{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:20:44Z","timestamp":1789172444880,"version":"build-2803163510"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alzheimer\u2019s disease (AD) is associated with aberrant neuronal activity, which is believed to critically determine disease symptoms. How these activity alterations emerge, how stable they are over time, and whether cellular activity dynamics are affected by the amyloid plaque pathology remains incompletely understood. We here repeatedly recorded the activity from identified neurons in cortex of awake APPPS1 transgenic mice over four weeks during the early phase of plaque deposition using in vivo two-photon calcium imaging. We found that aberrant activity during this stage largely persisted over the observation time. Novel highly active neurons slowly emerged from former intermediately active neurons. Furthermore, activity fluctuations were independent of plaque proximity, but aberrant activity was more likely to persist close to plaques. These results support the notion that neuronal network pathology observed in models of cerebral amyloidosis is the consequence of persistent single cell aberrant neuronal activity, a finding of potential diagnostic and therapeutic relevance for AD.<\/jats:p>","DOI":"10.1038\/s42003-021-02884-7","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T11:03:14Z","timestamp":1638874994000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Long-term dynamics of aberrant neuronal activity in awake Alzheimer\u2019s disease transgenic mice"],"prefix":"10.1038","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0514-6298","authenticated-orcid":false,"given":"V.","family":"Korzhova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Marinkovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Rudan","family":"Njavro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8895-0841","authenticated-orcid":false,"given":"P. M.","family":"Goltstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2063-8242","authenticated-orcid":false,"given":"F.","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4403-9559","authenticated-orcid":false,"given":"S.","family":"Tahirovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Herms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5633-8981","authenticated-orcid":false,"given":"S.","family":"Liebscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,7]]},"reference":[{"key":"2884_CR1","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1126\/science.1162844","volume":"321","author":"MA Busche","year":"2008","unstructured":"Busche, M. A. et al. Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer\u2019s disease. Science 321, 1686\u20131689 (2008).","journal-title":"Science"},{"key":"2884_CR2","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1038\/nrn.2016.141","volume":"17","author":"JJ Palop","year":"2016","unstructured":"Palop, J. J. & Mucke, L. Network abnormalities and interneuron dysfunction in Alzheimer disease. Nat. Rev. Neurosci. 17, 777\u2013792 (2016).","journal-title":"Nat. Rev. Neurosci."},{"key":"2884_CR3","doi-asserted-by":"publisher","first-page":"a006338","DOI":"10.1101\/cshperspect.a006338","volume":"2","author":"L Mucke","year":"2012","unstructured":"Mucke, L. & Selkoe, D. J. Neurotoxicity of amyloid beta-protein: synaptic and network dysfunction. Cold Spring Harb. Perspect. Med 2, a006338 (2012).","journal-title":"Cold Spring Harb. Perspect. Med"},{"key":"2884_CR4","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.cell.2012.02.046","volume":"149","author":"L Verret","year":"2012","unstructured":"Verret, L. et al. Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model. Cell 149, 708\u2013721 (2012).","journal-title":"Cell"},{"key":"2884_CR5","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1783","volume":"3","author":"C Grienberger","year":"2012","unstructured":"Grienberger, C. et al. Staged decline of neuronal function in vivo in an animal model of Alzheimer\u2019s disease. Nat. Commun. 3, 774 (2012).","journal-title":"Nat. Commun."},{"key":"2884_CR6","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1038\/nn.4163","volume":"18","author":"MA Busche","year":"2015","unstructured":"Busche, M. A. et al. Decreased amyloid-beta and increased neuronal hyperactivity by immunotherapy in Alzheimer\u2019s models. Nat. Neurosci. 18, 1725\u20131727 (2015).","journal-title":"Nat. Neurosci."},{"key":"2884_CR7","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1126\/science.aay0198","volume":"365","author":"B Zott","year":"2019","unstructured":"Zott, B. et al. A vicious cycle of beta amyloid-dependent neuronal hyperactivation. Science 365, 559\u2013565 (2019).","journal-title":"Science"},{"key":"2884_CR8","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/j.neuron.2020.06.023","volume":"107","author":"H Jun","year":"2020","unstructured":"Jun, H. et al. Disrupted place cell remapping and impaired grid cells in a knockin model of Alzheimer\u2019s Disease. Neuron 107, 1095\u20131112 e1096 (2020).","journal-title":"Neuron"},{"key":"2884_CR9","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.neurobiolaging.2020.08.013","volume":"96","author":"JL Klee","year":"2020","unstructured":"Klee, J. L., Kiliaan, A. J., Lipponen, A. & Battaglia, F. P. Reduced firing rates of pyramidal cells in the frontal cortex of APP\/PS1 can be restored by acute treatment with levetiracetam. Neurobiol. Aging 96, 79\u201386 (2020).","journal-title":"Neurobiol. Aging"},{"key":"2884_CR10","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s13024-017-0228-2","volume":"12","author":"Y Bai","year":"2017","unstructured":"Bai, Y. et al. Abnormal dendritic calcium activity and synaptic depotentiation occur early in a mouse model of Alzheimer\u2019s disease. Mol. Neurodegener. 12, 86 (2017).","journal-title":"Mol. Neurodegener."},{"key":"2884_CR11","doi-asserted-by":"publisher","first-page":"7852","DOI":"10.1523\/JNEUROSCI.5901-11.2012","volume":"32","author":"J Brouillette","year":"2012","unstructured":"Brouillette, J. et al. Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-beta1-42 oligomers are revealed in vivo by using a novel animal model. J. Neurosci. 32, 7852\u20137861 (2012).","journal-title":"J. Neurosci."},{"key":"2884_CR12","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1126\/science.1242077","volume":"341","author":"T Kim","year":"2013","unstructured":"Kim, T. et al. Human LilrB2 is a beta-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer\u2019s model. Science 341, 1399\u20131404 (2013).","journal-title":"Science"},{"key":"2884_CR13","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.neuron.2010.04.029","volume":"66","author":"M Renner","year":"2010","unstructured":"Renner, M. et al. Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5. Neuron 66, 739\u2013754 (2010).","journal-title":"Neuron"},{"key":"2884_CR14","doi-asserted-by":"publisher","first-page":"6627","DOI":"10.1523\/JNEUROSCI.0203-11.2011","volume":"31","author":"S Li","year":"2011","unstructured":"Li, S. et al. Soluble Abeta oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors. J. Neurosci. 31, 6627\u20136638 (2011).","journal-title":"J. Neurosci."},{"key":"2884_CR15","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1038\/nm1782","volume":"14","author":"GM Shankar","year":"2008","unstructured":"Shankar, G. M. et al. Amyloid-beta protein dimers isolated directly from Alzheimer\u2019s brains impair synaptic plasticity and memory. Nat. Med 14, 837\u2013842 (2008).","journal-title":"Nat. Med"},{"key":"2884_CR16","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1038\/mp.2013.122","volume":"19","author":"S Liebscher","year":"2014","unstructured":"Liebscher, S. et al. Chronic gamma-secretase inhibition reduces amyloid plaque-associated instability of pre- and postsynaptic structures. Mol. Psychiatry 19, 937\u2013946 (2014).","journal-title":"Mol. Psychiatry"},{"key":"2884_CR17","doi-asserted-by":"publisher","first-page":"8740","DOI":"10.1073\/pnas.1206171109","volume":"109","author":"MA Busche","year":"2012","unstructured":"Busche, M. A. et al. Critical role of soluble amyloid-beta for early hippocampal hyperactivity in a mouse model of Alzheimer\u2019s disease. Proc. Natl Acad. Sci. USA 109, 8740\u20138745 (2012).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2884_CR18","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.ceca.2009.12.010","volume":"47","author":"E Alberdi","year":"2010","unstructured":"Alberdi, E. et al. Amyloid beta oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors. Cell Calcium 47, 264\u2013272 (2010).","journal-title":"Cell Calcium"},{"key":"2884_CR19","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1038\/nn.2213","volume":"11","author":"RO Sanchez-Mejia","year":"2008","unstructured":"Sanchez-Mejia, R. O. et al. Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer\u2019s disease. Nat. Neurosci. 11, 1311\u20131318 (2008).","journal-title":"Nat. Neurosci."},{"key":"2884_CR20","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1038\/nn.2433","volume":"12","author":"E Abramov","year":"2009","unstructured":"Abramov, E. et al. Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses. Nat. Neurosci. 12, 1567\u20131576 (2009).","journal-title":"Nat. Neurosci."},{"key":"2884_CR21","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/j.neuron.2009.05.012","volume":"62","author":"S Li","year":"2009","unstructured":"Li, S. et al. Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake. Neuron 62, 788\u2013801 (2009).","journal-title":"Neuron"},{"key":"2884_CR22","doi-asserted-by":"publisher","first-page":"E1279","DOI":"10.1073\/pnas.1714409115","volume":"115","author":"C Lerdkrai","year":"2018","unstructured":"Lerdkrai, C. et al. Intracellular Ca(2+) stores control in vivo neuronal hyperactivity in a mouse model of Alzheimer\u2019s disease. Proc. Natl Acad. Sci. USA 115, E1279\u2013E1288 (2018).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2884_CR23","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/j.cub.2016.01.070","volume":"26","author":"S Liebscher","year":"2016","unstructured":"Liebscher, S., Keller, G. B., Goltstein, P. M., Bonhoeffer, T. & Hubener, M. Selective persistence of sensorimotor mismatch signals in visual cortex of behaving Alzheimer\u2019s disease mice. Curr. Biol. 26, 956\u2013964 (2016).","journal-title":"Curr. Biol."},{"key":"2884_CR24","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.neuron.2016.08.034","volume":"92","author":"LC Schmid","year":"2016","unstructured":"Schmid, L. C. et al. Dysfunction of somatostatin-positive interneurons associated with memory deficits in an Alzheimer\u2019s disease model. Neuron 92, 114\u2013125 (2016).","journal-title":"Neuron"},{"key":"2884_CR25","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1126\/science.aad3358","volume":"352","author":"T Rose","year":"2016","unstructured":"Rose, T., Jaepel, J., Hubener, M. & Bonhoeffer, T. Cell-specific restoration of stimulus preference after monocular deprivation in the visual cortex. Science 352, 1319\u20131322 (2016).","journal-title":"Science"},{"key":"2884_CR26","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/nature12354","volume":"499","author":"TW Chen","year":"2013","unstructured":"Chen, T. W. et al. Ultrasensitive fluorescent proteins for imaging neuronal activity. Nature 499, 295\u2013300 (2013).","journal-title":"Nature"},{"key":"2884_CR27","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1038\/sj.embor.7400784","volume":"7","author":"R Radde","year":"2006","unstructured":"Radde, R. et al. Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. EMBO Rep. 7, 940\u2013946 (2006).","journal-title":"EMBO Rep."},{"key":"2884_CR28","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/s00401-010-0787-6","volume":"121","author":"S Burgold","year":"2011","unstructured":"Burgold, S. et al. In vivo multiphoton imaging reveals gradual growth of newborn amyloid plaques over weeks. Acta Neuropathol. 121, 327\u2013335 (2011).","journal-title":"Acta Neuropathol."},{"key":"2884_CR29","doi-asserted-by":"publisher","first-page":"595","DOI":"10.15252\/emmm.201606210","volume":"8","author":"DJ Selkoe","year":"2016","unstructured":"Selkoe, D. J. & Hardy, J. The amyloid hypothesis of Alzheimer\u2019s disease at 25 years. EMBO Mol. Med 8, 595\u2013608 (2016).","journal-title":"EMBO Mol. Med"},{"key":"2884_CR30","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3389\/fpsyt.2012.00026","volume":"3","author":"S Liebscher","year":"2012","unstructured":"Liebscher, S. & Meyer-Luehmann, M. A peephole into the brain: neuropathological features of Alzheimer\u2019s disease revealed by in vivo two-photon imaging. Front Psychiatry 3, 26 (2012).","journal-title":"Front Psychiatry"},{"key":"2884_CR31","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1126\/science.1169096","volume":"323","author":"KV Kuchibhotla","year":"2009","unstructured":"Kuchibhotla, K. V., Lattarulo, C. R., Hyman, B. T. & Bacskai, B. J. Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice. Science 323, 1211\u20131215 (2009).","journal-title":"Science"},{"key":"2884_CR32","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.neuron.2008.06.008","volume":"59","author":"KV Kuchibhotla","year":"2008","unstructured":"Kuchibhotla, K. V. et al. Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks. Neuron 59, 214\u2013225 (2008).","journal-title":"Neuron"},{"key":"2884_CR33","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s00401-013-1137-2","volume":"126","author":"JF McCarter","year":"2013","unstructured":"McCarter, J. F. et al. Clustering of plaques contributes to plaque growth in a mouse model of Alzheimer\u2019s disease. Acta neuropathologica 126, 179\u2013188 (2013).","journal-title":"Acta neuropathologica"},{"key":"2884_CR34","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1038\/nature06616","volume":"451","author":"M Meyer-Luehmann","year":"2008","unstructured":"Meyer-Luehmann, M. et al. Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer\u2019s disease. Nature 451, 720\u2013724 (2008).","journal-title":"Nature"},{"key":"2884_CR35","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1007\/s00401-017-1804-9","volume":"135","author":"F Peters","year":"2018","unstructured":"Peters, F. et al. BACE1 inhibition more effectively suppresses initiation than progression of beta-amyloid pathology. Acta Neuropathol. 135, 695\u2013710 (2018).","journal-title":"Acta Neuropathol."},{"key":"2884_CR36","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1038\/nature07150","volume":"454","author":"JF Poulet","year":"2008","unstructured":"Poulet, J. F. & Petersen, C. C. Internal brain state regulates membrane potential synchrony in barrel cortex of behaving mice. Nature 454, 881\u2013885 (2008).","journal-title":"Nature"},{"key":"2884_CR37","doi-asserted-by":"publisher","first-page":"e0118277","DOI":"10.1371\/journal.pone.0118277","volume":"10","author":"PM Goltstein","year":"2015","unstructured":"Goltstein, P. M., Montijn, J. S. & Pennartz, C. M. Effects of isoflurane anesthesia on ensemble patterns of Ca2+ activity in mouse v1: reduced direction selectivity independent of increased correlations in cellular activity. PLoS ONE 10, e0118277 (2015).","journal-title":"PLoS ONE"},{"key":"2884_CR38","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3389\/fncel.2016.00064","volume":"10","author":"T Lissek","year":"2016","unstructured":"Lissek, T. et al. General anesthetic conditions induce network synchrony and disrupt sensory processing in the cortex. Front Cell Neurosci. 10, 64 (2016).","journal-title":"Front Cell Neurosci."},{"key":"2884_CR39","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/nature11665","volume":"493","author":"B Haider","year":"2013","unstructured":"Haider, B., Hausser, M. & Carandini, M. Inhibition dominates sensory responses in the awake cortex. Nature 493, 97\u2013100 (2013).","journal-title":"Nature"},{"key":"2884_CR40","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.cell.2016.01.046","volume":"165","author":"KB Hengen","year":"2016","unstructured":"Hengen, K. B., Torrado Pacheco, A., McGregor, J. N., Van Hooser, S. D. & Turrigiano, G. G. Neuronal firing rate homeostasis is inhibited by sleep and promoted by wake. Cell 165, 180\u2013191 (2016).","journal-title":"Cell"},{"key":"2884_CR41","doi-asserted-by":"publisher","first-page":"15208","DOI":"10.1523\/JNEUROSCI.1747-14.2014","volume":"34","author":"TJ Ellender","year":"2014","unstructured":"Ellender, T. J., Raimondo, J. V., Irkle, A., Lamsa, K. P. & Akerman, C. J. Excitatory effects of parvalbumin-expressing interneurons maintain hippocampal epileptiform activity via synchronous afterdischarges. J. Neurosci. 34, 15208\u201315222 (2014).","journal-title":"J. Neurosci."},{"key":"2884_CR42","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/0896-6273(91)90170-5","volume":"6","author":"E Masliah","year":"1991","unstructured":"Masliah, E. et al. Patterns of aberrant sprouting in Alzheimer\u2019s disease. Neuron 6, 729\u2013739 (1991).","journal-title":"Neuron"},{"key":"2884_CR43","doi-asserted-by":"publisher","first-page":"e13788","DOI":"10.1371\/journal.pone.0013788","volume":"5","author":"EJ Sanz-Arigita","year":"2010","unstructured":"Sanz-Arigita, E. J. et al. Loss of \u2018small-world\u2019 networks in Alzheimer\u2019s disease: graph analysis of FMRI resting-state functional connectivity. PLoS ONE 5, e13788 (2010).","journal-title":"PLoS ONE"},{"key":"2884_CR44","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-43024-w","volume":"9","author":"J Burgold","year":"2019","unstructured":"Burgold, J. et al. Cortical circuit alterations precede motor impairments in Huntington\u2019s disease mice. Sci. Rep. 9, 6634 (2019).","journal-title":"Sci. Rep."},{"key":"2884_CR45","doi-asserted-by":"publisher","first-page":"7278","DOI":"10.1523\/JNEUROSCI.1879-05.2005","volume":"25","author":"TL Spires","year":"2005","unstructured":"Spires, T. L. et al. Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. J. Neurosci. 25, 7278\u20137287 (2005).","journal-title":"J. Neurosci."},{"key":"2884_CR46","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1196\/annals.1379.003","volume":"1097","author":"J Grutzendler","year":"2007","unstructured":"Grutzendler, J., Helmin, K., Tsai, J. & Gan, W. B. Various dendritic abnormalities are associated with fibrillar amyloid deposits in Alzheimer\u2019s disease. Ann. N. Y Acad. Sci. 1097, 30\u201339 (2007).","journal-title":"Ann. N. Y Acad. Sci."},{"key":"2884_CR47","doi-asserted-by":"publisher","first-page":"e0119768","DOI":"10.1371\/journal.pone.0119768","volume":"10","author":"CK Jung","year":"2015","unstructured":"Jung, C. K., Keppler, K., Steinbach, S., Blazquez-Llorca, L. & Herms, J. Fibrillar amyloid plaque formation precedes microglial activation. PLoS ONE 10, e0119768 (2015).","journal-title":"PLoS ONE"},{"key":"2884_CR48","doi-asserted-by":"publisher","first-page":"4012","DOI":"10.1073\/pnas.0811698106","volume":"106","author":"RM Koffie","year":"2009","unstructured":"Koffie, R. M. et al. Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques. Proc. Natl Acad. Sci. USA 106, 4012\u20134017 (2009).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2884_CR49","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1126\/science.aab1687","volume":"349","author":"A Wertz","year":"2015","unstructured":"Wertz, A. et al. PRESYNAPTIC NETWORKS. Single-cell-initiated monosynaptic tracing reveals layer-specific cortical network modules. Science 349, 70\u201374 (2015).","journal-title":"Science"},{"key":"2884_CR50","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.neuron.2017.11.028","volume":"97","author":"S Frere","year":"2018","unstructured":"Frere, S. & Slutsky, I. Alzheimer\u2019s disease: from firing instability to homeostasis network collapse. Neuron 97, 32\u201358 (2018).","journal-title":"Neuron"},{"key":"2884_CR51","doi-asserted-by":"publisher","first-page":"6778","DOI":"10.1523\/JNEUROSCI.0618-17.2017","volume":"37","author":"A Joseph","year":"2017","unstructured":"Joseph, A. & Turrigiano, G. G. All for one but not one for all: excitatory synaptic scaling and intrinsic excitability are coregulated by CaMKIV, whereas inhibitory synaptic scaling is under independent control. J. Neurosci. 37, 6778\u20136785 (2017).","journal-title":"J. Neurosci."},{"key":"2884_CR52","doi-asserted-by":"crossref","unstructured":"Sebastian Monasor, L. et al. Fibrillar abeta triggers microglial proteome alterations and dysfunction in Alzheimer mouse models. Elife 9, e54083 (2020).","DOI":"10.7554\/eLife.54083"},{"key":"2884_CR53","doi-asserted-by":"publisher","first-page":"583","DOI":"10.15252\/embj.201694591","volume":"36","author":"A Daria","year":"2017","unstructured":"Daria, A. et al. Young microglia restore amyloid plaque clearance of aged microglia. EMBO J. 36, 583\u2013603 (2017).","journal-title":"EMBO J."},{"key":"2884_CR54","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1093\/jnen\/61.9.797","volume":"61","author":"WE Klunk","year":"2002","unstructured":"Klunk, W. E. et al. Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J. Neuropathol. Exp. Neurol. 61, 797\u2013805 (2002).","journal-title":"J. Neuropathol. Exp. Neurol."}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-021-02884-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-021-02884-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-021-02884-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T04:56:28Z","timestamp":1676004988000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-021-02884-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,7]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["2884"],"URL":"https:\/\/doi.org\/10.1038\/s42003-021-02884-7","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,7]]},"assertion":[{"value":"11 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1368"}}