{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:09:55Z","timestamp":1772136595314,"version":"3.50.1"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21ek0109555"],"award-info":[{"award-number":["JP21ek0109555"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21tm0424220"],"award-info":[{"award-number":["JP21tm0424220"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21ck0106642"],"award-info":[{"award-number":["JP21ck0106642"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23ek0410114"],"award-info":[{"award-number":["JP23ek0410114"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23tm0424225"],"award-info":[{"award-number":["JP23tm0424225"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Takeda Hosho Grants for Research in Medicine"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sarcopenia is a common skeletal muscle disease in older people. Lower limb muscle strength is a good predictive value for sarcopenia; however, little is known about its genetic components. Here, we conducted a genome-wide association study (GWAS) for knee extension strength in a total of 3452 Japanese aged 60 years or older from two independent cohorts. We identified a significant locus, rs10749438 which is an intronic variant in\n                    <jats:italic>TACC2<\/jats:italic>\n                    (transforming acidic coiled-coil-containing 2) (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20094.2\u2009\u00d7\u200910\n                    <jats:sup>\u22128<\/jats:sup>\n                    ).\n                    <jats:italic>TACC2<\/jats:italic>\n                    , encoding a cytoskeleton-related protein, is highly expressed in skeletal muscle, and is reported as a target of myotonic dystrophy 1-associated splicing alterations. These suggest that changes in TACC2 expression are associated with variations in muscle strength in older people. The association was consistently observed in young and middle-aged subjects. Our findings would shed light on genetic components of lower limb muscle strength and indicate\n                    <jats:italic>TACC2<\/jats:italic>\n                    as a potential therapeutic target for sarcopenia.\n                  <\/jats:p>","DOI":"10.1038\/s42003-024-06108-6","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T06:01:25Z","timestamp":1716184885000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A genome-wide association study identifies a locus associated with knee extension strength in older Japanese individuals"],"prefix":"10.1038","volume":"7","author":[{"given":"Shuji","family":"Ito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Takuwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saori","family":"Kakehi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Someya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyoshi","family":"Kaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Kumahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suguru","family":"Kuwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Wakatsuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Kadowaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichiro","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miwako","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1933-8613","authenticated-orcid":false,"given":"Xiaoxi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nao","family":"Otomo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Suetsugu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5431-5572","authenticated-orcid":false,"given":"Yoshinao","family":"Koike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4852-2401","authenticated-orcid":false,"given":"Keiko","family":"Hikino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Tomizuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5638-3504","authenticated-orcid":false,"given":"Yukihide","family":"Momozawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0028-1570","authenticated-orcid":false,"given":"Kouichi","family":"Ozaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Isomura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Nabika","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruka","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muneaki","family":"Ishijima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuzo","family":"Kawamori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5961-1816","authenticated-orcid":false,"given":"Hirotaka","family":"Watada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1685-7821","authenticated-orcid":false,"given":"Yoshifumi","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5858-9861","authenticated-orcid":false,"given":"Yuji","family":"Uchio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Ikegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6452-4095","authenticated-orcid":false,"given":"Chikashi","family":"Terao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,20]]},"reference":[{"key":"6108_CR1","doi-asserted-by":"publisher","first-page":"2793","DOI":"10.1007\/s00198-015-3194-y","volume":"26","author":"HA Bischoff-Ferrari","year":"2015","unstructured":"Bischoff-Ferrari, H. A. et al. Comparative performance of current definitions of sarcopenia against the prospective incidence of falls among community-dwelling seniors age 65 and older. Osteoporos. Int. 26, 2793\u20132802 (2015).","journal-title":"Osteoporos. Int."},{"key":"6108_CR2","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1093\/gerona\/glx245","volume":"73","author":"LA Schaap","year":"2018","unstructured":"Schaap, L. A., van Schoor, N. M., Lips, P. & Visser, M. Associations of sarcopenia definitions, and their components, with the incidence of recurrent falling and fractures: the longitudinal aging study Amsterdam. J. Gerontol. A Biol. Sci. Med Sci. 73, 1199\u20131204 (2018).","journal-title":"J. Gerontol. A Biol. Sci. Med Sci."},{"key":"6108_CR3","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1093\/ageing\/afw071","volume":"45","author":"SL De Buyser","year":"2016","unstructured":"De Buyser, S. L. et al. Validation of the FNIH sarcopenia criteria and SOF frailty index as predictors of long-term mortality in ambulatory older men. Age Ageing 45, 602\u2013608 (2016).","journal-title":"Age Ageing"},{"key":"6108_CR4","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1093\/ageing\/afq034","volume":"39","author":"AJ Cruz-Jentoft","year":"2010","unstructured":"Cruz-Jentoft, A. J. et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on sarcopenia in older people. Age Ageing 39, 412\u2013423 (2010).","journal-title":"Age Ageing"},{"key":"6108_CR5","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/ageing\/afy169","volume":"48","author":"AJ Cruz-Jentoft","year":"2019","unstructured":"Cruz-Jentoft, A. J. et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 48, 16\u201331 (2019).","journal-title":"Age Ageing"},{"key":"6108_CR6","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1016\/S0140-6736(19)31138-9","volume":"393","author":"AJ Cruz-Jentoft","year":"2019","unstructured":"Cruz-Jentoft, A. J. & Sayer, A. A. Sarcopenia. Lancet 393, 2636\u20132646 (2019).","journal-title":"Lancet"},{"key":"6108_CR7","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1093\/epirev\/mxs006","volume":"35","author":"LA Schaap","year":"2013","unstructured":"Schaap, L. A., Koster, A. & Visser, M. Adiposity, muscle mass, and muscle strength in relation to functional decline in older persons. Epidemiol. Rev. 35, 51\u201365 (2013).","journal-title":"Epidemiol. Rev."},{"key":"6108_CR8","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s00198-016-3691-7","volume":"28","author":"JC Menant","year":"2017","unstructured":"Menant, J. C. et al. Strength measures are better than muscle mass measures in predicting health-related outcomes in older people: time to abandon the term sarcopenia? Osteoporos. Int. 28, 59\u201370 (2017).","journal-title":"Osteoporos. Int."},{"key":"6108_CR9","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3390\/jfmk3040053","volume":"3","author":"M Harris-Love","year":"2018","unstructured":"Harris-Love, M., Benson, K., Leasure, E., Adams, B. & McIntosh, V. The influence of upper and lower extremity strength on performance-based sarcopenia assessment tests. J. Funct. Morphol. Kinesiol 3, 53 (2018).","journal-title":"J. Funct. Morphol. Kinesiol"},{"key":"6108_CR10","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3390\/geriatrics6010008","volume":"6","author":"MT Kristensen","year":"2021","unstructured":"Kristensen, M. T., Hulsb\u00e6k, S., Faber, L. L. & Kronborg, L. Knee extension strength measures indicating probable sarcopenia is associated with health-related outcomes and a strong predictor of 1-year mortality in patients following hip fracture surgery. Geriatrics 6, 8 (2021).","journal-title":"Geriatrics"},{"key":"6108_CR11","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s12877-018-0815-2","volume":"18","author":"SSY Yeung","year":"2018","unstructured":"Yeung, S. S. Y. et al. Knee extension strength measurements should be considered as part of the comprehensive geriatric assessment. BMC Geriatr. 18, 130 (2018).","journal-title":"BMC Geriatr."},{"key":"6108_CR12","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1111\/sms.12804","volume":"27","author":"H Zempo","year":"2017","unstructured":"Zempo, H. et al. Heritability estimates of muscle strength-related phenotypes: a systematic review and meta-analysis. Scand. J. Med Sci. Sports 27, 1537\u20131546 (2017).","journal-title":"Scand. J. Med Sci. Sports"},{"key":"6108_CR13","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1002\/gepi.20308","volume":"32","author":"K Silventoinen","year":"2008","unstructured":"Silventoinen, K., Magnusson, P. K. E., Tynelius, P., Kaprio, J. & Rasmussen, F. Heritability of body size and muscle strength in young adulthood: a study of one million Swedish men. Genet Epidemiol. 32, 341\u2013349 (2008).","journal-title":"Genet Epidemiol."},{"key":"6108_CR14","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1093\/gerona\/glq154","volume":"65A","author":"AM Matteini","year":"2010","unstructured":"Matteini, A. M. et al. Heritability estimates of endophenotypes of long and health life: the long life family study. J. Gerontol. A Biol. Sci. Med Sci. 65A, 1375\u20131379 (2010).","journal-title":"J. Gerontol. A Biol. Sci. Med Sci."},{"key":"6108_CR15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24735-y","volume":"8","author":"E Tikkanen","year":"2018","unstructured":"Tikkanen, E. et al. Biological insights into muscular strength: genetic findings in the UK biobank. Sci. Rep. 8, 6451 (2018).","journal-title":"Sci. Rep."},{"key":"6108_CR16","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms16015","volume":"8","author":"SM Willems","year":"2017","unstructured":"Willems, S. M. et al. Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness. Nat. Commun. 8, 16015 (2017).","journal-title":"Nat. Commun."},{"key":"6108_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-20918-w","volume":"12","author":"G Jones","year":"2021","unstructured":"Jones, G. et al. Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women. Nat. Commun. 12, 654 (2021).","journal-title":"Nat. Commun."},{"key":"6108_CR18","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1111\/acel.12468","volume":"15","author":"AM Matteini","year":"2016","unstructured":"Matteini, A. M. et al. GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium. Aging Cell 15, 792\u2013800 (2016).","journal-title":"Aging Cell"},{"key":"6108_CR19","doi-asserted-by":"publisher","first-page":"758","DOI":"10.3390\/nu15030758","volume":"15","author":"EA Semenova","year":"2023","unstructured":"Semenova, E. A., Pranckevi\u010dien\u0117, E., Bondareva, E. A., Gabdrakhmanova, L. J. & Ahmetov, I. I. Identification and characterization of genomic predictors of sarcopenia and sarcopenic obesity using UK biobank data. Nutrients 15, 758 (2023).","journal-title":"Nutrients"},{"key":"6108_CR20","doi-asserted-by":"publisher","first-page":"e49122","DOI":"10.1371\/journal.pone.0049122","volume":"7","author":"T Hamano","year":"2012","unstructured":"Hamano, T. et al. Effect of environmental and lifestyle factors on hypertension: Shimane COHRE study. PLoS One 7, e49122 (2012).","journal-title":"PLoS One"},{"key":"6108_CR21","doi-asserted-by":"publisher","first-page":"3225","DOI":"10.3390\/jcm10153225","volume":"10","author":"A Garu","year":"2021","unstructured":"Garu, A. et al. Effect of multimorbidity on fragility fractures in community-dwelling older adults: Shimane CoHRE Study. J. Clin. Med 10, 3225 (2021).","journal-title":"J. Clin. Med"},{"key":"6108_CR22","doi-asserted-by":"publisher","first-page":"e031584","DOI":"10.1136\/bmjopen-2019-031584","volume":"9","author":"Y Someya","year":"2019","unstructured":"Someya, Y. et al. Skeletal muscle function and need for long-term care of urban elderly people in Japan (the Bunkyo Health Study): a prospective cohort study. BMJ Open 9, e031584 (2019).","journal-title":"BMJ Open"},{"key":"6108_CR23","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1038\/s41588-019-0530-8","volume":"51","author":"L Jiang","year":"2019","unstructured":"Jiang, L. et al. A resource-efficient tool for mixed model association analysis of large-scale data. Nat. Genet 51, 1749\u20131755 (2019).","journal-title":"Nat. Genet"},{"key":"6108_CR24","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","volume":"26","author":"CJ Willer","year":"2010","unstructured":"Willer, C. J., Li, Y. & Abecasis, G. R. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26, 2190\u20132191 (2010).","journal-title":"Bioinformatics"},{"key":"6108_CR25","doi-asserted-by":"publisher","first-page":"D794","DOI":"10.1093\/nar\/gkx1081","volume":"46","author":"CA Davis","year":"2018","unstructured":"Davis, C. A. et al. The Encyclopedia of DNA Elements (ENCODE): data portal update. Nucleic Acids Res. 46, D794\u2013D801 (2018).","journal-title":"Nucleic Acids Res."},{"key":"6108_CR26","doi-asserted-by":"publisher","first-page":"D930","DOI":"10.1093\/nar\/gkr917","volume":"40","author":"LD Ward","year":"2012","unstructured":"Ward, L. D. & Kellis, M. HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res. 40, D930\u2013D934 (2012).","journal-title":"Nucleic Acids Res."},{"key":"6108_CR27","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-10-48","volume":"10","author":"E Eden","year":"2009","unstructured":"Eden, E., Navon, R., Steinfeld, I., Lipson, D. & Yakhini, Z. GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists. BMC Bioinformatics 10, 48 (2009).","journal-title":"BMC Bioinformatics"},{"key":"6108_CR28","doi-asserted-by":"publisher","first-page":"e107324","DOI":"10.1371\/journal.pone.0107324","volume":"9","author":"R Klinck","year":"2014","unstructured":"Klinck, R. et al. RBFOX1 cooperates with MBNL1 to control splicing in muscle, including events altered in myotonic dystrophy type 1. PloS One 9, e107324 (2014).","journal-title":"PloS One"},{"key":"6108_CR29","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1126\/science.aaz1776","volume":"369","author":"The GTEx Consortium","year":"2020","unstructured":"The GTEx Consortium The GTEx Consortium atlas of genetic regulatory effects across human tissues. Science 369, 1318\u20131330 (2020).","journal-title":"Science"},{"key":"6108_CR30","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1210\/me.2011-1242","volume":"26","author":"K Takayama","year":"2012","unstructured":"Takayama, K. et al. TACC2 is an androgen-responsive cell cycle regulator promoting androgen-mediated and castration-resistant growth of prostate cancer. Mol. Endocrinol. Balt. Md 26, 748\u2013761 (2012).","journal-title":"Mol. Endocrinol. Balt. Md"},{"key":"6108_CR31","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/0092-8674(87)90579-4","volume":"51","author":"EP Hoffman","year":"1987","unstructured":"Hoffman, E. P., Brown, R. H. & Kunkel, L. M. Dystrophin: the protein product of the Duchenne muscular dystrophy locus. Cell 51, 919\u2013928 (1987).","journal-title":"Cell"},{"key":"6108_CR32","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/0003-9993(92)90004-G","volume":"73","author":"JP Lord","year":"1992","unstructured":"Lord, J. P., Aitkens, S. G., McCrory, M. A. & Bernauer, E. M. Isometric and isokinetic measurement of hamstring and quadriceps strength. Arch. Phys. Med Rehabil. 73, 324\u2013330 (1992).","journal-title":"Arch. Phys. Med Rehabil."},{"key":"6108_CR33","doi-asserted-by":"publisher","first-page":"339","DOI":"10.2466\/pms.108.2.339-342","volume":"108","author":"RW Bohannon","year":"2009","unstructured":"Bohannon, R. W. Dynamometer measurements of grip and knee extension strength: are they indicative of overall limb and trunk muscle strength? Percept. Mot. Skills 108, 339\u2013342 (2009).","journal-title":"Percept. Mot. Skills"},{"key":"6108_CR34","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1111\/ggi.12077","volume":"14","author":"DC Felicio","year":"2014","unstructured":"Felicio, D. C. et al. Poor correlation between handgrip strength and isokinetic performance of knee flexor and extensor muscles in community-dwelling elderly women: handgrip strength and isokinetic performance. Geriatr. Gerontol. Int 14, 185\u2013189 (2014).","journal-title":"Geriatr. Gerontol. Int"},{"key":"6108_CR35","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1002\/agm2.12109","volume":"3","author":"S Singhal","year":"2020","unstructured":"Singhal, S. et al. Low one\u2010repetition\u2010maximum knee extension is significantly associated with poor grip strength, female sex, and various aging\u2010related syndromes. AGING Med. 3, 125\u2013131 (2020).","journal-title":"AGING Med."},{"key":"6108_CR36","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1038\/s42003-020-01334-0","volume":"3","author":"Y-F Pei","year":"2020","unstructured":"Pei, Y.-F. et al. The genetic architecture of appendicular lean mass characterized by association analysis in the UK Biobank study. Commun. Biol. 3, 608 (2020).","journal-title":"Commun. Biol."},{"key":"6108_CR37","doi-asserted-by":"publisher","first-page":"e13459","DOI":"10.1111\/acel.13459","volume":"20","author":"JL Atkins","year":"2021","unstructured":"Atkins, J. L. et al. A genome\u2010wide association study of the frailty index highlights brain pathways in ageing. Aging Cell 20, e13459 (2021).","journal-title":"Aging Cell"},{"key":"6108_CR38","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1038\/s42003-020-01357-7","volume":"3","author":"IR Timmins","year":"2020","unstructured":"Timmins, I. R. et al. Genome-wide association study of self-reported walking pace suggests beneficial effects of brisk walking on health and survival. Commun. Biol. 3, 634 (2020).","journal-title":"Commun. Biol."},{"key":"6108_CR39","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/mp.2017.5","volume":"23","author":"International Consortium for Blood Pressure GWAS, CHARGE Consortium Aging and Longevity Group, CHARGE Consortium Inflammation Group.","year":"2018","unstructured":"International Consortium for Blood Pressure GWAS, CHARGE Consortium Aging and Longevity Group, CHARGE Consortium Inflammation Group. et al. Genetic contributions to self-reported tiredness. Mol. Psychiatry 23, 609\u2013620 (2018).","journal-title":"Mol. Psychiatry"},{"key":"6108_CR40","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/s41591-020-0751-5","volume":"26","author":"KS Ruth","year":"2020","unstructured":"Ruth, K. S. et al. Using human genetics to understand the disease impacts of testosterone in men and women. Nat. Med. 26, 252\u2013258 (2020).","journal-title":"Nat. Med."},{"key":"6108_CR41","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/s41588-020-00757-z","volume":"53","author":"N Sinnott-Armstrong","year":"2021","unstructured":"Sinnott-Armstrong, N. et al. Genetics of 35 blood and urine biomarkers in the UK Biobank. Nat. Genet 53, 185\u2013194 (2021).","journal-title":"Nat. Genet"},{"key":"6108_CR42","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.tcb.2008.06.005","volume":"18","author":"I Peset","year":"2008","unstructured":"Peset, I. & Vernos, I. The TACC proteins: TACC-ling microtubule dynamics and centrosome function. Trends Cell Biol. 18, 379\u2013388 (2008).","journal-title":"Trends Cell Biol."},{"key":"6108_CR43","doi-asserted-by":"publisher","first-page":"14352","DOI":"10.1073\/pnas.97.26.14352","volume":"97","author":"F Gergely","year":"2000","unstructured":"Gergely, F. et al. The TACC domain identifies a family of centrosomal proteins that can interact with microtubules. Proc. Natl. Acad. Sci. 97, 14352\u201314357 (2000).","journal-title":"Proc. Natl. Acad. Sci."},{"key":"6108_CR44","doi-asserted-by":"publisher","first-page":"611","DOI":"10.3233\/CBM-170091","volume":"22","author":"M Shakya","year":"2018","unstructured":"Shakya, M. et al. High expression of TACC2 in hepatocellular carcinoma is associated with poor prognosis. Cancer Biomark. 22, 611\u2013619 (2018).","journal-title":"Cancer Biomark."},{"key":"6108_CR45","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1002\/cam4.736","volume":"5","author":"Y Onodera","year":"2016","unstructured":"Onodera, Y. et al. TACC2 (transforming acidic coiled\u2010coil protein 2) in breast carcinoma as a potent prognostic predictor associated with cell proliferation. Cancer Med. 5, 1973\u20131982 (2016).","journal-title":"Cancer Med."},{"key":"6108_CR46","first-page":"67","volume":"7","author":"S Cheng","year":"2010","unstructured":"Cheng, S., Douglas-Jones, A., Yang, X., Mansel, R. E. & Jiang, W. G. Transforming acidic coiled-coil-containing protein 2 (TACC2) in human breast cancer, expression pattern and clinical\/prognostic relevance. Cancer Genom. Proteom. 7, 67\u201373 (2010).","journal-title":"Cancer Genom. Proteom."},{"key":"6108_CR47","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1016\/j.je.2016.12.005","volume":"27","author":"A Nagai","year":"2017","unstructured":"Nagai, A. et al. Overview of the BioBank Japan Project: Study design and profile. J. Epidemiol. 27, S2\u2013S8 (2017).","journal-title":"J. Epidemiol."},{"key":"6108_CR48","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12276-5","volume":"10","author":"M Akiyama","year":"2019","unstructured":"Akiyama, M. et al. Characterizing rare and low-frequency height-associated variants in the Japanese population. Nat. Commun. 10, 4393 (2019).","journal-title":"Nat. Commun."},{"key":"6108_CR49","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9111","volume":"6","author":"J Huang","year":"2015","unstructured":"UK10K Consortium, Huang, J. et al. Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel. Nat. Commun. 6, 8111 (2015).","journal-title":"Nat. Commun."},{"key":"6108_CR50","doi-asserted-by":"publisher","first-page":"e1000529","DOI":"10.1371\/journal.pgen.1000529","volume":"5","author":"BN Howie","year":"2009","unstructured":"Howie, B. N., Donnelly, P. & Marchini, J. A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet 5, e1000529 (2009).","journal-title":"PLoS Genet"},{"key":"6108_CR51","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1038\/ng.3656","volume":"48","author":"S Das","year":"2016","unstructured":"Das, S. et al. Next-generation genotype imputation service and methods. Nat. Genet 48, 1284\u20131287 (2016).","journal-title":"Nat. Genet"},{"key":"6108_CR52","doi-asserted-by":"publisher","first-page":"e164","DOI":"10.1093\/nar\/gkq603","volume":"38","author":"K Wang","year":"2010","unstructured":"Wang, K., Li, M. & Hakonarson, H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res. 38, e164\u2013e164 (2010).","journal-title":"Nucleic Acids Res."},{"key":"6108_CR53","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/nrg2322","volume":"9","author":"PM Visscher","year":"2008","unstructured":"Visscher, P. M., Hill, W. G. & Wray, N. R. Heritability in the genomics era\u2013concepts and misconceptions. Nat. Rev. Genet 9, 255\u2013266 (2008).","journal-title":"Nat. Rev. Genet"},{"key":"6108_CR54","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1093\/bioinformatics\/btw018","volume":"32","author":"C Benner","year":"2016","unstructured":"Benner, C. et al. FINEMAP: efficient variable selection using summary data from genome-wide association studies. Bioinformatics 32, 1493\u20131501 (2016).","journal-title":"Bioinformatics"},{"key":"6108_CR55","doi-asserted-by":"publisher","unstructured":"Ito S. Shuji2022\/Code: v1.0.0. Zenodo https:\/\/doi.org\/10.5281\/zenodo.10675274 (2024).","DOI":"10.5281\/zenodo.10675274"}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-06108-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-06108-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-06108-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T06:02:55Z","timestamp":1716184975000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-06108-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,20]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["6108"],"URL":"https:\/\/doi.org\/10.1038\/s42003-024-06108-6","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3171930\/v1","asserted-by":"object"}]},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,20]]},"assertion":[{"value":"14 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"513"}}