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Sporogony is metabolically demanding, and successful oocyst maturation is dependent on host lipids. In insects, lipid energy reserves are mobilized by adipokinetic hormones (AKHs). We hypothesized that <jats:italic>Plasmodium falciparum<\/jats:italic> infection activates <jats:italic>Anopheles gambiae<\/jats:italic> AKH signaling and lipid mobilization. We profiled the expression patterns of AKH pathway genes and <jats:italic>Ag<\/jats:italic>Akh1 peptide levels in <jats:italic>An. gambiae<\/jats:italic> during starvation, after blood feeding, and following infection and observed a significant time-dependent up-regulation of AKH pathway genes and peptide levels\u00a0during infection. Depletion of <jats:italic>AgAkh1<\/jats:italic> and <jats:italic>AgAkhR<\/jats:italic> by RNAi reduced salivary gland sporozoite production, while synthetic <jats:italic>Ag<\/jats:italic>Akh1 peptide supplementation rescued sporozoite numbers. Inoculation of uninfected female mosquitoes with supernatant from <jats:italic>P. falciparum-<\/jats:italic>infected midguts activated AKH signaling. Clearly, identifying the parasite molecules mediating AKH signaling in <jats:italic>P. falciparum<\/jats:italic> sporogony is paramount.<\/jats:p>","DOI":"10.1038\/s42003-023-04518-6","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T17:03:35Z","timestamp":1676307815000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Adipokinetic hormone signaling in the malaria vector Anopheles gambiae facilitates Plasmodium falciparum sporogony"],"prefix":"10.1038","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8018-5687","authenticated-orcid":false,"given":"Vincent O.","family":"Nyasembe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8670-3721","authenticated-orcid":false,"given":"Timothy","family":"Hamerly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borja","family":"L\u00f3pez-Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra M.","family":"Leyte-Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Coatsworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5433-8179","authenticated-orcid":false,"given":"Rhoel R.","family":"Dinglasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,13]]},"reference":[{"key":"4518_CR1","unstructured":"World Health Organization, \u201cWorld Malaria Report 2018\u201d (2018)."},{"key":"4518_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1017\/S0031182000050824","volume":"86","author":"RE Sinden","year":"1983","unstructured":"Sinden, R. 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