{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:39:54Z","timestamp":1793108394324,"version":"4.5.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-025-07654-3","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T13:45:04Z","timestamp":1740750304000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Elevated levels of S100A8 and S100A9 exacerbate muscle mitochondrial fragmentation in sepsis-induced muscle atrophy"],"prefix":"10.1038","volume":"8","author":[{"given":"Dongqin","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqian","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengcao","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2558-0676","authenticated-orcid":false,"given":"Kai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2283-1863","authenticated-orcid":false,"given":"Xiangming","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"7654_CR1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer, M. et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 315, 801\u2013810 (2016).","journal-title":"JAMA"},{"key":"7654_CR2","doi-asserted-by":"publisher","first-page":"e169","DOI":"10.1097\/CCM.0000000000002056","volume":"45","author":"X Zhu","year":"2017","unstructured":"Zhu, X. et al. Secreted frizzled-related protein 2 and inflammation-induced skeletal muscle atrophy. Crit. Care Med. 45, e169\u2013e183 (2017).","journal-title":"Crit. Care Med."},{"key":"7654_CR3","doi-asserted-by":"crossref","unstructured":"Liu, Y. et al. Gut-muscle axis and sepsis-induced myopathy: the potential role of gut microbiota. Biomed. Pharmacother. 163, 114837 (2023).","DOI":"10.1016\/j.biopha.2023.114837"},{"key":"7654_CR4","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1001\/jama.2017.17687","volume":"319","author":"H. C Prescott","year":"2018","unstructured":"Prescott, H. C. & Angus, D. C. Enhancing recovery from sepsis: a review. JAMA 319, 62\u201375 (2018).","journal-title":"JAMA"},{"key":"7654_CR5","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","volume":"47","author":"L Evans","year":"2021","unstructured":"Evans, L. et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intens. Care Med. 47, 1181\u20131247 (2021).","journal-title":"Intens. Care Med."},{"key":"7654_CR6","doi-asserted-by":"publisher","first-page":"588","DOI":"10.3390\/antiox10040588","volume":"10","author":"H. W Hyatt","year":"2021","unstructured":"Hyatt, H. W. & Powers, S. K. Mitochondrial dysfunction is a common denominator linking skeletal muscle wasting due to disease, aging, and prolonged inactivity. Antioxidants10, 588 (2021).","journal-title":"Antioxidants"},{"key":"7654_CR7","doi-asserted-by":"publisher","first-page":"e49920","DOI":"10.7554\/eLife.49920","volume":"8","author":"A. M Owen","year":"2019","unstructured":"Owen, A. M. et al. Chronic muscle weakness and mitochondrial dysfunction in the absence of sustained atrophy in a preclinical sepsis model. Elife 8, e49920 (2019).","journal-title":"Elife"},{"key":"7654_CR8","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1146\/annurev-physiol-020518-114310","volume":"81","author":"D. A Hood","year":"2019","unstructured":"Hood, D. A. et al. Maintenance of skeletal muscle mitochondria in health, exercise, and aging. Annu. Rev. Physiol. 81, 19\u201341 (2019).","journal-title":"Annu. Rev. Physiol."},{"key":"7654_CR9","doi-asserted-by":"publisher","first-page":"155578","DOI":"10.1016\/j.metabol.2023.155578","volume":"144","author":"M Castro-Sepulveda","year":"2023","unstructured":"Castro-Sepulveda, M. et al. Mitochondria-SR interaction and mitochondrial fusion\/fission in the regulation of skeletal muscle metabolism. Metabolism 144, 155578 (2023).","journal-title":"Metabolism"},{"key":"7654_CR10","doi-asserted-by":"crossref","unstructured":"Romanello, V. & Sandri, M. Implications of mitochondrial fusion and fission in skeletal muscle mass and health. Semin. Cell Dev. Biol. 143, 46\u201353 (2022).","DOI":"10.1016\/j.semcdb.2022.02.011"},{"key":"7654_CR11","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/j.molmed.2021.07.013","volume":"27","author":"C. E Fealy","year":"2021","unstructured":"Fealy, C. E. et al. Skeletal muscle mitochondrial network dynamics in metabolic disorders and aging. Trends Mol. Med. 27, 1033\u20131044 (2021).","journal-title":"Trends Mol. Med."},{"key":"7654_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07543-w","volume":"9","author":"S. C Kamerkar","year":"2018","unstructured":"Kamerkar, S. C. et al. Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission. Nat. Commun. 9, 5239 (2018).","journal-title":"Nat. Commun."},{"key":"7654_CR13","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1016\/j.stem.2022.07.009","volume":"29","author":"X Hong","year":"2022","unstructured":"Hong, X. et al. Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy. Cell Stem Cell 29, 1298\u20131314.e10 (2022).","journal-title":"Cell Stem Cell"},{"key":"7654_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10226-9","volume":"10","author":"G Favaro","year":"2019","unstructured":"Favaro, G. et al. DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass. Nat. Commun. 10, 2576 (2019).","journal-title":"Nat. Commun."},{"key":"7654_CR15","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.3390\/jcm10091874","volume":"10","author":"R. T Mankowski","year":"2021","unstructured":"Mankowski, R. T. et al. Pathophysiology and treatment strategies of acute myopathy and muscle wasting after sepsis. J. Clin. Med. 10, 1874 (2021).","journal-title":"J. Clin. Med."},{"key":"7654_CR16","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/s41569-018-0064-2","volume":"15","author":"L Ferrucci","year":"2018","unstructured":"Ferrucci, L. & Fabbri, E. Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. Nat. Rev. Cardiol. 15, 505\u2013522 (2018).","journal-title":"Nat. Rev. Cardiol."},{"key":"7654_CR17","doi-asserted-by":"publisher","first-page":"S354","DOI":"10.1097\/CCM.0b013e3181b6e439","volume":"37","author":"L. A Callahan","year":"2009","unstructured":"Callahan, L. A & Supinski, G. S Sepsis-induced myopathy. Crit., Care Med. 37, S354\u2013S367 (2009).","journal-title":"Crit., Care Med"},{"key":"7654_CR18","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1002\/jcsm.12867","volume":"13","author":"L Zanders","year":"2022","unstructured":"Zanders, L. et al. Sepsis induces interleukin 6, gp130\/JAK2\/STAT3, and muscle wasting. J. Cachexia Sarcopenia Muscle 13, 713\u2013727 (2022).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"7654_CR19","doi-asserted-by":"publisher","first-page":"3048","DOI":"10.1002\/jcsm.13062","volume":"13","author":"M Eggelbusch","year":"2022","unstructured":"Eggelbusch, M. et al. The NLRP3 inflammasome contributes to inflammation-induced morphological and metabolic alterations in skeletal muscle. J. Cachexia, Sarcopenia Muscle 13, 3048\u20133061 (2022).","journal-title":"J. Cachexia, Sarcopenia Muscle"},{"key":"7654_CR20","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1002\/jcsm.12491","volume":"11","author":"A Hahn","year":"2020","unstructured":"Hahn, A. et al. Serum amyloid A1 mediates myotube atrophy via Toll-like receptors. J. Cachexia Sarcopenia Muscle 11, 103\u2013119 (2020).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"7654_CR21","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/nrd4467","volume":"14","author":"S Cohen","year":"2015","unstructured":"Cohen, S., Nathan, J. A. & Goldberg, A. L. Muscle wasting in disease: molecular mechanisms and promising therapies. Nat. Rev. Drug Discov. 14, 58\u201374 (2015).","journal-title":"Nat. Rev. Drug Discov."},{"key":"7654_CR22","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1172\/JCI92450","volume":"127","author":"M. J Kraakman","year":"2017","unstructured":"Kraakman, M. J. et al. Neutrophil-derived S100 calcium-binding proteins A8\/A9 promote reticulated thrombocytosis and atherogenesis in diabetes. J. Clin. Investig. 127, 2133\u20132147 (2017).","journal-title":"J. Clin. Investig."},{"key":"7654_CR23","first-page":"e97","volume":"7","author":"S Akira","year":"2009","unstructured":"Akira, S. et al. Identification of hHuman S100A9 as a novel target for treatment of autoimmune disease via binding to Quinoline-3-Carboxamides. PLoS Biol. 7, e97 (2009).","journal-title":"PLoS Biol."},{"key":"7654_CR24","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1002\/jcsm.12752","volume":"12","author":"M. C Cox","year":"2021","unstructured":"Cox, M. C. et al. The impact of sarcopenia and acute muscle mass loss on long-term outcomes in critically ill patients with intra-abdominal sepsis. J. Cachexia Sarcopenia Muscle 12, 1203\u20131213 (2021).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"7654_CR25","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1002\/jcp.30950","volume":"238","author":"Y Zheng","year":"2023","unstructured":"Zheng, Y. et al. Endoplasmic reticulum stress promotes sepsis-induced muscle atrophy via activation of STAT3 and Smad3. J. Cell Physiol. 238, 582\u2013596 (2023).","journal-title":"J. Cell Physiol."},{"key":"7654_CR26","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1007\/s00018-024-05286-0","volume":"81","author":"J. C Casas-Martinez","year":"2024","unstructured":"Casas-Martinez, J. C., Samali, A. & McDonagh, B. Redox regulation of UPR signalling and mitochondrial ER contact sites. Cell Mol. Life Sci. 81, 250 (2024).","journal-title":"Cell Mol. Life Sci."},{"key":"7654_CR27","doi-asserted-by":"publisher","first-page":"101265","DOI":"10.1016\/j.xcrm.2023.101265","volume":"4","author":"H. L. D. M Willemen","year":"2023","unstructured":"Willemen, H. L. D. M. et al. Inflammation-induced mitochondrial and metabolic disturbances in sensory neurons control the switch from acute to chronic pain. Cell Rep. Med. 4, 101265 (2023).","journal-title":"Cell Rep. Med."},{"key":"7654_CR28","doi-asserted-by":"crossref","unstructured":"Wang, S. et al. S100A8\/A9 in Inflammation. Front. Immunol. 9, 1298 (2018).","DOI":"10.3389\/fimmu.2018.01298"},{"key":"7654_CR29","doi-asserted-by":"crossref","unstructured":"Jakobsson, G. et al. Therapeutic S100A8\/A9 blockade inhibits myocardial and systemic inflammation and mitigates sepsis-induced myocardial dysfunction. Crit. Care 27, 374 (2023).","DOI":"10.1186\/s13054-023-04652-x"},{"key":"7654_CR30","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1161\/CIRCRESAHA.107.167544","volume":"102","author":"J. H Boyd","year":"2008","unstructured":"Boyd, J. H. et al. S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end products. Circ. Res. 102, 1239\u20131246 (2008).","journal-title":"Circ. Res"},{"key":"7654_CR31","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1161\/CIRCULATIONAHA.118.039262","volume":"140","author":"Y Li","year":"2019","unstructured":"Li, Y. et al. S100a8\/a9 signaling causes mitochondrial dysfunction and cardiomyocyte death in response to ischemic\/reperfusion injury. Circulation 140, 751\u2013764 (2019).","journal-title":"Circulation"},{"key":"7654_CR32","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1002\/jcsm.12596","volume":"11","author":"D. S Cho","year":"2020","unstructured":"Cho, D. S. et al. Single-cell deconstruction of post-sepsis skeletal muscle and adipose tissue microenvironments. J. Cachexia Sarcopenia Muscle 11, 1351\u20131363 (2020).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"7654_CR33","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.3390\/ijms24032112","volume":"24","author":"Y Zhang","year":"2023","unstructured":"Zhang, Y. et al. Deficiency of S100A9 alleviates sepsis-induced acute liver injury through regulating AKT-AMPK-dependent mitochondrial energy metabolism. Int. J. Mol. Sci. 24, 2112 (2023).","journal-title":"Int. J. Mol. Sci."},{"key":"7654_CR34","doi-asserted-by":"publisher","first-page":"109716","DOI":"10.1016\/j.intimp.2023.109716","volume":"115","author":"F Wu","year":"2023","unstructured":"Wu, F. et al. S100a8\/a9 contributes to sepsis-induced cardiomyopathy by activating ERK1\/2-Drp1-mediated mitochondrial fission and respiratory dysfunction. Int. Immunopharmacol. 115, 109716 (2023).","journal-title":"Int. Immunopharmacol."},{"key":"7654_CR35","doi-asserted-by":"publisher","first-page":"1172356","DOI":"10.3389\/fphar.2023.1172356","volume":"14","author":"W Shi","year":"2023","unstructured":"Shi, W. et al. Blockage of S100A8\/A9 ameliorates septic nephropathy in mice. Front. Pharmacol. 14, 1172356 (2023).","journal-title":"Front. Pharmacol."},{"key":"7654_CR36","doi-asserted-by":"publisher","first-page":"118677","DOI":"10.1016\/j.bbamcr.2020.118677","volume":"1867","author":"L. L Gonzalez","year":"2020","unstructured":"Gonzalez, L. L., Garrie, K. & Turner, M. D Role of S100 proteins in health and disease. Biochim. Biophys. Acta Mol. Cell Res. 1867, 118677 (2020).","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"7654_CR37","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1097\/CCM.0b013e318170aa97","volume":"36","author":"W Zink","year":"2008","unstructured":"Zink, W. et al. Alterations in intracellular Ca2+-homeostasis of skeletal muscle fibers during sepsis. Crit. Care Med. 36, 1559\u20131563 (2008).","journal-title":"Crit. Care Med."},{"key":"7654_CR38","doi-asserted-by":"publisher","first-page":"111247","DOI":"10.1016\/j.exger.2021.111247","volume":"146","author":"F. N Daussin","year":"2021","unstructured":"Daussin, F. N., Boulanger, E. & Lancel, S. From mitochondria to sarcopenia: role of inflammaging and RAGE-ligand axis implication. Exp. Gerontol. 146, 111247 (2021).","journal-title":"Exp. Gerontol."},{"key":"7654_CR39","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1002\/jcsm.12350","volume":"9","author":"F Riuzzi","year":"2018","unstructured":"Riuzzi, F. et al. RAGE in the pathophysiology of skeletal muscle. J. Cachexia Sarcopenia Muscle 9, 1213\u20131234 (2018).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"7654_CR40","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1002\/jcsm.12561","volume":"11","author":"S Chiappalupi","year":"2020","unstructured":"Chiappalupi, S. et al. Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia. J. Cachexia Sarcopenia Muscle 11, 929\u2013946 (2020).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"7654_CR41","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1002\/path.4674","volume":"238","author":"C. Y Chiu","year":"2016","unstructured":"Chiu, C. Y. et al. Advanced glycation end-products induce skeletal muscle atrophy and dysfunction in diabetic mice via a RAGE-mediated, AMPK-down-regulated, Akt pathway. J. Pathol. 238, 470\u2013482 (2016).","journal-title":"J. Pathol."},{"key":"7654_CR42","doi-asserted-by":"crossref","unstructured":"Su, S.-C. et al. Cilostazol inhibits hyperglucose-induced vascular smooth muscle cell dysfunction by modulating the RAGE\/ERK\/NF-\u03baB signaling pathways. J. Biomed. Sci. 26, 1\u201313 (2019).","DOI":"10.1186\/s12929-019-0550-9"},{"key":"7654_CR43","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0718-3","volume":"9","author":"Y. X Mao","year":"2018","unstructured":"Mao, Y. X. et al. RAGE-dependent mitochondria pathway: a novel target of silibinin against apoptosis of osteoblastic cells induced by advanced glycation end products. Cell Death Dis. 9, 674 (2018).","journal-title":"Cell Death Dis."},{"key":"7654_CR44","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-1019-6","volume":"9","author":"C. Y Huang","year":"2018","unstructured":"Huang, C. Y. et al. HMGB1 promotes ERK-mediated mitochondrial Drp1 phosphorylation for chemoresistance through RAGE in colorectal cancer. Cell Death Dis. 9, 1004 (2018).","journal-title":"Cell Death Dis."},{"key":"7654_CR45","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/s41586-021-03214-x","volume":"590","author":"F Kraus","year":"2021","unstructured":"Kraus, F. et al. Function and regulation of the divisome for mitochondrial fission. Nature 590, 57\u201366 (2021).","journal-title":"Nature"},{"key":"7654_CR46","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1007\/s00018-020-03662-0","volume":"78","author":"V Romanello","year":"2020","unstructured":"Romanello, V. & Sandri, M. The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass. Cell. Mol. Life Sci. 78, 1305\u20131328 (2020).","journal-title":"Cell. Mol. Life Sci."},{"key":"7654_CR47","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.595","volume":"6","author":"T Touvier","year":"2015","unstructured":"Touvier, T. et al. Muscle-specific Drp1 overexpression impairs skeletal muscle growth via translational attenuation. Cell Death Dis. 6, e1663 (2015).","journal-title":"Cell Death Dis."},{"key":"7654_CR48","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1038\/emboj.2010.60","volume":"29","author":"V Romanello","year":"2010","unstructured":"Romanello, V. et al. Mitochondrial fission and remodelling contributes to muscle atrophy. EMBO J. 29, 1774\u20131785 (2010).","journal-title":"EMBO J."},{"key":"7654_CR49","doi-asserted-by":"publisher","first-page":"673618","DOI":"10.3389\/fcell.2021.673618","volume":"9","author":"X Mao","year":"2021","unstructured":"Mao, X. et al. Phosphorylation of Dynamin-Related Protein 1 (DRP1) regulates mitochondrial dynamics and skeletal muscle wasting in cancer cachexia. Front. Cell Dev. Biol. 9, 673618 (2021).","journal-title":"Front. Cell Dev. Biol."},{"key":"7654_CR50","doi-asserted-by":"publisher","first-page":"11562","DOI":"10.1096\/fj.201901039RR","volume":"34","author":"M. L Rexius-Hall","year":"2020","unstructured":"Rexius-Hall, M. L. et al. Mitochondrial division inhibitor 1 (mdivi-1) increases oxidative capacity and contractile stress generated by engineered skeletal muscle. FASEB J. 34, 11562\u201311576 (2020).","journal-title":"FASEB J."},{"key":"7654_CR51","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1002\/jcsm.12794","volume":"12","author":"H Lee","year":"2021","unstructured":"Lee, H. et al. Mitochondrial dysfunction in skeletal muscle contributes to the development of acute insulin resistance in mice. J. Cachexia Sarcopenia Muscle 12, 1925\u20131939 (2021).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"7654_CR52","first-page":"25","volume":"9","author":"X Zeng","year":"2022","unstructured":"Zeng, X. et al. Activated Drp1 regulates p62-mediated autophagic flux and aggravates inflammation in cerebral ischemia-reperfusion via the ROS-RIP1\/RIP3-exosome axis. Mil. Med. Res. 9, 25 (2022).","journal-title":"Mil. Med. Res."},{"key":"7654_CR53","doi-asserted-by":"publisher","first-page":"W255","DOI":"10.2214\/AJR.15.14635","volume":"205","author":"R. D Boutin","year":"2015","unstructured":"Boutin, R. D. et al. Sarcopenia: current concepts and imaging implications. AJR Am. J. Roentgenol. 205, W255\u2013W266 (2015).","journal-title":"AJR Am. J. Roentgenol."},{"key":"7654_CR54","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1165\/rcmb.2022-0351OC","volume":"69","author":"J Xia","year":"2023","unstructured":"Xia, J. et al. RAGE is a receptor for SARS-CoV-2 N protein and mediates N Protein\u2013induced Acute Lung Injury. Am. J. Respir. Cell Mol. Biol. 69, 508\u2013520 (2023).","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"7654_CR55","doi-asserted-by":"crossref","unstructured":"He, X. et al. BAY61\u20113606 attenuates neuroinflammation and neurofunctional damage by inhibiting microglial Mincle\/Syk signaling response after traumatic brain injury. Int. J. Mol. Med. 49, 1\u201313 (2022).","DOI":"10.3892\/ijmm.2021.5060"},{"key":"7654_CR56","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1038\/s41401-020-00597-x","volume":"42","author":"S. N Chen","year":"2021","unstructured":"Chen, S. N. et al. Deletion of TLR4 attenuates lipopolysaccharide-induced acute liver injury by inhibiting inflammation and apoptosis. Acta Pharm. Sin. 42, 1610\u20131619 (2021).","journal-title":"Acta Pharm. Sin."},{"key":"7654_CR57","doi-asserted-by":"publisher","first-page":"2573","DOI":"10.1016\/j.neuron.2021.06.012","volume":"109","author":"P Cao","year":"2021","unstructured":"Cao, P. et al. Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines. Neuron 109, 2573\u20132589.e9 (2021).","journal-title":"Neuron"},{"key":"7654_CR58","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2353-z","volume":"11","author":"L Hou","year":"2020","unstructured":"Hou, L. et al. Nontoxic concentration of ochratoxin A decreases the dosage of cyclosporine A to induce chronic nephropathy model via autophagy mediated by toll-like receptor 4. Cell Death Dis. 11, 153 (2020).","journal-title":"Cell Death Dis."},{"key":"7654_CR59","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/nprot.2008.214","volume":"4","author":"D Rittirsch","year":"2009","unstructured":"Rittirsch, D. et al. Immunodesign of experimental sepsis by cecal ligation and puncture. Nat. Protoc. 4, 31\u201336 (2009).","journal-title":"Nat. Protoc."},{"key":"7654_CR60","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0545-6","volume":"18","author":"F Schmidt","year":"2014","unstructured":"Schmidt, F. et al. The E3 ubiquitin ligase TRIM62 and inflammationinduced skeletal muscle atrophy. Crit. Care 18, 545 (2014).","journal-title":"Crit. Care"},{"key":"7654_CR61","first-page":"9148246","volume":"27","author":"B Yang","year":"2022","unstructured":"Yang, B. et al. IL-6 deficiency attenuates skeletal muscle atrophy by inhibiting mitochondrial ROS production through the upregulation of PGC-1\u03b1 in Septic Mice. Oxid. Med. Cell. Longev. 27, 9148246 (2022).","journal-title":"Oxid. Med. Cell. Longev."},{"key":"7654_CR62","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1164\/ajrccm.161.5.9907043","volume":"161","author":"E. D Crouser","year":"2000","unstructured":"Crouser, E. D. et al. Endotoxin-induced ileal mucosal injury and nitric oxide dysregulation are temporally dissociated. Am. J. Respir. Crit. Care Med. 161, 1705\u20131712 (2000).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"7654_CR63","doi-asserted-by":"crossref","unstructured":"Deacon, R. M. Measuring the strength of mice. J. Vis. Exp. 76, 2610 (2013).","DOI":"10.3791\/2610"}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-07654-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-07654-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-07654-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T13:45:09Z","timestamp":1740750309000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-07654-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,28]]},"references-count":63,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["7654"],"URL":"https:\/\/doi.org\/10.1038\/s42003-025-07654-3","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,28]]},"assertion":[{"value":"29 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"338"}}