{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:30:13Z","timestamp":1791894613494,"version":"4.3.4"},"reference-count":99,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100006206","name":"DOE | SC | Biological and Environmental Research","doi-asserted-by":"publisher","award":["DE-AC02-05CH11231"],"award-info":[{"award-number":["DE-AC02-05CH11231"]}],"id":[{"id":"10.13039\/100006206","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-024-07142-0","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T11:30:46Z","timestamp":1731065446000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The \u2018photosynthetic C1 pathway\u2019 links carbon assimilation and growth in California poplar"],"prefix":"10.1038","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8491-9310","authenticated-orcid":false,"given":"Kolby J.","family":"Jardine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5604-2780","authenticated-orcid":false,"given":"Luiza","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7389-5982","authenticated-orcid":false,"given":"Melissa","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3330-4305","authenticated-orcid":false,"given":"Shivani","family":"Upadhyaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8404-3259","authenticated-orcid":false,"given":"Trent","family":"Northen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2885-1248","authenticated-orcid":false,"given":"Suzanne","family":"Kosina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3339-956X","authenticated-orcid":false,"given":"Guillaume","family":"Tcherkez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aymerick","family":"Eudes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2857-9838","authenticated-orcid":false,"given":"Tomas","family":"Domingues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9958-8371","authenticated-orcid":false,"given":"Markus","family":"Greule","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suman","family":"Som","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2766-8812","authenticated-orcid":false,"given":"Frank","family":"Keppler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"key":"7142_CR1","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1126\/science.105.2738.648","volume":"105","author":"A Benson","year":"1947","unstructured":"Benson, A. & Calvin, M. The dark reductions of photosynthesis. Science 105, 648\u2013649 (1947).","journal-title":"Science"},{"key":"7142_CR2","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.1111\/gcb.14950","volume":"26","author":"V Haverd","year":"2020","unstructured":"Haverd, V. et al. Higher than expected CO2 fertilization inferred from leaf to global observations. Glob. Change Biol. 26, 2390\u20132402 (2020).","journal-title":"Glob. Change Biol."},{"key":"7142_CR3","unstructured":"Pachauri, R. K. & Reisinger, A. IPCC Fourth Assessment Report 044023 (IPCC, 2007) (2007)."},{"key":"7142_CR4","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1111\/pce.13206","volume":"41","author":"D Gamage","year":"2018","unstructured":"Gamage, D. et al. New insights into the cellular mechanisms of plant growth at elevated atmospheric carbon dioxide concentrations. Plant Cell Environ. 41, 1233\u20131246 (2018).","journal-title":"Plant Cell Environ."},{"key":"7142_CR5","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1111\/j.1438-8677.2012.00710.x","volume":"15","author":"I Voss","year":"2013","unstructured":"Voss, I., Sunil, B., Scheibe, R. & Raghavendra, A. Emerging concept for the role of photorespiration as an important part of abiotic stress response. Plant Biol. 15, 713\u2013722 (2013).","journal-title":"Plant Biol."},{"key":"7142_CR6","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/j.1399-3054.1997.tb03463.x","volume":"100","author":"B Colman","year":"1997","unstructured":"Colman, B. & Norman, E. G. Serine synthesis in cyanobacteria by a nonphotorespiratory pathway. Physiologia Plant. 100, 133\u2013136 (1997).","journal-title":"Physiologia Plant."},{"key":"7142_CR7","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.tplants.2014.06.003","volume":"19","author":"R Ros","year":"2014","unstructured":"Ros, R., Mu\u00f1oz-Bertomeu, J. & Krueger, S. Serine in plants: biosynthesis, metabolism, and functions. Trends Plant Sci. 19, 564\u2013569 (2014).","journal-title":"Trends Plant Sci."},{"key":"7142_CR8","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.3389\/fpls.2018.01712","volume":"9","author":"S Wulfert","year":"2018","unstructured":"Wulfert, S. & Krueger, S. Phosphoserine Aminotransferase1 is part of the phosphorylated pathways for serine biosynthesis and essential for light and sugar-dependent growth promotion. Front. Plant Sci. 9, 1712 (2018).","journal-title":"Front. Plant Sci."},{"key":"7142_CR9","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s007260170042","volume":"20","author":"C-L Ho","year":"2001","unstructured":"Ho, C.-L. & Saito, K. Molecular biology of the plastidic phosphorylated serine biosynthetic pathway in Arabidopsis thaliana. Amino Acids 20, 243\u2013259 (2001).","journal-title":"Amino Acids"},{"key":"7142_CR10","doi-asserted-by":"publisher","first-page":"5011","DOI":"10.1105\/tpc.113.118992","volume":"25","author":"RM Benstein","year":"2013","unstructured":"Benstein, R. M. et al. Arabidopsis phosphoglycerate dehydrogenase1 of the phosphoserine pathway is essential for development and required for ammonium assimilation and tryptophan biosynthesis. Plant Cell 25, 5011\u20135029 (2013).","journal-title":"Plant Cell"},{"key":"7142_CR11","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1093\/plcell\/koad256","volume":"36","author":"S Rosa-T\u00e9llez","year":"2024","unstructured":"Rosa-T\u00e9llez, S. et al. The serine\u2013glycine\u2013one-carbon metabolic network orchestrates changes in nitrogen and sulfur metabolism and shapes plant development. Plant Cell 36, 404\u2013426 (2024).","journal-title":"Plant Cell"},{"key":"7142_CR12","doi-asserted-by":"publisher","DOI":"10.4161\/psb.27104","volume":"8","author":"J Mu\u00f1oz-Bertomeu","year":"2013","unstructured":"Mu\u00f1oz-Bertomeu, J. et al. The essential role of the phosphorylated pathway of serine biosynthesis in Arabidopsis. Plant Signal. Behav. 8, e27104 (2013).","journal-title":"Plant Signal. Behav."},{"key":"7142_CR13","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1105\/tpc.113.112359","volume":"25","author":"B Cascales-Mi\u00f1ana","year":"2013","unstructured":"Cascales-Mi\u00f1ana, B. et al. The phosphorylated pathway of serine biosynthesis is essential both for male gametophyte and embryo development and for root growth in Arabidopsis. Plant Cell 25, 2084\u20132101 (2013).","journal-title":"Plant Cell"},{"key":"7142_CR14","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1104\/pp.113.226720","volume":"163","author":"W Toujani","year":"2013","unstructured":"Toujani, W. et al. Functional characterization of the plastidial 3-phosphoglycerate dehydrogenase family in Arabidopsis. Plant Physiol. 163, 1164\u20131178 (2013).","journal-title":"Plant Physiol."},{"key":"7142_CR15","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1093\/plphys\/kiab167","volume":"186","author":"SE Zimmermann","year":"2021","unstructured":"Zimmermann, S. E. et al. The phosphorylated pathway of serine biosynthesis links plant growth with nitrogen metabolism. Plant Physiol. 186, 1487\u20131506 (2021).","journal-title":"Plant Physiol."},{"key":"7142_CR16","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1146\/annurev-arplant-042110-103819","volume":"62","author":"AD Hanson","year":"2011","unstructured":"Hanson, A. D. & Gregory, J. F. III Folate biosynthesis, turnover, and transport in plants. Annu. Rev. Plant Biol. 62, 105\u2013125 (2011).","journal-title":"Annu. Rev. Plant Biol."},{"key":"7142_CR17","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1146\/annurev.arplant.52.1.119","volume":"52","author":"AD Hanson","year":"2001","unstructured":"Hanson, A. D. & Roje, S. One-carbon metabolism in higher plants. Annu. Rev. Plant Biol. 52, 119\u2013137 (2001).","journal-title":"Annu. Rev. Plant Biol."},{"key":"7142_CR18","doi-asserted-by":"publisher","first-page":"22548","DOI":"10.1074\/jbc.M313250200","volume":"279","author":"S Ravanel","year":"2004","unstructured":"Ravanel, S. et al. Methionine metabolism in plants: chloroplasts are autonomous for de novo methionine synthesis and can import S-adenosylmethionine from the cytosol. J. Biol. Chem. 279, 22548\u201322557 (2004).","journal-title":"J. Biol. Chem."},{"key":"7142_CR19","doi-asserted-by":"publisher","first-page":"584","DOI":"10.3389\/fpls.2018.00584","volume":"9","author":"M Ruszkowski","year":"2018","unstructured":"Ruszkowski, M., Sekula, B., Ruszkowska, A. & Dauter, Z. Chloroplastic serine hydroxymethyltransferase from Medicago truncatula: a structural characterization. Front. Plant Sci. 9, 584 (2018).","journal-title":"Front. Plant Sci."},{"key":"7142_CR20","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1016\/j.phytochem.2006.04.019","volume":"67","author":"S Roje","year":"2006","unstructured":"Roje, S. S-Adenosyl-L-methionine: beyond the universal methyl group donor. Phytochemistry 67, 1686\u20131698 (2006).","journal-title":"Phytochemistry"},{"key":"7142_CR21","doi-asserted-by":"crossref","unstructured":"Amir, R & Hacham, Y. in A Missing Link Between Soils, Crops and Nutrition Vol. 50 (ed. Jez, J.) 251\u2013279 (Wiley, 2008). .","DOI":"10.2134\/agronmonogr50.c16"},{"key":"7142_CR22","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.tplants.2020.05.007","volume":"25","author":"D Zhang","year":"2020","unstructured":"Zhang, D. & Zhang, B. Pectin drives cell wall morphogenesis without turgor pressure. Trends Plant Sci. 25, 719\u2013722 (2020).","journal-title":"Trends Plant Sci."},{"key":"7142_CR23","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1126\/science.aaz5103","volume":"367","author":"KT Haas","year":"2020","unstructured":"Haas, K. T., Wightman, R., Meyerowitz, E. M. & Peaucelle, A. Pectin homogalacturonan nanofilament expansion drives morphogenesis in plant epidermal cells. Science 367, 1003\u20131007 (2020).","journal-title":"Science"},{"key":"7142_CR24","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3389\/fpls.2012.00121","volume":"3","author":"A Peaucelle","year":"2012","unstructured":"Peaucelle, A., Braybrook, S. & H\u00f6fte, H. Cell wall mechanics and growth control in plants: the role of pectins revisited. Front. plant Sci. 3, 121 (2012).","journal-title":"Front. plant Sci."},{"key":"7142_CR25","doi-asserted-by":"publisher","first-page":"813","DOI":"10.3390\/catal11070813","volume":"11","author":"IC Tommasi","year":"2021","unstructured":"Tommasi, I. C. The mechanism of Rubisco catalyzed carboxylation reaction: chemical aspects involving acid-base chemistry and functioning of the molecular machine. Catalysts 11, 813 (2021).","journal-title":"Catalysts"},{"key":"7142_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-42777-8","volume":"9","author":"P Zhang","year":"2019","unstructured":"Zhang, P. et al. Revisiting fragmentation reactions of protonated \u03b1-amino acids by high-resolution electrospray ionization tandem mass spectrometry with collision-induced dissociation. Sci. Rep. 9, 6453 (2019).","journal-title":"Sci. Rep."},{"key":"7142_CR27","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1515\/znc-1987-0513","volume":"42","author":"D Schulze-Siebert","year":"1987","unstructured":"Schulze-Siebert, D., Heintze, A. & Schultz, G. Substrate flow from photosynthetic carbon metabolism to chloroplast isoprenoid synthesis in spinach evidence for a plastidic phosphoglycerate mutase. Z. Naturforsch. C 42, 570\u2013580 (1987).","journal-title":"Z. Naturforsch. C"},{"key":"7142_CR28","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1104\/pp.113.215970","volume":"162","author":"S Timm","year":"2013","unstructured":"Timm, S. et al. Serine acts as a metabolic signal for the transcriptional control of photorespiration-related genes in Arabidopsis. Plant Physiol. 162, 379\u2013389 (2013).","journal-title":"Plant Physiol."},{"key":"7142_CR29","doi-asserted-by":"crossref","unstructured":"Siqueira, J. A., Zhang, Y., Nunes-Nesi, A., Fernie, A. R. & Ara\u00fajo, W. L. Beyond photorespiration: the significance of glycine and serine in leaf metabolism. Trends Plant Sci. 28, 1092\u20131094 (2023).","DOI":"10.1016\/j.tplants.2023.06.012"},{"key":"7142_CR30","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/s42003-019-0616-y","volume":"2","author":"C Abadie","year":"2019","unstructured":"Abadie, C. & Tcherkez, G. Plant sulphur metabolism is stimulated by photorespiration. Commun. Biol. 2, 379 (2019).","journal-title":"Commun. Biol."},{"key":"7142_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nplants.2015.220","volume":"2","author":"C Abadie","year":"2016","unstructured":"Abadie, C., Boex-Fontvieille, E. R., Carroll, A. J. & Tcherkez, G. In vivo stoichiometry of photorespiratory metabolism. Nat. Plants 2, 1\u20134 (2016).","journal-title":"Nat. Plants"},{"key":"7142_CR32","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/s41477-017-0065-x","volume":"4","author":"FA Busch","year":"2018","unstructured":"Busch, F. A., Sage, R. F. & Farquhar, G. D. Plants increase CO2 uptake by assimilating nitrogen via the photorespiratory pathway. Nat. Plants 4, 46\u201354 (2018).","journal-title":"Nat. Plants"},{"key":"7142_CR33","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/s41477-022-01294-9","volume":"9","author":"X Fu","year":"2023","unstructured":"Fu, X., Gregory, L. M., Weise, S. E. & Walker, B. J. Integrated flux and pool size analysis in plant central metabolism reveals unique roles of glycine and serine during photorespiration. Nat. Plants 9, 169\u2013178 (2023).","journal-title":"Nat. Plants"},{"key":"7142_CR34","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1111\/j.1399-3054.1966.tb07046.x","volume":"19","author":"O Bj\u00f6rkman","year":"1966","unstructured":"Bj\u00f6rkman, O. The effect of oxygen concentration on photosynthesis in higher plants. Physiologia Plant. 19, 618\u2013633 (1966).","journal-title":"Physiologia Plant."},{"key":"7142_CR35","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1071\/FP16355","volume":"44","author":"C Abadie","year":"2017","unstructured":"Abadie, C., Blanchet, S., Carroll, A. & Tcherkez, G. Metabolomics analysis of postphotosynthetic effects of gaseous O2 on primary metabolism in illuminated leaves. Funct. Plant Biol. 44, 929\u2013940 (2017).","journal-title":"Funct. Plant Biol."},{"key":"7142_CR36","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1104\/pp.114.247494","volume":"166","author":"K Jardine","year":"2014","unstructured":"Jardine, K. et al. Dynamic balancing of isoprene carbon sources reflects photosynthetic and photorespiratory responses to temperature stress. Plant Physiol. 166, 2051\u20132064 (2014).","journal-title":"Plant Physiol."},{"key":"7142_CR37","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1007\/s00425-002-0825-2","volume":"215","author":"T Karl","year":"2002","unstructured":"Karl, T. et al. On-line analysis of the 13 CO 2 labelling of leaf isoprene suggests multiple subcellular origins of isoprene precursors. Planta 215, 894\u2013905 (2002).","journal-title":"Planta"},{"key":"7142_CR38","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1104\/pp.93.3.1121","volume":"93","author":"A Heintze","year":"1990","unstructured":"Heintze, A. et al. Plastidic isoprenoid synthesis during chloroplast development: change from metabolic autonomy to a division-of-labor stage. Plant Physiol. 93, 1121\u20131127 (1990).","journal-title":"Plant Physiol."},{"key":"7142_CR39","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1046\/j.1432-1033.2003.03469.x","volume":"270","author":"A Tovar\u2010M\u00e9ndez","year":"2003","unstructured":"Tovar\u2010M\u00e9ndez, A., Miernyk, J. A. & Randall, D. D. Regulation of pyruvate dehydrogenase complex activity in plant cells. Eur. J. Biochem. 270, 1043\u20131049 (2003).","journal-title":"Eur. J. Biochem."},{"key":"7142_CR40","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1046\/j.1365-3040.2002.00889.x","volume":"25","author":"T Karl","year":"2002","unstructured":"Karl, T., Curtis, A., Rosenstiel, T., Monson, R. & Fall, R. Transient releases of acetaldehyde from tree leaves\u2212 products of a pyruvate overflow mechanism? Plant Cell Environ. 25, 1121\u20131131 (2002).","journal-title":"Plant Cell Environ."},{"key":"7142_CR41","doi-asserted-by":"crossref","unstructured":"Jardine, K. J. & McDowell, N. Fermentation\u2010mediated growth, signaling, and defense in plants. New Phytol. 239, 839\u2013851 (2023).","DOI":"10.1111\/nph.19015"},{"key":"7142_CR42","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s11120-012-9746-5","volume":"113","author":"K Jardine","year":"2012","unstructured":"Jardine, K. et al. Green leaf volatiles and oxygenated metabolite emission bursts from mesquite branches following light\u2013dark transitions. Photosynthesis Res. 113, 321\u2013333 (2012).","journal-title":"Photosynthesis Res."},{"key":"7142_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2091-10-7","volume":"10","author":"Y Wei","year":"2009","unstructured":"Wei, Y., Lin, M., Oliver, D. J. & Schnable, P. S. The roles of aldehyde dehydrogenases (ALDHs) in the PDH bypass of Arabidopsis. BMC Biochem. 10, 1\u201310 (2009).","journal-title":"BMC Biochem."},{"key":"7142_CR44","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1111\/nph.14816","volume":"216","author":"G Tcherkez","year":"2017","unstructured":"Tcherkez, G. et al. Leaf day respiration: low CO2 flux but high significance for metabolism and carbon balance. N. Phytologist 216, 986\u20131001 (2017).","journal-title":"N. Phytologist"},{"key":"7142_CR45","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1111\/j.1365-3040.2012.02550.x","volume":"35","author":"G Tcherkez","year":"2012","unstructured":"Tcherkez, G. et al. Short\u2010term effects of CO2 and O2 on citrate metabolism in illuminated leaves. Plant, Cell Environ. 35, 2208\u20132220 (2012).","journal-title":"Plant, Cell Environ."},{"key":"7142_CR46","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1111\/j.1399-3054.2006.00834.x","volume":"129","author":"HV Scheller","year":"2007","unstructured":"Scheller, H. V., Jensen, J. K., S\u00f8rensen, S. O., Harholt, J. & Geshi, N. Biosynthesis of pectin. Physiologia Plant. 129, 283\u2013295 (2007).","journal-title":"Physiologia Plant."},{"key":"7142_CR47","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1104\/pp.110.156588","volume":"153","author":"J Harholt","year":"2010","unstructured":"Harholt, J., Suttangkakul, A. & Vibe Scheller, H. Biosynthesis of pectin. Plant Physiol. 153, 384\u2013395 (2010).","journal-title":"Plant Physiol."},{"key":"7142_CR48","doi-asserted-by":"publisher","first-page":"34823","DOI":"10.1074\/jbc.M506045200","volume":"280","author":"M Bedhomme","year":"2005","unstructured":"Bedhomme, M. et al. Folate metabolism in plants: an Arabidopsis homolog of the mammalian mitochondrial folate transporter mediates folate import into chloroplasts. J. Biol. Chem. 280, 34823\u201334831 (2005).","journal-title":"J. Biol. Chem."},{"key":"7142_CR49","doi-asserted-by":"publisher","first-page":"3429","DOI":"10.1111\/pce.14464","volume":"45","author":"KJ Jardine","year":"2022","unstructured":"Jardine, K. J. et al. Cell wall ester modifications and volatile emission signatures of plant response to abiotic stress. Plant, Cell Environ. 45, 3429\u20133444 (2022).","journal-title":"Plant, Cell Environ."},{"key":"7142_CR50","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.abb.2017.10.012","volume":"635","author":"KM Romek","year":"2017","unstructured":"Romek, K. M. et al. Insights into the role of methionine synthase in the universal 13C depletion in O-and N-methyl groups of natural products. Arch. Biochem. Biophys. 635, 60\u201365 (2017).","journal-title":"Arch. Biochem. Biophys."},{"key":"7142_CR51","doi-asserted-by":"publisher","first-page":"123","DOI":"10.5194\/bg-1-123-2004","volume":"1","author":"F Keppler","year":"2004","unstructured":"Keppler, F., Kalin, R., Harper, D., McRoberts, W. & Hamilton, J. T. Carbon isotope anomaly in the major plant C 1 pool and its global biogeochemical implications. Biogeosciences 1, 123\u2013131 (2004).","journal-title":"Biogeosciences"},{"key":"7142_CR52","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.5194\/bg-4-1083-2007","volume":"4","author":"P Harley","year":"2007","unstructured":"Harley, P., Greenberg, J., Niinemets, \u00dc. & Guenther, A. Environmental controls over methanol emission from leaves. Biogeosciences 4, 1083\u20131099 (2007).","journal-title":"Biogeosciences"},{"key":"7142_CR53","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax5343","volume":"6","author":"M Bi\u017ei\u0107","year":"2020","unstructured":"Bi\u017ei\u0107, M. et al. Aquatic and terrestrial cyanobacteria produce methane. Sci. Adv. 6, eaax5343 (2020).","journal-title":"Sci. Adv."},{"key":"7142_CR54","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.5194\/bg-12-1907-2015","volume":"12","author":"K Lenhart","year":"2015","unstructured":"Lenhart, K., Althoff, F., Greule, M. & Keppler, F. Methionine, a precursor of methane in living plants. Biogeosciences 12, 1907\u20131914 (2015).","journal-title":"Biogeosciences"},{"key":"7142_CR55","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1038\/s41586-022-04511-9","volume":"603","author":"L Ernst","year":"2022","unstructured":"Ernst, L. et al. Methane formation driven by reactive oxygen species across all living organisms. Nature 603, 482\u2013487 (2022).","journal-title":"Nature"},{"key":"7142_CR56","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5205","volume":"5","author":"F Althoff","year":"2014","unstructured":"Althoff, F. et al. Abiotic methanogenesis from organosulphur compounds under ambient conditions. Nat. Commun. 5, 4205 (2014).","journal-title":"Nat. Commun."},{"key":"7142_CR57","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2308516120","volume":"120","author":"L Kohl","year":"2023","unstructured":"Kohl, L. et al. Radiation and temperature drive diurnal variation of aerobic methane emissions from Scots pine canopy. Proc. Natl Acad. Sci. 120, e2308516120 (2023).","journal-title":"Proc. Natl Acad. Sci."},{"key":"7142_CR58","doi-asserted-by":"publisher","first-page":"2878","DOI":"10.3390\/ijms19102878","volume":"19","author":"A Wormit","year":"2018","unstructured":"Wormit, A. & Usadel, B. The multifaceted role of pectin methylesterase inhibitors (PMEIs). Int. J. Mol. Sci. 19, 2878 (2018).","journal-title":"Int. J. Mol. Sci."},{"key":"7142_CR59","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","volume":"51","author":"D Szklarczyk","year":"2023","unstructured":"Szklarczyk, D. et al. The STRING database in 2023: protein\u2013protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res. 51, D638\u2013D646 (2023).","journal-title":"Nucleic Acids Res."},{"key":"7142_CR60","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1021\/pr300952g","volume":"12","author":"M Huang","year":"2013","unstructured":"Huang, M. et al. Construction of plastid reference proteomes for maize and Arabidopsis and evaluation of their orthologous relationships; the concept of orthoproteomics. J. Proteome Res. 12, 491\u2013504 (2013).","journal-title":"J. Proteome Res."},{"key":"7142_CR61","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1111\/nph.18426","volume":"236","author":"E Rowland","year":"2022","unstructured":"Rowland, E. et al. The CLP and PREP protease systems coordinate maturation and degradation of the chloroplast proteome in Arabidopsis thaliana. N. Phytol. 236, 1339\u20131357 (2022).","journal-title":"N. Phytol."},{"key":"7142_CR62","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-63372-2","volume":"10","author":"H Lu","year":"2020","unstructured":"Lu, H., Gordon, M. I., Amarasinghe, V. & Strauss, S. H. Extensive transcriptome changes during seasonal leaf senescence in field-grown black cottonwood (Populus trichocarpa Nisqually-1). Sci. Rep. 10, 6581 (2020).","journal-title":"Sci. Rep."},{"key":"7142_CR63","doi-asserted-by":"publisher","first-page":"9794","DOI":"10.1073\/pnas.89.20.9794","volume":"89","author":"A Nonomura","year":"1992","unstructured":"Nonomura, A. & Benson, A. The path of carbon in photosynthesis: improved crop yields with methanol. Proc. Natl Acad. Sci. 89, 9794\u20139798 (1992).","journal-title":"Proc. Natl Acad. Sci."},{"key":"7142_CR64","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.3390\/ijms18102045","volume":"18","author":"KJ Jardine","year":"2017","unstructured":"Jardine, K. J. et al. Integration of C1 and C2 metabolism in trees. Int. J. Mol. Sci. 18, 2045 (2017).","journal-title":"Int. J. Mol. Sci."},{"key":"7142_CR65","first-page":"38","volume":"3","author":"A Alekseeva","year":"2011","unstructured":"Alekseeva, A., Savin, S. & Tishkov, V. NAD+-dependent formate dehydrogenase from plants. Acta Nat. (\u0430\u043d\u0433\u043b\u043e\u044f\u0437\u044b\u0447\u043d\u0430\u044f \u0432\u0435\u0440\u0441\u0438\u044f) 3, 38\u201354 (2011).","journal-title":"Acta Nat. (\u0430\u043d\u0433\u043b\u043e\u044f\u0437\u044b\u0447\u043d\u0430\u044f \u0432\u0435\u0440\u0441\u0438\u044f)"},{"key":"7142_CR66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/bbb\/zbac176","volume":"87","author":"H Yurimoto","year":"2023","unstructured":"Yurimoto, H. & Sakai, Y. Interaction between C1-microorganisms and plants: contribution to the global carbon cycle and microbial survival strategies in the phyllosphere. Biosci. Biotechnol. Biochem. 87, 1\u20136 (2023).","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"7142_CR67","doi-asserted-by":"publisher","first-page":"137","DOI":"10.3390\/microorganisms3020137","volume":"3","author":"H Iguchi","year":"2015","unstructured":"Iguchi, H., Yurimoto, H. & Sakai, Y. Interactions of methylotrophs with plants and other heterotrophic bacteria. Microorganisms 3, 137\u2013151 (2015).","journal-title":"Microorganisms"},{"key":"7142_CR68","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1046\/j.1365-3040.1999.00505.x","volume":"22","author":"\u00dc Niinemets","year":"1999","unstructured":"Niinemets, \u00dc., Tenhunen, J., Harley, P. C. & Steinbrecher, R. A model of isoprene emission based on energetic requirements for isoprene synthesis and leaf photosynthetic properties for Liquidambar and Quercus. Plant Cell Environ. 22, 1319\u20131335 (1999).","journal-title":"Plant Cell Environ."},{"key":"7142_CR69","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/nph.12770","volume":"203","author":"C Morfopoulos","year":"2014","unstructured":"Morfopoulos, C. et al. A model of plant isoprene emission based on available reducing power captures responses to atmospheric CO 2. N. Phytol. 203, 125\u2013139 (2014).","journal-title":"N. Phytol."},{"key":"7142_CR70","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1093\/pcp\/pcaa149","volume":"62","author":"Y Suzuki","year":"2021","unstructured":"Suzuki, Y. et al. Overproduction of chloroplast glyceraldehyde-3-phosphate dehydrogenase improves photosynthesis slightly under elevated [CO2] conditions in rice. Plant Cell Physiol. 62, 156\u2013165 (2021).","journal-title":"Plant Cell Physiol."},{"key":"7142_CR71","doi-asserted-by":"publisher","unstructured":"Suzuki, Y. et al. Effects of simultaneous Rubisco, glyceraldehyde-3-phosphate dehydrogenase, and triosephosphate isomerase overexpression on photosynthesis in rice. Soil Sci. Plant Nutr. 1\u20138. https:\/\/doi.org\/10.1080\/00380768.2023.2255213 (2023).","DOI":"10.1080\/00380768.2023.2255213"},{"key":"7142_CR72","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20132-0","volume":"11","author":"N Atkinson","year":"2020","unstructured":"Atkinson, N., Mao, Y., Chan, K. X. & McCormick, A. J. Condensation of Rubisco into a proto-pyrenoid in higher plant chloroplasts. Nat. Commun. 11, 6303 (2020).","journal-title":"Nat. Commun."},{"key":"7142_CR73","doi-asserted-by":"publisher","first-page":"3499","DOI":"10.1016\/j.cell.2023.06.008","volume":"186","author":"L Wang","year":"2023","unstructured":"Wang, L. et al. A chloroplast protein atlas reveals punctate structures and spatial organization of biosynthetic pathways. Cell 186, 3499\u20133518.e3414 (2023).","journal-title":"Cell"},{"key":"7142_CR74","doi-asserted-by":"publisher","first-page":"3061","DOI":"10.5194\/acp-20-3061-2020","volume":"20","author":"SJ Lawson","year":"2020","unstructured":"Lawson, S. J. et al. Methanethiol, dimethyl sulfide and acetone over biologically productive waters in the southwest Pacific Ocean. Atmos. Chem. Phys. 20, 3061\u20133078 (2020).","journal-title":"Atmos. Chem. Phys."},{"key":"7142_CR75","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/nature04420","volume":"439","author":"F Keppler","year":"2006","unstructured":"Keppler, F., Hamilton, J. T., Bra\u00df, M. & R\u00f6ckmann, T. Methane emissions from terrestrial plants under aerobic conditions. Nature 439, 187\u2013191 (2006).","journal-title":"Nature"},{"key":"7142_CR76","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1071\/EN09137","volume":"6","author":"F Keppler","year":"2009","unstructured":"Keppler, F. et al. Methane formation in aerobic environments. Environ. Chem. 6, 459\u2013465 (2009).","journal-title":"Environ. Chem."},{"key":"7142_CR77","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.tree.2006.05.017","volume":"21","author":"AJ Parsons","year":"2006","unstructured":"Parsons, A. J., Newton, P. C., Clark, H. & Kelliher, F. M. Scaling methane emissions from vegetation. Trends Ecol. Evol. 21, 423\u2013424 (2006).","journal-title":"Trends Ecol. Evol."},{"key":"7142_CR78","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1098\/rspb.2008.1731","volume":"276","author":"R Nisbet","year":"2009","unstructured":"Nisbet, R. et al. Emission of methane from plants. Proc. R. Soc. B: Biol. Sci. 276, 1347\u20131354 (2009).","journal-title":"Proc. R. Soc. B: Biol. Sci."},{"key":"7142_CR79","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquabot.2022.103596","volume":"184","author":"D Bastviken","year":"2023","unstructured":"Bastviken, D. et al. The importance of plants for methane emission at the ecosystem scale. Aquat. Bot. 184, 103596 (2023).","journal-title":"Aquat. Bot."},{"key":"7142_CR80","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/S0968-0004(98)01186-4","volume":"23","author":"RE Blankenship","year":"1998","unstructured":"Blankenship, R. E. & Hartman, H. The origin and evolution of oxygenic photosynthesis. Trends Biochem. Sci. 23, 94\u201397 (1998).","journal-title":"Trends Biochem. Sci."},{"key":"7142_CR81","doi-asserted-by":"publisher","first-page":"6441","DOI":"10.5194\/acp-16-6441-2016","volume":"16","author":"KJ Jardine","year":"2016","unstructured":"Jardine, K. J. et al. Methanol and isoprene emissions from the fast growing tropical pioneer species Vismia guianensis (Aubl.) Pers.(Hypericaceae) in the central Amazon forest. Atmos. Chem. Phys. 16, 6441\u20136452 (2016).","journal-title":"Atmos. Chem. Phys."},{"key":"7142_CR82","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1038\/nbt.2377","volume":"30","author":"MC Chambers","year":"2012","unstructured":"Chambers, M. C. et al. A cross-platform toolkit for mass spectrometry and proteomics. Nat. Biotechnol. 30, 918\u2013920 (2012).","journal-title":"Nat. Biotechnol."},{"key":"7142_CR83","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2105-11-395","volume":"11","author":"T Pluskal","year":"2010","unstructured":"Pluskal, T., Castillo, S., Villar-Briones, A. & Ore\u0161i\u010d, M. MZmine 2: modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data. BMC Bioinform. 11, 1\u201311 (2010).","journal-title":"BMC Bioinform."},{"key":"7142_CR84","doi-asserted-by":"crossref","unstructured":"Kumler, W., & Ingalls, A. E. Tidy Data Neatly Resolves Mass-Spectrometry's Ragged Arrays. The R Journal, 14, 193\u2013202 (2022).","DOI":"10.32614\/RJ-2022-050"},{"key":"7142_CR85","unstructured":"R Core Team. R: A Language and Environment for Statistical Computing (R Foundation for Statistical Computing, 2013)."},{"key":"7142_CR86","doi-asserted-by":"publisher","first-page":"e0227591","DOI":"10.1371\/journal.pone.0227591","volume":"15","author":"RA Dewhirst","year":"2020","unstructured":"Dewhirst, R. A., Afseth, C. A., Castanha, C., Mortimer, J. C. & Jardine, K. J. Cell wall O-acetyl and methyl esterification patterns of leaves reflected in atmospheric emission signatures of acetic acid and methanol. PLoS ONE 15, e0227591 (2020).","journal-title":"PLoS ONE"},{"key":"7142_CR87","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1002\/rcm.4057","volume":"23","author":"M Greule","year":"2009","unstructured":"Greule, M., Mosandl, A., Hamilton, J. T. & Keppler, F. A simple rapid method to precisely determine 13C\/12C ratios of plant methoxyl groups. Rapid Commun. Mass Spectrom. 23, 1710\u20131714 (2009).","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"7142_CR88","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1002\/rcm.8355","volume":"33","author":"M Greule","year":"2019","unstructured":"Greule, M., Moossen, H., Geilmann, H., Brand, W. A. & Keppler, F. Methyl sulfates as methoxy isotopic reference materials for \u03b413C and \u03b42H measurements. Rapid Commun. Mass Spectrom. 33, 343\u2013350 (2019).","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"7142_CR89","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemgeo.2019.119428","volume":"533","author":"M Greule","year":"2020","unstructured":"Greule, M. et al. Three wood isotopic reference materials for \u03b42H and \u03b413C measurements of plant methoxy groups. Chem. Geol. 533, 119428 (2020).","journal-title":"Chem. Geol."},{"key":"7142_CR90","doi-asserted-by":"publisher","first-page":"D1178","DOI":"10.1093\/nar\/gkr944","volume":"40","author":"DM Goodstein","year":"2012","unstructured":"Goodstein, D. M. et al. Phytozome: a comparative platform for green plant genomics. Nucleic Acids Res. 40, D1178\u2013D1186 (2012).","journal-title":"Nucleic Acids Res."},{"key":"7142_CR91","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1074\/jbc.274.1.397","volume":"274","author":"C-L Ho","year":"1999","unstructured":"Ho, C.-L., Noji, M., Saito, M. & Saito, K. Regulation of serine biosynthesis in Arabidopsis: crucial role of plastidic 3-phosphoglycerate dehydrogenase in non-photosynthetic tissues. J. Biol. Chem. 274, 397\u2013402 (1999).","journal-title":"J. Biol. Chem."},{"key":"7142_CR92","doi-asserted-by":"publisher","first-page":"D1004","DOI":"10.1093\/nar\/gkaa898","volume":"49","author":"IV Grigoriev","year":"2021","unstructured":"Grigoriev, I. V. et al. PhycoCosm, a comparative algal genomics resource. Nucleic acids Res. 49, D1004\u2013D1011 (2021).","journal-title":"Nucleic acids Res."},{"key":"7142_CR93","doi-asserted-by":"publisher","first-page":"D551","DOI":"10.1093\/nar\/gkw1131","volume":"45","author":"T Fujisawa","year":"2017","unstructured":"Fujisawa, T. et al. CyanoBase: a large-scale update on its 20th anniversary. Nucleic Acids Res. 45, D551\u2013D554 (2017).","journal-title":"Nucleic Acids Res."},{"key":"7142_CR94","doi-asserted-by":"publisher","first-page":"3997","DOI":"10.1093\/bioinformatics\/btv494","volume":"31","author":"U Bodenhofer","year":"2015","unstructured":"Bodenhofer, U., Bonatesta, E., Horej\u0161-Kainrath, C. & Hochreiter, S. msa: an R package for multiple sequence alignment. Bioinformatics 31, 3997\u20133999 (2015).","journal-title":"Bioinformatics"},{"key":"7142_CR95","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1093\/bioinformatics\/btq706","volume":"27","author":"KP Schliep","year":"2011","unstructured":"Schliep, K. P. phangorn: phylogenetic analysis in R. Bioinformatics 27, 592\u2013593 (2011).","journal-title":"Bioinformatics"},{"key":"7142_CR96","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/2041-210X.12628","volume":"8","author":"G Yu","year":"2017","unstructured":"Yu, G., Smith, D. K., Zhu, H., Guan, Y. & Lam, T. T. Y. ggtree: an R package for visualization and annotation of phylogenetic trees with their covariates and other associated data. Methods Ecol. Evol. 8, 28\u201336 (2017).","journal-title":"Methods Ecol. Evol."},{"key":"7142_CR97","doi-asserted-by":"publisher","first-page":"e201900429","DOI":"10.26508\/lsa.201900429","volume":"2","author":"JJA Armenteros","year":"2019","unstructured":"Armenteros, J. J. A. et al. Detecting sequence signals in targeting peptides using deep learning. Life Sci. Alliance 2, e201900429 (2019).","journal-title":"Life Sci. Alliance"},{"key":"7142_CR98","doi-asserted-by":"publisher","first-page":"W228","DOI":"10.1093\/nar\/gkac278","volume":"50","author":"V Thumuluri","year":"2022","unstructured":"Thumuluri, V., Almagro Armenteros, J. J., Johansen, A. R., Nielsen, H. & Winther, O. DeepLoc 2.0: multi-label subcellular localization prediction using protein language models. Nucleic Acids Res. 50, W228\u2013W234 (2022).","journal-title":"Nucleic Acids Res."},{"key":"7142_CR99","doi-asserted-by":"publisher","first-page":"116389","DOI":"10.1016\/j.carbpol.2020.116389","volume":"242","author":"L Cao","year":"2020","unstructured":"Cao, L., Lu, W., Mata, A., Nishinari, K. & Fang, Y. Egg-box model-based gelation of alginate and pectin: a review. Carbohydr. Polym. 242, 116389 (2020).","journal-title":"Carbohydr. Polym."}],"updated-by":[{"DOI":"10.1038\/s42003-026-09552-8","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000}}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-07142-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-07142-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-07142-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T08:03:07Z","timestamp":1769241787000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-07142-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,8]]},"references-count":99,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["7142"],"URL":"https:\/\/doi.org\/10.1038\/s42003-024-07142-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4116025\/v1","asserted-by":"object"}]},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,8]]},"assertion":[{"value":"22 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s42003-026-09552-8","URL":"https:\/\/doi.org\/10.1038\/s42003-026-09552-8","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1469"}}