{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T03:20:29Z","timestamp":1792984829137,"version":"4.5.0"},"reference-count":97,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T00:00:00Z","timestamp":1731196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T00:00:00Z","timestamp":1731196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000053","name":"U.S. Department of Health & Human Services | NIH | National Eye Institute","doi-asserted-by":"publisher","award":["R01EY020581"],"award-info":[{"award-number":["R01EY020581"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-024-07179-1","type":"journal-article","created":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T04:51:39Z","timestamp":1731214299000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Modulation of ATM enhances DNA repair in G2\/M phase of cell cycle and averts senescence in Fuchs endothelial corneal dystrophy"],"prefix":"10.1038","volume":"7","author":[{"given":"Shazia","family":"Ashraf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Deshpande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Queenie","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey Boakye","family":"Asabere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6132-0759","authenticated-orcid":false,"given":"Raymond Jeff","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7222-7015","authenticated-orcid":false,"given":"Alex G.","family":"Gauthier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5186-068X","authenticated-orcid":false,"given":"Mohit","family":"Parekh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadav","family":"Adhikari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetha","family":"Melangath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5059-608X","authenticated-orcid":false,"given":"Ula V.","family":"Jurkunas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,10]]},"reference":[{"key":"7179_CR1","doi-asserted-by":"publisher","first-page":"S50","DOI":"10.1097\/ICO.0000000000001775","volume":"37","author":"UV Jurkunas","year":"2018","unstructured":"Jurkunas, U. V. Fuchs Endothelial Corneal Dystrophy Through the Prism of Oxidative Stress. Cornea 37, S50\u2013S54 (2018).","journal-title":"Cornea"},{"key":"7179_CR2","doi-asserted-by":"publisher","first-page":"e51427","DOI":"10.1371\/journal.pone.0051427","volume":"7","author":"T Schmedt","year":"2012","unstructured":"Schmedt, T. et al. Telomerase immortalization of human corneal endothelial cells yields functional hexagonal monolayers. PLoS One 7, e51427 (2012).","journal-title":"PLoS One"},{"key":"7179_CR3","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1167\/iovs.05-1199","volume":"47","author":"T Mimura","year":"2006","unstructured":"Mimura, T. & Joyce, N. C. Replication competence and senescence in central and peripheral human corneal endothelium. Invest Ophthalmol. Vis. Sci. 47, 1387\u20131396 (2006).","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"7179_CR4","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.1167\/iovs.08-3007","volume":"50","author":"NC Joyce","year":"2009","unstructured":"Joyce, N. C., Zhu, C. C. & Harris, D. L. Relationship among oxidative stress, DNA damage, and proliferative capacity in human corneal endothelium. Invest Ophthalmol. Vis. Sci. 50, 2116\u20132122 (2009).","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"7179_CR5","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1146\/annurev-vision-091718-014852","volume":"5","author":"M Matthaei","year":"2019","unstructured":"Matthaei, M. et al. Fuchs Endothelial Corneal Dystrophy: Clinical, Genetic, Pathophysiologic, and Therapeutic Aspects. Annu Rev. Vis. Sci. 5, 151\u2013175 (2019).","journal-title":"Annu Rev. Vis. Sci."},{"key":"7179_CR6","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.1001\/archopht.1978.03910060424004","volume":"96","author":"JH Krachmer","year":"1978","unstructured":"Krachmer, J. H., Purcell, J. J. Jr., Young, C. W. & Bucher, K. D. Corneal endothelial dystrophy. A study of 64 families. Arch. Ophthalmol. 96, 2036\u20132039 (1978).","journal-title":"Arch. Ophthalmol."},{"key":"7179_CR7","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/S0002-9394(14)75011-1","volume":"90","author":"P Rosenblum","year":"1980","unstructured":"Rosenblum, P., Stark, W. J., Maumenee, I. H., Hirst, L. W. & Maumenee, A. E. Hereditary Fuchs\u2019 Dystrophy. Am. J. Ophthalmol. 90, 455\u2013462 (1980).","journal-title":"Am. J. Ophthalmol."},{"key":"7179_CR8","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/S0161-6420(84)34249-X","volume":"91","author":"CF Bahn","year":"1984","unstructured":"Bahn, C. F. et al. Classification of corneal endothelial disorders based on neural crest origin. Ophthalmology 91, 558\u2013563 (1984).","journal-title":"Ophthalmology"},{"key":"7179_CR9","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1089\/ars.2015.6532","volume":"24","author":"A Halilovic","year":"2016","unstructured":"Halilovic, A. et al. Menadione-Induced DNA Damage Leads to Mitochondrial Dysfunction and Fragmentation During Rosette Formation in Fuchs Endothelial Corneal Dystrophy. Antioxid. Redox Signal 24, 1072\u20131083 (2016).","journal-title":"Antioxid. Redox Signal"},{"key":"7179_CR10","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.freeradbiomed.2017.12.036","volume":"116","author":"KR Katikireddy","year":"2018","unstructured":"Katikireddy, K. R. et al. NQO1 downregulation potentiates menadione-induced endothelial-mesenchymal transition during rosette formation in Fuchs endothelial corneal dystrophy. Free Radic. Biol. Med. 116, 19\u201330 (2018).","journal-title":"Free Radic. Biol. Med."},{"key":"7179_CR11","doi-asserted-by":"publisher","first-page":"2278","DOI":"10.2353\/ajpath.2010.100279","volume":"177","author":"UV Jurkunas","year":"2010","unstructured":"Jurkunas, U. V., Bitar, M. S., Funaki, T. & Azizi, B. Evidence of oxidative stress in the pathogenesis of fuchs endothelial corneal dystrophy. Am. J. Pathol. 177, 2278\u20132289 (2010).","journal-title":"Am. J. Pathol."},{"key":"7179_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.xops.2021.100006","volume":"1","author":"S Ong Tone","year":"2021","unstructured":"Ong Tone, S. et al. Increased Corneal Endothelial Cell Migration in Fuchs Endothelial Corneal Dystrophy: A Live Cell Imaging Study. Ophthalmol. Sci. 1, 100006 (2021).","journal-title":"Ophthalmol. Sci."},{"key":"7179_CR13","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1073\/pnas.1912546116","volume":"117","author":"C Liu","year":"2020","unstructured":"Liu, C. et al. Ultraviolet A light induces DNA damage and estrogen-DNA adducts in Fuchs endothelial corneal dystrophy causing females to be more affected. Proc. Natl Acad. Sci. USA 117, 573\u2013583 (2020).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"7179_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102986","volume":"69","author":"V Kumar","year":"2024","unstructured":"Kumar, V. et al. Estrogen genotoxicity causes preferential development of Fuchs endothelial corneal dystrophy in females. Redox Biol. 69, 102986 (2024).","journal-title":"Redox Biol."},{"key":"7179_CR15","doi-asserted-by":"publisher","first-page":"10469","DOI":"10.1073\/pnas.171202698","volume":"98","author":"ML Hamilton","year":"2001","unstructured":"Hamilton, M. L. et al. Does oxidative damage to DNA increase with age? Proc. Natl Acad. Sci. USA 98, 10469\u201310474 (2001).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"7179_CR16","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/35044005","volume":"408","author":"BB Zhou","year":"2000","unstructured":"Zhou, B. B. & Elledge, S. J. The DNA damage response: putting checkpoints in perspective. Nature 408, 433\u2013439 (2000).","journal-title":"Nature"},{"key":"7179_CR17","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/S0896-6273(04)00017-0","volume":"41","author":"II Kruman","year":"2004","unstructured":"Kruman, I. I. et al. Cell cycle activation linked to neuronal cell death initiated by DNA damage. Neuron 41, 549\u2013561 (2004).","journal-title":"Neuron"},{"key":"7179_CR18","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.mrfmmm.2009.11.003","volume":"685","author":"P Fortini","year":"2010","unstructured":"Fortini, P. & Dogliotti, E. Mechanisms of dealing with DNA damage in terminally differentiated cells. Mutat. Res. 685, 38\u201344 (2010).","journal-title":"Mutat. Res."},{"key":"7179_CR19","doi-asserted-by":"publisher","first-page":"318","DOI":"10.4161\/cc.6.3.3752","volume":"6","author":"EI Schwartz","year":"2007","unstructured":"Schwartz, E. I. et al. Cell cycle activation in postmitotic neurons is essential for DNA repair. Cell Cycle 6, 318\u2013329 (2007).","journal-title":"Cell Cycle"},{"key":"7179_CR20","doi-asserted-by":"publisher","DOI":"10.1038\/srep41892","volume":"7","author":"FP Vendetti","year":"2017","unstructured":"Vendetti, F. P. et al. Pharmacologic ATM but not ATR kinase inhibition abrogates p21-dependent G1 arrest and promotes gastrointestinal syndrome after total body irradiation. Sci. Rep. 7, 41892 (2017).","journal-title":"Sci. Rep."},{"key":"7179_CR21","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.celrep.2015.04.014","volume":"11","author":"KM Aird","year":"2015","unstructured":"Aird, K. M. et al. ATM couples replication stress and metabolic reprogramming during cellular senescence. Cell Rep. 11, 893\u2013901 (2015).","journal-title":"Cell Rep."},{"key":"7179_CR22","doi-asserted-by":"publisher","unstructured":"Stuart, A. & de Lange, T. Replicative senescence is ATM driven, reversible, and accelerated by hyperactivation of ATM at normoxia. bioRxiv. https:\/\/doi.org\/10.1101\/2024.06.24.600514 (2024).","DOI":"10.1101\/2024.06.24.600514"},{"key":"7179_CR23","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1038\/35056049","volume":"2","author":"DC van Gent","year":"2001","unstructured":"van Gent, D. C., Hoeijmakers, J. H. & Kanaar, R. Chromosomal stability and the DNA double-stranded break connection. Nat. Rev. Genet 2, 196\u2013206 (2001).","journal-title":"Nat. Rev. Genet"},{"key":"7179_CR24","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1038\/sj.cdd.4400874","volume":"8","author":"KK Khanna","year":"2001","unstructured":"Khanna, K. K., Lavin, M. F., Jackson, S. P. & Mulhern, T. D. ATM, a central controller of cellular responses to DNA damage. Cell Death Differ. 8, 1052\u20131065 (2001).","journal-title":"Cell Death Differ."},{"key":"7179_CR25","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1146\/annurev-biochem-060614-034335","volume":"84","author":"TT Paull","year":"2015","unstructured":"Paull, T. T. Mechanisms of ATM Activation. Annu Rev. Biochem. 84, 711\u2013738 (2015).","journal-title":"Annu Rev. Biochem."},{"key":"7179_CR26","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nature01368","volume":"421","author":"CJ Bakkenist","year":"2003","unstructured":"Bakkenist, C. J. & Kastan, M. B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421, 499\u2013506 (2003).","journal-title":"Nature"},{"key":"7179_CR27","doi-asserted-by":"publisher","first-page":"3504","DOI":"10.1038\/sj.emboj.7601231","volume":"25","author":"SV Kozlov","year":"2006","unstructured":"Kozlov, S. V. et al. Involvement of novel autophosphorylation sites in ATM activation. EMBO J. 25, 3504\u20133514 (2006).","journal-title":"EMBO J."},{"key":"7179_CR28","doi-asserted-by":"publisher","first-page":"8502","DOI":"10.1128\/MCB.01382-07","volume":"27","author":"Y Sun","year":"2007","unstructured":"Sun, Y., Xu, Y., Roy, K. & Price, B. D. DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity. Mol. Cell Biol. 27, 8502\u20138509 (2007).","journal-title":"Mol. Cell Biol."},{"key":"7179_CR29","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1126\/science.1108297","volume":"308","author":"JH Lee","year":"2005","unstructured":"Lee, J. H. & Paull, T. T. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 308, 551\u2013554 (2005).","journal-title":"Science"},{"key":"7179_CR30","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/nrm3047","volume":"12","author":"TH Stracker","year":"2011","unstructured":"Stracker, T. H. & Petrini, J. H. The MRE11 complex: starting from the ends. Nat. Rev. Mol. Cell Biol. 12, 90\u2013103 (2011).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"7179_CR31","doi-asserted-by":"publisher","first-page":"42462","DOI":"10.1074\/jbc.C100466200","volume":"276","author":"S Burma","year":"2001","unstructured":"Burma, S., Chen, B. P., Murphy, M., Kurimasa, A. & Chen, D. J. ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J. Biol. Chem. 276, 42462\u201342467 (2001).","journal-title":"J. Biol. Chem."},{"key":"7179_CR32","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.molcel.2009.04.012","volume":"34","author":"V Savic","year":"2009","unstructured":"Savic, V. et al. Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin. Mol. Cell 34, 298\u2013310 (2009).","journal-title":"Mol. Cell"},{"key":"7179_CR33","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1126\/science.281.5383.1674","volume":"281","author":"S Banin","year":"1998","unstructured":"Banin, S. et al. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 281, 1674\u20131677 (1998).","journal-title":"Science"},{"key":"7179_CR34","doi-asserted-by":"publisher","first-page":"13777","DOI":"10.1073\/pnas.96.24.13777","volume":"96","author":"NH Chehab","year":"1999","unstructured":"Chehab, N. H., Malikzay, A., Stavridi, E. S. & Halazonetis, T. D. Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. Proc. Natl Acad. Sci. USA 96, 13777\u201313782 (1999).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"7179_CR35","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/cdd.2009.68","volume":"17","author":"JC Marine","year":"2010","unstructured":"Marine, J. C. & Lozano, G. Mdm2-mediated ubiquitylation: p53 and beyond. Cell Death Differ. 17, 93\u2013102 (2010).","journal-title":"Cell Death Differ."},{"key":"7179_CR36","first-page":"229","volume":"1825","author":"KD Sullivan","year":"2012","unstructured":"Sullivan, K. D., Gallant-Behm, C. L., Henry, R. E., Fraikin, J. L. & Espinosa, J. M. The p53 circuit board. Biochim Biophys. Acta 1825, 229\u2013244 (2012).","journal-title":"Biochim Biophys. Acta"},{"key":"7179_CR37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.bjc.6690312","volume":"80","author":"DP Lane","year":"1999","unstructured":"Lane, D. P. Exploiting the p53 pathway for cancer diagnosis and therapy. Br. J. Cancer 80, 1\u20135 (1999).","journal-title":"Br. J. Cancer"},{"key":"7179_CR38","doi-asserted-by":"publisher","first-page":"3709","DOI":"10.1093\/nar\/8.16.3709","volume":"8","author":"J Houldsworth","year":"1980","unstructured":"Houldsworth, J. & Lavin, M. F. Effect of ionizing radiation on DNA synthesis in ataxia telangiectasia cells. Nucleic Acids Res. 8, 3709\u20133720 (1980).","journal-title":"Nucleic Acids Res."},{"key":"7179_CR39","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1038\/35071124","volume":"410","author":"J Falck","year":"2001","unstructured":"Falck, J., Mailand, N., Syljuasen, R. G., Bartek, J. & Lukas, J. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 410, 842\u2013847 (2001).","journal-title":"Nature"},{"key":"7179_CR40","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1074\/mcp.M900616-MCP200","volume":"9","author":"MV Bennetzen","year":"2010","unstructured":"Bennetzen, M. V. et al. Site-specific phosphorylation dynamics of the nuclear proteome during the DNA damage response. Mol. Cell Proteom. 9, 1314\u20131323 (2010).","journal-title":"Mol. Cell Proteom."},{"key":"7179_CR41","doi-asserted-by":"publisher","first-page":"rs3","DOI":"10.1126\/scisignal.2001034","volume":"3","author":"A Bensimon","year":"2010","unstructured":"Bensimon, A. et al. ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage. Sci. Signal 3, rs3 (2010).","journal-title":"Sci. Signal"},{"key":"7179_CR42","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.1101\/gad.10.19.2411","volume":"10","author":"Y Xu","year":"1996","unstructured":"Xu, Y. et al. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev. 10, 2411\u20132422 (1996).","journal-title":"Genes Dev."},{"key":"7179_CR43","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1126\/science.1192912","volume":"330","author":"Z Guo","year":"2010","unstructured":"Guo, Z., Kozlov, S., Lavin, M. F., Person, M. D. & Paull, T. T. ATM activation by oxidative stress. Science 330, 517\u2013521 (2010).","journal-title":"Science"},{"key":"7179_CR44","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.freeradbiomed.2019.12.014","volume":"147","author":"T Miyajima","year":"2020","unstructured":"Miyajima, T. et al. Loss of NQO1 generates genotoxic estrogen-DNA adducts in Fuchs Endothelial Corneal Dystrophy. Free Radic. Biol. Med 147, 69\u201379 (2020).","journal-title":"Free Radic. Biol. Med"},{"key":"7179_CR45","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.freeradbiomed.2020.12.445","volume":"164","author":"TL White","year":"2021","unstructured":"White, T. L., Deshpande, N., Kumar, V., Gauthier, A. G. & Jurkunas, U. V. Cell cycle re-entry and arrest in G2\/M phase induces senescence and fibrosis in Fuchs Endothelial Corneal Dystrophy. Free Radic. Biol. Med 164, 34\u201343 (2021).","journal-title":"Free Radic. Biol. Med"},{"key":"7179_CR46","doi-asserted-by":"publisher","first-page":"9152","DOI":"10.1158\/0008-5472.CAN-04-2727","volume":"64","author":"I Hickson","year":"2004","unstructured":"Hickson, I. et al. Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res 64, 9152\u20139159 (2004).","journal-title":"Cancer Res"},{"key":"7179_CR47","doi-asserted-by":"crossref","unstructured":"Phan, L. M. & Rezaeian, A. H. ATM: Main Features, Signaling Pathways, and Its Diverse Roles in DNA Damage Response, Tumor Suppression, and Cancer Development. Genes (Basel). 12, 845 (2021).","DOI":"10.3390\/genes12060845"},{"key":"7179_CR48","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1038\/sj.cdd.4401130","volume":"9","author":"M Castedo","year":"2002","unstructured":"Castedo, M., Perfettini, J. L., Roumier, T. & Kroemer, G. Cyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe. Cell Death Differ. 9, 1287\u20131293 (2002).","journal-title":"Cell Death Differ."},{"key":"7179_CR49","doi-asserted-by":"publisher","first-page":"645593","DOI":"10.3389\/fcell.2021.645593","volume":"9","author":"R Kumari","year":"2021","unstructured":"Kumari, R. & Jat, P. Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype. Front Cell Dev. Biol. 9, 645593 (2021).","journal-title":"Front Cell Dev. Biol."},{"key":"7179_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2023.109499","volume":"231","author":"S Ashraf","year":"2023","unstructured":"Ashraf, S. et al. Dysregulation of DNA repair genes in Fuchs endothelial corneal dystrophy. Exp. Eye Res 231, 109499 (2023).","journal-title":"Exp. Eye Res"},{"key":"7179_CR51","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/leu.2010.6","volume":"24","author":"LJ Mah","year":"2010","unstructured":"Mah, L. J., El-Osta, A. & Karagiannis, T. C. gammaH2AX: a sensitive molecular marker of DNA damage and repair. Leukemia 24, 679\u2013686 (2010).","journal-title":"Leukemia"},{"key":"7179_CR52","doi-asserted-by":"crossref","unstructured":"Reimann, M., Lee, S. & Schmitt, C. A. Cellular senescence: Neither irreversible nor reversible. J. Exp. Med. 221, e20232136 (2024).","DOI":"10.1084\/jem.20232136"},{"key":"7179_CR53","doi-asserted-by":"publisher","first-page":"103","DOI":"10.14336\/AD.2021.0927","volume":"13","author":"C Hu","year":"2022","unstructured":"Hu, C., Zhang, X., Teng, T., Ma, Z. G. & Tang, Q. Z. Cellular Senescence in Cardiovascular Diseases: A Systematic Review. Aging Dis. 13, 103\u2013128 (2022).","journal-title":"Aging Dis."},{"key":"7179_CR54","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1038\/cdd.2009.221","volume":"17","author":"A Tomashevski","year":"2010","unstructured":"Tomashevski, A., Webster, D. R., Grammas, P., Gorospe, M. & Kruman, I. I. Cyclin-C-dependent cell-cycle entry is required for activation of non-homologous end joining DNA repair in postmitotic neurons. Cell Death Differ. 17, 1189\u20131198 (2010).","journal-title":"Cell Death Differ."},{"key":"7179_CR55","doi-asserted-by":"publisher","first-page":"9291","DOI":"10.1167\/iovs.11-8312","volume":"52","author":"B Azizi","year":"2011","unstructured":"Azizi, B. et al. p53-regulated increase in oxidative-stress-induced apoptosis in Fuchs endothelial corneal dystrophy: a native tissue model. Invest Ophthalmol. Vis. Sci. 52, 9291\u20139297 (2011).","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"7179_CR56","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.4161\/cc.6.14.4480","volume":"6","author":"A Krempler","year":"2007","unstructured":"Krempler, A., Deckbar, D., Jeggo, P. A. & Lobrich, M. An imperfect G2M checkpoint contributes to chromosome instability following irradiation of S and G2 phase cells. Cell Cycle 6, 1682\u20131686 (2007).","journal-title":"Cell Cycle"},{"key":"7179_CR57","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1038\/27001","volume":"395","author":"C Santocanale","year":"1998","unstructured":"Santocanale, C. & Diffley, J. F. A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication. Nature 395, 615\u2013618 (1998).","journal-title":"Nature"},{"key":"7179_CR58","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/35087607","volume":"412","author":"JA Tercero","year":"2001","unstructured":"Tercero, J. A. & Diffley, J. F. Regulation of DNA replication fork progression through damaged DNA by the Mec1\/Rad53 checkpoint. Nature 412, 553\u2013557 (2001).","journal-title":"Nature"},{"key":"7179_CR59","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/S1097-2765(00)00063-0","volume":"6","author":"V Costanzo","year":"2000","unstructured":"Costanzo, V. et al. Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage. Mol. Cell 6, 649\u2013659 (2000).","journal-title":"Mol. Cell"},{"key":"7179_CR60","doi-asserted-by":"publisher","first-page":"8552","DOI":"10.1128\/MCB.22.24.8552-8561.2002","volume":"22","author":"TP Heffernan","year":"2002","unstructured":"Heffernan, T. P. et al. An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage. Mol. Cell Biol. 22, 8552\u20138561 (2002).","journal-title":"Mol. Cell Biol."},{"key":"7179_CR61","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.dnarep.2014.03.018","volume":"19","author":"J Zhang","year":"2014","unstructured":"Zhang, J. & Walter, J. C. Mechanism and regulation of incisions during DNA interstrand cross-link repair. DNA Repair (Amst.) 19, 135\u2013142 (2014).","journal-title":"DNA Repair (Amst.)"},{"key":"7179_CR62","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.cell.2016.09.008","volume":"167","author":"DR Semlow","year":"2016","unstructured":"Semlow, D. R., Zhang, J., Budzowska, M., Drohat, A. C. & Walter, J. C. Replication-Dependent Unhooking of DNA Interstrand Cross-Links by the NEIL3 Glycosylase. Cell 167, 498\u2013511 e14 (2016).","journal-title":"Cell"},{"key":"7179_CR63","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nrm.2016.48","volume":"17","author":"R Ceccaldi","year":"2016","unstructured":"Ceccaldi, R., Sarangi, P. & D\u2019Andrea, A. D. The Fanconi anaemia pathway: new players and new functions. Nat. Rev. Mol. Cell Biol. 17, 337\u2013349 (2016).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"7179_CR64","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/nrm805","volume":"3","author":"D D\u2019Amours","year":"2002","unstructured":"D\u2019Amours, D. & Jackson, S. P. The Mre11 complex: at the crossroads of dna repair and checkpoint signalling. Nat. Rev. Mol. Cell Biol. 3, 317\u2013327 (2002).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"7179_CR65","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/nrc970","volume":"3","author":"AD D\u2019Andrea","year":"2003","unstructured":"D\u2019Andrea, A. D. & Grompe, M. The Fanconi anaemia\/BRCA pathway. Nat. Rev. Cancer 3, 23\u201334 (2003).","journal-title":"Nat. Rev. Cancer"},{"key":"7179_CR66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.dnarep.2015.12.009","volume":"39","author":"A Guleria","year":"2016","unstructured":"Guleria, A. & Chandna, S. ATM kinase: Much more than a DNA damage responsive protein. DNA Repair (Amst.) 39, 1\u201320 (2016).","journal-title":"DNA Repair (Amst.)"},{"key":"7179_CR67","unstructured":"Kumar, V. et al. Loss of NQO1 exacerbates female susceptibility to the development of Fuchs dystrophy in response to ultraviolet light. Invest. Ophthalmol. Vis. Sci. 61, 1470 (2020)."},{"key":"7179_CR68","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.abb.2014.05.030","volume":"557","author":"S Yamazaki","year":"2014","unstructured":"Yamazaki, S., Miyoshi, N., Kawabata, K., Yasuda, M. & Shimoi, K. Quercetin-3-O-glucuronide inhibits noradrenaline-promoted invasion of MDA-MB-231 human breast cancer cells by blocking beta(2)-adrenergic signaling. Arch. Biochem Biophys. 557, 18\u201327 (2014).","journal-title":"Arch. Biochem Biophys."},{"key":"7179_CR69","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.psyneuen.2007.02.013","volume":"32","author":"MS Flint","year":"2007","unstructured":"Flint, M. S., Baum, A., Chambers, W. H. & Jenkins, F. J. Induction of DNA damage, alteration of DNA repair and transcriptional activation by stress hormones. Psychoneuroendocrinology 32, 470\u2013479 (2007).","journal-title":"Psychoneuroendocrinology"},{"key":"7179_CR70","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111909","volume":"42","author":"RA Najnin","year":"2023","unstructured":"Najnin, R. A. et al. ATM suppresses c-Myc overexpression in the mammary epithelium in response to estrogen. Cell Rep. 42, 111909 (2023).","journal-title":"Cell Rep."},{"key":"7179_CR71","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1128\/MCB.22.4.1049-1059.2002","volume":"22","author":"B Xu","year":"2002","unstructured":"Xu, B., Kim, S. T., Lim, D. S. & Kastan, M. B. Two molecularly distinct G(2)\/M checkpoints are induced by ionizing irradiation. Mol. Cell Biol. 22, 1049\u20131059 (2002).","journal-title":"Mol. Cell Biol."},{"key":"7179_CR72","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1111\/j.1474-9726.2012.00870.x","volume":"11","author":"D Jurk","year":"2012","unstructured":"Jurk, D. et al. Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response. Aging Cell 11, 996\u20131004 (2012).","journal-title":"Aging Cell"},{"key":"7179_CR73","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1038\/ncb1909","volume":"11","author":"F Rodier","year":"2009","unstructured":"Rodier, F. et al. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat. Cell Biol. 11, 973\u2013979 (2009).","journal-title":"Nat. Cell Biol."},{"key":"7179_CR74","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/ncb2466","volume":"14","author":"M Fumagalli","year":"2012","unstructured":"Fumagalli, M. et al. Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. Nat. Cell Biol. 14, 355\u2013365 (2012).","journal-title":"Nat. Cell Biol."},{"key":"7179_CR75","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/S0960-9822(98)70137-X","volume":"8","author":"BB McConnell","year":"1998","unstructured":"McConnell, B. B., Starborg, M., Brookes, S. & Peters, G. Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts. Curr. Biol. 8, 351\u2013354 (1998).","journal-title":"Curr. Biol."},{"key":"7179_CR76","doi-asserted-by":"publisher","first-page":"a000950","DOI":"10.1101\/cshperspect.a000950","volume":"1","author":"DW Meek","year":"2009","unstructured":"Meek, D. W. & Anderson, C. W. Posttranslational modification of p53: cooperative integrators of function. Cold Spring Harb. Perspect. Biol. 1, a000950 (2009).","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"7179_CR77","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1080\/15384101.2014.1000134","volume":"14","author":"V Gire","year":"2015","unstructured":"Gire, V. & Dulic, V. Senescence from G2 arrest, revisited. Cell Cycle 14, 297\u2013304 (2015).","journal-title":"Cell Cycle"},{"key":"7179_CR78","doi-asserted-by":"publisher","first-page":"L1164","DOI":"10.1152\/ajplung.00220.2017","volume":"313","author":"D Alvarez","year":"2017","unstructured":"Alvarez, D. et al. IPF lung fibroblasts have a senescent phenotype. Am. J. Physiol. Lung Cell Mol. Physiol. 313, L1164\u2013L1173 (2017).","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"7179_CR79","doi-asserted-by":"publisher","first-page":"2557","DOI":"10.1523\/JNEUROSCI.23-07-02557.2003","volume":"23","author":"Y Yang","year":"2003","unstructured":"Yang, Y., Mufson, E. J. & Herrup, K. Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer\u2019s disease. J. Neurosci. 23, 2557\u20132563 (2003).","journal-title":"J. Neurosci."},{"key":"7179_CR80","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1007\/s004010050617","volume":"93","author":"Z Nagy","year":"1997","unstructured":"Nagy, Z., Esiri, M. M. & Smith, A. D. Expression of cell division markers in the hippocampus in Alzheimer\u2019s disease and other neurodegenerative conditions. Acta Neuropathol. 93, 294\u2013300 (1997).","journal-title":"Acta Neuropathol."},{"key":"7179_CR81","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.ijdevneu.2008.07.016","volume":"26","author":"C Pelegri","year":"2008","unstructured":"Pelegri, C. et al. Cell cycle activation in striatal neurons from Huntington\u2019s disease patients and rats treated with 3-nitropropionic acid. Int J. Dev. Neurosci. 26, 665\u2013671 (2008).","journal-title":"Int J. Dev. Neurosci."},{"key":"7179_CR82","unstructured":"Adhikari, Y., Parekh. M., Losick, V. P., Jurkunas, U. V. Polyploidy leads to senescence in an UVA-based mouse model of Fuchs Dystrophy. ARVO Annual Meeting Abstract. 65, 5787 (2024)."},{"key":"7179_CR83","doi-asserted-by":"publisher","first-page":"2504","DOI":"10.2741\/2862","volume":"13","author":"II Kruman","year":"2008","unstructured":"Kruman, I. I. & Schwartz, E. I. DNA damage response and neuroprotection. Front Biosci. 13, 2504\u20132515 (2008).","journal-title":"Front Biosci."},{"key":"7179_CR84","doi-asserted-by":"publisher","first-page":"268ra178","DOI":"10.1126\/scitranslmed.3010523","volume":"6","author":"XH Lu","year":"2014","unstructured":"Lu, X. H. et al. Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington\u2019s disease. Sci. Transl. Med 6, 268ra178 (2014).","journal-title":"Sci. Transl. Med"},{"key":"7179_CR85","doi-asserted-by":"publisher","first-page":"eabq2611","DOI":"10.1126\/sciadv.abq2611","volume":"8","author":"MJ Taylor","year":"2022","unstructured":"Taylor, M. J., Thompson, A. M., Alhajlah, S., Tuxworth, R. I. & Ahmed, Z. Inhibition of Chk2 promotes neuroprotection, axon regeneration, and functional recovery after CNS injury. Sci. Adv. 8, eabq2611 (2022).","journal-title":"Sci. Adv."},{"key":"7179_CR86","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1080\/15476286.2016.1191735","volume":"14","author":"S Ruzickova","year":"2017","unstructured":"Ruzickova, S. & Stanek, D. Mutations in spliceosomal proteins and retina degeneration. RNA Biol. 14, 544\u2013552 (2017).","journal-title":"RNA Biol."},{"key":"7179_CR87","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.12688\/f1000research.15579.1","volume":"7","author":"V Bhatia","year":"2018","unstructured":"Bhatia, V., Valdes-Sanchez, L., Rodriguez-Martinez, D. & Bhattacharya, S. S. Formation of 53BP1 foci and ATM activation under oxidative stress is facilitated by RNA:DNA hybrids and loss of ATM-53BP1 expression promotes photoreceptor cell survival in mice. F1000Res 7, 1233 (2018).","journal-title":"F1000Res"},{"key":"7179_CR88","doi-asserted-by":"publisher","DOI":"10.1038\/srep34426","volume":"6","author":"T Hirozane","year":"2016","unstructured":"Hirozane, T. et al. Conditional abrogation of Atm in osteoclasts extends osteoclast lifespan and results in reduced bone mass. Sci. Rep. 6, 34426 (2016).","journal-title":"Sci. Rep."},{"key":"7179_CR89","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3389\/fonc.2017.00098","volume":"7","author":"AB Herrero","year":"2017","unstructured":"Herrero, A. B. & Gutierrez, N. C. Targeting Ongoing DNA Damage in Multiple Myeloma: Effects of DNA Damage Response Inhibitors on Plasma Cell Survival. Front Oncol. 7, 98 (2017).","journal-title":"Front Oncol."},{"key":"7179_CR90","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.pharmthera.2014.12.001","volume":"149","author":"AM Weber","year":"2015","unstructured":"Weber, A. M. & Ryan, A. J. ATM and ATR as therapeutic targets in cancer. Pharm. Ther. 149, 124\u2013138 (2015).","journal-title":"Pharm. Ther."},{"key":"7179_CR91","doi-asserted-by":"crossref","unstructured":"Wang, Z. Regulation of Cell Cycle Progression by Growth Factor-Induced Cell Signaling. Cells. 10, 3327 (2021).","DOI":"10.3390\/cells10123327"},{"key":"7179_CR92","doi-asserted-by":"publisher","first-page":"2853","DOI":"10.1371\/journal.pbio.0060301","volume":"6","author":"JP Coppe","year":"2008","unstructured":"Coppe, J. P. et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 6, 2853\u20132868 (2008).","journal-title":"PLoS Biol."},{"key":"7179_CR93","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1093\/carcin\/bgi357","volume":"27","author":"SY Lu","year":"2006","unstructured":"Lu, S. Y. et al. Ripe areca nut extract induces G1 phase arrests and senescence-associated phenotypes in normal human oral keratinocyte. Carcinogenesis 27, 1273\u20131284 (2006).","journal-title":"Carcinogenesis"},{"key":"7179_CR94","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/j.cell.2008.03.039","volume":"133","author":"T Kuilman","year":"2008","unstructured":"Kuilman, T. et al. Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell 133, 1019\u20131031 (2008).","journal-title":"Cell"},{"key":"7179_CR95","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1007\/s11060-018-2838-0","volume":"138","author":"YC Lim","year":"2018","unstructured":"Lim, Y. C. et al. ATM inhibition prevents interleukin-6 from contributing to the proliferation of glioblastoma cells after ionizing radiation. J. Neurooncol. 138, 509\u2013518 (2018).","journal-title":"J. Neurooncol."},{"key":"7179_CR96","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06523-2","volume":"7","author":"AS Benischke","year":"2017","unstructured":"Benischke, A. S. et al. Activation of mitophagy leads to decline in Mfn2 and loss of mitochondrial mass in Fuchs endothelial corneal dystrophy. Sci. Rep. 7, 6656 (2017).","journal-title":"Sci. Rep."},{"key":"7179_CR97","doi-asserted-by":"publisher","first-page":"6331","DOI":"10.1093\/hmg\/ddv342","volume":"24","author":"A Campbell","year":"2015","unstructured":"Campbell, A. et al. A novel mouse model for ataxia-telangiectasia with a N-terminal mutation displays a behavioral defect and a low incidence of lymphoma but no increased oxidative burden. Hum. Mol. Genet 24, 6331\u20136349 (2015).","journal-title":"Hum. Mol. Genet"}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-07179-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-07179-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-07179-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T21:11:55Z","timestamp":1731359515000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-024-07179-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,10]]},"references-count":97,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["7179"],"URL":"https:\/\/doi.org\/10.1038\/s42003-024-07179-1","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,10]]},"assertion":[{"value":"2 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests. Author disclosure The research presented in this manuscript is associated with an invention disclosure that has been submitted to our institution\u2019s technology transfer office. This invention disclosure relates to the application of ATM inhibitor in Fuchs Endothelial Corneal Dystrophy. For further inquiries regarding the invention disclosure or its relation to the manuscript, please contact Dr. Ula V. Jurkunas, Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA USA (ula_jurkunas@meei.harvard.edu).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1482"}}