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We re-assessed diverse\n                    <jats:italic>SrC<\/jats:italic>\n                    from European horseshoe bats and analyzed the spike-encoding genomic region harboring the FCS in SARS-CoV-2. We reveal molecular features in\n                    <jats:italic>SrC<\/jats:italic>\n                    such as purine richness and RNA secondary structures that resemble those required for FCS acquisition in avian influenza viruses. We discuss the potential acquisition of FCS through molecular mechanisms such as nucleotide substitution, insertion, or recombination, and show that a single nucleotide exchange in two European bat-associated\n                    <jats:italic>SrC<\/jats:italic>\n                    may suffice to enable furin cleavage. Furthermore, we show that FCS occurrence is variable in bat- and rodent-borne counterparts of human coronaviruses. Our results suggest that furin cleavage sites can be acquired in\n                    <jats:italic>SrC<\/jats:italic>\n                    via conserved molecular mechanisms known in other reservoir-bound RNA viruses and thus support a natural origin of SARS-CoV-2.\n                  <\/jats:p>","DOI":"10.1038\/s42003-022-03421-w","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T06:04:00Z","timestamp":1653890640000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Genomic determinants of Furin cleavage in diverse European SARS-related bat coronaviruses"],"prefix":"10.1038","volume":"5","author":[{"given":"Anna-Lena","family":"Sander","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9224-5157","authenticated-orcid":false,"given":"Andres","family":"Moreira-Soto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stoian","family":"Yordanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Toplak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8049-6645","authenticated-orcid":false,"given":"Andrea","family":"Balboni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n Seage","family":"Ameneiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3605-0136","authenticated-orcid":false,"given":"Victor","family":"Corman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7923-0519","authenticated-orcid":false,"given":"Christian","family":"Drosten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3509-0232","authenticated-orcid":false,"given":"Jan Felix","family":"Drexler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,30]]},"reference":[{"key":"3421_CR1","doi-asserted-by":"publisher","first-page":"veab020","DOI":"10.1093\/ve\/veab020","volume":"7","author":"WK Jo","year":"2021","unstructured":"Jo, W. 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