{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:24:58Z","timestamp":1793147098053,"version":"4.5.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Phenol-soluble modulin \u03b1 (PSM\u03b1) is identified as potent virulence factors in\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (\n                    <jats:italic>S. aureus<\/jats:italic>\n                    ) infections. Very little is known about the role of PSM\u03b2 which belongs to the same toxin family. Here we compared the role of PSMs in\n                    <jats:italic>S. aureus<\/jats:italic>\n                    -induced septic arthritis in a murine model using three isogenic\n                    <jats:italic>S. aureus<\/jats:italic>\n                    strains differing in the expression of PSMs (Newman, \u0394\n                    <jats:italic>psm\u03b1<\/jats:italic>\n                    , and \u0394\n                    <jats:italic>psm\u03b2<\/jats:italic>\n                    ). The effects of PSMs on neutrophil NADPH-oxidase activity were determined in vitro. We show that the PSM\u03b1 activates neutrophils via the formyl peptide receptor (FPR) 2 and reduces their NADPH-oxidase activity in response to the phorbol ester PMA. Despite being a poor neutrophil activator, PSM\u03b2 has the ability to reduce the neutrophil activating effect of PSM\u03b1 and to partly reverse the effect of PSM\u03b1 on the neutrophil response to PMA. Mice infected with\n                    <jats:italic>S. aureus<\/jats:italic>\n                    lacking PSM\u03b1 had better weight development and lower bacterial burden in the kidneys compared to mice infected with the parental strain, whereas mice infected with bacteria lacking PSM\u03b2 strain developed more severe septic arthritis accompanied with higher IL-6 and KC. We conclude that PSM\u03b1 and PSM\u03b2 play distinct roles in septic arthritis: PSM\u03b1 aggravates systemic infection, whereas PSM\u03b2 protects arthritis development.\n                  <\/jats:p>","DOI":"10.1038\/s42003-022-03839-2","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T10:03:04Z","timestamp":1662372184000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Phenol-soluble modulin \u03b1 and \u03b2 display divergent roles in mice with staphylococcal septic arthritis"],"prefix":"10.1038","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3899-0711","authenticated-orcid":false,"given":"Zhicheng","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3941-748X","authenticated-orcid":false,"given":"Pradeep Kumar","family":"Kopparapu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Ebner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3672-2991","authenticated-orcid":false,"given":"Majd","family":"Mohammad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Lind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Jarneborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claes","family":"Dahlgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5798-7593","authenticated-orcid":false,"given":"Michelle","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghshree","family":"Deshmukh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5383-9817","authenticated-orcid":false,"given":"Rille","family":"Pullerits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mulugeta","family":"Nega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6510-0684","authenticated-orcid":false,"given":"Minh-Thu","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huamei","family":"Forsman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2042-0518","authenticated-orcid":false,"given":"Friedrich","family":"G\u00f6tz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9039-0628","authenticated-orcid":false,"given":"Tao","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,5]]},"reference":[{"key":"3839_CR1","doi-asserted-by":"publisher","first-page":"e0171222","DOI":"10.1371\/journal.pone.0171222","volume":"12","author":"F Fatima","year":"2017","unstructured":"Fatima, F. et al. 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