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Oppenheimer Trust."},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The Stone Age record of South Africa provides some of the earliest evidence for the biological and cultural origins of\n                    <jats:italic>Homo sapiens<\/jats:italic>\n                    . While there is extensive genomic evidence for the selection of polymorphisms in response to pathogen-pressure in sub-Saharan Africa, e.g., the sickle cell trait which provides protection against malaria, there is inadequate direct human genomic evidence for ancient human-pathogen infection in the region. Here, we analysed shotgun metagenome libraries derived from the sequencing of a Later Stone Age hunter-gatherer child who lived near Ballito Bay, South Africa,\n                    <jats:italic>c<\/jats:italic>\n                    . 2000 years ago. This resulted in the identification of ancient DNA sequence reads homologous to\n                    <jats:italic>Rickettsia felis<\/jats:italic>\n                    , the causative agent of typhus-like flea-borne rickettsioses, and the reconstruction of an ancient\n                    <jats:italic>R. felis<\/jats:italic>\n                    genome.\n                  <\/jats:p>","DOI":"10.1038\/s42003-023-04582-y","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T10:02:50Z","timestamp":1677837770000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Rickettsia felis DNA recovered from a child who lived in southern Africa 2000 years ago"],"prefix":"10.1038","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1791-3706","authenticated-orcid":false,"given":"Riaan F.","family":"Rifkin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4721-2890","authenticated-orcid":false,"given":"Surendra","family":"Vikram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Alcorta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4790-6232","authenticated-orcid":false,"given":"Jean-Baptiste","family":"Ramond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8059-861X","authenticated-orcid":false,"given":"Don A.","family":"Cowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7840-7853","authenticated-orcid":false,"given":"Mattias","family":"Jakobsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8160-9621","authenticated-orcid":false,"given":"Carina M.","family":"Schlebusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0675-0414","authenticated-orcid":false,"given":"Marlize","family":"Lombard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"key":"4582_CR1","doi-asserted-by":"publisher","unstructured":"Mounier, A. et al. 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