{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:14:25Z","timestamp":1790190865653,"version":"4.1.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T00:00:00Z","timestamp":1719619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T00:00:00Z","timestamp":1719619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Spotted fever group rickettsiae (SFGR) are obligate intracellular bacteria that cause spotted fever. The limitations of gene manipulation pose great challenges to studying the infection mechanisms of <jats:italic>Rickettsia<\/jats:italic>. By combining bioorthogonal metabolism and click chemistry, we developed a method to label <jats:italic>R. heilongjiangensis<\/jats:italic> via azide moieties and achieved rapid pathogen localization without complex procedures. Moreover, we constructed a C57BL\/6 mice infection model by simulating tick bites and discovered that the stomach is the target organ of <jats:italic>R. heilongjiangensis<\/jats:italic> infection through in vivo imaging systems, which explained the occurrence of gastrointestinal symptoms following <jats:italic>R. heilongjiangensis<\/jats:italic> infection in some cases. This study offers a unique perspective for subsequent investigations into the pathogenic mechanisms of SFGR and identifies a potential target organ for <jats:italic>R. heilongjiangensis<\/jats:italic>.<\/jats:p>","DOI":"10.1038\/s42003-024-06468-z","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T01:04:36Z","timestamp":1719882276000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Stomach as the target organ of Rickettsia heilongjiangensis infection in C57BL\/6 mice identified by click chemistry"],"prefix":"10.1038","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0147-1044","authenticated-orcid":false,"given":"Juan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Feng","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Zhu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Yun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1656-3401","authenticated-orcid":false,"given":"Luo-Yuan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4784-8813","authenticated-orcid":false,"given":"Jia-Fu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1458-7466","authenticated-orcid":false,"given":"Wen-Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6825-5806","authenticated-orcid":false,"given":"Dai-Yun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0532-7064","authenticated-orcid":false,"given":"Na","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5090-2251","authenticated-orcid":false,"given":"Wu-Chun","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,29]]},"reference":[{"key":"6468_CR1","doi-asserted-by":"publisher","first-page":"816547","DOI":"10.3389\/fcimb.2021.816547","volume":"11","author":"G Neelakanta","year":"2021","unstructured":"Neelakanta, G. & Sultana, H. Tick saliva and salivary glands: what do we know so far on their role in arthropod blood feeding and pathogen transmission. Front Cell Infect. Microbiol. 11, 816547 (2021).","journal-title":"Front Cell Infect. Microbiol."},{"key":"6468_CR2","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.molmed.2011.05.009","volume":"17","author":"A Renvois\u00e9","year":"2011","unstructured":"Renvois\u00e9, A., Merhej, V., Georgiades, K. & Raoult, D. Intracellular rickettsiales: insights into manipulators of eukaryotic cells. Trends Mol. Med. 17, 573\u2013583 (2011).","journal-title":"Trends Mol. Med."},{"key":"6468_CR3","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1111\/j.1469-185X.2010.00151.x","volume":"86","author":"V Merhej","year":"2011","unstructured":"Merhej, V. & Raoult, D. Rickettsial evolution in the light of comparative genomics. Biol. Rev. Camb. Philos. Soc. 86, 379\u2013405 (2011).","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"6468_CR4","doi-asserted-by":"publisher","first-page":"e0021022","DOI":"10.1128\/aem.00210-22","volume":"88","author":"NY Burkhardt","year":"2022","unstructured":"Burkhardt, N. Y. et al. Examination of rickettsial host range for shuttle vectors based on dnaA and parA Genes from the pRM Plasmid of Rickettsia monacensis. Appl Environ. Microbiol. 88, e0021022 (2022).","journal-title":"Appl Environ. Microbiol."},{"key":"6468_CR5","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3369","volume":"4","author":"W Pan","year":"2013","unstructured":"Pan, W. et al. Visualizing influenza virus infection in living mice. Nat. Commun. 4, 2369 (2013).","journal-title":"Nat. Commun."},{"key":"6468_CR6","first-page":"1521","volume":"11","author":"HC Kolb","year":"2001","unstructured":"Kolb, H. C., Finn, M. G. & Sharpless, K. B. Click chemistry: diverse chemical function from a few good reactions. Angew. Chem. Int Ed. Engl. 11, 1521\u20133773 (2001).","journal-title":"Angew. Chem. Int Ed. Engl."},{"key":"6468_CR7","first-page":"1521","volume":"14","author":"VV Rostovtsev","year":"2002","unstructured":"Rostovtsev, V. V., Green, L. G., Fokin, V. V. & Sharpless, K. B. A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective \u201cligation\u201d of azides and terminal alkynes. Angew. Chem. Int. Ed. Engl. 14, 1521\u20133773 (2002).","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"6468_CR8","doi-asserted-by":"publisher","first-page":"6974","DOI":"10.1002\/anie.200900942","volume":"38","author":"EM Sletten","year":"2009","unstructured":"Sletten, E. M. & Bertozzi, C. R. Bioorthogonal chemistry: fishing for selectivity in a sea of functionality. Angew. Chem. Int. Ed. Engl. 38, 6974\u20136998 (2009).","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"6468_CR9","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1038\/nm.3929","volume":"21","author":"N Geva-Zatorsky","year":"2015","unstructured":"Geva-Zatorsky, N. et al. In vivo imaging and tracking of host-microbiota interactions via metabolic labeling of gut anaerobic bacteria. Nat. Med. 21, 1091\u20131100 (2015).","journal-title":"Nat. Med."},{"key":"6468_CR10","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7600","volume":"6","author":"S Fukuyama","year":"2015","unstructured":"Fukuyama, S. et al. Multi-spectral fluorescent reporter influenza viruses (Color-flu) as powerful tools for in vivo studies. Nat. Commun. 6, 6600 (2015).","journal-title":"Nat. Commun."},{"key":"6468_CR11","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1021\/acs.bioconjchem.5b00310","volume":"26","author":"X Zhao","year":"2015","unstructured":"Zhao, X. et al. Labeling of enveloped virus via metabolic incorporation of azido sugars. Bioconjug. Chem. 26, 1868\u20131872 (2015).","journal-title":"Bioconjug. Chem."},{"key":"6468_CR12","doi-asserted-by":"publisher","first-page":"2386","DOI":"10.1021\/acs.bioconjchem.6b00372","volume":"27","author":"SB Carvalho","year":"2016","unstructured":"Carvalho, S. B. et al. Bioorthogonal strategy for bioprocessing of specific-site-functionalized enveloped influenza-virus-like particles. Bioconjug. Chem. 27, 2386\u20132399 (2016).","journal-title":"Bioconjug. Chem."},{"key":"6468_CR13","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/nsmb.2255","volume":"19","author":"X Wang","year":"2012","unstructured":"Wang, X. et al. A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71. Nat. Struct. Mol. Biol. 19, 424\u2013429 (2012).","journal-title":"Nat. Struct. Mol. Biol."},{"key":"6468_CR14","doi-asserted-by":"crossref","unstructured":"Pan, H. et al. In situ bioorthogonal metabolic labeling for fluorescence imaging of virus infection in vivo. Small. 13, 1604036 (2017).","DOI":"10.1002\/smll.201604036"},{"key":"6468_CR15","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.biomaterials.2018.07.061","volume":"181","author":"H Pan","year":"2018","unstructured":"Pan, H. et al. Dissecting complicated viral spreading of enterovirus 71 using in situ bioorthogonal fluorescent labeling. Biomaterials 181, 199\u2013209 (2018).","journal-title":"Biomaterials"},{"key":"6468_CR16","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/nchembio.2297","volume":"13","author":"H Wang","year":"2017","unstructured":"Wang, H. et al. Selective in vivo metabolic cell-labeling-mediated cancer targeting. Nat. Chem. Biol. 13, 415\u2013424 (2017).","journal-title":"Nat. Chem. Biol."},{"key":"6468_CR17","doi-asserted-by":"publisher","first-page":"6458","DOI":"10.1002\/smll.201502972","volume":"11","author":"H Koo","year":"2015","unstructured":"Koo, H. et al. Bioorthogonal click chemistry-based synthetic cell glue. Small 11, 6458\u20136466 (2015).","journal-title":"Small"},{"key":"6468_CR18","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/24094","volume":"396","author":"SG Andersson","year":"1998","unstructured":"Andersson, S. G. et al. The genome sequence of Rickettsia prowazekii and the origin of mitochondria. Nature 396, 133\u2013140 (1998).","journal-title":"Nature"},{"key":"6468_CR19","doi-asserted-by":"publisher","first-page":"e14","DOI":"10.1371\/journal.pgen.0030014","volume":"3","author":"G Blanc","year":"2007","unstructured":"Blanc, G. et al. Reductive genome evolution from the mother of Rickettsia. PLoS Genet. 3, e14 (2007).","journal-title":"PLoS Genet."},{"key":"6468_CR20","doi-asserted-by":"crossref","unstructured":"Driscoll, T. P. et al. Wholly Rickettsia! Reconstructed metabolic profile of the quintessential bacterial parasite of eukaryotic cells. mBio 8, e00859-17 (2017).","DOI":"10.1128\/mBio.00859-17"},{"key":"6468_CR21","doi-asserted-by":"publisher","first-page":"2855","DOI":"10.1161\/ATVBAHA.121.316290","volume":"41","author":"ErikAL Biessen","year":"2021","unstructured":"Biessen, ErikA. L. & Van Berkel, TheoJ. C. N-acetyl galactosamine targeting: paving the way for clinical application of nucleotide medicines in cardiovascular diseases. Arterioscler. Thromb. Vasc. Biol. 41, 2855\u20132865 (2021).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"6468_CR22","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2022.2153085","volume":"12","author":"M He","year":"2023","unstructured":"He, M. et al. Complete genome sequencing and comparative genomic analyses of a new spotted-fever Rickettsia heilongjiangensis strain B8. Emerg. Microbes Infect. 12, 2153085 (2023).","journal-title":"Emerg. Microbes Infect."},{"key":"6468_CR23","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6150-4-13","volume":"4","author":"V Merhej","year":"2009","unstructured":"Merhej, V., Royer-Carenzi, M., Pontarotti, P. & Raoult, D. Massive comparative genomic analysis reveals convergent evolution of specialized bacteria. Biol. Direct 4, 13 (2009).","journal-title":"Biol. Direct"},{"key":"6468_CR24","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1126\/science.1061471","volume":"293","author":"H Ogata","year":"2001","unstructured":"Ogata, H. et al. Mechanisms of evolution in Rickettsia conorii and R. prowazekii. Science 293, 2093\u20132098 (2001).","journal-title":"Science"},{"key":"6468_CR25","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-10-166","volume":"10","author":"PE Fournier","year":"2009","unstructured":"Fournier, P. E. et al. Analysis of the Rickettsia africae genome reveals that virulence acquisition in Rickettsia species may be explained by genome reduction. BMC Genomics 10, 166 (2009).","journal-title":"BMC Genomics"},{"key":"6468_CR26","doi-asserted-by":"publisher","first-page":"e8265","DOI":"10.1371\/journal.pone.0008265","volume":"4","author":"JE Foley","year":"2009","unstructured":"Foley, J. E., Nieto, N. C., Barbet, A. & Foley, P. Antigen diversity in the parasitic bacterium Anaplasma phagocytophilum arises from selectively-represented, spatially clustered functional pseudogenes. PloS ONE 4, e8265 (2009).","journal-title":"PloS ONE"},{"key":"6468_CR27","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.tig.2007.08.002","volume":"23","author":"AC Darby","year":"2007","unstructured":"Darby, A. C., Cho, N. H., Fuxelius, H. H., Westberg, J. & Andersson, S. G. Intracellular pathogens go extreme: genome evolution in the Rickettsiales. Trends Genet. 23, 511\u2013520 (2007).","journal-title":"Trends Genet."},{"key":"6468_CR28","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1101\/gr.103564.109","volume":"20","author":"Y Bechah","year":"2010","unstructured":"Bechah, Y. et al. Genomic, proteomic, and transcriptomic analysis of virulent and avirulent Rickettsia prowazekii reveals its adaptive mutation capabilities. Genome Res. 20, 655\u2013663 (2010).","journal-title":"Genome Res."},{"key":"6468_CR29","doi-asserted-by":"publisher","first-page":"14934","DOI":"10.1073\/pnas.0806554105","volume":"105","author":"I Tamas","year":"2008","unstructured":"Tamas, I. et al. Endosymbiont gene functions impaired and rescued by polymerase infidelity at poly(A) tracts. Proc. Natl Acad. Sci. USA 105, 14934\u201314939 (2008).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"6468_CR30","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1038\/nrmicro2318","volume":"8","author":"Y Rikihisa","year":"2010","unstructured":"Rikihisa, Y. Anaplasma phagocytophilum and Ehrlichia chaffeensis: subversive manipulators of host cells. Nat. Rev. Microbiol. 8, 328\u2013339 (2010).","journal-title":"Nat. Rev. Microbiol."},{"key":"6468_CR31","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00621-21","volume":"90","author":"HK Kim","year":"2022","unstructured":"Kim, H. K. Rickettsia-host-tick interactions: knowledge advances and gaps. Infect. Immun. 90, e0062121 (2022).","journal-title":"Infect. Immun."},{"key":"6468_CR32","doi-asserted-by":"publisher","first-page":"810","DOI":"10.3201\/eid1005.030437","volume":"10","author":"OY Mediannikov","year":"2004","unstructured":"Mediannikov, O. Y. et al. Acute tick-borne rickettsiosis caused by Rickettsia heilongjiangensis in Russian Far East. Emerg. Infect. Dis. 10, 810\u2013817 (2004).","journal-title":"Emerg. Infect. Dis."},{"key":"6468_CR33","doi-asserted-by":"publisher","first-page":"641","DOI":"10.7326\/M15-2572","volume":"164","author":"W Liu","year":"2016","unstructured":"Liu, W. et al. Candidatus Rickettsia tarasevichiae Infection in Eastern Central China: a case series. Ann. Intern. Med. 164, 641\u2013648 (2016).","journal-title":"Ann. Intern. Med."},{"key":"6468_CR34","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/S1473-3099(07)70261-X","volume":"7","author":"F Dantas-Torres","year":"2007","unstructured":"Dantas-Torres, F. Rocky Mountain spotted fever. Lancet Infect. Dis. 7, 724\u2013732 (2007).","journal-title":"Lancet Infect. Dis."},{"key":"6468_CR35","first-page":"963","volume":"108","author":"MB Randall","year":"1984","unstructured":"Randall, M. B. & Walker, D. H. Rocky Mountain spotted fever. Gastrointestinal and pancreatic lesions and rickettsial infection. Arch. Pathol. Lab. Med. 108, 963\u2013967 (1984).","journal-title":"Arch. Pathol. Lab. Med."},{"key":"6468_CR36","doi-asserted-by":"publisher","first-page":"e0004884","DOI":"10.1371\/journal.pntd.0004884","volume":"10","author":"Soong","year":"2016","unstructured":"Soong et al. An intradermal inoculation mouse model for immunological investigations of acute scrub typhus and persistent infection. PLoS Negl. Trop. Dis. 10, e0004884 (2016).","journal-title":"PLoS Negl. Trop. Dis."},{"key":"6468_CR37","doi-asserted-by":"publisher","first-page":"3379","DOI":"10.1128\/IAI.00185-16","volume":"84","author":"Mohammad Gharaibeh","year":"2016","unstructured":"Gharaibeh, Mohammad et al. Toll-like receptor 2 recognizes Orientia tsutsugamushi and increases susceptibility to murine experimental scrub typhus. Infect. Immun. 84, 3379\u20133387 (2016).","journal-title":"Infect. Immun."},{"key":"6468_CR38","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s11427-014-4720-4","volume":"58","author":"YanFen Meng","year":"2015","unstructured":"Meng, YanFen et al. Protective immunity against Rickettsia heilongjiangensis in a C3H\/HeN mouse model mediated by outer membrane protein B-pulsed dendritic cells. Sci. China Life Sci. 58, 287\u2013296 (2015).","journal-title":"Sci. China Life Sci."},{"key":"6468_CR39","doi-asserted-by":"publisher","first-page":"504","DOI":"10.4269\/ajtmh.2011.10-0660","volume":"85","author":"Changsong Duan","year":"2011","unstructured":"Duan, Changsong et al. Exploratory study on pathogenesis of far-eastern spotted fever. Am. J. Trop. Med. Hyg. 85, 504\u2013509 (2011).","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"6468_CR40","doi-asserted-by":"publisher","first-page":"e0005453","DOI":"10.1371\/journal.pntd.0005453","volume":"11","author":"NicoleL Mendell","year":"2017","unstructured":"Mendell, NicoleL. et al. Murine models of scrub typhus associated with host control of Orientia tsutsugamushi infection. PLoS Negl. Trop. Dis. 11, e0005453 (2017).","journal-title":"PLoS Negl. Trop. Dis."},{"key":"6468_CR41","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.67029","volume":"10","author":"ThomasP Burke","year":"2021","unstructured":"Burke, ThomasP. et al. Interferon receptor-deficient mice are susceptible to eschar-associated rickettsiosis. elife 10, e67029 (2021).","journal-title":"elife"},{"key":"6468_CR42","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.vascn.2009.12.002","volume":"61","author":"Noriko Daneshtalab","year":"2010","unstructured":"Daneshtalab, Noriko et al. Troubleshooting tissue specificity and antibody selection: procedures in immunohistochemical studies. J. Pharm. Toxicol. Methods 61, 127\u2013135 (2010).","journal-title":"J. Pharm. Toxicol. Methods"},{"key":"6468_CR43","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1111\/j.1462-5822.2008.01279.x","volume":"11","author":"YG Chan","year":"2009","unstructured":"Chan, Y. G., Cardwell, M. M., Hermanas, T. M., Uchiyama, T. & Martinez, J. J. Rickettsial outer-membrane protein B (rOmpB) mediates bacterial invasion through Ku70 in an actin, c-Cbl, clathrin and caveolin 2-dependent manner. Cell Microbiol. 11, 629\u2013644 (2009).","journal-title":"Cell Microbiol."},{"key":"6468_CR44","doi-asserted-by":"publisher","first-page":"4201","DOI":"10.1128\/IAI.67.8.4201-4207.1999","volume":"67","author":"RA Heinzen","year":"1999","unstructured":"Heinzen, R. A., Grieshaber, S. S., Van Kirk, L. S. & Devin, C. J. Dynamics of actin-based movement by Rickettsia rickettsii in vero cells. Infect. Immun. 67, 4201\u20134207 (1999).","journal-title":"Infect. Immun."},{"key":"6468_CR45","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/s41579-020-00507-2","volume":"19","author":"J Salje","year":"2021","unstructured":"Salje, J. Cells within cells: Rickettsiales and the obligate intracellular bacterial lifestyle. Nat. Rev. Microbiol. 19, 375\u2013390 (2021).","journal-title":"Nat. Rev. Microbiol."},{"key":"6468_CR46","doi-asserted-by":"crossref","unstructured":"Ammerman N. C., Beier-Sexton M., Azad A. F. Laboratory maintenance of Rickettsia rickettsii. Curr. Protoc. Microbiol. Chapter 3, Unit 3A.5 (2008).","DOI":"10.1002\/9780471729259.mc03a05s11"},{"key":"6468_CR47","doi-asserted-by":"publisher","first-page":"e00686","DOI":"10.1128\/IAI.00686-19","volume":"88","author":"N Jia","year":"2020","unstructured":"Jia, N. et al. Cutaneous immunoprofiles of three spotted fever group Rickettsia cases. Infect. Immun. 88, e00686 (2020).","journal-title":"Infect. Immun."},{"key":"6468_CR48","doi-asserted-by":"publisher","first-page":"121080","DOI":"10.1016\/j.biomaterials.2021.121080","volume":"277","author":"Y Li","year":"2021","unstructured":"Li, Y. et al. CaCO3 nanoparticles incorporated with KAE to enable amplified calcium overload cancer therapy. Biomaterials 277, 121080 (2021).","journal-title":"Biomaterials"}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-06468-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-06468-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-06468-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T02:03:17Z","timestamp":1719885797000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-06468-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,29]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["6468"],"URL":"https:\/\/doi.org\/10.1038\/s42003-024-06468-z","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,29]]},"assertion":[{"value":"19 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"784"}}