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Furthermore, the addition of BBM downregulates the phosphorylation of p38 mitogen-activated protein kinase and enhanced mitochondrial respiration. CD19-CAR-T cells cultured with BBM also extend the survival of leukaemia mouse models due to their superior in vivo persistence. 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S-i.T., S.C., S.H., K.F., N.W., N.O., Y.Kurimoto., A.F., A.K., M.K., and H.N. are employed by Kirin Holdings, Co., Ltd. Sh.K. is a founder, shareholder, and board member at Shinobi Therapeutics, Inc., and received research fundings from Kirin Holdings, Co., Ltd., Takeda Pharmaceutical Co., Ltd., Shinobi Therapeutics, Inc., Astellas Co., Ltd., Terumo Co., Ltd., and Tosoh Co., Ltd. The remaining authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"685"}}