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To investigate the artemisinin resistance mechanism, transcriptome analysis was conducted of 577\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    isolates collected in the GMS between 2016\u20132018. A specific artemisinin resistance-associated transcriptional profile was identified that involves a broad but discrete set of biological functions related to proteotoxic stress, host cytoplasm remodelling, and REDOX metabolism. The artemisinin resistance-associated transcriptional profile evolved from initial transcriptional responses of susceptible parasites to artemisinin. The genetic basis for this adapted response is likely to be complex.\n                  <\/jats:p>","DOI":"10.1038\/s42003-022-03215-0","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T06:22:53Z","timestamp":1648448573000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response"],"prefix":"10.1038","volume":"5","author":[{"given":"Lei","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob W.","family":"van der Pluijm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1505-5608","authenticated-orcid":false,"given":"Michal","family":"Kucharski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sourav","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaishree","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas P. 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