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However, the underlying epigenetic mechanisms which reflect these gene-environment interactions are poorly studied. Herein, we measure genome-wide DNA methylation profiles of post-mortem brain tissue (Broadmann area 7) from 15 pathologically confirmed DLB brains and compare them with 16 cognitively normal controls using Illumina MethylationEPIC arrays. We identify 17 significantly differentially methylated CpGs (DMCs) and 17 differentially methylated regions (DMRs) between the groups. The DMCs are mainly located at the CpG islands, promoter and first exon regions. Genes associated with the DMCs are linked to \u201cParkinson\u2019s disease\u201d and \u201cmetabolic pathway\u201d, as well as the diseases of \u201csevere intellectual disability\u201d and \u201cmood disorders\u201d. Overall, our study highlights previously unreported DMCs offering insights into DLB pathogenesis with the possibility that some of these could be used as biomarkers of DLB in the future.<\/jats:p>","DOI":"10.1038\/s42003-022-03965-x","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T17:57:49Z","timestamp":1669312669000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dementia with Lewy bodies post-mortem brains reveal differentially methylated CpG sites with biomarker potential"],"prefix":"10.1038","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3044-621X","authenticated-orcid":false,"given":"Xiaojian","family":"Shao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5681-5143","authenticated-orcid":false,"given":"Sangeetha","family":"Vishweswaraiah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miroslava","family":"\u010cuperlovi\u0107-Culf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2427-5696","authenticated-orcid":false,"given":"Celia M. 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