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Recently, biosynthesis and biodegradation of phenols has attracted increasing attention, while phenols\u2019 toxicity is a major issue. Here, we evolved phloroglucinol-tolerant\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    strains via adaptive evolution, and three mutations (\u0394\n                    <jats:italic>sodB<\/jats:italic>\n                    , \u0394\n                    <jats:italic>clpX<\/jats:italic>\n                    and\n                    <jats:italic>fetAB<\/jats:italic>\n                    overexpression) prove of great assistance in the tolerance improvement. We discover that phloroglucinol complexes with iron and promotes the generation of hydroxyl radicals in Fenton reaction, which leads to reducing power depletion, lipid peroxidation, and ferroptosis-like cell death of\n                    <jats:italic>E. coli<\/jats:italic>\n                    . Besides phloroglucinol, various phenols can trigger ferroptosis-like death in diverse organisms, from bacteria to mammalian cells. Furthermore, repressing this ferroptosis-like death improves phloroglucinol production and phenol degradation by corresponding strains respectively, showing great application potential in microbial degradation or production of desired phenolic compounds, and phloroglucinol-induced ferroptosis suppresses tumor growth in mice, indicating phloroglucinol as a promising drug for cancer treatment.\n                  <\/jats:p>","DOI":"10.1038\/s42003-024-05903-5","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T08:02:03Z","timestamp":1708156923000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Phenolic compounds induce ferroptosis-like death by promoting hydroxyl radical generation in the Fenton reaction"],"prefix":"10.1038","volume":"7","author":[{"given":"Xinyue","family":"Sui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jichao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjun","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxin","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5244-870X","authenticated-orcid":false,"given":"Shengying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9015-4561","authenticated-orcid":false,"given":"Qingsheng","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mo","family":"Xian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0002-5972","authenticated-orcid":false,"given":"Guang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,17]]},"reference":[{"key":"5903_CR1","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.apcata.2004.08.030","volume":"280","author":"RJ Schmidt","year":"2005","unstructured":"Schmidt, R. 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