017","unstructured":"Gopal, P. P. et al. Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neurons. Proc. Natl Acad. Sci. USA 114, 2466\u20132475 (2017).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2788_CR34","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.cotox.2017.11.003","volume":"7","author":"JM Hansen","year":"2018","unstructured":"Hansen, J. M., Jacob, B. R. & Piorczynski, T. D. Oxidative stress during development: chemical-induced teratogenesis. Curr. Opin. Toxicol. 7, 110\u2013115 (2018).","journal-title":"Curr. Opin. Toxicol."},{"key":"2788_CR35","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.cotox.2018.02.003","volume":"7","author":"M Neal","year":"2018","unstructured":"Neal, M. & Richardson, J. R. Time to get personal: a framework for personalized targeting of oxidative stress in neurotoxicity and neurodegenerative disease. Curr. Opin. Toxicol. 7, 127\u2013132 (2018).","journal-title":"Curr. Opin. Toxicol."},{"key":"2788_CR36","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1159\/000013846","volume":"4","author":"KK Ohlemiller","year":"1999","unstructured":"Ohlemiller, K. K., Wright, J. S. & Dugan, L. L. Early elevation of cochlear reactive oxygen species following noise exposure. Audio. Neurootol. 4, 229\u2013236 (1999).","journal-title":"Audio. Neurootol."},{"key":"2788_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0378-5955(96)00169-4","volume":"104","author":"K Hirose","year":"1997","unstructured":"Hirose, K., Hokenbery, D. M. & Rubel, E. W. Reactive oxygen species in chick hair cells after gentamicin exposure in vitro. Hear Res 104, 1\u201314 (1997).","journal-title":"Hear Res"},{"key":"2788_CR38","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1242\/jcs.076141","volume":"124","author":"ER Towers","year":"2011","unstructured":"Towers, E. R. et al. Caprin-1 is a target of the deafness gene Pou4f3 and is recruited to stress granules in cochlear hair cells in response to ototoxic damage. J. Cell Sci. 124, 1145\u20131155 (2011).","journal-title":"J. Cell Sci."},{"key":"2788_CR39","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-48393-w","volume":"9","author":"Goncalves","year":"2019","unstructured":"Goncalves et al. Drug-induced stress granule formation protects sensory hair cells in mouse cochlear explants during ototoxicity. Sci. Rep. 9, 12501 (2019).","journal-title":"Sci. Rep."},{"key":"2788_CR40","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-08111-y","volume":"10","author":"S Moore","year":"2019","unstructured":"Moore, S. et al. The CHD6 chromatin remodeler is an oxidative DNA damage response factor. Nat. Commun. 10, 241 (2019).","journal-title":"Nat. Commun."},{"key":"2788_CR41","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.molcel.2016.01.019","volume":"61","author":"MS Luijsterburg","year":"2016","unstructured":"Luijsterburg, M. S. et al. PARP1 links CHD2-mediated chromatin expansion and H3.3 deposition to DNA repair by non-homologous end-joining. Mol. Cell 61, 547\u2013562 (2016).","journal-title":"Mol. Cell"},{"key":"2788_CR42","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1083\/jcb.200912135","volume":"190","author":"DH Larsen","year":"2010","unstructured":"Larsen, D. H. et al. The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage. J. Cell. Biol. 190, 731\u2013740 (2010).","journal-title":"J. Cell. Biol."},{"key":"2788_CR43","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.15252\/embr.201642352","volume":"17","author":"V Kari","year":"2016","unstructured":"Kari, V. et al. Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness. EMBO Rep. 17, 1609\u20131623 (2016).","journal-title":"EMBO Rep."},{"key":"2788_CR44","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.ydbio.2021.05.009","volume":"477","author":"V Balendran","year":"2021","unstructured":"Balendran, V. et al. Chromatin remodeler CHD7 is critical for cochlear morphogenesis and neurosensory patterning. Dev. Biol. 477, 11\u201321 (2021).","journal-title":"Dev. Biol."},{"key":"2788_CR45","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.cell.2018.07.007","volume":"174","author":"BR Shrestha","year":"2018","unstructured":"Shrestha, B. R. et al. Sensory neuron diversity in the inner ear is shaped by activity. Cell 174, 1229\u20131246 (2018).","journal-title":"Cell"},{"key":"2788_CR46","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06033-3","volume":"9","author":"C Petitpr\u00e9","year":"2018","unstructured":"Petitpr\u00e9, C. et al. Neuronal heterogeneity and stereotyped connectivity in the auditory afferent system. Nat. Commun. 9, 3691 (2018).","journal-title":"Nat. Commun."},{"key":"2788_CR47","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3389\/fnmol.2020.00083","volume":"13","author":"FC Grandi","year":"2020","unstructured":"Grandi, F. C., Tomasi, L. D. & Mustapha, M. Single-cell RNA analysis of type I spiral ganglion neurons reveals a Lmx1a population in the cochlea. Front. Mol. Neurosci. 13, 83 (2020).","journal-title":"Front. Mol. Neurosci."},{"key":"2788_CR48","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1002\/dvdy.20551","volume":"234","author":"V Matei","year":"2005","unstructured":"Matei, V. et al. Smaller inner ear sensory epithelia in Neurog1 null mice are related to earlier hair cell terminal mitosis. Dev. Dyn. 234, 633\u2013650 (2005).","journal-title":"Dev. Dyn."},{"key":"2788_CR49","doi-asserted-by":"publisher","first-page":"9817","DOI":"10.1523\/JNEUROSCI.2707-07.2007","volume":"27","author":"S Gong","year":"2007","unstructured":"Gong, S. et al. Targeting CRE recombinase to specific neuron populations with bacterial artificial chromosome constructs. J. Neurosci. 27, 9817\u20139823 (2007).","journal-title":"J. Neurosci."},{"key":"2788_CR50","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1002\/dvg.20335","volume":"45","author":"MD Muzumdar","year":"2007","unstructured":"Muzumdar, M. D. et al. A global double\u2010fluorescent Cre reporter mouse. Genesis 45, 593\u2013605 (2007).","journal-title":"Genesis"},{"key":"2788_CR51","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1002\/9780470942390.mo110059","volume":"1","author":"NJ Ingham","year":"2011","unstructured":"Ingham, N. J., Pearson, S. & Steel, K. P. Using the auditory brainstem response (ABR) to determine sensitivity of hearing in mutant mice. Curr. Protoc. Mouse Biol. 1, 279\u2013287 (2011).","journal-title":"Curr. Protoc. Mouse Biol."},{"key":"2788_CR52","doi-asserted-by":"publisher","first-page":"W537","DOI":"10.1093\/nar\/gky379","volume":"46","author":"E Afgan","year":"2018","unstructured":"Afgan, E. et al. The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2018 update. Nucleic Acids Res 46, W537\u2013W544 (2018).","journal-title":"Nucleic Acids Res"},{"key":"2788_CR53","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.3317","volume":"12","author":"D Kim","year":"2015","unstructured":"Kim, D., Langmead, B. & Salzberg, S. L. HISAT: a fast spliced aligner with low memory requirements. Nat. Methods 12, 357\u2013360 (2015).","journal-title":"Nat. Methods"},{"key":"2788_CR54","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","volume":"30","author":"Y Liao","year":"2014","unstructured":"Liao, Y., Gordon, K. S. & Shi, W. featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics 30, 923\u2013930 (2014).","journal-title":"Bioinformatics"},{"key":"2788_CR55","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"M Love","year":"2014","unstructured":"Love, M., Huber, W. & Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15, 550 (2014).","journal-title":"Genome Biol."}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-021-02788-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-021-02788-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-021-02788-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T01:02:52Z","timestamp":1699750972000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-021-02788-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,3]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["2788"],"URL":"https:\/\/doi.org\/10.1038\/s42003-021-02788-6","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.01.05.425431","asserted-by":"object"}]},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,3]]},"assertion":[{"value":"19 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2022","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"In the original version of this article, the given and family names of M. Albert Basson were incorrectly structured. The name was displayed correctly in all versions at the time of publication. The original article has been corrected.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1260"}}