{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T10:53:10Z","timestamp":1786272790958,"version":"build-2736575974"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FDN-159903"],"award-info":[{"award-number":["FDN-159903"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","award":["MJFF-019029"],"award-info":[{"award-number":["MJFF-019029"]}],"id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-024-06656-x","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T17:03:07Z","timestamp":1723136587000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Naturally occurring hyperactive variants of human parkin"],"prefix":"10.1038","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1808-2532","authenticated-orcid":false,"given":"Tahrima Saiha","family":"Huq","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayan","family":"Fakih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5981-4573","authenticated-orcid":false,"given":"V\u00e9ronique","family":"Sauv\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6500-1184","authenticated-orcid":false,"given":"Kalle","family":"Gehring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,8]]},"reference":[{"key":"6656_CR1","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1016\/S1474-4422(16)30230-7","volume":"15","author":"A Ascherio","year":"2016","unstructured":"Ascherio, A. & Schwarzschild, M. A. The epidemiology of Parkinson\u2019s disease: risk factors and prevention. Lancet Neurol. 15, 1257\u20131272 (2016).","journal-title":"Lancet Neurol."},{"key":"6656_CR2","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/ene.14108","volume":"27","author":"R Balestrino","year":"2020","unstructured":"Balestrino, R. & Schapira, A. H. V. Parkinson disease. Eur. J. Neurol. 27, 27\u201342 (2020).","journal-title":"Eur. J. Neurol."},{"key":"6656_CR3","doi-asserted-by":"publisher","first-page":"168090","DOI":"10.1016\/j.jmb.2023.168090","volume":"435","author":"JF Trempe","year":"2023","unstructured":"Trempe, J. F. & Gehring, K. Mechanisms of mitochondrial quality control mediated by PINK1 and Parkin. J. Mol. Biol. 435, 168090 (2023).","journal-title":"J. Mol. Biol."},{"key":"6656_CR4","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.neuron.2014.12.007","volume":"85","author":"AM Pickrell","year":"2015","unstructured":"Pickrell, A. M. & Youle, R. J. The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson\u2019s disease. Neuron 85, 257\u2013273 (2015).","journal-title":"Neuron"},{"key":"6656_CR5","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1083\/jcb.200910140","volume":"189","author":"N Matsuda","year":"2010","unstructured":"Matsuda, N. et al. PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J. Cell Biol. 189, 211\u2013221 (2010).","journal-title":"J. Cell Biol."},{"key":"6656_CR6","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1083\/jcb.200809125","volume":"183","author":"D Narendra","year":"2008","unstructured":"Narendra, D., Tanaka, A., Suen, D.-F. & Youle, R. J. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J. Cell Biol. 183, 795\u2013803 (2008).","journal-title":"J. Cell Biol."},{"key":"6656_CR7","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nrm3028","volume":"12","author":"RJ Youle","year":"2011","unstructured":"Youle, R. J. & Narendra, D. P. Mechanisms of mitophagy. Nat. Rev. Mol. Cell Biol. 12, 9\u201314 (2011).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"6656_CR8","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.15252\/embj.201488104","volume":"33","author":"A Sugiura","year":"2014","unstructured":"Sugiura, A., McLelland, G. L., Fon, E. A. & McBride, H. M. A new pathway for mitochondrial quality control: mitochondrial-derived vesicles. EMBO J. 33, 2142\u20132156 (2014).","journal-title":"EMBO J."},{"key":"6656_CR9","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.15252\/embr.201642641","volume":"17","author":"KK Dove","year":"2016","unstructured":"Dove, K. K., Stieglitz, B., Duncan, E. D., Rittinger, K. & Klevit, R. E. Molecular insights into RBR E3 ligase ubiquitin transfer mechanisms. EMBO Rep. 17, 1221\u20131235 (2016).","journal-title":"EMBO Rep."},{"key":"6656_CR10","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1002\/embr.201338166","volume":"15","author":"JJ Smit","year":"2014","unstructured":"Smit, J. J. & Sixma, T. K. RBR E3-ligases at work. EMBO Rep. 15, 142\u2013154 (2014).","journal-title":"EMBO Rep."},{"key":"6656_CR11","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/nature09966","volume":"474","author":"DM Wenzel","year":"2011","unstructured":"Wenzel, D. M., Lissounov, A., Brzovic, P. S. & Klevit, R. E. UBCH7 reactivity profile reveals parkin and HHARI to be RING\/HECT hybrids. Nature 474, 105\u2013108 (2011).","journal-title":"Nature"},{"key":"6656_CR12","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/s41594-018-0063-3","volume":"25","author":"H Walden","year":"2018","unstructured":"Walden, H. & Rittinger, K. RBR ligase\u2013mediated ubiquitin transfer: a tale with many twists and turns. Nat. Struct. Mol. Biol. 25, 440\u2013445 (2018).","journal-title":"Nat. Struct. Mol. Biol."},{"key":"6656_CR13","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1126\/science.1237908","volume":"340","author":"JF Trempe","year":"2013","unstructured":"Trempe, J. F. et al. Structure of parkin reveals mechanisms for ubiquitin ligase activation. Science 340, 1451\u20131455 (2013).","journal-title":"Science"},{"key":"6656_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2982","volume":"4","author":"BE Riley","year":"2013","unstructured":"Riley, B. E. et al. Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases. Nat. Commun. 4, 1982 (2013).","journal-title":"Nat. Commun."},{"key":"6656_CR15","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1038\/emboj.2013.125","volume":"32","author":"T Wauer","year":"2013","unstructured":"Wauer, T. & Komander, D. Structure of the human Parkin ligase domain in an autoinhibited state. EMBO J. 32, 2099\u20132112 (2013).","journal-title":"EMBO J."},{"key":"6656_CR16","doi-asserted-by":"publisher","first-page":"120080","DOI":"10.1098\/rsob.120080","volume":"2","author":"C Kondapalli","year":"2012","unstructured":"Kondapalli, C. et al. PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biol. 2, 120080 (2012).","journal-title":"Open Biol."},{"key":"6656_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/srep01002","volume":"2","author":"K Shiba-Fukushima","year":"2012","unstructured":"Shiba-Fukushima, K. et al. PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy. Sci. Rep. 2, 1002 (2012).","journal-title":"Sci. Rep."},{"key":"6656_CR18","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1083\/jcb.201402104","volume":"205","author":"LA Kane","year":"2014","unstructured":"Kane, L. A. et al. PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. J. Cell Biol. 205, 143\u2013153 (2014).","journal-title":"J. Cell Biol."},{"key":"6656_CR19","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/nature13392","volume":"510","author":"F Koyano","year":"2014","unstructured":"Koyano, F. et al. Ubiquitin is phosphorylated by PINK1 to activate parkin. Nature 510, 162\u2013166 (2014).","journal-title":"Nature"},{"key":"6656_CR20","doi-asserted-by":"publisher","first-page":"2492","DOI":"10.15252\/embj.201592237","volume":"34","author":"V Sauve","year":"2015","unstructured":"Sauve, V. et al. A Ubl\/ubiquitin switch in the activation of Parkin. EMBO J. 34, 2492\u20132505 (2015).","journal-title":"EMBO J."},{"key":"6656_CR21","doi-asserted-by":"publisher","first-page":"939","DOI":"10.15252\/embr.201540352","volume":"16","author":"A Kazlauskaite","year":"2015","unstructured":"Kazlauskaite, A. et al. Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation. EMBO Rep. 16, 939\u2013954 (2015).","journal-title":"EMBO Rep."},{"key":"6656_CR22","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.molcel.2014.09.007","volume":"56","author":"A Ordureau","year":"2014","unstructured":"Ordureau, A. et al. Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis. Mol. Cell 56, 360\u2013375 (2014).","journal-title":"Mol. Cell"},{"key":"6656_CR23","doi-asserted-by":"publisher","first-page":"2506","DOI":"10.15252\/embj.201592337","volume":"34","author":"A Kumar","year":"2015","unstructured":"Kumar, A. et al. Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis. EMBO J. 34, 2506\u20132521 (2015).","journal-title":"EMBO J."},{"key":"6656_CR24","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1038\/nature14879","volume":"524","author":"T Wauer","year":"2015","unstructured":"Wauer, T., Simicek, M., Schubert, A. & Komander, D. Mechanism of phospho-ubiquitin-induced PARKIN activation. Nature 524, 370\u2013374 (2015).","journal-title":"Nature"},{"key":"6656_CR25","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/s41594-018-0088-7","volume":"25","author":"V Sauv\u00e9","year":"2018","unstructured":"Sauv\u00e9, V. et al. Mechanism of parkin activation by phosphorylation. Nat. Struct. Mol. Biol. 25, 623\u2013630 (2018).","journal-title":"Nat. Struct. Mol. Biol."},{"key":"6656_CR26","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1038\/s41586-018-0224-x","volume":"559","author":"C Gladkova","year":"2018","unstructured":"Gladkova, C., Maslen, S. L., Skehel, J. M. & Komander, D. Mechanism of parkin activation by PINK1. Nature 559, 410\u2013414 (2018).","journal-title":"Nature"},{"key":"6656_CR27","doi-asserted-by":"publisher","first-page":"102114","DOI":"10.1016\/j.jbc.2022.102114","volume":"298","author":"R Fakih","year":"2022","unstructured":"Fakih, R., Sauv\u00e9, V. & Gehring, K. Structure of the second phosphoubiquitin-binding site in parkin. J. Biol. Chem. 298, 102114 (2022).","journal-title":"J. Biol. Chem."},{"key":"6656_CR28","doi-asserted-by":"publisher","first-page":"e109460","DOI":"10.15252\/embj.2021109460","volume":"41","author":"V Sauv\u00e9","year":"2022","unstructured":"Sauv\u00e9, V. et al. Structural basis for feedforward control in the PINK1\/Parkin pathway. EMBO J. 41, e109460 (2022).","journal-title":"EMBO J."},{"key":"6656_CR29","doi-asserted-by":"publisher","first-page":"2811","DOI":"10.1093\/hmg\/ddz080","volume":"28","author":"W Yi","year":"2019","unstructured":"Yi, W. et al. The landscape of Parkin variants reveals pathogenic mechanisms and therapeutic targets in Parkinson\u2019s disease. Hum. Mol. Genet 28, 2811\u20132825 (2019).","journal-title":"Hum. Mol. Genet"},{"key":"6656_CR30","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nmeth.2089","volume":"9","author":"CA Schneider","year":"2012","unstructured":"Schneider, C. A., Rasband, W. S. & Eliceiri, K. W. NIH Image to ImageJ: 25 years of image analysis. Nat. Methods 9, 671\u2013675 (2012).","journal-title":"Nat. Methods"},{"key":"6656_CR31","doi-asserted-by":"publisher","first-page":"5187","DOI":"10.1093\/emboj\/20.18.5187","volume":"20","author":"A Borodovsky","year":"2001","unstructured":"Borodovsky, A. et al. A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14. EMBO J. 20, 5187\u20135196 (2001).","journal-title":"EMBO J."},{"key":"6656_CR32","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1042\/BJ20140006","volume":"458","author":"DE Spratt","year":"2014","unstructured":"Spratt, D. E., Walden, H. & Shaw, G. S. RBR E3 ubiquitin ligases: new structures, new insights, new questions. Biochem. J. 458, 421\u2013437 (2014).","journal-title":"Biochem. J."},{"key":"6656_CR33","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.1021\/bi200065g","volume":"50","author":"SS Safadi","year":"2011","unstructured":"Safadi, S. S., Barber, K. R. & Shaw, G. S. Impact of autosomal recessive juvenile Parkinson\u2019s disease mutations on the structure and interactions of the parkin ubiquitin-like domain. Biochemistry 50, 2603\u20132610 (2011).","journal-title":"Biochemistry"},{"key":"6656_CR34","doi-asserted-by":"publisher","first-page":"6337","DOI":"10.1074\/jbc.RA117.000605","volume":"293","author":"JD Aguirre","year":"2018","unstructured":"Aguirre, J. D., Dunkerley, K. M., Lam, R., Rusal, M. & Shaw, G. S. Impact of altered phosphorylation on loss of function of juvenile Parkinsonism-associated genetic variants of the E3 ligase parkin. J. Biol. Chem. 293, 6337\u20136348 (2018).","journal-title":"J. Biol. Chem."},{"key":"6656_CR35","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3233\/JPD-2011-11041","volume":"1","author":"M Oliveras-Salv\u00e1","year":"2011","unstructured":"Oliveras-Salv\u00e1, M., Van Rompuy, A. S., Heeman, B., Van den Haute, C. & Baekelandt, V. Loss-of-function rodent models for parkin and PINK1. J. Parkinsons Dis. 1, 229\u2013251 (2011).","journal-title":"J. Parkinsons Dis."},{"key":"6656_CR36","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.3390\/cells11152426","volume":"11","author":"BJ Broadway","year":"2022","unstructured":"Broadway, B. J. et al. Systematic functional analysis of PINK1 and PRKN coding variants. Cells 11, 2426 (2022).","journal-title":"Cells"},{"key":"6656_CR37","doi-asserted-by":"publisher","first-page":"103650","DOI":"10.1016\/j.isci.2021.103650","volume":"25","author":"E Shlevkov","year":"2022","unstructured":"Shlevkov, E. et al. Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase. iScience 25, 103650 (2022).","journal-title":"iScience"},{"key":"6656_CR38","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14697","volume":"8","author":"MY Tang","year":"2017","unstructured":"Tang, M. Y. et al. Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation. Nat. Commun. 8, 14697 (2017).","journal-title":"Nat. Commun."},{"key":"6656_CR39","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1002\/humu.22808","volume":"36","author":"FC Fiesel","year":"2015","unstructured":"Fiesel, F. C. et al. Structural and functional impact of Parkinson disease-associated mutations in the E3 ubiquitin ligase parkin. Hum. Mutat. 36, 774\u2013786 (2015).","journal-title":"Hum. Mutat."},{"key":"6656_CR40","doi-asserted-by":"publisher","first-page":"210255","DOI":"10.1098\/rsob.210255","volume":"12","author":"M Vranas","year":"2022","unstructured":"Vranas, M. et al. Selective localization of Mfn2 near PINK1 enables its preferential ubiquitination by Parkin on mitochondria. Open Biol. 12, 210255 (2022).","journal-title":"Open Biol."},{"key":"6656_CR41","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1111\/j.1468-1331.2006.01249.x","volume":"13","author":"JM Hertz","year":"2006","unstructured":"Hertz, J. M. et al. Low frequency of Parkin, Tyrosine Hydroxylase, and GTP Cyclohydrolase I gene mutations in a Danish population of early-onset Parkinson\u2019s Disease. Eur. J. Neurol. 13, 385\u2013390 (2006).","journal-title":"Eur. J. Neurol."},{"key":"6656_CR42","doi-asserted-by":"publisher","first-page":"e202201419","DOI":"10.26508\/lsa.202201419","volume":"6","author":"MU Stevens","year":"2023","unstructured":"Stevens, M. U. et al. Structure-based design and characterization of Parkin-activating mutations. Life Sci. Alliance 6, e202201419 (2023).","journal-title":"Life Sci. Alliance"},{"key":"6656_CR43","doi-asserted-by":"publisher","first-page":"eadg7492","DOI":"10.1126\/science.adg7492","volume":"381","author":"J Cheng","year":"2023","unstructured":"Cheng, J. et al. Accurate proteome-wide missense variant effect prediction with AlphaMissense. Science 381, eadg7492 (2023).","journal-title":"Science"},{"key":"6656_CR44","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1038\/s41422-019-0142-y","volume":"29","author":"W Yang","year":"2019","unstructured":"Yang, W. et al. CRISPR\/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys. Cell Res. 29, 334\u2013336 (2019).","journal-title":"Cell Res."},{"key":"6656_CR45","doi-asserted-by":"publisher","first-page":"242","DOI":"10.24272\/j.issn.2095-8137.2023.241","volume":"45","author":"XS Chen","year":"2024","unstructured":"Chen, X. S. et al. Comparative analysis of primate and pig cells reveals primate-specific PINK1 expression and phosphorylation. Zool. Res. 45, 242\u2013252 (2024).","journal-title":"Zool. Res."},{"key":"6656_CR46","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s13238-021-00888-x","volume":"13","author":"W Yang","year":"2022","unstructured":"Yang, W. et al. PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis. Protein Cell 13, 26\u201346 (2022).","journal-title":"Protein Cell"},{"key":"6656_CR47","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.gde.2017.01.016","volume":"44","author":"AJ Whitworth","year":"2017","unstructured":"Whitworth, A. J. & Pallanck, L. J. PINK1\/Parkin mitophagy and neurodegeneration-what do we really know in vivo? Curr. Opin. Genet Dev. 44, 47\u201353 (2017).","journal-title":"Curr. Opin. Genet Dev."},{"key":"6656_CR48","doi-asserted-by":"publisher","first-page":"3775","DOI":"10.1016\/j.neuron.2023.08.018","volume":"111","author":"P Song","year":"2023","unstructured":"Song, P. et al. Parkinson\u2019s disease-linked parkin mutation disrupts recycling of synaptic vesicles in human dopaminergic neurons. Neuron 111, 3775\u20133788 e3777 (2023).","journal-title":"Neuron"},{"key":"6656_CR49","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1016\/j.molcel.2009.11.021","volume":"36","author":"JF Trempe","year":"2009","unstructured":"Trempe, J. F. et al. SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination. Mol. Cell 36, 1034\u20131047 (2009).","journal-title":"Mol. Cell"},{"key":"6656_CR50","doi-asserted-by":"publisher","first-page":"16544","DOI":"10.1523\/JNEUROSCI.1710-14.2014","volume":"34","author":"M Cao","year":"2014","unstructured":"Cao, M., Milosevic, I., Giovedi, S. & De Camilli, P. Upregulation of Parkin in endophilin mutant mice. J. Neurosci. 34, 16544\u201316549 (2014).","journal-title":"J. Neurosci."},{"key":"6656_CR51","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.parkreldis.2005.12.004","volume":"12","author":"S Chaudhary","year":"2006","unstructured":"Chaudhary, S. et al. Parkin mutations in familial and sporadic Parkinson\u2019s disease among Indians. Parkinsonism Relat. Disord. 12, 239\u2013245 (2006).","journal-title":"Parkinsonism Relat. Disord."},{"key":"6656_CR52","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-45829-4","volume":"15","author":"L Clausen","year":"2024","unstructured":"Clausen, L. et al. A mutational atlas for Parkin proteostasis. Nat. Commun. 15, 1541 (2024).","journal-title":"Nat. Commun."}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-06656-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-06656-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-06656-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T18:17:09Z","timestamp":1723141029000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-06656-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,8]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["6656"],"URL":"https:\/\/doi.org\/10.1038\/s42003-024-06656-x","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,8]]},"assertion":[{"value":"12 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"961"}}