{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:15:24Z","timestamp":1790900124043,"version":"4.1.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22122703, 32100764, 32170767, 32470808, 91953110"],"award-info":[{"award-number":["22122703, 32100764, 32170767, 32470808, 91953110"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2019YFA0508402"],"award-info":[{"award-number":["2019YFA0508402"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-025-07761-1","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T17:56:43Z","timestamp":1740506203000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Structural insights into calcium-dependent CIB2-TMC1 interaction in hair cell mechanotransduction"],"prefix":"10.1038","volume":"8","author":[{"given":"Yahong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiasheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3192-2780","authenticated-orcid":false,"given":"Chao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"key":"7761_CR1","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1146\/annurev.cb.08.110192.001353","volume":"8","author":"L. G Tilney","year":"1992","unstructured":"Tilney, L. G., Tilney, M. S. & DeRosier, D. J. Actin Filaments, Stereocilia, and Hair Cells: How Cells Count and Measure. Annu. Rev. Cell Biol. 8, 257\u2013274 (1992).","journal-title":"Annu. Rev. Cell Biol."},{"key":"7761_CR2","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.neuron.2013.06.019","volume":"79","author":"B Pan","year":"2013","unstructured":"Pan, B. et al. TMC1 and TMC2 Are Components of the Mechanotransduction Channel in Hair Cells of the Mammalian Inner Ear. Neuron 79, 504\u2013515 (2013).","journal-title":"Neuron"},{"key":"7761_CR3","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1016\/j.celrep.2015.07.058","volume":"12","author":"K Kurima","year":"2015","unstructured":"Kurima, K. et al. TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia. Cell Rep. 12, 1606\u20131617 (2015).","journal-title":"Cell Rep."},{"key":"7761_CR4","first-page":"1398","volume":"48","author":"X. Q Pan","year":"2021","unstructured":"Pan, X. Q. & Yan, Z. Q. Discovery of Touch Receptor NOMPC and Hearing Receptor TMC. Prog. Biochem. Biophys.48, 1398\u20131403 (2021).","journal-title":"Prog. Biochem. Biophys."},{"key":"7761_CR5","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1152\/physrev.00038.2013","volume":"94","author":"R Fettiplace","year":"2014","unstructured":"Fettiplace, R. & Kim, K. X. The physiology of mechanoelectrical transduction channels in hearing. Physiol. Rev. 94, 951\u2013986 (2014).","journal-title":"Physiol. Rev."},{"key":"7761_CR6","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.neuron.2018.07.033","volume":"99","author":"B Pan","year":"2018","unstructured":"Pan, B. et al. TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells. Neuron 99, 736\u2013753.e736 (2018).","journal-title":"Neuron"},{"key":"7761_CR7","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.neuron.2019.10.017","volume":"105","author":"Y Jia","year":"2020","unstructured":"Jia, Y. et al. TMC1 and TMC2 Proteins Are Pore-Forming Subunits of Mechanosensitive Ion Channels. Neuron 105, 310 (2020).","journal-title":"Neuron"},{"key":"7761_CR8","doi-asserted-by":"publisher","first-page":"20743","DOI":"10.1073\/pnas.1908058116","volume":"116","author":"M Beurg","year":"2019","unstructured":"Beurg, M., Barlow, A., Furness, D. N. & Fettiplace, R. A Tmc1 mutation reduces calcium permeability and expression of mechanoelectrical transduction channels in cochlear hair cells. Proc. Natl. Acad. Sci. 116, 20743\u201320749 (2019).","journal-title":"Proc. Natl. Acad. Sci."},{"key":"7761_CR9","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00061-1","volume":"8","author":"A. P. J Giese","year":"2017","unstructured":"Giese, A. P. J. et al. CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells. Nat. Commun. 8, 43 (2017).","journal-title":"Nat. Commun."},{"key":"7761_CR10","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1038\/ng.2426","volume":"44","author":"S Riazuddin","year":"2012","unstructured":"Riazuddin, S. et al. Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48. Nat. Genet. 44, 1265\u20131271 (2012).","journal-title":"Nat. Genet."},{"key":"7761_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-51573-3","volume":"9","author":"G Dal Cortivo","year":"2019","unstructured":"Dal Cortivo, G. et al. Oligomeric state, hydrodynamic properties and target recognition of human Calcium and Integrin Binding protein 2 (CIB2). Sci. Rep. 9, 15058 (2019).","journal-title":"Sci. Rep."},{"key":"7761_CR12","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.neuron.2020.03.026","volume":"107","author":"Y.-Q Tang","year":"2020","unstructured":"Tang, Y.-Q. et al. Ankyrin Is An Intracellular Tether for TMC Mechanotransduction Channels. Neuron 107, 112 (2020).","journal-title":"Neuron"},{"key":"7761_CR13","doi-asserted-by":"publisher","unstructured":"Giese, A. P. J., et al. Complexes of vertebrate TMC1\/2 and CIB2\/3 proteins form hair-cell mechanotransduction cation channels. bioRxiv, 2023.2005.2026.542533. https:\/\/doi.org\/10.1101\/2023.05.26.542533. (2024).","DOI":"10.1101\/2023.05.26.542533"},{"key":"7761_CR14","doi-asserted-by":"publisher","first-page":"3552","DOI":"10.3390\/ijms23073552","volume":"23","author":"G Dal Cortivo","year":"2022","unstructured":"Dal Cortivo, G. & Dell\u2019Orco, D. Calcium- and Integrin-Binding Protein 2 (CIB2) in Physiology and Disease: Bright and Dark Sides. Int. J. Mol. Sci. 23, 3552 (2022).","journal-title":"Int. J. Mol. Sci."},{"key":"7761_CR15","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1016\/j.neuron.2021.05.007","volume":"109","author":"X Liang","year":"2021","unstructured":"Liang, X. et al. CIB2 and CIB3 are auxiliary subunits of the mechanotransduction channel of hair cells. Neuron 109, 2131\u20132149.e2115 (2021).","journal-title":"Neuron"},{"key":"7761_CR16","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44230-x","volume":"15","author":"J. H Lee","year":"2024","unstructured":"Lee, J. H. et al. The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell. Nat. Commun. 15, 526 (2024).","journal-title":"Nat. Commun."},{"key":"7761_CR17","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1038\/s41586-022-05314-8","volume":"610","author":"H Jeong","year":"2022","unstructured":"Jeong, H. et al. Structures of the TMC-1 complex illuminate mechanosensory transduction. Nature 610, 796\u2013803 (2022).","journal-title":"Nature"},{"key":"7761_CR18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2314096121","volume":"121","author":"S Clark","year":"2024","unstructured":"Clark, S., Jeong, H., Posert, R., Goehring, A. & Gouaux, E. The structure of the Caenorhabditis elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction. Proc. Natl. Acad. Sci. USA 121, e2314096121 (2024).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"7761_CR19","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.neuron.2016.05.023","volume":"91","author":"X Wang","year":"2016","unstructured":"Wang, X., Li, G., Liu, J., Liu, J. & Xu, X. Z. S. TMC-1 Mediates Alkaline Sensation in C. elegans through Nociceptive Neurons. Neuron 91, 146\u2013154 (2016).","journal-title":"Neuron"},{"key":"7761_CR20","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.neuron.2017.12.041","volume":"97","author":"X Yue","year":"2018","unstructured":"Yue, X. et al. TMC Proteins Modulate Egg Laying and Membrane Excitability through a Background Leak Conductance in&IT C. elegans&IT. Neuron 97, 571 (2018).","journal-title":"Neuron"},{"key":"7761_CR21","doi-asserted-by":"publisher","first-page":"8407","DOI":"10.1074\/jbc.M411515200","volume":"280","author":"H. R Gentry","year":"2005","unstructured":"Gentry, H. R. et al. Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins. J. Biol. Chem. 280, 8407\u20138415 (2005).","journal-title":"J. Biol. Chem."},{"key":"7761_CR22","doi-asserted-by":"publisher","first-page":"10012","DOI":"10.1021\/jp0716583","volume":"111","author":"M Lep\u0161\u00edk","year":"2007","unstructured":"Lep\u0161\u00edk, M. & Field, M. J. Binding of Calcium and Other Metal Ions to the EF-Hand Loops of Calmodulin Studied by Quantum Chemical Calculations and Molecular Dynamics Simulations.  J. Phys. Chem. B 111, 10012\u201310022 (2007).","journal-title":"J. Phys. Chem. B"},{"key":"7761_CR23","doi-asserted-by":"publisher","unstructured":"Tang, S. & Yang, J. J. Magnesium Binding Sites in Proteins. In Encyclopedia of Metalloproteins, R. H. Kretsinger, V. N. Uversky, and E. A. Permyakov, eds. (Springer New York), pp. 1243\u20131250. https:\/\/doi.org\/10.1007\/978-1-4614-1533-6_257 (2013).","DOI":"10.1007\/978-1-4614-1533-6_257"},{"key":"7761_CR24","doi-asserted-by":"publisher","first-page":"274","DOI":"10.3389\/fnmol.2018.00274","volume":"11","author":"R Vallone","year":"2018","unstructured":"Vallone, R., Dal Cortivo, G., D\u2019Onofrio, M. & Dell\u2019Orco, D. Preferential Binding of Mg2+ Over Ca2+ to CIB2 Triggers an Allosteric Switch Impaired in Usher Syndrome Type 1J. Front. Mol. Neurosci. 11, 274 (2018).","journal-title":"Front. Mol. Neurosci."},{"key":"7761_CR25","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/j.bbamcr.2011.01.017","volume":"1813","author":"Z Grabarek","year":"2011","unstructured":"Grabarek, Z. Insights into modulation of calcium signaling by magnesium in calmodulin, troponin C and related EF-hand proteins. Biochimica et. Biophysica Acta (BBA) - Mol. Cell Res. 1813, 913\u2013921 (2011).","journal-title":"Biochimica et. Biophysica Acta (BBA) - Mol. Cell Res."},{"key":"7761_CR26","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.abb.2009.05.002","volume":"487","author":"M Blazejczyk","year":"2009","unstructured":"Blazejczyk, M. et al. Biochemical characterization and expression analysis of a novel EF-hand Ca2+ binding protein calmyrin2 (Cib2) in brain indicates its function in NMDA receptor mediated Ca2+ signaling. Arch. Biochem Biophys. 487, 66\u201378 (2009).","journal-title":"Arch. Biochem Biophys."},{"key":"7761_CR27","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1111\/cge.13170","volume":"93","author":"K. T Booth","year":"2018","unstructured":"Booth, K. T. et al. Variants in CIB2 cause DFNB48 and not USH1J. Clin. Genet. 93, 812\u2013821 (2018).","journal-title":"Clin. Genet."},{"key":"7761_CR28","doi-asserted-by":"publisher","first-page":"e0133082","DOI":"10.1371\/journal.pone.0133082","volume":"10","author":"K Patel","year":"2015","unstructured":"Patel, K. et al. A Novel C-Terminal CIB2 (Calcium and Integrin Binding Protein 2) Mutation Associated with Non-Syndromic Hearing Loss in a Hispanic Family. PLOS ONE 10, e0133082 (2015).","journal-title":"PLOS ONE"},{"key":"7761_CR29","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1007\/s00424-013-1278-0","volume":"465","author":"N. V Kovalevskaya","year":"2013","unstructured":"Kovalevskaya, N. V. et al. Structural analysis of calmodulin binding to ion channels demonstrates the role of its plasticity in regulation. Pflug. Arch. 465, 1507\u20131519 (2013).","journal-title":"Pflug. Arch."},{"key":"7761_CR30","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.bbamcr.2017.12.004","volume":"1865","author":"A Villalobo","year":"2018","unstructured":"Villalobo, A., Ishida, H., Vogel, H. J. & Berchtold, M. W. Calmodulin as a protein linker and a regulator of adaptor\/scaffold proteins. Biochim Biophys. Acta Mol. Cell Res. 1865, 507\u2013521 (2018).","journal-title":"Biochim Biophys. Acta Mol. Cell Res."},{"key":"7761_CR31","doi-asserted-by":"publisher","first-page":"39846","DOI":"10.1074\/jbc.M005881200","volume":"275","author":"T Ivanina","year":"2000","unstructured":"Ivanina, T., Blumenstein, Y., Shistik, E., Barzilai, R. & Dascal, N. Modulation of L-type Ca2+ channels by gbeta gamma and calmodulin via interactions with N and C termini of alpha 1C. J. Biol. Chem. 275, 39846\u201339854 (2000).","journal-title":"J. Biol. Chem."},{"key":"7761_CR32","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3389\/fnmol.2012.00038","volume":"5","author":"Z Liu","year":"2012","unstructured":"Liu, Z. & Vogel, H. J. Structural basis for the regulation of L-type voltage-gated calcium channels: interactions between the N-terminal cytoplasmic domain and Ca(2+)-calmodulin. Front Mol. Neurosci. 5, 38 (2012).","journal-title":"Front Mol. Neurosci."},{"key":"7761_CR33","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1152\/jn.00019.2010","volume":"104","author":"M Beurg","year":"2010","unstructured":"Beurg, M., Nam, J.-H., Chen, Q. & Fettiplace, R. Calcium Balance and Mechanotransduction in Rat Cochlear Hair Cells. J. Neurophysiol. 104, 18\u201334 (2010).","journal-title":"J. Neurophysiol."},{"key":"7761_CR34","doi-asserted-by":"publisher","first-page":"14918","DOI":"10.1073\/pnas.1409920111","volume":"111","author":"L. F Corns","year":"2014","unstructured":"Corns, L. F., Johnson, S. L., Kros, C. J. & Marcotti, W. Calcium entry into stereocilia drives adaptation of the mechanoelectrical transducer current of mammalian cochlear hair cells. Proc. Natl. Acad. Sci. 111, 14918\u201314923 (2014).","journal-title":"Proc. Natl. Acad. Sci."},{"key":"7761_CR35","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1016\/j.neuron.2011.04.024","volume":"70","author":"S. L Johnson","year":"2011","unstructured":"Johnson, S. L., Beurg, M., Marcotti, W. & Fettiplace, R. Prestin-Driven Cochlear Amplification Is Not Limited by the Outer Hair Cell Membrane Time Constant. Neuron 70, 1143\u20131154 (2011).","journal-title":"Neuron"},{"key":"7761_CR36","doi-asserted-by":"publisher","unstructured":"Fettiplace, R. Hair Cell Transduction, Tuning, and Synaptic Transmission in the Mammalian Cochlea. In Comprehensive Physiology, pp. 1197\u20131227. https:\/\/doi.org\/10.1002\/cphy.c160049 (2017).","DOI":"10.1002\/cphy.c160049"},{"key":"7761_CR37","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.tins.2018.12.006","volume":"42","author":"D \u00d3 Maoil\u00e9idigh","year":"2019","unstructured":"\u00d3 Maoil\u00e9idigh, D. & Ricci, A. J. A Bundle of Mechanisms: Inner-Ear Hair-Cell Mechanotransduction. Trends Neurosci. 42, 221\u2013236 (2019).","journal-title":"Trends Neurosci."},{"key":"7761_CR38","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/nn1822","volume":"10","author":"H Wang","year":"2007","unstructured":"Wang, H. et al. Structural basis for modulation of Kv4 K+ channels by auxiliary KChIP subunits. Nat. Neurosci. 10, 32\u201339 (2007).","journal-title":"Nat. Neurosci."},{"key":"7761_CR39","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1038\/nsmb1164","volume":"13","author":"M Pioletti","year":"2006","unstructured":"Pioletti, M., Findeisen, F., Hura, G. L. & Minor, D. L. Jr. Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer. Nat. Struct. Mol. Biol. 13, 987\u2013995 (2006).","journal-title":"Nat. Struct. Mol. Biol."},{"key":"7761_CR40","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/0896-6273(94)90251-8","volume":"13","author":"M. P Gray-Keller","year":"1994","unstructured":"Gray-Keller, M. P. & Detwiler, P. B. The calcium feedback signal in the phototransduction cascade of vertebrate rods. Neuron 13, 849\u2013861 (1994).","journal-title":"Neuron"},{"key":"7761_CR41","doi-asserted-by":"publisher","first-page":"14143","DOI":"10.3390\/ijms232214143","volume":"23","author":"A Bej","year":"2022","unstructured":"Bej, A. & Ames, J. B. Retinal Cyclic Nucleotide-Gated Channel Regulation by Calmodulin. Int. J. Mol. Sci. 23, 14143 (2022).","journal-title":"Int. J. Mol. Sci."},{"key":"7761_CR42","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1107\/S0021889807021206","volume":"40","author":"A. J McCoy","year":"2007","unstructured":"McCoy, A. J. et al. Phaser crystallographic software. J. Appl. Crystallogr. 40, 658\u2013674 (2007).","journal-title":"J. Appl. Crystallogr."},{"key":"7761_CR43","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1107\/S0907444910007493","volume":"66","author":"P Emsley","year":"2010","unstructured":"Emsley, P., Lohkamp, B., Scott, W. G. & Cowtan, K. Features and development of Coot. Acta Crystallogr D. Biol. Crystallogr 66, 486\u2013501 (2010).","journal-title":"Acta Crystallogr D. Biol. Crystallogr"},{"key":"7761_CR44","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1107\/S0907444909042073","volume":"66","author":"V. B Chen","year":"2010","unstructured":"Chen, V. B. et al. MolProbity: all-atom structure validation for macromolecular crystallography. Acta Crystallogr D. Biol. Crystallogr 66, 12\u201321 (2010).","journal-title":"Acta Crystallogr D. Biol. Crystallogr"},{"key":"7761_CR45","doi-asserted-by":"publisher","first-page":"3022","DOI":"10.1093\/molbev\/msab120","volume":"38","author":"K Tamura","year":"2021","unstructured":"Tamura, K., Stecher, G. & Kumar, S. MEGA11: Molecular Evolutionary Genetics Analysis Version 11. Mol. Biol. Evol. 38, 3022\u20133027 (2021).","journal-title":"Mol. Biol. Evol."},{"key":"7761_CR46","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1126\/science.1218231","volume":"336","author":"P. A Karplus","year":"2012","unstructured":"Karplus, P. A. & Diederichs, K. Linking crystallographic model and data quality. Science 336, 1030\u20131033 (2012).","journal-title":"Science"}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-07761-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-07761-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-07761-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T18:44:09Z","timestamp":1740509049000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-07761-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,25]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["7761"],"URL":"https:\/\/doi.org\/10.1038\/s42003-025-07761-1","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,25]]},"assertion":[{"value":"5 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"306"}}