{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:14:28Z","timestamp":1787505268945,"version":"build-2736575974"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801397"],"award-info":[{"award-number":["81801397"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-024-07097-2","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T13:22:52Z","timestamp":1731072172000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sulfated galactofucan from Sargassum fusiforme protects against postmenopausal osteoporosis by regulating bone remodeling"],"prefix":"10.1038","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2935-7121","authenticated-orcid":false,"given":"Bao","family":"Yizhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihua","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genxiang","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boshan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"key":"7097_CR1","first-page":"e5328","volume":"11","author":"B Imam","year":"2019","unstructured":"Imam, B., Aziz, K., Khan, M., Zubair, T. & Iqbal, A. Role of bisphosphonates in postmenopausal women with osteoporosis to prevent future fractures: a literature review. Cureus 11, e5328 (2019).","journal-title":"Cureus"},{"key":"7097_CR2","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1146\/annurev-pathol-011110-130203","volume":"6","author":"X Feng","year":"2011","unstructured":"Feng, X. & McDonald, J. M. Disorders of bone remodeling. Annu. Rev. Pathol. 6, 121\u2013145 (2011).","journal-title":"Annu. Rev. Pathol."},{"key":"7097_CR3","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.cytogfr.2020.02.003","volume":"52","author":"J Li","year":"2020","unstructured":"Li, J., Chen, X., Lu, L. & Yu, X. The relationship between bone marrow adipose tissue and bone metabolism in postmenopausal osteoporosis. Cytokine Growth Factor Rev. 52, 88\u201398 (2020).","journal-title":"Cytokine Growth Factor Rev."},{"key":"7097_CR4","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s40266-018-0525-7","volume":"35","author":"ED Deeks","year":"2018","unstructured":"Deeks, E. D. Denosumab: a review in postmenopausal osteoporosis. Drugs Aging 35, 163\u2013173 (2018).","journal-title":"Drugs Aging"},{"key":"7097_CR5","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-022-01061-5","volume":"17","author":"CL Gregson","year":"2022","unstructured":"Gregson, C. L. et al. UK clinical guideline for the prevention and treatment of osteoporosis. Arch Osteoporos 17, 58 (2022).","journal-title":"Arch Osteoporos"},{"key":"7097_CR6","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1056\/NEJMoa1916525","volume":"383","author":"DM Black","year":"2020","unstructured":"Black, D. M. et al. Atypical femur fracture risk versus fragility fracture prevention with bisphosphonates. N. Engl. J. Med. 383, 743\u2013753 (2020).","journal-title":"N. Engl. J. Med."},{"key":"7097_CR7","doi-asserted-by":"publisher","first-page":"108252","DOI":"10.1016\/j.celrep.2020.108252","volume":"33","author":"H Wei","year":"2020","unstructured":"Wei, H. et al. Identification of fibroblast activation protein as an osteogenic suppressor and anti-osteoporosis drug target. Cell Rep. 33, 108252 (2020).","journal-title":"Cell Rep."},{"key":"7097_CR8","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/j.1749-6632.2010.05666.x","volume":"1205","author":"GP Lyritis","year":"2010","unstructured":"Lyritis, G. P., Georgoulas, T. & Zafeiris, C. P. Bone anabolic versus bone anticatabolic treatment of postmenopausal osteoporosis. Ann. N Y Acad. Sci. 1205, 277\u2013283 (2010).","journal-title":"Ann. N Y Acad. Sci."},{"key":"7097_CR9","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1002\/jbmr.5650110307","volume":"11","author":"P Garnero","year":"1996","unstructured":"Garnero, P., Sornay-Rendu, E., Chapuy, M. C. & Delmas, P. D. Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis. J. Bone Miner. Res. 11, 337\u2013349 (1996).","journal-title":"J. Bone Miner. Res."},{"key":"7097_CR10","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.yexcr.2014.07.005","volume":"330","author":"F Xiao","year":"2015","unstructured":"Xiao, F. et al. Geraniin suppresses RANKL-induced osteoclastogenesis in vitro and ameliorates wear particle-induced osteolysis in mouse model. Exp. Cell Res. 330, 91\u2013101 (2015).","journal-title":"Exp. Cell Res."},{"key":"7097_CR11","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.cytogfr.2020.03.003","volume":"55","author":"X Xia","year":"2020","unstructured":"Xia, X., Wang, W., Yin, K. & Wang, S. Interferon regulatory factor 8 governs myeloid cell development. Cytokine Growth Factor Rev. 55, 48\u201357 (2020).","journal-title":"Cytokine Growth Factor Rev."},{"key":"7097_CR12","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/s41586-019-1105-7","volume":"568","author":"CE Jacome-Galarza","year":"2019","unstructured":"Jacome-Galarza, C. E. et al. Developmental origin, functional maintenance and genetic rescue of osteoclasts. Nature 568, 541\u2013545 (2019).","journal-title":"Nature"},{"key":"7097_CR13","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1038\/nm.2007","volume":"15","author":"B Zhao","year":"2009","unstructured":"Zhao, B. et al. Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis. Nat. Med. 15, 1066\u20131071 (2009).","journal-title":"Nat. Med."},{"key":"7097_CR14","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1002\/jbmr.3689","volume":"34","author":"N Izawa","year":"2019","unstructured":"Izawa, N. et al. Cooperation of PU.1 With IRF8 and NFATc1 defines chromatin landscapes during RANKL-Induced Osteoclastogenesis. J. Bone Miner. Res. 34, 1143\u20131154 (2019).","journal-title":"J. Bone Miner. Res."},{"key":"7097_CR15","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/s10616-016-0013-z","volume":"69","author":"E Saito","year":"2017","unstructured":"Saito, E. et al. Down-regulation of Irf8 by Lyz2-cre\/loxP accelerates osteoclast differentiation in vitro. Cytotechnology 69, 443\u2013450 (2017).","journal-title":"Cytotechnology"},{"key":"7097_CR16","doi-asserted-by":"publisher","first-page":"112057","DOI":"10.1016\/j.exger.2022.112057","volume":"172","author":"W Jin","year":"2023","unstructured":"Jin, W., Chen, F., Fang, Q., Mao, G. & Bao, Y. Oligosaccharides from Sargassum thunbergii inhibit osteoclast differentiation via regulation of IRF-8 signaling. Exp. Gerontol. 172, 112057 (2023).","journal-title":"Exp. Gerontol."},{"key":"7097_CR17","doi-asserted-by":"publisher","first-page":"C111","DOI":"10.1152\/ajpcell.00120.2019","volume":"318","author":"PH Schlesinger","year":"2020","unstructured":"Schlesinger, P. H. et al. Cellular and extracellular matrix of bone, with principles of synthesis and dependency of mineral deposition on cell membrane transport. Am. J. Physiol. Cell Physiol. 318, C111\u2013C124 (2020).","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"7097_CR18","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1111\/odi.13829","volume":"28","author":"NY Shim","year":"2022","unstructured":"Shim, N. Y., Ryu, J. I. & Heo, J. S. Osteoinductive function of fucoidan on periodontal ligament stem cells: role of PI3K\/Akt and Wnt\/beta-catenin signaling pathways. Oral Dis. 28, 1628\u20131639 (2022).","journal-title":"Oral Dis."},{"key":"7097_CR19","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2014.95","volume":"47","author":"BS Kim","year":"2015","unstructured":"Kim, B. S., Kang, H. J., Park, J. Y. & Lee, J. Fucoidan promotes osteoblast differentiation via JNK- and ERK-dependent BMP2-Smad 1\/5\/8 signaling in human mesenchymal stem cells. Exp. Mol. Med. 47, e128 (2015).","journal-title":"Exp. Mol. Med."},{"key":"7097_CR20","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.ijbiomac.2013.03.011","volume":"57","author":"HS Jeong","year":"2013","unstructured":"Jeong, H. S., Venkatesan, J. & Kim, S. K. Hydroxyapatite-fucoidan nanocomposites for bone tissue engineering. Int. J. Biol. Macromol. 57, 138\u2013141 (2013).","journal-title":"Int. J. Biol. Macromol."},{"key":"7097_CR21","doi-asserted-by":"publisher","unstructured":"Deng, L. et al. Isolation and characterization of a novel homopolysaccharide (SFP-1) from Sargassum fusiforme: Promising anti-osteoporosis activity by modulating adipo-osteogenic differentiation. Ind. Crops Products 207, https:\/\/doi.org\/10.1016\/j.indcrop.2023.117749 (2024).","DOI":"10.1016\/j.indcrop.2023.117749"},{"key":"7097_CR22","doi-asserted-by":"publisher","unstructured":"Gupta, D., Martinez, D. C., Puertas-Mejia, M. A., Hearnden, V. L. & Reilly, G. C. The effects of Fucoidan Derived from Sargassum filipendula and Fucus vesiculosus on the Survival and Mineralisation of Osteogenic Progenitors. Int. J. Mol. Sci. 25, https:\/\/doi.org\/10.3390\/ijms25042085 (2024).","DOI":"10.3390\/ijms25042085"},{"key":"7097_CR23","doi-asserted-by":"publisher","unstructured":"Lu, S. H., Hsia, Y. J., Shih, K. C. & Chou, T. C. Fucoidan Prevents RANKL-Stimulated Osteoclastogenesis and LPS-Induced Inflammatory Bone Loss via Regulation of Akt\/GSK3beta\/PTEN\/NFATc1 Signaling Pathway and Calcineurin Activity. Mar. Drugs 17, https:\/\/doi.org\/10.3390\/md17060345 (2019).","DOI":"10.3390\/md17060345"},{"key":"7097_CR24","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.ijbiomac.2022.11.047","volume":"223","author":"NM Liyanage","year":"2022","unstructured":"Liyanage, N. M. et al. Characterization and therapeutic effect of Sargassum coreanum fucoidan that inhibits lipopolysaccharide-induced inflammation in RAW 264.7 macrophages by blocking NF-kappaB signaling. Int. J. Biol. Macromol. 223, 500\u2013510 (2022).","journal-title":"Int. J. Biol. Macromol."},{"key":"7097_CR25","doi-asserted-by":"publisher","first-page":"25230","DOI":"10.1074\/jbc.M109.008391","volume":"284","author":"YD Cho","year":"2009","unstructured":"Cho, Y. D. et al. Molecular regulation of matrix extracellular phosphoglycoprotein expression by bone morphogenetic protein-2. J. Biol. Chem. 284, 25230\u201325240 (2009).","journal-title":"J. Biol. Chem."},{"key":"7097_CR26","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1089\/ten.tea.2013.0028","volume":"20","author":"J Pereira","year":"2014","unstructured":"Pereira, J. et al. The in vitro and in vivo effects of a low-molecular-weight fucoidan on the osteogenic capacity of human adipose-derived stromal cells. Tissue Eng. Part A 20, 275\u2013284 (2014).","journal-title":"Tissue Eng. Part A"},{"key":"7097_CR27","doi-asserted-by":"publisher","first-page":"890","DOI":"10.3892\/mmr.2016.6062","volume":"15","author":"X Jin","year":"2017","unstructured":"Jin, X. et al. Low\u2011molecular weight fucoidan inhibits the differentiation of osteoclasts and reduces osteoporosis in ovariectomized rats. Mol. Med. Rep. 15, 890\u2013898 (2017).","journal-title":"Mol. Med. Rep."},{"key":"7097_CR28","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1007\/s10616-015-9894-5","volume":"68","author":"PA Hwang","year":"2016","unstructured":"Hwang, P. A. et al. The in vitro and in vivo effects of the low molecular weight fucoidan on the bone osteogenic differentiation properties. Cytotechnology 68, 1349\u20131359 (2016).","journal-title":"Cytotechnology"},{"key":"7097_CR29","doi-asserted-by":"publisher","first-page":"111057","DOI":"10.1016\/j.exger.2020.111057","volume":"140","author":"J Wang","year":"2020","unstructured":"Wang, J. et al. Tectoridin inhibits osteoclastogenesis and bone loss in a murine model of ovariectomy-induced osteoporosis. Exp. Gerontol. 140, 111057 (2020).","journal-title":"Exp. Gerontol."},{"key":"7097_CR30","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.biocel.2013.10.008","volume":"46","author":"PP Eleniste","year":"2014","unstructured":"Eleniste, P. P., Huang, S., Wayakanon, K., Largura, H. W. & Bruzzaniti, A. Osteoblast differentiation and migration are regulated by dynamin GTPase activity. Int. J. Biochem. Cell Biol. 46, 9\u201318 (2014).","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"7097_CR31","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S0092-8674(01)00622-5","volume":"108","author":"K Nakashima","year":"2002","unstructured":"Nakashima, K. et al. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108, 17\u201329 (2002).","journal-title":"Cell"},{"key":"7097_CR32","doi-asserted-by":"publisher","first-page":"111113","DOI":"10.1016\/j.exger.2020.111113","volume":"142","author":"SN Mann","year":"2020","unstructured":"Mann, S. N. et al. 17alpha-Estradiol prevents ovariectomy-mediated obesity and bone loss. Exp. Gerontol. 142, 111113 (2020).","journal-title":"Exp. Gerontol."},{"key":"7097_CR33","doi-asserted-by":"publisher","first-page":"18840","DOI":"10.3390\/ijms151018840","volume":"15","author":"YW Kim","year":"2014","unstructured":"Kim, Y. W., Baek, S. H., Lee, S. H., Kim, T. H. & Kim, S. Y. Fucoidan, a sulfated polysaccharide, inhibits osteoclast differentiation and function by modulating RANKL signaling. Int. J. Mol. Sci. 15, 18840\u201318855 (2014).","journal-title":"Int. J. Mol. Sci."},{"key":"7097_CR34","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1089\/jmf.2015.3646","volume":"19","author":"YT Jeong","year":"2016","unstructured":"Jeong, Y. T. et al. Osteoprotective effects of Polysaccharide-Enriched Hizikia fusiforme processing byproduct in vitro and in vivo models. J. Med. Food 19, 805\u2013814 (2016).","journal-title":"J. Med. Food"},{"key":"7097_CR35","doi-asserted-by":"publisher","first-page":"115381","DOI":"10.1016\/j.carbpol.2019.115381","volume":"228","author":"R Zhang","year":"2020","unstructured":"Zhang, R., Zhang, X., Tang, Y. & Mao, J. Composition, isolation, purification and biological activities of Sargassum fusiforme polysaccharides: a review. Carbohydr. Polym. 228, 115381 (2020).","journal-title":"Carbohydr. Polym."},{"key":"7097_CR36","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1126\/science.1224310","volume":"338","author":"PE Savage","year":"2012","unstructured":"Savage, P. E. Chemistry. Algae under pressure and in hot water. Science 338, 1039\u20131040 (2012).","journal-title":"Science"},{"key":"7097_CR37","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.ijbiomac.2022.07.110","volume":"216","author":"M Silva","year":"2022","unstructured":"Silva, M. et al. Comparison of in vitro and in vivo antioxidant activities of commercial fucoidans from Macrocystis pyrifera, Undaria pinnatifida, and Fucus vesiculosus. Int. J. Biol. Macromol. 216, 757\u2013767 (2022).","journal-title":"Int. J. Biol. Macromol."},{"key":"7097_CR38","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1016\/j.fitote.2012.09.014","volume":"83","author":"KJ Kim","year":"2012","unstructured":"Kim, K. J., Yoon, K. Y. & Lee, B. Y. Low molecular weight fucoidan from the sporophyll of Undaria pinnatifida suppresses inflammation by promoting the inhibition of mitogen-activated protein kinases and oxidative stress in RAW264.7 cells. Fitoterapia 83, 1628\u20131635 (2012).","journal-title":"Fitoterapia"},{"key":"7097_CR39","doi-asserted-by":"publisher","first-page":"636930","DOI":"10.3389\/fnut.2021.636930","volume":"8","author":"J Yu","year":"2021","unstructured":"Yu, J. et al. Fucoidan extracted from Sporophyll of Undaria pinnatifida Grown in Weihai, China - chemical composition and comparison of antioxidant activity of different molecular weight fractions. Front. Nutr. 8, 636930 (2021).","journal-title":"Front. Nutr."},{"key":"7097_CR40","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.carbpol.2014.08.068","volume":"115","author":"TT Thuy","year":"2015","unstructured":"Thuy, T. T. et al. Anti-HIV activity of fucoidans from three brown seaweed species. Carbohydr. Polym. 115, 122\u2013128 (2015).","journal-title":"Carbohydr. Polym."},{"key":"7097_CR41","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.ijbiomac.2020.05.183","volume":"160","author":"W Jin","year":"2020","unstructured":"Jin, W. et al. Interactions of fibroblast growth factors with sulfated galactofucan from Saccharina japonica. Int. J. Biol. Macromol. 160, 26\u201334 (2020).","journal-title":"Int. J. Biol. Macromol."},{"key":"7097_CR42","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1111\/jcmm.14790","volume":"24","author":"X Zhi","year":"2020","unstructured":"Zhi, X. et al. l-tetrahydropalmatine suppresses osteoclastogenesis in vivo and in vitro via blocking RANK-TRAF6 interactions and inhibiting NF-kappaB and MAPK pathways. J. Cell Mol. Med. 24, 785\u2013798 (2020).","journal-title":"J. Cell Mol. Med."},{"key":"7097_CR43","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1111\/jcmm.13942","volume":"23","author":"Q Wang","year":"2019","unstructured":"Wang, Q. et al. Madecassoside inhibits estrogen deficiency-induced osteoporosis by suppressing RANKL-induced osteoclastogenesis. J. Cell Mol. Med. 23, 380\u2013394 (2019).","journal-title":"J. Cell Mol. Med."},{"key":"7097_CR44","doi-asserted-by":"publisher","unstructured":"Bernar, A., Gebetsberger, J. V., Bauer, M., Streif, W. & Schirmer, M. Optimization of the Alizarin Red S Assay by Enhancing Mineralization of Osteoblasts. Int. J. Mol. Sci. 24, https:\/\/doi.org\/10.3390\/ijms24010723 (2022).","DOI":"10.3390\/ijms24010723"},{"key":"7097_CR45","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.bbrc.2015.03.033","volume":"460","author":"H Kiyomiya","year":"2015","unstructured":"Kiyomiya, H. et al. IL-33 inhibits RANKL-induced osteoclast formation through the regulation of Blimp-1 and IRF-8 expression. Biochem. Biophys. Res. Commun. 460, 320\u2013326 (2015).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"7097_CR46","doi-asserted-by":"publisher","first-page":"118044","DOI":"10.1016\/j.lfs.2020.118044","volume":"257","author":"R Zhao","year":"2020","unstructured":"Zhao, R. et al. Melatonin rescues glucocorticoid-induced inhibition of osteoblast differentiation in MC3T3-E1 cells via the PI3K\/AKT and BMP\/Smad signalling pathways. Life Sci. 257, 118044 (2020).","journal-title":"Life Sci."},{"key":"7097_CR47","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1080\/13697137.2020.1828853","volume":"24","author":"Y Tang","year":"2021","unstructured":"Tang, Y., Lv, X. L., Bao, Y. Z. & Wang, J. R. Glycyrrhizin improves bone metabolism in ovariectomized mice via inactivating NF-kappaB signaling. Climacteric 24, 253\u2013260 (2021).","journal-title":"Climacteric"},{"key":"7097_CR48","doi-asserted-by":"publisher","first-page":"627","DOI":"10.3389\/fphar.2017.00627","volume":"8","author":"X Liu","year":"2017","unstructured":"Liu, X. et al. The beneficial effect of Praeruptorin C on osteoporotic bone in ovariectomized mice via suppression of osteoclast formation and bone resorption. Front. Pharmacol. 8, 627 (2017).","journal-title":"Front. Pharmacol."},{"key":"7097_CR49","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s10557-022-07383-3","volume":"38","author":"K Zhu","year":"2024","unstructured":"Zhu, K. et al. Sulfated Galactofucan from Sargassum Thunbergii Attenuates Atherosclerosis by suppressing inflammation via the TLR4\/MyD88\/NF-kappaB Signaling Pathway. Cardiovasc. Drugs Ther. 38, 69\u201378 (2024).","journal-title":"Cardiovasc. Drugs Ther."},{"key":"7097_CR50","doi-asserted-by":"publisher","first-page":"10700","DOI":"10.1039\/D0FO01488E","volume":"11","author":"Y Liu","year":"2020","unstructured":"Liu, Y., Wu, X., Wang, Y., Jin, W. & Guo, Y. The immunoenhancement effects of starfish Asterias rollestoni polysaccharides in macrophages and cyclophosphamide-induced immunosuppression mouse models. Food Funct. 11, 10700\u201310708 (2020).","journal-title":"Food Funct."}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-07097-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-07097-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-07097-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T15:03:15Z","timestamp":1731078195000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-07097-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,8]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["7097"],"URL":"https:\/\/doi.org\/10.1038\/s42003-024-07097-2","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,8]]},"assertion":[{"value":"18 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1471"}}