{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:48:45Z","timestamp":1791496125518,"version":"4.3.4"},"reference-count":113,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T00:00:00Z","timestamp":1728086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T00:00:00Z","timestamp":1728086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-024-06968-y","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T18:01:59Z","timestamp":1728151319000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Importance of copy number variants in childhood apraxia of speech and other speech sound disorders"],"prefix":"10.1038","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9277-5329","authenticated-orcid":false,"given":"E. Ricky","family":"Chan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope","family":"Benchek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Brustoski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashleigh","family":"Schaffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Truitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Tag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Freebairn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9763-5023","authenticated-orcid":false,"given":"Catherine M.","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7488-250X","authenticated-orcid":false,"given":"Sudha K.","family":"Iyengar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,5]]},"reference":[{"key":"6968_CR1","unstructured":"American-Speech-Language-Hearing-Association. Definitions of communication disorders and variations. 1993."},{"key":"6968_CR2","unstructured":"Black, L. I., Vahratian, A. & Hoffman, H. J. Communication Disorders and Use of Intervention Services Among Children Aged 3-17 Years: United States, 2012. NCHS data brief, 1-8 (2015)."},{"key":"6968_CR3","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1080\/01690960903498424","volume":"26","author":"JA Tourville","year":"2011","unstructured":"Tourville, J. A. & Guenther, F. H. The DIVA model: A neural theory of speech acquisition and production. Lang. Cogn. Process. 26, 952\u2013981 (2011).","journal-title":"Lang. Cogn. Process."},{"key":"6968_CR4","doi-asserted-by":"publisher","first-page":"250","DOI":"10.3171\/2014.10.JNS132647","volume":"122","author":"EF Chang","year":"2015","unstructured":"Chang, E. F., Raygor, K. P. & Berger, M. S. Contemporary model of language organization: an overview for neurosurgeons. J. Neurosurg. 122, 250\u2013261 (2015).","journal-title":"J. Neurosurg."},{"key":"6968_CR5","doi-asserted-by":"publisher","first-page":"e3002178","DOI":"10.1371\/journal.pbio.3002178","volume":"21","author":"O Abbasi","year":"2023","unstructured":"Abbasi, O., Steingr\u00e4ber, N., Chalas, N., Kluger, D. S. & Gross, J. Spatiotemporal dynamics characterise spectral connectivity profiles of continuous speaking and listening. PLoS Biol. 21, e3002178 (2023).","journal-title":"PLoS Biol."},{"key":"6968_CR6","unstructured":"Bauman-W\u00e4ngler, J. A. (Pearson Educatoin, United Kingdom, 2020)."},{"key":"6968_CR7","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1044\/1092-4388(2005\/096)","volume":"48","author":"HW Catts","year":"2005","unstructured":"Catts, H. W., Adlof, S. M., Hogan, T. P. & Weismer, S. E. Are specific language impairment and dyslexia distinct disorders. J. Speech, Lang., Hearing Res. : JSLHR 48, 1378\u20131396 (2005).","journal-title":"J. Speech, Lang., Hearing Res. : JSLHR"},{"key":"6968_CR8","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1044\/jslhr.4206.1461","volume":"42","author":"L Shriberg","year":"1999","unstructured":"Shriberg, L., Tomblin, J. & McSweeny, J. Prevalence of speech delay in 6-year-old children and comorbidity with language impairment. J. Speech, Lang., Hearing Res. 42, 1461\u20131481 (1999).","journal-title":"J. Speech, Lang., Hearing Res."},{"key":"6968_CR9","unstructured":"American-Speech-Language-Hearing-Association. Chilldhood Apraxia of Speech (Practice Portal), 2007)."},{"key":"6968_CR10","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-020-02421-1","volume":"20","author":"CM Stein","year":"2020","unstructured":"Stein, C. M. et al. Feature-driven classification reveals potential comorbid subtypes within childhood apraxia of speech. BMC Pediatrics 20, 519 (2020).","journal-title":"BMC Pediatrics"},{"key":"6968_CR11","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1044\/jslhr.4002.273","volume":"40","author":"LD Shriberg","year":"1997","unstructured":"Shriberg, L. D., Aram, D. M. & Kwiatkowski, J. Developmental apraxia of speech: I. Descriptive and theoretical perspectives. J. Speech Lang. Hear Res. 40, 273\u2013285 (1997).","journal-title":"J. Speech Lang. Hear Res"},{"key":"6968_CR12","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1080\/02699206.2019.1595731","volume":"33","author":"LD Shriberg","year":"2019","unstructured":"Shriberg, L. D., Kwiatkowski, J. & Mabie, H. L. Estimates of the prevalence of motor speech disorders in children with idiopathic speech delay. Clin. Linguist. phonetics 33, 679\u2013706 (2019).","journal-title":"Clin. Linguist. phonetics"},{"key":"6968_CR13","unstructured":"Lewis, B. A., Miller, G.; Iyengar, S. K.; Stein, C. M.; Benchek, P. Long-term Outcomes for Individuals with Childhood Apraxia of Speech. Journal of Speech, Language, and Hearing Research (in press)."},{"key":"6968_CR14","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1044\/2021_PERSP-20-00283","volume":"7","author":"J Iuzzini-Seigel","year":"2022","unstructured":"Iuzzini-Seigel, J., Delaney, A. L. & Kent, R. D. Retrospective case-control study of communication and motor abilities in 143 children with suspected childhood apraxia of speech: effect of concomitant diagnosis. Perspect. ASHA Spec. Interest Groups 7, 45\u201355 (2022).","journal-title":"Perspect. ASHA Spec. Interest Groups"},{"key":"6968_CR15","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.bandl.2015.10.002","volume":"150","author":"AM Chilosi","year":"2015","unstructured":"Chilosi, A. M. et al. Behavioral and neurobiological correlates of childhood apraxia of speech in Italian children. Brain Lang. 150, 177\u2013185 (2015).","journal-title":"Brain Lang."},{"key":"6968_CR16","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3390\/jpm12020313","volume":"12","author":"AM Chilosi","year":"2022","unstructured":"Chilosi, A. M. et al. Differences and commonalities in children with childhood apraxia of speech and comorbid neurodevelopmental disorders: a multidimensional perspective. J. Personalized Med. 12, 313 (2022).","journal-title":"J. Personalized Med."},{"key":"6968_CR17","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/ng0298-168","volume":"18","author":"S Fisher","year":"1998","unstructured":"Fisher, S., Vargha-Khadem, F., Watkins, K., Monaco, A. & Pembrey, M. Localisation of a gene implicated in a severe speech and language disorder. Nat. Genet. 18, 168\u2013170 (1998).","journal-title":"Nat. Genet."},{"key":"6968_CR18","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1086\/303011","volume":"67","author":"CS Lai","year":"2000","unstructured":"Lai, C. S. et al. The SPCH1 region on human 7q31: genomic characterization of the critical interval and localization of translocations associated with speech and language disorder. Am. J. Hum. Genet. 67, 357\u2013368 (2000).","journal-title":"Am. J. Hum. Genet."},{"key":"6968_CR19","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/35097076","volume":"413","author":"CS Lai","year":"2001","unstructured":"Lai, C. S., Fisher, S. E., Hurst, J. A., Vargha-Khadem, F. & Monaco, A. P. A forkhead-domain gene is mutated in a severe speech and language disorder. Nature 413, 519\u2013523 (2001).","journal-title":"Nature"},{"key":"6968_CR20","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/nrg3241","volume":"13","author":"JA Veltman","year":"2012","unstructured":"Veltman, J. A. & Brunner, H. G. De novo mutations in human genetic disease. Nat. Rev. Genet. 13, 565\u2013575 (2012).","journal-title":"Nat. Rev. Genet."},{"key":"6968_CR21","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/ejhg.2012.165","volume":"21","author":"G Raca","year":"2013","unstructured":"Raca, G. et al. Childhood Apraxia of Speech (CAS) in two patients with 16p11.2 microdeletion syndrome. Eur. J. Hum. Genet. 21, 455\u2013459 (2013).","journal-title":"Eur. J. Hum. Genet."},{"key":"6968_CR22","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1038\/ejhg.2015.149","volume":"24","author":"E Fedorenko","year":"2016","unstructured":"Fedorenko, E. et al. A highly penetrant form of childhood apraxia of speech due to deletion of 16p11.2. Eur. J. Hum. Genet. 24, 302\u2013306 (2016).","journal-title":"Eur. J. Hum. Genet."},{"key":"6968_CR23","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1038\/s41380-024-02409-8","volume":"29","author":"AT Morgan","year":"2024","unstructured":"Morgan, A. T., Amor, D. J., St John, M. D., Scheffer, I. E. & Hildebrand, M. S. Genetic architecture of childhood speech disorder: a review. Mol. Psychiatry 29, 1281\u20131292 (2024).","journal-title":"Mol. Psychiatry"},{"key":"6968_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.920390","volume":"13","author":"R Kingdom","year":"2022","unstructured":"Kingdom, R. & Wright, C. F. Incomplete penetrance and variable expressivity: from clinical studies to population cohorts. Front. Genet. 13, 920390 (2022).","journal-title":"Front. Genet."},{"key":"6968_CR25","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1038\/nrg3373","volume":"14","author":"J Weischenfeldt","year":"2013","unstructured":"Weischenfeldt, J., Symmons, O., Spitz, F. & Korbel, J. O. Phenotypic impact of genomic structural variation: insights from and for human disease. Nat. Rev. Genet. 14, 125\u2013138 (2013).","journal-title":"Nat. Rev. Genet."},{"key":"6968_CR26","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1038\/s41588-024-01754-2","volume":"56","author":"K Grimes","year":"2024","unstructured":"Grimes, K. et al. Cell-type-specific consequences of mosaic structural variants in hematopoietic stem and progenitor cells. Nat. Genet. 56, 1134\u20131146 (2024).","journal-title":"Nat. Genet."},{"key":"6968_CR27","doi-asserted-by":"publisher","DOI":"10.1186\/1866-1955-5-29","volume":"5","author":"EA Worthey","year":"2013","unstructured":"Worthey, E. A. et al. Whole-exome sequencing supports genetic heterogeneity in childhood apraxia of speech. J. Neurodev. Disord. 5, 29 (2013).","journal-title":"J. Neurodev. Disord."},{"key":"6968_CR28","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1038\/s41380-018-0020-x","volume":"24","author":"E Eising","year":"2019","unstructured":"Eising, E. et al. A set of regulatory genes co-expressed in embryonic human brain is implicated in disrupted speech development. Mol. Psychiatry 24, 1065\u20131078 (2019).","journal-title":"Mol. Psychiatry"},{"key":"6968_CR29","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1038\/gim.2012.72","volume":"14","author":"JJ Laffin","year":"2012","unstructured":"Laffin, J. J. et al. Novel candidate genes and regions for childhood apraxia of speech identified by array comparative genomic hybridization. Genet. Med. 14, 928\u2013936 (2012).","journal-title":"Genet. Med"},{"key":"6968_CR30","doi-asserted-by":"publisher","first-page":"3041","DOI":"10.1016\/j.cell.2022.06.036","volume":"185","author":"RL Collins","year":"2022","unstructured":"Collins, R. L. et al. A cross-disorder dosage sensitivity map of the human genome. Cell 185, 3041\u20133055.e3025 (2022).","journal-title":"Cell"},{"key":"6968_CR31","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1002\/ajmg.a.62998","volume":"191","author":"B Peter","year":"2023","unstructured":"Peter, B. A case with cardiac, skeletal, speech, and motor traits narrows the subtelomeric 19p13.3 microdeletion region to 46\u2009kb. Am. J. Med Genet. A 191, 120\u2013129 (2023).","journal-title":"Am. J. Med Genet. A"},{"key":"6968_CR32","doi-asserted-by":"publisher","first-page":"2659","DOI":"10.1002\/ajmg.a.38385","volume":"173","author":"B Peter","year":"2017","unstructured":"Peter, B. et al. Two unrelated children with overlapping 6q25.3 deletions, motor speech disorders, and language delays. Am. J. Med Genet. A 173, 2659\u20132669 (2017).","journal-title":"Am. J. Med Genet. A"},{"key":"6968_CR33","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1002\/ajmg.a.36599","volume":"164a","author":"B Peter","year":"2014","unstructured":"Peter, B., Matsushita, M., Oda, K. & Raskind, W. De novo microdeletion of BCL11A is associated with severe speech sound disorder. Am. J. Med. Genet. A 164a, 2091\u20132096 (2014).","journal-title":"Am. J. Med. Genet. A"},{"key":"6968_CR34","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/s41431-018-0102-x","volume":"26","author":"C Mei","year":"2018","unstructured":"Mei, C. et al. Deep phenotyping of speech and language skills in individuals with 16p11.2 deletion. Eur. J. Hum. Genet. 26, 676\u2013686 (2018).","journal-title":"Eur. J. Hum. Genet."},{"key":"6968_CR35","doi-asserted-by":"publisher","unstructured":"Kaspi, A., et al. Genetic aetiologies for childhood speech disorder: novel pathways co-expressed during brain development. Mol Psychiatry, https:\/\/doi.org\/10.1038\/s41380-022-01764-8 (2022).","DOI":"10.1038\/s41380-022-01764-8"},{"key":"6968_CR36","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.ejmg.2014.04.009","volume":"57","author":"I Fanizza","year":"2014","unstructured":"Fanizza, I. et al. Genotype-phenotype relationship in a child with 2.3 Mb de novo interstitial 12p13.33-p13.32 deletion. Eur. J. Med. Genet. 57, 334\u2013338 (2014).","journal-title":"Eur. J. Med. Genet."},{"key":"6968_CR37","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1034\/j.1399-0004.2001.600604.x","volume":"60","author":"F Boyar","year":"2001","unstructured":"Boyar, F. et al. A family with a grand-maternally derived interstitial duplication of proximal 15q. Clin. Genet. 60, 421\u2013430 (2001).","journal-title":"Clin. Genet."},{"key":"6968_CR38","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1002\/ajmg.a.32363","volume":"146a","author":"LD Shriberg","year":"2008","unstructured":"Shriberg, L. D., Jakielski, K. J. & El-Shanti, H. Breakpoint localization using array-CGH in three siblings with an unbalanced 4q;16q translocation and childhood apraxia of speech (CAS). Am. J. Med Genet. A 146a, 2227\u20132233 (2008).","journal-title":"Am. J. Med Genet. A"},{"key":"6968_CR39","doi-asserted-by":"publisher","DOI":"10.1186\/s11689-016-9147-8","volume":"8","author":"A Gialluisi","year":"2016","unstructured":"Gialluisi, A. et al. Investigating the effects of copy number variants on reading and language performance. J. Neurodev. Disord. 8, 17 (2016).","journal-title":"J. Neurodev. Disord."},{"key":"6968_CR40","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.ajhg.2015.11.017","volume":"98","author":"MH Duyzend","year":"2016","unstructured":"Duyzend, M. H. et al. Maternal modifiers and parent-of-origin bias of the autism-associated 16p11.2 CNV. Am. J. Hum. Genet. 98, 45\u201357 (2016).","journal-title":"Am. J. Hum. Genet."},{"key":"6968_CR41","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1016\/j.ajhg.2022.08.012","volume":"109","author":"DJC Tai","year":"2022","unstructured":"Tai, D. J. C. et al. Tissue- and cell-type-specific molecular and functional signatures of 16p11.2 reciprocal genomic disorder across mouse brain and human neuronal models. Am. J. Hum. Genet. 109, 1789\u20131813 (2022).","journal-title":"Am. J. Hum. Genet."},{"key":"6968_CR42","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1136\/jmg.29.2.103","volume":"29","author":"PA Jacobs","year":"1992","unstructured":"Jacobs, P. A., Browne, C., Gregson, N., Joyce, C. & White, H. Estimates of the frequency of chromosome abnormalities detectable in unselected newborns using moderate levels of banding. J. Med. Genet. 29, 103\u2013108 (1992).","journal-title":"J. Med. Genet."},{"key":"6968_CR43","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1086\/302041","volume":"63","author":"C Brewer","year":"1998","unstructured":"Brewer, C., Holloway, S., Zawalnyski, P., Schinzel, A. & FitzPatrick, D. A chromosomal deletion map of human malformations. Am. J. Hum. Genet. 63, 1153\u20131159 (1998).","journal-title":"Am. J. Hum. Genet."},{"key":"6968_CR44","doi-asserted-by":"publisher","first-page":"e1002334","DOI":"10.1371\/journal.pgen.1002334","volume":"7","author":"S Girirajan","year":"2011","unstructured":"Girirajan, S. et al. Relative burden of large CNVs on a range of neurodevelopmental phenotypes. PLoS Genet. 7, e1002334 (2011).","journal-title":"PLoS Genet."},{"key":"6968_CR45","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16736-1","volume":"11","author":"L Han","year":"2020","unstructured":"Han, L. et al. Functional annotation of rare structural variation in the human brain. Nat. Commun. 11, 2990 (2020).","journal-title":"Nat. Commun."},{"key":"6968_CR46","doi-asserted-by":"publisher","unstructured":"Macnee, M., et al. CNV-ClinViewer: enhancing the clinical interpretation of large copy-number variants online. Bioinformatics 39, https:\/\/doi.org\/10.1093\/bioinformatics\/btad290 (2023).","DOI":"10.1093\/bioinformatics\/btad290"},{"key":"6968_CR47","volume":"3","author":"B Peter","year":"2022","unstructured":"Peter, B. et al. Translating principles of precision medicine into speech-language pathology: Clinical trial of a proactive speech and language intervention for infants with classic galactosemia. HGG Adv. 3, 100119 (2022).","journal-title":"HGG Adv."},{"key":"6968_CR48","doi-asserted-by":"publisher","first-page":"3401","DOI":"10.1002\/ajmg.a.62904","volume":"188","author":"L Bruce","year":"2022","unstructured":"Bruce, L. & Peter, B. Three children with different de novo BCL11A variants and diverse developmental phenotypes, but shared global motor discoordination and apraxic speech: Evidence for a functional gene network influencing the developing cerebellum and motor and auditory cortices. Am. J. Med Genet. A 188, 3401\u20133415 (2022).","journal-title":"Am. J. Med Genet. A"},{"key":"6968_CR49","unstructured":"Goldman, R. & Fristoe, M. (American Guidance Service, Circle Pinesm MN, 1986)."},{"key":"6968_CR50","unstructured":"Wechsler, D. (The Psychological Coporation, San Antonio, TX, 1991)."},{"key":"6968_CR51","unstructured":"American-Speech-Language-Hearing-Association. Childhood Apraxia of Speech [Technical Report], 2007)."},{"key":"6968_CR52","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1044\/1092-4388(2011\/10-0124)","volume":"54","author":"BA Lewis","year":"2011","unstructured":"Lewis, B. A. et al. Literacy outcomes of children with early childhood speech sound disorders: impact of endophenotypes. J. Speech Lang. Hear. Res 54, 1628\u20131643 (2011).","journal-title":"J. Speech Lang. Hear. Res"},{"key":"6968_CR53","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1097\/TLD.0b013e318217b5dd","volume":"31","author":"BA Lewis","year":"2011","unstructured":"Lewis, B. A. et al. Subtyping children with speech sound disorders by endophenotypes. Top. Lang. Disord. 31, 112\u2013127 (2011).","journal-title":"Top. Lang. Disord."},{"key":"6968_CR54","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1044\/2014_AJSLP-14-0075","volume":"24","author":"BA Lewis","year":"2015","unstructured":"Lewis, B. A. et al. Adolescent outcomes of children with early speech sound disorders with and without language impairment. Am. J. Speech Lang. Pathol. 24, 150\u2013163 (2015).","journal-title":"Am. J. Speech Lang. Pathol."},{"key":"6968_CR55","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1044\/0161-1461(2004\/014)","volume":"35","author":"BA Lewis","year":"2004","unstructured":"Lewis, B. A., Freebairn, L. A., Hansen, A. J., Iyengar, S. K. & Taylor, H. G. School-age follow-up of children with childhood apraxia of speech. Lang., speech, hearing Serv. Sch. 35, 122\u2013140 (2004).","journal-title":"Lang., speech, hearing Serv. Sch."},{"key":"6968_CR56","unstructured":"American-Speech-Language-Hearing-Association. Latest Forum From Perspectives Tackles SLI\/DLD Terminology Discussion, 2020."},{"key":"6968_CR57","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1007\/s10519-012-9532-3","volume":"42","author":"H Anthoni","year":"2012","unstructured":"Anthoni, H. et al. The aromatase gene CYP19A1: several genetic and functional lines of evidence supporting a role in reading, speech and language. Behav. Genet. 42, 509\u2013527 (2012).","journal-title":"Behav. Genet."},{"key":"6968_CR58","doi-asserted-by":"publisher","DOI":"10.1038\/s41525-021-00225-5","volume":"6","author":"P Benchek","year":"2021","unstructured":"Benchek, P. et al. Association between genes regulating neural pathways for quantitative traits of speech and language disorders. NPJ Genom. Med. 6, 64 (2021).","journal-title":"NPJ Genom. Med."},{"key":"6968_CR59","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1177\/002221940003300504","volume":"33","author":"B Lewis","year":"2000","unstructured":"Lewis, B., Freebairn, L. & Taylor, H. Follow-up of children with early expressive phonology disorders. J. Learn. Disabilities 33, 433\u2013444 (2000).","journal-title":"J. Learn. Disabilities"},{"key":"6968_CR60","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1086\/381562","volume":"74","author":"CM Stein","year":"2004","unstructured":"Stein, C. M. et al. Pleiotropic effects of a chromosome 3 locus on speech-sound disorder and reading. Am. J. Hum. Genet. 74, 283\u2013297 (2004).","journal-title":"Am. J. Hum. Genet."},{"key":"6968_CR61","unstructured":"Trim Galore!. https:\/\/www.bioinformatics.babraham.ac.uk\/projects\/trim_galore\/."},{"key":"6968_CR62","unstructured":"GATK. https:\/\/gatk.broadinstitute.org\/."},{"key":"6968_CR63","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1093\/bioinformatics\/btx699","volume":"34","author":"BS Pedersen","year":"2018","unstructured":"Pedersen, B. S. & Quinlan, A. R. Mosdepth: quick coverage calculation for genomes and exomes. Bioinformatics 34, 867\u2013868 (2018).","journal-title":"Bioinformatics"},{"key":"6968_CR64","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1038\/ng.3200","volume":"47","author":"RE Handsaker","year":"2015","unstructured":"Handsaker, R. E. et al. Large multiallelic copy number variations in humans. Nat. Genet. 47, 296\u2013303 (2015).","journal-title":"Nat. Genet."},{"key":"6968_CR65","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-45839-z","volume":"9","author":"HM Amemiya","year":"2019","unstructured":"Amemiya, H. M., Kundaje, A. & Boyle, A. P. The ENCODE blacklist: identification of problematic regions of the genome. Sci. Rep. 9, 9354 (2019).","journal-title":"Sci. Rep."},{"key":"6968_CR66","unstructured":"Kundaje, A. A comprehensive collection of signal artifact blacklist regions in the human genome. 2021."},{"key":"6968_CR67","doi-asserted-by":"publisher","first-page":"e31","DOI":"10.1158\/0008-5472.CAN-17-0337","volume":"77","author":"JT Robinson","year":"2017","unstructured":"Robinson, J. T., Thorvaldsd\u00f3ttir, H., Wenger, A. M., Zehir, A. & Mesirov, J. P. Variant review with the integrative genomics viewer. Cancer Res. 77, e31\u2013e34 (2017).","journal-title":"Cancer Res."},{"key":"6968_CR68","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/nbt.1754","volume":"29","author":"JT Robinson","year":"2011","unstructured":"Robinson, J. T. et al. Integrative genomics viewer. Nat. Biotechnol. 29, 24\u201326 (2011).","journal-title":"Nat. Biotechnol."},{"key":"6968_CR69","doi-asserted-by":"publisher","unstructured":"Robinson, J. T., Thorvaldsd\u00f3ttir, H., Turner, D. & Mesirov, J. P. igv.js: an embeddable JavaScript implementation of the Integrative Genomics Viewer (IGV). bioRxiv, 2020.2005.2003.075499 https:\/\/doi.org\/10.1101\/2020.05.03.075499 (2020).","DOI":"10.1101\/2020.05.03.075499"},{"key":"6968_CR70","unstructured":"Illumina. www.illumina.com\/documents\/products\/technotes\/technote_cnv_algorithms.pdf."},{"key":"6968_CR71","doi-asserted-by":"publisher","first-page":"D986","DOI":"10.1093\/nar\/gkt958","volume":"42","author":"JR MacDonald","year":"2014","unstructured":"MacDonald, J. R., Ziman, R., Yuen, R. K., Feuk, L. & Scherer, S. W. The Database of Genomic Variants: a curated collection of structural variation in the human genome. Nucleic Acids Res. 42, D986\u2013992 (2014).","journal-title":"Nucleic Acids Res."},{"key":"6968_CR72","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/nature19057","volume":"536","author":"M Lek","year":"2016","unstructured":"Lek, M. et al. Analysis of protein-coding genetic variation in 60,706 humans. Nature 536, 285\u2013291 (2016).","journal-title":"Nature"},{"key":"6968_CR73","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-017-0418-y","volume":"15","author":"AM Rice","year":"2017","unstructured":"Rice, A. M. & McLysaght, A. Dosage-sensitive genes in evolution and disease. BMC Biol. 15, 78 (2017).","journal-title":"BMC Biol."},{"key":"6968_CR74","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1097\/YPG.0000000000000259","volume":"30","author":"R Fetit","year":"2020","unstructured":"Fetit, R., Price, D. J., Lawrie, S. M. & Johnstone, M. Understanding the clinical manifestations of 16p11.2 deletion syndrome: a series of developmental case reports in children. Psychiatr. Genet. 30, 136\u2013140 (2020).","journal-title":"Psychiatr. Genet."},{"key":"6968_CR75","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01358-y","volume":"11","author":"N Usui","year":"2021","unstructured":"Usui, N. et al. Zbtb16 regulates social cognitive behaviors and neocortical development. Transl. Psychiatry 11, 242 (2021).","journal-title":"Transl. Psychiatry"},{"key":"6968_CR76","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.3389\/fpsyg.2014.01324","volume":"5","author":"C Boeckx","year":"2014","unstructured":"Boeckx, C., & Ben\u00edtez-Burraco, A. Globularity and language-readiness: generating new predictions by expanding the set of genes of interest. Front. Psychol. 5, 1324 (2014).","journal-title":"Front. Psychol."},{"key":"6968_CR77","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.bbr.2018.11.012","volume":"359","author":"X Yang","year":"2019","unstructured":"Yang, X. et al. The association between NCAM1 levels and behavioral phenotypes in children with autism spectrum disorder. Behav. Brain Res. 359, 234\u2013238 (2019).","journal-title":"Behav. Brain Res."},{"key":"6968_CR78","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-00899-y","volume":"10","author":"V Vukojevic","year":"2020","unstructured":"Vukojevic, V. et al. Evolutionary conserved role of neural cell adhesion molecule-1 in memory. Transl. psychiatry 10, 217 (2020).","journal-title":"Transl. psychiatry"},{"key":"6968_CR79","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1534\/genetics.120.303533","volume":"216","author":"Y Hu","year":"2020","unstructured":"Hu, Y. et al. Functional divergence of mammalian TFAP2a and TFAP2b transcription factors for bidirectional sleep control. Genetics 216, 735\u2013752 (2020).","journal-title":"Genetics"},{"key":"6968_CR80","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.ejmg.2008.11.002","volume":"52","author":"M Poot","year":"2009","unstructured":"Poot, M. et al. Three de novo losses and one insertion within a pericentric inversion of chromosome 6 in a patient with complete absence of expressive speech and reduced pain perception. Eur. J. Med. Genet. 52, 27\u201330 (2009).","journal-title":"Eur. J. Med. Genet."},{"key":"6968_CR81","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.gene.2014.01.060","volume":"539","author":"V Belengeanu","year":"2014","unstructured":"Belengeanu, V. et al. A de novo 2.3 Mb deletion in 2q24.2q24.3 in a 20-month-old developmentally delayed girl. Gene 539, 168\u2013172 (2014).","journal-title":"Gene"},{"key":"6968_CR82","doi-asserted-by":"publisher","first-page":"2664","DOI":"10.1002\/ajmg.a.37269","volume":"167a","author":"KN Riley","year":"2015","unstructured":"Riley, K. N. et al. Recurrent deletions and duplications of chromosome 2q11.2 and 2q13 are associated with variable outcomes. Am. J. Med. Genet. A 167a, 2664\u20132673 (2015).","journal-title":"Am. J. Med. Genet. A"},{"key":"6968_CR83","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1002\/ajmg.1203","volume":"99","author":"A Rauch","year":"2001","unstructured":"Rauch, A. et al. First known microdeletion within the Wolf-Hirschhorn syndrome critical region refines genotype-phenotype correlation. Am. J. Med. Genet. 99, 338\u2013342 (2001).","journal-title":"Am. J. Med. Genet."},{"key":"6968_CR84","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S1028-4559(10)60025-3","volume":"49","author":"CP Chen","year":"2010","unstructured":"Chen, C. P. et al. Prenatal diagnosis of a 4.9-Mb deletion of 10q11.21 -> q11.23 by array comparative genomic hybridization. Taiwan. J. Obstet. Gynecol. 49, 117\u2013119 (2010).","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"6968_CR85","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1002\/humu.21614","volume":"33","author":"P Stankiewicz","year":"2012","unstructured":"Stankiewicz, P. et al. Recurrent deletions and reciprocal duplications of 10q11.21q11.23 including CHAT and SLC18A3 are likely mediated by complex low-copy repeats. Hum. Mutat. 33, 165\u2013179 (2012).","journal-title":"Hum. Mutat."},{"key":"6968_CR86","doi-asserted-by":"publisher","DOI":"10.1186\/s13039-015-0148-1","volume":"8","author":"D Moralli","year":"2015","unstructured":"Moralli, D. et al. Language impairment in a case of a complex chromosomal rearrangement with a breakpoint downstream of FOXP2. Mol. Cytogenet. 8, 36 (2015).","journal-title":"Mol. Cytogenet."},{"key":"6968_CR87","doi-asserted-by":"publisher","first-page":"e415","DOI":"10.18295\/squmj.2015.15.03.018","volume":"15","author":"AM Udayakumar","year":"2015","unstructured":"Udayakumar, A. M., Al-Mamari, W., Al-Sayegh, A. & Al-Kindy, A. De Novo Duplication of 7p21.1p22.2 in a child with autism spectrum disorder and craniofacial dysmorphism. Sultan Qaboos Univ. Med. J. 15, e415\u2013e419 (2015).","journal-title":"Sultan Qaboos Univ. Med. J."},{"key":"6968_CR88","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1097\/MCD.0000000000000096","volume":"24","author":"RS Akilapa","year":"2015","unstructured":"Akilapa, R. S., Smith, K. & Balasubramanian, M. Clinical report: inherited deletion of chromosome 12q21.31q21.32 associated with a distinct phenotype and intellectual disability. Clin. Dysmorphol. 24, 151\u2013155 (2015).","journal-title":"Clin. Dysmorphol."},{"key":"6968_CR89","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26880-w","volume":"8","author":"J Chernus","year":"2018","unstructured":"Chernus, J. et al. GWAS reveals loci associated with velopharyngeal dysfunction. Sci. Rep. 8, 8470 (2018).","journal-title":"Sci. Rep."},{"key":"6968_CR90","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1002\/ajmg.a.32695","volume":"149a","author":"B Dallapiccola","year":"2009","unstructured":"Dallapiccola, B., Bernardini, L., Novelli, A. & Mingarelli, R. Phenocopy of Wolf-Hirschhorn syndrome in a patient with duplication 12q13.3q14.1. Am. J. Med Genet. A 149a, 546\u2013548 (2009).","journal-title":"Am. J. Med Genet. A"},{"key":"6968_CR91","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1002\/ajmg.a.35991","volume":"161a","author":"M Bertoli","year":"2013","unstructured":"Bertoli, M. et al. Another patient with 12q13 microduplication. Am. J. Med Genet. A 161a, 2004\u20132008 (2013).","journal-title":"Am. J. Med Genet. A"},{"key":"6968_CR92","doi-asserted-by":"publisher","first-page":"3345","DOI":"10.1093\/hmg\/dds166","volume":"21","author":"AV Dharmadhikari","year":"2012","unstructured":"Dharmadhikari, A. V. et al. Small rare recurrent deletions and reciprocal duplications in 2q21.1, including brain-specific ARHGEF4 and GPR148. Hum. Mol. Genet. 21, 3345\u20133355 (2012).","journal-title":"Hum. Mol. Genet."},{"key":"6968_CR93","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1002\/ajmg.a.36357","volume":"164a","author":"S Gimelli","year":"2014","unstructured":"Gimelli, S. et al. Recurrent microdeletion 2q21.1: report on a new patient with neurological disorders. Am. J. Med Genet. A 164a, 801\u2013805 (2014).","journal-title":"Am. J. Med Genet. A"},{"key":"6968_CR94","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/ng.534","volume":"42","author":"S Girirajan","year":"2010","unstructured":"Girirajan, S. et al. A recurrent 16p12.1 microdeletion supports a two-hit model for severe developmental delay. Nat. Genet. 42, 203\u2013209 (2010).","journal-title":"Nat. Genet."},{"key":"6968_CR95","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/mp.2014.179","volume":"20","author":"G Desachy","year":"2015","unstructured":"Desachy, G. et al. Increased female autosomal burden of rare copy number variants in human populations and in autism families. Mol. Psychiatry 20, 170\u2013175 (2015).","journal-title":"Mol. Psychiatry"},{"key":"6968_CR96","unstructured":"Delaney, A. L. K., R.D. Developmental profiles of children diagnosed with apraxia of speech. Paper presented at the American Speech-Language-Hearing Association Convention, Philadelpha, PA (2004)."},{"key":"6968_CR97","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/0021-9924(83)90008-4","volume":"16","author":"B Ekelman","year":"1983","unstructured":"Ekelman, B. & Aram, D. Syntactic findings in developmental verbal apraxia. J. Commun. Disord. 16, 237\u2013250 (1983).","journal-title":"J. Commun. Disord."},{"key":"6968_CR98","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3109\/13682829709021455","volume":"32","author":"G Thoonen","year":"1997","unstructured":"Thoonen, G., Maassen, B., Gabre\u00ebls, F., Schreuder, R. & de Swart, B. Towards a standardised assessment procedure for developmental apraxia of speech. Eur. J. Disord. Commun. : J. Coll. Speech Lang. Therapists, Lond. 32, 37\u201360 (1997).","journal-title":"Eur. J. Disord. Commun. : J. Coll. Speech Lang. Therapists, Lond."},{"key":"6968_CR99","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1044\/2019_AJSLP-18-0132","volume":"28","author":"GJ Miller","year":"2019","unstructured":"Miller, G. J. et al. Reading outcomes for individuals with histories of suspected childhood apraxia of speech. Am. J. Speech Lang. Pathol. 28, 1432\u20131447 (2019).","journal-title":"Am. J. Speech Lang. Pathol."},{"key":"6968_CR100","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1044\/1058-0360(2012\/12-0022)","volume":"22","author":"JL Preston","year":"2013","unstructured":"Preston, J. L., Hull, M. & Edwards, M. L. Preschool speech error patterns predict articulation and phonological awareness outcomes in children with histories of speech sound disorders. Am. J. Speech Lang. Pathol. 22, 173\u2013184 (2013).","journal-title":"Am. J. Speech Lang. Pathol."},{"key":"6968_CR101","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1044\/jshr.3705.1100","volume":"37","author":"L Shriberg","year":"1994","unstructured":"Shriberg, L. & Kwiatkowski, J. Developmental phonological disorders I: A clinical profile. J. Speech Hearing Res. 37, 1100\u20131126 (1994).","journal-title":"J. Speech Hearing Res."},{"key":"6968_CR102","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1044\/2015_JSLHR-S-14-0282","volume":"59","author":"Y Wren","year":"2016","unstructured":"Wren, Y., Miller, L. L., Peters, T. J., Emond, A. & Roulstone, S. Prevalence and predictors of persistent speech sound disorder at eight years old: findings from a population cohort study. J. Speech Lang. Hear. Res. 59, 647\u2013673 (2016).","journal-title":"J. Speech Lang. Hear. Res."},{"key":"6968_CR103","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.gde.2021.02.015","volume":"68","author":"D Moreno-De-Luca","year":"2021","unstructured":"Moreno-De-Luca, D. & Martin, C. L. All for one and one for all: heterogeneity of genetic etiologies in neurodevelopmental psychiatric disorders. Curr. Opin. Genet. Dev. 68, 71\u201378 (2021).","journal-title":"Curr. Opin. Genet. Dev."},{"key":"6968_CR104","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.ajhg.2019.07.001","volume":"105","author":"M Aguirre","year":"2019","unstructured":"Aguirre, M., Rivas, M. A. & Priest, J. Phenome-wide burden of copy-number variation in the UK Biobank. Am. J. Hum. Genet. 105, 373\u2013383 (2019).","journal-title":"Am. J. Hum. Genet."},{"key":"6968_CR105","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/0021-9924(84)90002-9","volume":"17","author":"DD Sanger","year":"1984","unstructured":"Sanger, D. D., Stick, S. L., Sanger, W. G. & Dawson, K. Specific syndromes and associated communication disorders: a review. J. Commun. Disord. 17, 385\u2013405 (1984).","journal-title":"J. Commun. Disord."},{"key":"6968_CR106","unstructured":"Shprintzen, R. Genetics, syndromes and communication disorders. (Singular Publishing Group, 1997)."},{"key":"6968_CR107","unstructured":"Batshaw, M. N., NJ; Pelligino, L. Children with Disabilities. Eighth edition edn. (Brookes Publishing, 2019)."},{"key":"6968_CR108","doi-asserted-by":"publisher","first-page":"445","DOI":"10.3109\/02699206.2012.655841","volume":"26","author":"LD Shriberg","year":"2012","unstructured":"Shriberg, L. D., Lohmeier, H. L., Strand, E. A. & Jakielski, K. J. Encoding, memory, and transcoding deficits in Childhood Apraxia of Speech. Clin. Linguist. Phonetics 26, 445\u2013482 (2012).","journal-title":"Clin. Linguist. Phonetics"},{"key":"6968_CR109","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3389\/fgene.2017.00047","volume":"8","author":"V Bertini","year":"2017","unstructured":"Bertini, V. et al. Deletion extents are not the cause of clinical variability in 22q11.2 deletion syndrome: does the interaction between DGCR8 and miRNA-CNVs play a major role? Front Genet. 8, 47 (2017).","journal-title":"Front Genet."},{"key":"6968_CR110","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1016\/j.tig.2019.08.005","volume":"35","author":"JM Goldmann","year":"2019","unstructured":"Goldmann, J. M., Veltman, J. A. & Gilissen, C. De novo mutations reflect development and aging of the human germline. Trends Genet. 35, 828\u2013839 (2019).","journal-title":"Trends Genet."},{"key":"6968_CR111","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s12940-023-01029-z","volume":"22","author":"CV Goodman","year":"2023","unstructured":"Goodman, C. V. et al. Sex difference of pre- and post-natal exposure to six developmental neurotoxicants on intellectual abilities: a systematic review and meta-analysis of human studies. Environ. Health 22, 80 (2023).","journal-title":"Environ. Health"},{"key":"6968_CR112","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.jcomdis.2015.07.002","volume":"57","author":"KL Dzwilewski","year":"2015","unstructured":"Dzwilewski, K. L. & Schantz, S. L. Prenatal chemical exposures and child language development. J. Commun. Disord. 57, 41\u201365 (2015).","journal-title":"J. Commun. Disord."},{"key":"6968_CR113","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1177\/074193258600700104","volume":"7","author":"PB Gough","year":"1986","unstructured":"Gough, P. B. & Tunmer, W. E. Decoding, reading, and reading disability. Remedial Spec. Educ. 7, 6\u201310 (1986).","journal-title":"Remedial Spec. Educ."}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-06968-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-06968-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-06968-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T18:02:24Z","timestamp":1728151344000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-06968-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,5]]},"references-count":113,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["6968"],"URL":"https:\/\/doi.org\/10.1038\/s42003-024-06968-y","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,5]]},"assertion":[{"value":"18 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1273"}}