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As a fundamental step towards addressing this gap, here we study predictive dynamical models of human intracranial EEG (iEEG) response under parametrically rich neurostimulation. Using data from\n                    <jats:italic>n<\/jats:italic>\n                    = 13 DRE patients, we find that stimulation-triggered switched-linear models with ~300\u2009ms of causal historical dependence best explain evoked iEEG dynamics. These models are highly consistent across different stimulation amplitudes and frequencies, allowing for learning a generalizable model from abundant STIM OFF and limited STIM ON data. Further, evoked iEEG in nearly all subjects exhibited a distance-dependent pattern, whereby stimulation\n                    <jats:italic>directly<\/jats:italic>\n                    impacts the actuation site and nearby regions (\u2272\u00a020\u2009mm), affects medium-distance regions (20\u00a0~\u00a0100\u2009mm) through network interactions, and hardly reaches more distal areas (\u2273\u00a0100\u2009mm). Peak network interaction occurs at 60 ~\u00a080\u2009mm from the stimulation site. Due to their predictive accuracy and mechanistic interpretability, these models hold significant potential for model-based seizure forecasting and closed-loop neurostimulation design.\n                  <\/jats:p>","DOI":"10.1038\/s42003-024-06859-2","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T04:01:41Z","timestamp":1727496101000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Predictive modeling of evoked intracranial EEG response to medial temporal lobe stimulation in patients with epilepsy"],"prefix":"10.1038","volume":"7","author":[{"given":"Gagan","family":"Acharya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7020-6480","authenticated-orcid":false,"given":"Kathryn A.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1981-8959","authenticated-orcid":false,"given":"Erfan","family":"Nozari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,28]]},"reference":[{"key":"6859_CR1","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.eplepsyres.2019.02.003","volume":"153","author":"TL Skarpaas","year":"2019","unstructured":"Skarpaas, T. 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