{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:12:48Z","timestamp":1792066368651,"version":"4.4.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:00:00Z","timestamp":1712620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:00:00Z","timestamp":1712620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The study aims to explore the effect of PPAR\u03b3 signaling on ferroptosis and preeclampsia (PE) development. Serum and placental tissue are collected from healthy subjects and PE patients. The PPAR\u03b3 and Nrf2 decreases in the PE. Rosiglitazone intervention reverses hypoxia-induced trophoblast ferroptosis and decreases lipid synthesis by regulating Nfr2 and SREBP1. Compared to the Hypoxia group, the migratory and invasive abilities enhance after rosiglitazone and ferr1 treatment. Rosiglitazone reduces the effect of hypoxia and erastin. The si-Nrf2 treatment attenuats the effects of rosiglitazone on proliferation, migration, and invasion. The si-Nrf2 does not affect SREBP1 expression. PPAR\u03b3 agonists alleviates ferroptosis in the placenta of the PE rats. The study confirms that PPAR\u03b3 signaling and ferroptosis-related indicators were dysregulated in PE. PPAR\u03b3\/Nrf2 signaling affects ferroptosis by regulating lipid oxidation rather than SREBP1-mediated lipid synthesis. In conclusion, our study find that PPAR\u03b3 can alleviate PE development by regulating lipid oxidation and ferroptosis.<\/jats:p>","DOI":"10.1038\/s42003-024-06063-2","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T15:02:23Z","timestamp":1712674943000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["PPAR\u03b3 alleviates preeclampsia development by regulating lipid metabolism and ferroptosis"],"prefix":"10.1038","volume":"7","author":[{"given":"Weisi","family":"Lai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9228-4052","authenticated-orcid":false,"given":"Yali","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,9]]},"reference":[{"key":"6063_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/ijgo.12802","volume":"145","author":"LC Poon","year":"2019","unstructured":"Poon, L. C. et al. The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: a pragmatic guide for first-trimester screening and prevention. Int J. Gynaecol. Obstet. 145, 1\u201333 (2019).","journal-title":"Int J. Gynaecol. Obstet."},{"key":"6063_CR2","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.preghy.2018.05.004","volume":"13","author":"MA Brown","year":"2018","unstructured":"Brown, M. A. et al. The hypertensive disorders of pregnancy: ISSHP classification, diagnosis & management recommendations for international practice. Pregnancy Hypertens. 13, 291\u2013310 (2018).","journal-title":"Pregnancy Hypertens."},{"key":"6063_CR3","doi-asserted-by":"publisher","first-page":"F1315","DOI":"10.1152\/ajprenal.00071.2020","volume":"318","author":"HR Turbeville","year":"2020","unstructured":"Turbeville, H. R. & Sasser, J. M. Preeclampsia beyond pregnancy: long-term consequences for mother and child. Am. J. Physiol. Ren. Physiol. 318, F1315\u2013f1326 (2020).","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"6063_CR4","doi-asserted-by":"publisher","first-page":"11202","DOI":"10.3390\/ijms222011202","volume":"22","author":"K Hong","year":"2021","unstructured":"Hong, K. et al. Defective uteroplacental vascular remodeling in preeclampsia: key molecular factors leading to long term cardiovascular disease. Int J. Mol. Sci. 22, 11202 (2021).","journal-title":"Int J. Mol. Sci."},{"key":"6063_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jri.2019.07.004","volume":"134-135","author":"AC Staff","year":"2019","unstructured":"Staff, A. C. The two-stage placental model of preeclampsia: an update. J. Reprod. Immunol. 134\u2013135, 1\u201310 (2019).","journal-title":"J. Reprod. Immunol."},{"key":"6063_CR6","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s11906-017-0757-7","volume":"19","author":"LM Amaral","year":"2017","unstructured":"Amaral, L. M. et al. Pathophysiology and current clinical management of preeclampsia. Curr. Hypertens. Rep. 19, 61 (2017).","journal-title":"Curr. Hypertens. Rep."},{"key":"6063_CR7","doi-asserted-by":"publisher","first-page":"786","DOI":"10.2174\/1389201019666180925120109","volume":"19","author":"W Dymara-Konopka","year":"2018","unstructured":"Dymara-Konopka, W., Laskowska, M. & Oleszczuk, J. Preeclampsia - current management and future approach. Curr. Pharm. Biotechnol. 19, 786\u2013796 (2018).","journal-title":"Curr. Pharm. Biotechnol."},{"key":"6063_CR8","doi-asserted-by":"publisher","first-page":"100118","DOI":"10.1016\/j.jlr.2021.100118","volume":"62","author":"B He","year":"2021","unstructured":"He, B. et al. The maternal blood lipidome is indicative of the pathogenesis of severe preeclampsia. J. Lipid Res. 62, 100118 (2021).","journal-title":"J. Lipid Res."},{"key":"6063_CR9","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.3892\/etm.2021.10563","volume":"22","author":"J Dong","year":"2021","unstructured":"Dong, J. et al. Association between the levels of CGI-58 and lipoprotein lipase in the placenta of patients with preeclampsia. Exp. Ther. Med. 22, 1129 (2021).","journal-title":"Exp. Ther. Med."},{"key":"6063_CR10","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1097\/HJH.0000000000002596","volume":"39","author":"AA Khaire","year":"2021","unstructured":"Khaire, A. A. et al. Placental lipid metabolism in preeclampsia. J. Hypertens. 39, 127\u2013134 (2021).","journal-title":"J. Hypertens."},{"key":"6063_CR11","doi-asserted-by":"publisher","first-page":"482.e1","DOI":"10.1016\/j.ajog.2009.05.032","volume":"201","author":"A Wiznitzer","year":"2009","unstructured":"Wiznitzer, A. et al. Association of lipid levels during gestation with preeclampsia and gestational diabetes mellitus: a population-based study. Am. J. Obstet. Gynecol. 201, 482.e1\u20138 (2009).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"6063_CR12","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/S0002-9378(96)70336-8","volume":"174","author":"CA Hubel","year":"1996","unstructured":"Hubel, C. A. et al. Fasting serum triglycerides, free fatty acids, and malondialdehyde are increased in preeclampsia, are positively correlated, and decrease within 48\u2009h post partum. Am. J. Obstet. Gynecol. 174, 975\u2013982 (1996).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"6063_CR13","doi-asserted-by":"publisher","first-page":"115","DOI":"10.2147\/IJWH.S233029","volume":"12","author":"K Hessami","year":"2020","unstructured":"Hessami, K. et al. Association of maternal and umbilical cord blood lipid parameters with uterine and fetal-placental blood flow in hypertensive and normotensive pregnancies. Int. J. Women\u2019s Health 12, 115\u2013125 (2020).","journal-title":"Int. J. Women\u2019s Health"},{"key":"6063_CR14","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","volume":"171","author":"BR Stockwell","year":"2017","unstructured":"Stockwell, B. R. et al. Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell 171, 273\u2013285 (2017).","journal-title":"Cell"},{"key":"6063_CR15","doi-asserted-by":"publisher","first-page":"4576","DOI":"10.3390\/cancers13184576","volume":"13","author":"HY Lin","year":"2021","unstructured":"Lin, H. Y. et al. The evolving role of ferroptosis in breast cancer: translational implications present and future. Cancers (Basel) 13, 4576 (2021).","journal-title":"Cancers (Basel)"},{"key":"6063_CR16","doi-asserted-by":"publisher","first-page":"3052","DOI":"10.7150\/thno.54113","volume":"11","author":"X Wu","year":"2021","unstructured":"Wu, X. et al. Ferroptosis as a novel therapeutic target for cardiovascular disease. Theranostics 11, 3052\u20133059 (2021).","journal-title":"Theranostics"},{"key":"6063_CR17","doi-asserted-by":"publisher","first-page":"101890","DOI":"10.1016\/j.pneurobio.2020.101890","volume":"196","author":"L Mahoney-S\u00e1nchez","year":"2021","unstructured":"Mahoney-S\u00e1nchez, L. et al. Ferroptosis and its potential role in the physiopathology of Parkinson\u2019s Disease. Prog. Neurobiol. 196, 101890 (2021).","journal-title":"Prog. Neurobiol."},{"key":"6063_CR18","doi-asserted-by":"publisher","first-page":"3283","DOI":"10.3390\/ijms20133283","volume":"20","author":"SW Ng","year":"2019","unstructured":"Ng, S. W., Norwitz, S. G. & Norwitz, E. R. The impact of iron overload and ferroptosis on reproductive disorders in humans: implications for preeclampsia. Int. J. Mol. Sci. 20, 3283 (2019).","journal-title":"Int. J. Mol. Sci."},{"key":"6063_CR19","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1126\/science.1224577","volume":"338","author":"H Drakesmith","year":"2012","unstructured":"Drakesmith, H. & Prentice, A. M. Hepcidin and the iron-infection axis. Science 338, 768\u2013772 (2012).","journal-title":"Science"},{"key":"6063_CR20","doi-asserted-by":"publisher","first-page":"100814","DOI":"10.1016\/j.jbc.2021.100814","volume":"297","author":"W Kilu","year":"2021","unstructured":"Kilu, W. et al. Heterodimer formation with retinoic acid receptor RXR\u03b1 modulates coactivator recruitment by peroxisome proliferator-activated receptor PPAR\u03b3. J. Biol. Chem. 297, 100814 (2021).","journal-title":"J. Biol. Chem."},{"key":"6063_CR21","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.pneurobio.2017.10.002","volume":"163-164","author":"W Cai","year":"2018","unstructured":"Cai, W. et al. Peroxisome proliferator-activated receptor \u03b3 (PPAR\u03b3): a master gatekeeper in CNS injury and repair. Prog. Neurobiol. 163\u2013164, 27\u201358 (2018).","journal-title":"Prog. Neurobiol."},{"key":"6063_CR22","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-020-05029-x","volume":"13","author":"W Permadi","year":"2020","unstructured":"Permadi, W. et al. Differences in expression of peroxisome proliferator-activated receptor-\u03b3 in early-onset preeclampsia and late-onset preeclampsia. BMC Res. Notes 13, 181 (2020).","journal-title":"BMC Res. Notes"},{"key":"6063_CR23","doi-asserted-by":"publisher","first-page":"R201","DOI":"10.1530\/JME-17-0315","volume":"60","author":"J Pham","year":"2018","unstructured":"Pham, J. et al. The role of Sirtuin1-PPAR\u03b3 axis in placental development and function. J. Mol. Endocrinol. 60, R201\u2013r212 (2018).","journal-title":"J. Mol. Endocrinol."},{"key":"6063_CR24","doi-asserted-by":"publisher","first-page":"2172","DOI":"10.3390\/nu14102172","volume":"14","author":"A Abascal-Saiz","year":"2022","unstructured":"Abascal-Saiz, A. et al. The relationship between angiogenic factors and energy metabolism in preeclampsia. Nutrients 14, 2172 (2022).","journal-title":"Nutrients"},{"key":"6063_CR25","doi-asserted-by":"publisher","first-page":"101402","DOI":"10.1016\/j.redox.2019.101402","volume":"29","author":"H Zhang","year":"2020","unstructured":"Zhang, H. et al. miR-30-5p-mediated ferroptosis of trophoblasts is implicated in the pathogenesis of preeclampsia. Redox Biol. 29, 101402 (2020).","journal-title":"Redox Biol."},{"key":"6063_CR26","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.placenta.2022.09.014","volume":"129","author":"Y Deng","year":"2022","unstructured":"Deng, Y. et al. miR-2115-3p inhibits ferroptosis by downregulating the expression of glutamic-oxaloacetic transaminase in preeclampsia. Placenta 129, 94\u2013103 (2022).","journal-title":"Placenta"},{"key":"6063_CR27","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1161\/HYPERTENSIONAHA.111.172627","volume":"58","author":"FP McCarthy","year":"2011","unstructured":"McCarthy, F. P. et al. Peroxisome proliferator-activated receptor-\u03b3 as a potential therapeutic target in the treatment of preeclampsia. Hypertension 58, 280\u2013286 (2011).","journal-title":"Hypertension"},{"key":"6063_CR28","doi-asserted-by":"publisher","first-page":"101412","DOI":"10.1016\/j.redox.2019.101412","volume":"30","author":"L Li","year":"2020","unstructured":"Li, L. et al. Hepatocyte-specific Nrf2 deficiency mitigates high-fat diet-induced hepatic steatosis: involvement of reduced PPAR\u03b3 expression. Redox Biol. 30, 101412 (2020).","journal-title":"Redox Biol."},{"key":"6063_CR29","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.2337\/db06-0267","volume":"56","author":"B Askari","year":"2007","unstructured":"Askari, B. et al. Rosiglitazone inhibits acyl-CoA synthetase activity and fatty acid partitioning to diacylglycerol and triacylglycerol via a peroxisome proliferator-activated receptor-gamma-independent mechanism in human arterial smooth muscle cells and macrophages. Diabetes 56, 1143\u20131152 (2007).","journal-title":"Diabetes"},{"key":"6063_CR30","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.placenta.2018.03.003","volume":"69","author":"MH Schoots","year":"2018","unstructured":"Schoots, M. H. et al. Oxidative stress in placental pathology. Placenta 69, 153\u2013161 (2018).","journal-title":"Placenta"},{"key":"6063_CR31","doi-asserted-by":"publisher","first-page":"104919","DOI":"10.1016\/j.phrs.2020.104919","volume":"159","author":"Y Qiu","year":"2020","unstructured":"Qiu, Y. et al. The application of ferroptosis in diseases. Pharm. Res. 159, 104919 (2020).","journal-title":"Pharm. Res."},{"key":"6063_CR32","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.apsb.2021.10.005","volume":"12","author":"X Wang","year":"2022","unstructured":"Wang, X. et al. Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK\/NRF2 pathways. Acta Pharm. Sin. B 12, 708\u2013722 (2022).","journal-title":"Acta Pharm. Sin. B"},{"key":"6063_CR33","doi-asserted-by":"publisher","first-page":"869300","DOI":"10.3389\/fphar.2022.869300","volume":"13","author":"C Duan","year":"2022","unstructured":"Duan, C. et al. Activation of the PPAR\u03b3 prevents ferroptosis-induced neuronal loss in response to intracerebral hemorrhage through synergistic actions with the Nrf2. Front. Pharm. 13, 869300 (2022).","journal-title":"Front. Pharm."},{"key":"6063_CR34","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.freeradbiomed.2022.12.092","volume":"195","author":"B Zhang","year":"2023","unstructured":"Zhang, B. et al. Anesthetic propofol inhibits ferroptosis and aggravates distant cancer metastasis via Nrf2 upregulation. Free Radic. Biol. Med. 195, 298\u2013308 (2023).","journal-title":"Free Radic. Biol. Med."},{"key":"6063_CR35","doi-asserted-by":"publisher","first-page":"9926","DOI":"10.1073\/pnas.91.21.9926","volume":"91","author":"P Moi","year":"1994","unstructured":"Moi, P. et al. Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2\/AP1 repeat of the beta-globin locus control region. Proc. Natl Acad. Sci. USA 91, 9926\u20139930 (1994).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"6063_CR36","doi-asserted-by":"publisher","first-page":"320","DOI":"10.3390\/biom10020320","volume":"10","author":"S Kasai","year":"2020","unstructured":"Kasai, S. et al. Regulation of Nrf2 by mitochondrial reactive oxygen species in physiology and pathology. Biomolecules 10, 320 (2020).","journal-title":"Biomolecules"},{"key":"6063_CR37","doi-asserted-by":"publisher","first-page":"4777","DOI":"10.3390\/ijms21134777","volume":"21","author":"F He","year":"2020","unstructured":"He, F., Ru, X. & Wen, T. NRF2, a transcription factor for stress response and beyond. Int. J. Mol. Sci. 21, 4777 (2020).","journal-title":"Int. J. Mol. Sci."},{"key":"6063_CR38","doi-asserted-by":"publisher","first-page":"101107","DOI":"10.1016\/j.redox.2019.101107","volume":"23","author":"M Dodson","year":"2019","unstructured":"Dodson, M., Castro-Portuguez, R. & Zhang, D. D. NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis. Redox Biol. 23, 101107 (2019).","journal-title":"Redox Biol."},{"key":"6063_CR39","doi-asserted-by":"publisher","first-page":"115887","DOI":"10.1016\/j.ecoenv.2023.115887","volume":"270","author":"S Wu","year":"2023","unstructured":"Wu, S. et al. Effect of chronic noise exposure on glucose and lipid metabolism in mice via modulating gut microbiota and regulating CREB\/CRTC2 and SREBP1\/SCD pathway. Ecotoxicol. Environ. Saf. 270, 115887 (2023).","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"6063_CR40","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/s42255-022-00568-y","volume":"4","author":"C Cheng","year":"2022","unstructured":"Cheng, C. et al. Ammonia stimulates SCAP\/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth. Nat. Metab. 4, 575\u2013588 (2022).","journal-title":"Nat. Metab."},{"key":"6063_CR41","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.taap.2012.05.010","volume":"262","author":"KC Wu","year":"2012","unstructured":"Wu, K. C., Liu, J. & Klaassen, C. D. Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation. Toxicol. Appl Pharm. 262, 321\u2013329 (2012).","journal-title":"Toxicol. Appl Pharm."},{"key":"6063_CR42","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01804-z","volume":"22","author":"M Jiang","year":"2023","unstructured":"Jiang, M. et al. Exosome-mediated miR-144-3p promotes ferroptosis to inhibit osteosarcoma proliferation, migration, and invasion through regulating ZEB1. Mol. Cancer 22, 113 (2023).","journal-title":"Mol. Cancer"},{"key":"6063_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.canlet.2021.09.014","volume":"522","author":"Y Lu","year":"2021","unstructured":"Lu, Y. et al. KLF2 inhibits cancer cell migration and invasion by regulating ferroptosis through GPX4 in clear cell renal cell carcinoma. Cancer Lett. 522, 1\u201313 (2021).","journal-title":"Cancer Lett."},{"key":"6063_CR44","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.cell.2017.11.048","volume":"172","author":"I Ingold","year":"2018","unstructured":"Ingold, I. et al. Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis. Cell 172, 409\u2013422.e21 (2018).","journal-title":"Cell"},{"key":"6063_CR45","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","volume":"156","author":"WS Yang","year":"2014","unstructured":"Yang, W. S. et al. Regulation of ferroptotic cancer cell death by GPX4. Cell 156, 317\u2013331 (2014).","journal-title":"Cell"},{"key":"6063_CR46","doi-asserted-by":"publisher","first-page":"14841","DOI":"10.1074\/jbc.M513737200","volume":"281","author":"M Salazar","year":"2006","unstructured":"Salazar, M. et al. Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2. J. Biol. Chem. 281, 14841\u201314851 (2006).","journal-title":"J. Biol. Chem."},{"key":"6063_CR47","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.abb.2006.08.005","volume":"454","author":"WO Osburn","year":"2006","unstructured":"Osburn, W. O. et al. Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion. Arch. Biochem Biophys. 454, 7\u201315 (2006).","journal-title":"Arch. Biochem Biophys."},{"key":"6063_CR48","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03718-4","volume":"12","author":"Q Wang","year":"2021","unstructured":"Wang, Q. et al. GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2\/GPX4 axis. Cell Death Dis. 12, 426 (2021).","journal-title":"Cell Death Dis."},{"key":"6063_CR49","doi-asserted-by":"publisher","first-page":"107844","DOI":"10.1016\/j.intimp.2021.107844","volume":"98","author":"N Yan","year":"2021","unstructured":"Yan, N. et al. Dimethyl fumarate improves cognitive deficits in chronic cerebral hypoperfusion rats by alleviating inflammation, oxidative stress, and ferroptosis via NRF2\/ARE\/NF-\u03baB signal pathway. Int. Immunopharmacol. 98, 107844 (2021).","journal-title":"Int. Immunopharmacol."},{"key":"6063_CR50","doi-asserted-by":"publisher","first-page":"11334","DOI":"10.3390\/ijms222111334","volume":"22","author":"K Cheng","year":"2021","unstructured":"Cheng, K., Huang, Y. & Wang, C. 1,25(OH)(2)D(3) Inhibited ferroptosis in zebrafish liver cells (ZFL) by regulating keap1-Nrf2-GPx4 and NF-\u03baB-hepcidin axis. Int. J. Mol. Sci. 22, 11334 (2021).","journal-title":"Int. J. Mol. Sci."},{"key":"6063_CR51","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.prp.2017.04.025","volume":"213","author":"H Zhao","year":"2017","unstructured":"Zhao, H. et al. Gpx 4 is involved in the proliferation, migration and apoptosis of glioma cells. Pathol. Res. Pr. 213, 626\u2013633 (2017).","journal-title":"Pathol. Res. Pr."},{"key":"6063_CR52","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-021-04313-3","volume":"22","author":"H Herlambang","year":"2022","unstructured":"Herlambang, H. et al. Comprehensive fatty acid fractionation profilling in preeclampsia: a case control study with multivariable analysis. BMC Pregnancy Childbirth 22, 8 (2022).","journal-title":"BMC Pregnancy Childbirth"},{"key":"6063_CR53","doi-asserted-by":"publisher","first-page":"e0237600","DOI":"10.1371\/journal.pone.0237600","volume":"15","author":"MW Meazaw","year":"2020","unstructured":"Meazaw, M. W. et al. Systematic and meta-analysis of factors associated with preeclampsia and eclampsia in sub-Saharan Africa. PLoS One 15, e0237600 (2020).","journal-title":"PLoS One"},{"key":"6063_CR54","doi-asserted-by":"publisher","first-page":"20340","DOI":"10.1074\/jbc.M412081200","volume":"280","author":"W Miao","year":"2005","unstructured":"Miao, W. et al. Transcriptional regulation of NF-E2 p45-related factor (NRF2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway: direct cross-talk between phase I and II drug-metabolizing enzymes. J. Biol. Chem. 280, 20340\u201320348 (2005).","journal-title":"J. Biol. Chem."}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-06063-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-06063-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-06063-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T15:07:57Z","timestamp":1712675277000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-06063-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,9]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["6063"],"URL":"https:\/\/doi.org\/10.1038\/s42003-024-06063-2","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,9]]},"assertion":[{"value":"3 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The tissue samples used in this study were approved by Second Xiangya Hospital of Central South University Ethics Committee (2020-584). All subjects were given informed consent. All animal experiments were approved by the Animal Ethical and Welfare Committee, the Second Xiangya Hospital, Central South University, China (2021806).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"429"}}