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However, the underlying regulatory mechanism between the two is unclear. To this end, this study explored the role and possible molecular mechanisms of adipocyte-derived exosomes under OSA in aggravating MASLD. Through sequencing technology, miR-455-3p was identified as a co-differentially expressed miRNA between the MASLD\u2009+\u2009OSA and Control groups and between the MASLD\u2009+\u2009OSA and MASLD groups. Upregulation of TCONS-00039830 and <jats:italic>Smad2<\/jats:italic> and downregulation of miR-455-3p in the MASLD and MASLD\u2009+\u2009OSA groups were validated in vivo and in vitro. TCONS-00039830, as a differentially expressed LncRNA in exosomes found in the sequencing results, transfection notably downregulated miR-455-3p and upregulated <jats:italic>Smad2<\/jats:italic> in hepatocytes. TCONS_00039830 overexpression increased fat, triglyceride and cholesterol levels, while miR-455-3p overexpression decreased these levels. Furthermore, exosome administration promoted the accumulation of fat, triglyceride and cholesterol, upregulated TCONS_00039830 and <jats:italic>Smad2<\/jats:italic>, and downregulated miR-455-3p. Overexpression of miR-455-3p reversed the increased fat accumulation and upregulated TCONS_00039830 and <jats:italic>Smad2<\/jats:italic>. In conclusion, OSA-derived exosomes promoted hepatocyte steatosis by regulating TCONS_00039830\/miR-455-3p\/<jats:italic>Smad2<\/jats:italic> axis, thereby aggravating liver damage in MASLD.<\/jats:p>","DOI":"10.1038\/s42003-024-06171-z","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T19:06:02Z","timestamp":1713899162000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Adipocyte-derived exosomes from obstructive sleep apnoea rats aggravate MASLD by TCONS_00039830\/miR-455-3p\/Smad2 axis"],"prefix":"10.1038","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6901-6703","authenticated-orcid":false,"given":"Li","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anni","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhuan","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixue","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"key":"6171_CR1","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1007\/s10620-016-4143-0","volume":"61","author":"ZA Sherif","year":"2016","unstructured":"Sherif, Z. 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