{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:42:57Z","timestamp":1792813377986,"version":"4.5.0"},"reference-count":87,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T00:00:00Z","timestamp":1729900800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T00:00:00Z","timestamp":1729900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-10-LABX-62-IBEID"],"award-info":[{"award-number":["ANR-10-LABX-62-IBEID"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Domaine d&apos;Int\u00e9r\u00eat Majeur de l&apos;Ile-de-France RESPORE. AAP petits \u00e9quipements."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-024-06967-z","type":"journal-article","created":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T11:01:59Z","timestamp":1729940519000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Validation of metaxin-2 deficient C. elegans as a model for MandibuloAcral Dysplasia associated to mtx-2 (MADaM) syndrome"],"prefix":"10.1038","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8261-9688","authenticated-orcid":false,"given":"Chlo\u00e9","family":"Talarmin-Gas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Smolyakov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2907-4025","authenticated-orcid":false,"given":"Cleo","family":"Parisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5305-9095","authenticated-orcid":false,"given":"Cyril","family":"Scandola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Andrianasolonirina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clo\u00e9","family":"Lecoq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentine","family":"Houtart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song-Hua","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homa","family":"Adle-Biassette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte","family":"Thi\u00e9bot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Ganderton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2510-6357","authenticated-orcid":false,"given":"Philippe","family":"Manivet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,26]]},"reference":[{"key":"6967_CR1","first-page":"e28629","volume":"14","author":"A Lamis","year":"2022","unstructured":"Lamis, A. et al. Hutchinson-Gilford progeria syndrome: a literature review. Cureus 14, e28629 (2022).","journal-title":"Cureus"},{"key":"6967_CR2","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.ajhg.2011.04.010","volume":"88","author":"XS Puente","year":"2011","unstructured":"Puente, X. S. et al. Exome sequencing and functional analysis identifies BANF1 mutation as the cause of a hereditary progeroid syndrome. Am J Hum Genet 88, 650\u2013656 (2011).","journal-title":"Am J Hum Genet"},{"key":"6967_CR3","first-page":"373","volume":"33","author":"A David","year":"2017","unstructured":"David, A. et al. Werner syndrome: Clinical features, pathogenesis and potential therapeutic interventions. Ageing Res Rev 33, 373\u2013378 (2017).","journal-title":"Ageing Res Rev"},{"key":"6967_CR4","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1001\/jama.2018.3264","volume":"319","author":"LB Gordon","year":"2018","unstructured":"Gordon, L. B. et al. Association of lonafarnib treatment vs no treatment with mortality rate in patients with Hutchinson-Gilford progeria syndrome. JAMA 319, 1687\u20131695 (2018).","journal-title":"JAMA"},{"key":"6967_CR5","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18146-9","volume":"11","author":"S Elouej","year":"2020","unstructured":"Elouej, S. et al. Loss of MTX2 causes mandibuloacral dysplasia and links mitochondrial dysfunction to altered nuclear morphology. Nat Commun 11, 4589 (2020).","journal-title":"Nat Commun"},{"key":"6967_CR6","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1002\/ajmg.a.63010","volume":"191","author":"B Yeter Do\u011fan","year":"2023","unstructured":"Yeter Do\u011fan, B., G\u00fcnay, N., Ada, Y. & Do\u011fan, M. E. A novel MTX2 gene splice site variant resulting in exon skipping, causing the recently described mandibuloacral dysplasia progeroid syndrome. Am J Med Genet A 191, 173\u2013182 (2023).","journal-title":"Am J Med Genet A"},{"key":"6967_CR7","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1056\/NEJMoa0706898","volume":"358","author":"MA Merideth","year":"2008","unstructured":"Merideth, M. A. et al. Phenotype and course of Hutchinson-Gilford progeria syndrome. N Engl J Med 358, 592\u2013604 (2008).","journal-title":"N Engl J Med"},{"key":"6967_CR8","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.1161\/ATVBAHA.110.209460","volume":"30","author":"M Olive","year":"2010","unstructured":"Olive, M. et al. Cardiovascular pathology in Hutchinson-Gilford progeria: correlation with the vascular pathology of aging. Arterioscler Thromb Vasc Biol 30, 2301\u20132309 (2010).","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"6967_CR9","unstructured":"BLAST | UniProt. https:\/\/www.uniprot.org\/blast."},{"key":"6967_CR10","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/(SICI)1097-4644(19990701)74:1<11::AID-JCB2>3.0.CO;2-V","volume":"74","author":"LC Armstrong","year":"1999","unstructured":"Armstrong, L. C., Saenz, A. J. & Bornstein, P. Metaxin 1 interacts with metaxin 2, a novel related protein associated with the mammalian mitochondrial outer membrane. J Cell Biochem 74, 11\u201322 (1999).","journal-title":"J Cell Biochem"},{"key":"6967_CR11","doi-asserted-by":"publisher","first-page":"6510","DOI":"10.1074\/jbc.272.10.6510","volume":"272","author":"LC Armstrong","year":"1997","unstructured":"Armstrong, L. C., Komiya, T., Bergman, B. E., Mihara, K. & Bornstein, P. Metaxin is a component of a preprotein import complex in the outer membrane of the mammalian mitochondrion. J Biol Chem 272, 6510\u20136518 (1997).","journal-title":"J Biol Chem"},{"key":"6967_CR12","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1038\/nature02208","volume":"426","author":"SA Paschen","year":"2003","unstructured":"Paschen, S. A. et al. Evolutionary conservation of biogenesis of beta-barrel membrane proteins. Nature 426, 862\u2013866 (2003).","journal-title":"Nature"},{"key":"6967_CR13","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1016\/j.bbamcr.2017.05.004","volume":"1864","author":"F Wollweber","year":"2017","unstructured":"Wollweber, F., von der Malsburg, K. & van der Laan, M. Mitochondrial contact site and cristae organizing system: A central player in membrane shaping and crosstalk. Biochim Biophys Acta Mol Cell Res 1864, 1481\u20131489 (2017).","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"6967_CR14","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s00441-016-2433-7","volume":"367","author":"V Kozjak-Pavlovic","year":"2017","unstructured":"Kozjak-Pavlovic, V. The MICOS complex of human mitochondria. Cell Tissue Res 367, 83\u201393 (2017).","journal-title":"Cell Tissue Res"},{"key":"6967_CR15","doi-asserted-by":"publisher","first-page":"279","DOI":"10.3389\/fgene.2014.00279","volume":"5","author":"AG Alexander","year":"2014","unstructured":"Alexander, A. G., Marfil, V. & Li, C. Use of Caenorhabditis elegans as a model to study Alzheimer\u2019s disease and other neurodegenerative diseases. Front Genet 5, 279 (2014).","journal-title":"Front Genet"},{"key":"6967_CR16","doi-asserted-by":"publisher","first-page":"288","DOI":"10.3390\/biomedicines10020288","volume":"10","author":"J Alvarez","year":"2022","unstructured":"Alvarez, J., Alvarez-Illera, P., Santo-Domingo, J., Fonteriz, R. I. & Montero, M. Modeling Alzheimer\u2019s Disease in Caenorhabditis elegans. Biomedicines 10, 288 (2022).","journal-title":"Biomedicines"},{"key":"6967_CR17","doi-asserted-by":"publisher","first-page":"2716","DOI":"10.1091\/mbc.e11-01-0064","volume":"22","author":"EM Bank","year":"2011","unstructured":"Bank, E. M. et al. A laminopathic mutation disrupting lamin filament assembly causes disease-like phenotypes in Caenorhabditis elegans. Mol Biol Cell 22, 2716 (2011).","journal-title":"Mol Biol Cell"},{"key":"6967_CR18","doi-asserted-by":"publisher","first-page":"31301","DOI":"10.1073\/pnas.2015050117","volume":"117","author":"G Huelgas-Morales","year":"2020","unstructured":"Huelgas-Morales, G., Sanders, M., Mekonnen, G., Tsukamoto, T. & Greenstein, D. Decreased mechanotransduction prevents nuclear collapse in a Caenorhabditis elegans laminopathy. Proc Natl Acad Sci 117, 31301\u201331308 (2020).","journal-title":"Proc Natl Acad Sci"},{"key":"6967_CR19","doi-asserted-by":"publisher","first-page":"e62449","DOI":"10.7554\/eLife.62449","volume":"10","author":"TY Hsu","year":"2021","unstructured":"Hsu, T. Y., Zhang, B., L\u2019Etoile, N. D. & Juang, B. T. C. elegans orthologs MUT-7\/CeWRN-1 of Werner syndrome protein regulate neuronal plasticity. Elife 10, e62449 (2021).","journal-title":"Elife"},{"key":"6967_CR20","doi-asserted-by":"publisher","unstructured":"Currey, H. N. & Liachko, N. F. Evaluation of motor impairment in C. Elegans models of amyotrophic lateral sclerosis. J. Vis. Exp. https:\/\/doi.org\/10.3791\/62699 (2021).","DOI":"10.3791\/62699"},{"key":"6967_CR21","doi-asserted-by":"publisher","first-page":"110195","DOI":"10.1016\/j.celrep.2021.110195","volume":"38","author":"SN Baskoylu","year":"2022","unstructured":"Baskoylu, S. N. et al. Disrupted autophagy and neuronal dysfunction in C. elegans knockin models of FUS amyotrophic lateral sclerosis. Cell Rep 38, 110195 (2022).","journal-title":"Cell Rep"},{"key":"6967_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16637-2","volume":"7","author":"JF Cooper","year":"2017","unstructured":"Cooper, J. F. et al. Activation of the mitochondrial unfolded protein response promotes longevity and dopamine neuron survival in Parkinson\u2019s disease models. Sci Rep 7, 16441 (2017).","journal-title":"Sci Rep"},{"key":"6967_CR23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-020-20314-w","volume":"12","author":"Y Zhao","year":"2021","unstructured":"Zhao, Y. et al. Metaxins are core components of mitochondrial transport adaptor complexes. Nat Commun 12, 1\u201317 (2021).","journal-title":"Nat Commun"},{"key":"6967_CR24","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.semcdb.2023.02.010","volume":"154","author":"PX Chen","year":"2024","unstructured":"Chen, P. X., Zhang, L., Chen, D. & Tian, Y. Mitochondrial stress and aging: Lessons from C. elegans. Semin Cell Dev Biol 154, 69\u201376 (2024).","journal-title":"Semin Cell Dev Biol"},{"key":"6967_CR25","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ddmod.2018.11.001","volume":"27","author":"HID Mack","year":"2018","unstructured":"Mack, H. I. D., Heimbucher, T. & Murphy, C. T. The nematode Caenorhabditis elegans as a model for aging research. Drug Discov Today Dis Models 27, 3\u201313 (2018).","journal-title":"Drug Discov Today Dis Models"},{"key":"6967_CR26","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1002\/wdev.77","volume":"1","author":"AD Chisholm","year":"2012","unstructured":"Chisholm, A. D. & Xu, S. The Caenorhabditis elegans epidermis as a model skin. II: differentiation and physiological roles. Wiley Interdiscip Rev Dev Biol 1, 879\u2013902 (2012).","journal-title":"Wiley Interdiscip Rev Dev Biol"},{"key":"6967_CR27","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1002\/wdev.79","volume":"1","author":"AD Chisholm","year":"2012","unstructured":"Chisholm, A. D. & Hsiao, T. I. The Caenorhabditis elegans epidermis as a model skin. I: development, patterning, and growth. Wiley Interdiscip Rev Dev Biol 1, 861\u2013878 (2012).","journal-title":"Wiley Interdiscip Rev Dev Biol"},{"key":"6967_CR28","doi-asserted-by":"publisher","first-page":"20551","DOI":"10.1074\/jbc.M011066200","volume":"276","author":"EB Kayser","year":"2001","unstructured":"Kayser, E. B., Morgan, P. G., Hoppel, C. L. & Sedensky, M. M. Mitochondrial expression and function of GAS-1 in Caenorhabditis elegans. J Biol Chem 276, 20551\u201320558 (2001).","journal-title":"J Biol Chem"},{"key":"6967_CR29","doi-asserted-by":"publisher","first-page":"564","DOI":"10.2144\/04374BI01","volume":"37","author":"BE Layton","year":"2004","unstructured":"Layton, B. E. et al. In situ imaging of mitochondrial outer-membrane pores using atomic force microscopy. Biotechniques 37, 564\u2013573 (2004).","journal-title":"Biotechniques"},{"key":"6967_CR30","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/978-1-61779-105-5_10","volume":"736","author":"BE Layton","year":"2011","unstructured":"Layton, B. E. & Boyd, M. B. Atomic force microscopy of isolated mitochondria. Methods Mol Biol 736, 133\u2013151 (2011).","journal-title":"Methods Mol Biol"},{"key":"6967_CR31","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1038\/nprot.2016.106","volume":"11","author":"M Koopman","year":"2016","unstructured":"Koopman, M. et al. A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans. Nat Protoc 11, 1798\u20131816 (2016).","journal-title":"Nat Protoc"},{"key":"6967_CR32","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1534\/genetics.119.302504","volume":"213","author":"TK Blackwell","year":"2019","unstructured":"Blackwell, T.K., Sewell, A.K., Wu, Z. & Han, M. TOR signaling in Caenorhabditis elegans development, metabolism, and aging. Genetics 213, 329\u2013360 (2019).","journal-title":"Genetics"},{"key":"6967_CR33","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1534\/genetics.119.302919","volume":"214","author":"AD Holdorf","year":"2020","unstructured":"Holdorf, A. D. et al. WormCat: an online tool for annotation and visualization of caenorhabditis elegans Genome-Scale Data. Genetics 214, 279\u2013294 (2020).","journal-title":"Genetics"},{"key":"6967_CR34","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-31121-w","volume":"13","author":"AB Fern\u00e1ndez Casafuz","year":"2023","unstructured":"Fern\u00e1ndez Casafuz, A. B., De Rossi, M. C. & Bruno, L. Mitochondrial cellular organization and shape fluctuations are differentially modulated by cytoskeletal networks. Sci Rep 13, 4065 (2023).","journal-title":"Sci Rep"},{"key":"6967_CR35","doi-asserted-by":"publisher","first-page":"20210324","DOI":"10.1098\/rstb.2021.0324","volume":"377","author":"T Solomon","year":"2022","unstructured":"Solomon, T., Rajendran, M., Rostovtseva, T. & Hool, L. How cytoskeletal proteins regulate mitochondrial energetics in cell physiology and diseases. Philos Trans R Soc B Biol Sci 377, 20210324 (2022).","journal-title":"Philos Trans R Soc B Biol Sci"},{"key":"6967_CR36","doi-asserted-by":"publisher","first-page":"W191","DOI":"10.1093\/nar\/gkz369","volume":"47","author":"U Raudvere","year":"2019","unstructured":"Raudvere, U. et al. g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update). Nucleic Acids Res 47, W191\u2013W198 (2019).","journal-title":"Nucleic Acids Res"},{"key":"6967_CR37","doi-asserted-by":"publisher","first-page":"e202201501","DOI":"10.26508\/lsa.202201501","volume":"5","author":"JP Trani","year":"2022","unstructured":"Trani, J. P. et al. Mesenchymal stem cells derived from patients with premature aging syndromes display hallmarks of physiological aging. Life Sci Alliance 5, e202201501 (2022).","journal-title":"Life Sci Alliance"},{"key":"6967_CR38","doi-asserted-by":"publisher","first-page":"12995","DOI":"10.1111\/acel.12995","volume":"18","author":"A Maierhofer","year":"2019","unstructured":"Maierhofer, A. et al. Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes. Aging Cell 18, 12995 (2019).","journal-title":"Aging Cell"},{"key":"6967_CR39","unstructured":"WormBase: Nematode Information Resource. https:\/\/wormbase.org\/\/#012-34-5."},{"key":"6967_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-020-14785-0","volume":"11","author":"CL Essmann","year":"2020","unstructured":"Essmann, C. L. et al. Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. elegans. Nat Commun 11, 1\u201316 (2020).","journal-title":"Nat Commun"},{"key":"6967_CR41","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.nano.2016.09.006","volume":"13","author":"CL Essmann","year":"2017","unstructured":"Essmann, C. L. et al. In-vivo high resolution AFM topographic imaging of Caenorhabditis elegans reveals previously unreported surface structures of cuticle mutants. Nanomedicine 13, 183\u2013189 (2017).","journal-title":"Nanomedicine"},{"key":"6967_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13071-021-04800-8","volume":"14","author":"VS Njom","year":"2021","unstructured":"Njom, V. S. et al. The effects of plant cysteine proteinases on the nematode cuticle. Parasit Vectors 14, 1\u201311 (2021).","journal-title":"Parasit Vectors"},{"key":"6967_CR43","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1091\/mbc.e02-08-0479","volume":"14","author":"L McMahon","year":"2003","unstructured":"McMahon, L., Muriel, J. M., Roberts, B., Quinn, M. & Johnstone, I. L. Two Sets of Interacting Collagens Form Functionally Distinct Substructures within a Caenorhabditis elegans Extracellular Matrix. Mol Biol Cell 14, 1366 (2003).","journal-title":"Mol Biol Cell"},{"key":"6967_CR44","doi-asserted-by":"publisher","first-page":"203780","DOI":"10.1016\/j.cdev.2022.203780","volume":"170","author":"J Nyaanga","year":"2022","unstructured":"Nyaanga, J. et al. Changes in body shape implicate cuticle stretch in C. elegans growth control. Cells Dev 170, 203780 (2022).","journal-title":"Cells Dev"},{"key":"6967_CR45","doi-asserted-by":"publisher","first-page":"160","DOI":"10.14348\/molcells.2021.2236","volume":"44","author":"JY Cho","year":"2021","unstructured":"Cho, J. Y., Choi, T. W., Kim, S. H., Ahnn, J. & Lee, S. K. Morphological Characterization of small, dumpy, and long Phenotypes in Caenorhabditis elegans. Mol Cells 44, 160 (2021).","journal-title":"Mol Cells"},{"key":"6967_CR46","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.1242\/jeb.00433","volume":"206","author":"L Avery","year":"2003","unstructured":"Avery, L. & Shtonda, B. B. Food transport in the C. elegans pharynx. J Exp Biol 206, 2441\u20132457 (2003).","journal-title":"J Exp Biol"},{"key":"6967_CR47","doi-asserted-by":"publisher","first-page":"26594","DOI":"10.1371\/journal.pone.0026594","volume":"6","author":"A Ferrier","year":"2011","unstructured":"Ferrier, A. et al. Multiple Phenotypes Resulting from a Mutagenesis Screen for Pharynx Muscle Mutations in Caenorhabditis elegans. PLoS One 6, 26594 (2011).","journal-title":"PLoS One"},{"key":"6967_CR48","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1093\/gerona\/glx230","volume":"74","author":"JC Russell","year":"2019","unstructured":"Russell, J. C. et al. Electrophysiological measures of aging pharynx function in C. elegans reveal enhanced organ functionality in older, long-lived mutants. J Gerontol A Biol Sci Med Sci 74, 1173 (2019).","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"6967_CR49","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.mad.2004.04.002","volume":"125","author":"EB Kayser","year":"2004","unstructured":"Kayser, E. B., Sedensky, M. M. & Morgan, P. G. The effects of complex I function and oxidative damage on lifespan and anesthetic sensitivity in Caenorhabditis elegans. Mech Ageing Dev 125, 455\u2013464 (2004).","journal-title":"Mech Ageing Dev"},{"key":"6967_CR50","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.mad.2011.08.006","volume":"132","author":"JM Van Raamsdonk","year":"2011","unstructured":"Van Raamsdonk, J. M. & Hekimi, S. FUdR causes a twofold increase in the lifespan of the mitochondrial mutant gas-1. Mech Ageing Dev 132, 519\u2013521 (2011).","journal-title":"Mech Ageing Dev"},{"key":"6967_CR51","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.exger.2005.12.004","volume":"41","author":"DK Chow","year":"2006","unstructured":"Chow, D. K., Glenn, C. F., Johnston, J. L., Goldberg, I. G. & Wolkow, C. A. Sarcopenia in the Caenorhabditis elegans pharynx correlates with muscle contraction rate over lifespan. Exp Gerontol 41, 252\u2013260 (2006).","journal-title":"Exp Gerontol"},{"key":"6967_CR52","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9919","volume":"6","author":"JH Hahm","year":"2015","unstructured":"Hahm, J. H. et al. C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation. Nat Commun 6, 8919 (2015).","journal-title":"Nat Commun"},{"key":"6967_CR53","doi-asserted-by":"publisher","unstructured":"Croft, J. C., Colunga, A., Solh, L., Dillon, M. K. & Lee, T. W. Pharyngeal pumping rate does not reflect lifespan extension in C. elegans transgenerational longevity mutants. MicroPubl Biol https:\/\/doi.org\/10.17912\/micropub.biology.000719 (2023).","DOI":"10.17912\/micropub.biology.000719"},{"key":"6967_CR54","unstructured":"Orphanet: Pigmentation anomaly of the skin. https:\/\/www.orpha.net\/en\/disease\/detail\/79374."},{"key":"6967_CR55","doi-asserted-by":"publisher","first-page":"9274","DOI":"10.1073\/pnas.1011711108","volume":"108","author":"CL Pan","year":"2011","unstructured":"Pan, C. L., Peng, C. Y., Chen, C. H. & McIntire, S. Genetic analysis of age-dependent defects of the Caenorhabditis elegans touch receptor neurons. Proc Natl Acad Sci 108, 9274\u20139279 (2011).","journal-title":"Proc Natl Acad Sci"},{"key":"6967_CR56","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.mad.2006.07.002","volume":"127","author":"K Yasuda","year":"2006","unstructured":"Yasuda, K. et al. Age-related changes of mitochondrial structure and function in Caenorhabditis elegans. Mech Ageing Dev 127, 763\u2013770 (2006).","journal-title":"Mech Ageing Dev"},{"key":"6967_CR57","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3233\/JPD-171258","volume":"8","author":"JF Cooper","year":"2018","unstructured":"Cooper, J. F. & Van Raamsdonk, J. M. Modeling Parkinson\u2019s Disease in C. elegans. J Parkinsons Dis 8, 17 (2018).","journal-title":"J Parkinsons Dis"},{"key":"6967_CR58","doi-asserted-by":"publisher","first-page":"e00721","DOI":"10.1002\/prp2.721","volume":"9","author":"S Giunti","year":"2021","unstructured":"Giunti, S., Andersen, N., Rayes, D. & De Rosa, M. J. Drug discovery: Insights from the invertebrate Caenorhabditis elegans. Pharmacol Res Perspect 9, e00721 (2021).","journal-title":"Pharmacol Res Perspect"},{"key":"6967_CR59","unstructured":"SydLabTM one - Nagi Bioscience. https:\/\/nagibio.ch\/products-services\/sydlab-system."},{"key":"6967_CR60","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-61054-7","volume":"10","author":"GD Preez","year":"2020","unstructured":"Preez, G. D. et al. Oxygen consumption rate of Caenorhabditis elegans as a high-throughput endpoint of toxicity testing using the Seahorse XFe96 Extracellular Flux Analyzer. Sci Rep 10, 4239 (2020).","journal-title":"Sci Rep"},{"key":"6967_CR61","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/164_2016_38","volume":"240","author":"MN Serasinghe","year":"2017","unstructured":"Serasinghe, M. N. & Chipuk, J. E. Mitochondrial Fission in Human Diseases. Handb Exp Pharmacol 240, 159\u2013188 (2017).","journal-title":"Handb Exp Pharmacol"},{"key":"6967_CR62","doi-asserted-by":"publisher","first-page":"17190","DOI":"10.1074\/jbc.M212754200","volume":"278","author":"D Bach","year":"2003","unstructured":"Bach, D. et al. Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity. J Biol Chem 278, 17190\u201317197 (2003).","journal-title":"J Biol Chem"},{"key":"6967_CR63","doi-asserted-by":"publisher","first-page":"3545","DOI":"10.1016\/j.febslet.2007.06.052","volume":"581","author":"J Xie","year":"2007","unstructured":"Xie, J., Marusich, M. F., Souda, P., Whitelegge, J. & Capaldi, R. A. The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11. FEBS Lett 581, 3545\u20133549 (2007).","journal-title":"FEBS Lett"},{"key":"6967_CR64","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/nature08908","volume":"463","author":"DA Fletcher","year":"2010","unstructured":"Fletcher, D. A. & Mullins, R. D. Cell mechanics and the cytoskeleton. Nature 463, 485\u2013492 (2010).","journal-title":"Nature"},{"key":"6967_CR65","doi-asserted-by":"publisher","first-page":"e0120213","DOI":"10.1371\/journal.pone.0120213","volume":"10","author":"C Ott","year":"2015","unstructured":"Ott, C., Dorsch, E., Fraunholz, M., Straub, S. & Kozjak-Pavlovic, V. Detailed Analysis of the Human Mitochondrial Contact Site Complex Indicate a Hierarchy of Subunits. PLoS One 10, e0120213 (2015).","journal-title":"PLoS One"},{"key":"6967_CR66","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1128\/MCB.06388-11","volume":"32","author":"C Ott","year":"2012","unstructured":"Ott, C. et al. Sam50 functions in mitochondrial intermembrane space bridging and biogenesis of respiratory complexes. Mol Cell Biol 32, 1173\u20131188 (2012).","journal-title":"Mol Cell Biol"},{"key":"6967_CR67","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1038\/nm1266","volume":"11","author":"B Liu","year":"2005","unstructured":"Liu, B. et al. Genomic instability in laminopathy-based premature aging. Nat Med 11, 780\u2013785 (2005).","journal-title":"Nat Med"},{"key":"6967_CR68","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1080\/19491034.2019.1589359","volume":"10","author":"MR Hamczyk","year":"2019","unstructured":"Hamczyk, M. R. & Andr\u00e9s, V. Vascular smooth muscle cell loss underpins the accelerated atherosclerosis in Hutchinson-Gilford progeria syndrome. Nucleus 10, 28\u201334 (2019).","journal-title":"Nucleus"},{"key":"6967_CR69","doi-asserted-by":"publisher","first-page":"33495","DOI":"10.1074\/jbc.273.50.33495","volume":"273","author":"L Del Peso","year":"1998","unstructured":"Del Peso, L., Gonz\u00e1lez, V. M. & N\u00fanez, G. Caenorhabditis elegans EGL-1 disrupts the interaction of CED-9 with CED-4 and promotes CED-3 activation. J Biol Chem 273, 33495\u201333500 (1998).","journal-title":"J Biol Chem"},{"key":"6967_CR70","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1038\/sj.cdd.4402215","volume":"14","author":"FJ Tan","year":"2007","unstructured":"Tan, F. J., Fire, A. Z. & Hill, R. B. Regulation of apoptosis by C. elegans CED-9 in the absence of the C-terminal transmembrane domain. Cell Death Differ 14, 1925\u20131935 (2007).","journal-title":"Cell Death Differ"},{"key":"6967_CR71","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.devcel.2007.05.004","volume":"12","author":"A Penkner","year":"2007","unstructured":"Penkner, A. et al. The nuclear envelope protein Matefin\/SUN-1 is required for homologous pairing in C. elegans meiosis. Dev Cell 12, 873\u2013885 (2007).","journal-title":"Dev Cell"},{"key":"6967_CR72","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1534\/g3.115.017715","volume":"5","author":"L Gorrepati","year":"2015","unstructured":"Gorrepati, L. et al. Identification of Wnt Pathway Target Genes Regulating the Division and Differentiation of Larval Seam Cells and Vulval Precursor Cells in Caenorhabditis elegans. G3 Genes|Genomes|Genetics 5, 1551\u20131566 (2015).","journal-title":"G3 Genes|Genomes|Genetics"},{"key":"6967_CR73","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1002\/jbmr.3549","volume":"33","author":"JY Choi","year":"2018","unstructured":"Choi, J. Y. et al. Diminished Canonical \u03b2-Catenin Signaling During Osteoblast Differentiation Contributes to Osteopenia in Progeria. J Bone Miner Res 33, 2059\u20132070 (2018).","journal-title":"J Bone Miner Res"},{"key":"6967_CR74","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.1016\/j.jid.2019.05.005","volume":"139","author":"A Sola-Carvajal","year":"2019","unstructured":"Sola-Carvajal, A. et al. Accumulation of Progerin Affects the Symmetry of Cell Division and Is Associated with Impaired Wnt Signaling and the Mislocalization of Nuclear Envelope Proteins. J Invest Dermatol 139, 2272\u20132280.e12 (2019).","journal-title":"J Invest Dermatol"},{"key":"6967_CR75","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1534\/g3.113.009522","volume":"4","author":"BM Jackson","year":"2014","unstructured":"Jackson, B. M., Abete-Luzi, P., Krause, M. W. & Eisenmann, D. M. Use of an activated beta-catenin to identify wnt pathway target genes in Caenorhabditis elegans, including a subset of collagen genes expressed in late larval development. G3 Genes|Genomes|Genetics 4, 733\u2013747 (2014).","journal-title":"G3 Genes|Genomes|Genetics"},{"key":"6967_CR76","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.devcel.2010.08.013","volume":"19","author":"L Hernandez","year":"2010","unstructured":"Hernandez, L. et al. Functional coupling between the extracellular matrix and nuclear lamina by Wnt signaling in progeria. Dev Cell 19, 413\u2013425 (2010).","journal-title":"Dev Cell"},{"key":"6967_CR77","doi-asserted-by":"publisher","unstructured":"Stiernagle, T. Maintenance of C. elegans. WormBook 1\u201311 https:\/\/doi.org\/10.1895\/WORMBOOK.1.101.1. (2006)","DOI":"10.1895\/WORMBOOK.1.101.1"},{"key":"6967_CR78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/6463063","volume":"2022","author":"SV Kontomaris","year":"2022","unstructured":"Kontomaris, S. V., Stylianou, A. & Malamou, A. Is It Possible to Directly Determine the Radius of a Spherical Indenter Using Force Indentation Data on Soft Samples? Scanning 2022, 1\u201313 (2022).","journal-title":"Scanning"},{"key":"6967_CR79","first-page":"156","volume":"92","author":"H Hertz","year":"2021","unstructured":"Hertz, H. Ueber die Ber\u00fchrung fester elastischer K\u00f6rper. Journal f\u00fcr die reine und angewandte Mathematik. Band 92, 156\u2013171 (2021).","journal-title":"Journal f\u00fcr die reine und angewandte Mathematik. Band"},{"key":"6967_CR80","doi-asserted-by":"publisher","first-page":"31849","DOI":"10.1371\/journal.pone.0031849","volume":"7","author":"Y Zhang","year":"2012","unstructured":"Zhang, Y., Chen, D., Smith, M. A., Zhang, B. & Pan, X. Selection of reliable reference genes in Caenorhabditis elegans for analysis of nanotoxicity. PLoS One 7, 31849 (2012).","journal-title":"PLoS One"},{"key":"6967_CR81","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","volume":"29","author":"A Dobin","year":"2013","unstructured":"Dobin, A. et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29, 15\u201321 (2013).","journal-title":"Bioinformatics"},{"key":"6967_CR82","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2105-12-323","volume":"12","author":"B Li","year":"2011","unstructured":"Li, B. & Dewey, C. N. RSEM: Accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinformatics 12, 1\u201316 (2011).","journal-title":"BMC Bioinformatics"},{"key":"6967_CR83","unstructured":"R Core Team (2018) R A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna. - References - Scientific Research Publishing. https:\/\/www.scirp.org\/reference\/ReferencesPapers?ReferenceID=2342186."},{"key":"6967_CR84","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love, M. I., Huber, W. & Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 15, 1\u201321 (2014).","journal-title":"Genome Biol"},{"key":"6967_CR85","doi-asserted-by":"publisher","first-page":"e31849","DOI":"10.1371\/journal.pone.0031849","volume":"7","author":"Y Zhang","year":"2012","unstructured":"Zhang, Y., Chen, D., Smith, M. A., Zhang, B. & Pan, X. Selection of reliable reference genes in Caenorhabditis elegans for analysis of nanotoxicity. PLoS One 7, e31849 (2012).","journal-title":"PLoS One"},{"key":"6967_CR86","doi-asserted-by":"publisher","unstructured":"Raizen, D., Song, B. M., Trojanowski, N. & You, Y. J. Methods for measuring pharyngeal behaviors. WormBook 1\u201313 https:\/\/doi.org\/10.1895\/WORMBOOK.1.154.1 (2012).","DOI":"10.1895\/WORMBOOK.1.154.1"},{"key":"6967_CR87","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","volume":"9","author":"J Schindelin","year":"2012","unstructured":"Schindelin, J. et al. Fiji: an open-source platform for biological-image analysis. Nat Methods 9, 676\u2013682 (2012).","journal-title":"Nat Methods"}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-06967-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-06967-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-06967-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T11:02:45Z","timestamp":1729940565000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-06967-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,26]]},"references-count":87,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["6967"],"URL":"https:\/\/doi.org\/10.1038\/s42003-024-06967-z","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,26]]},"assertion":[{"value":"7 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1398"}}