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Here we quantify movement in response to sudden darkness in larvae of two\n                    <jats:italic>shank3<\/jats:italic>\n                    zebrafish mutant models and show that both models exhibit dampened responses to this stimulus. Using brain-wide activity mapping, we find that\n                    <jats:italic>shank3<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    light-sensing brain regions show normal levels of activity while sensorimotor integration and motor regions are less active. Specifically restoring Shank3 function in a sensorimotor nucleus of the rostral brainstem enables the\n                    <jats:italic>shank3<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    model to respond like wild-type. In sum, we find that reduced sensory responsiveness in\n                    <jats:italic>shank3<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    models is associated with reduced activity in sensory processing brain regions and can be rescued by restoring Shank3 function in the rostral brainstem. These studies highlight the importance of Shank3 function in the rostral brainstem for integrating sensory inputs to generate behavioral adaptations to changing sensory stimuli.\n                  <\/jats:p>","DOI":"10.1038\/s42003-021-02920-6","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T06:14:56Z","timestamp":1639721696000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Restoring Shank3 in the rostral brainstem of shank3ab\u2212\/\u2212 zebrafish autism models rescues sensory deficits"],"prefix":"10.1038","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5320-1453","authenticated-orcid":false,"given":"Robert A.","family":"Kozol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Varela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sureni H.","family":"Sumathipala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8498-5235","authenticated-orcid":false,"given":"Stephan","family":"Z\u00fcchner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5839-807X","authenticated-orcid":false,"given":"Julia E.","family":"Dallman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,17]]},"reference":[{"key":"2920_CR1","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nrn.2017.112","volume":"18","author":"CE Robertson","year":"2017","unstructured":"Robertson, C. 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