{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T11:27:36Z","timestamp":1784719656339,"version":"3.55.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2021R1A2C2010460"],"award-info":[{"award-number":["NRF-2021R1A2C2010460"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022R1A2C2005930"],"award-info":[{"award-number":["2022R1A2C2005930"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017M3A9E4065333"],"award-info":[{"award-number":["2017M3A9E4065333"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-025-07770-0","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T13:03:59Z","timestamp":1744203839000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Regulating Sirtuin 3-mediated mitochondrial dynamics through vanillic acid improves muscle atrophy in cancer-induced cachexia"],"prefix":"10.1038","volume":"8","author":[{"given":"Gahee","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinbong","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunu","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Yong","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ja Yeon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Jin","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beomsu","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minji","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2102-973X","authenticated-orcid":false,"given":"Seong-Kyu","family":"Choe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Jeong","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kil Yeon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2882-0612","authenticated-orcid":false,"given":"Kwang Seok","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0568-9738","authenticated-orcid":false,"given":"Jae-Young","family":"Um","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"key":"7770_CR1","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1002\/jcsm.12528","volume":"11","author":"S Peixoto da Silva","year":"2020","unstructured":"Peixoto da Silva, S., Santos, J. M. O., Costa, E. S. M. P., Gil da Costa, R. M. & Medeiros, R. Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia. J. Cachexia Sarcopenia Muscle 11, 619\u2013635 (2020).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"7770_CR2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.105","volume":"4","author":"V. E Baracos","year":"2018","unstructured":"Baracos, V. E., Martin, L., Korc, M., Guttridge, D. C. & Fearon, K. C. H. Cancer-associated cachexia. Nat. Rev. Dis. Prim. 4, 17105 (2018).","journal-title":"Nat. Rev. Dis. Prim."},{"key":"7770_CR3","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1002\/jcsm.12402","volume":"10","author":"M. S Anker","year":"2019","unstructured":"Anker, M. S. et al. Orphan disease status of cancer cachexia in the USA and in the European Union: a systematic review. J. Cachexia Sarcopenia Muscle 10, 22\u201334 (2019).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"7770_CR4","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s13045-023-01454-0","volume":"16","author":"T Setiawan","year":"2023","unstructured":"Setiawan, T. et al. Cancer cachexia: molecular mechanisms and treatment strategies. J. Hematol. Oncol. 16, 54 (2023).","journal-title":"J. Hematol. Oncol."},{"key":"7770_CR5","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1002\/jcsm.13219","volume":"14","author":"B. Y Lee","year":"2023","unstructured":"Lee, B. Y. et al. GDNF family receptor alpha-like antagonist antibody alleviates chemotherapy-induced cachexia in melanoma-bearing mice. J. Cachexia Sarcopenia Muscle 14, 1441\u20131453 (2023).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"7770_CR6","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1002\/jcsm.12360","volume":"10","author":"F Pin","year":"2019","unstructured":"Pin, F., Barreto, R., Couch, M. E., Bonetto, A. & O\u2019Connell, T. M. Cachexia induced by cancer and chemotherapy yield distinct perturbations to energy metabolism. J. Cachexia Sarcopenia Muscle 10, 140\u2013154 (2019).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"7770_CR7","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/1440-1681.13024","volume":"46","author":"H Sakai","year":"2019","unstructured":"Sakai, H. et al. Dexamethasone exacerbates cisplatin-induced muscle atrophy. Clin. Exp. Pharm. Physiol. 46, 19\u201328 (2019).","journal-title":"Clin. Exp. Pharm. Physiol."},{"key":"7770_CR8","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1016\/j.cmet.2016.05.007","volume":"23","author":"G. D Cartee","year":"2016","unstructured":"Cartee, G. D., Hepple, R. T., Bamman, M. M. & Zierath, J. R. Exercise Promotes Healthy Aging of Skeletal Muscle. Cell Metab. 23, 1034\u20131047 (2016).","journal-title":"Cell Metab."},{"key":"7770_CR9","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1016\/j.biocel.2013.04.023","volume":"45","author":"M Sandri","year":"2013","unstructured":"Sandri, M. Protein breakdown in muscle wasting: role of autophagy-lysosome and ubiquitin-proteasome. Int. J. Biochem. Cell Biol. 45, 2121\u20132129 (2013).","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"7770_CR10","doi-asserted-by":"publisher","unstructured":"Conte, E. et al. Cisplatin-induced skeletal muscle dysfunction: mechanisms and counteracting therapeutic strategies. Int. J. Mol. Sci. https:\/\/doi.org\/10.3390\/ijms21041242 (2020).","DOI":"10.3390\/ijms21041242"},{"key":"7770_CR11","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3292087","volume":"2017","author":"B. N VanderVeen","year":"2017","unstructured":"VanderVeen, B. N., Fix, D. K. & Carson, J. A. Disrupted skeletal muscle mitochondrial dynamics, mitophagy, and biogenesis during cancer cachexia: a role for inflammation. Oxid. Med. Cell Longev. 2017, 3292087 (2017).","journal-title":"Oxid. Med. Cell Longev."},{"key":"7770_CR12","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1042\/EBC20170104","volume":"62","author":"L Tilokani","year":"2018","unstructured":"Tilokani, L., Nagashima, S., Paupe, V. & Prudent, J. Mitochondrial dynamics: overview of molecular mechanisms. Essays Biochem. 62, 341\u2013360 (2018).","journal-title":"Essays Biochem."},{"key":"7770_CR13","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1042\/bse0470069","volume":"47","author":"F. R Jornayvaz","year":"2010","unstructured":"Jornayvaz, F. R. & Shulman, G. I. Regulation of mitochondrial biogenesis. Essays Biochem. 47, 69\u201384 (2010).","journal-title":"Essays Biochem."},{"key":"7770_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/BJ20070140","volume":"404","author":"S Michan","year":"2007","unstructured":"Michan, S. & Sinclair, D. Sirtuins in mammals: insights into their biological function. Biochem. J. 404, 1\u201313 (2007).","journal-title":"Biochem. J."},{"key":"7770_CR15","doi-asserted-by":"publisher","first-page":"8315","DOI":"10.7150\/thno.45922","volume":"10","author":"J Zhang","year":"2020","unstructured":"Zhang, J. et al. Mitochondrial Sirtuin 3: new emerging biological function and therapeutic target. Theranostics 10, 8315\u20138342 (2020).","journal-title":"Theranostics"},{"key":"7770_CR16","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1152\/physrev.00022.2011","volume":"92","author":"R Nogueiras","year":"2012","unstructured":"Nogueiras, R. et al. Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol. Rev. 92, 1479\u20131514 (2012).","journal-title":"Physiol. Rev."},{"key":"7770_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5037","volume":"5","author":"N. J Gallage","year":"2014","unstructured":"Gallage, N. J. et al. Vanillin formation from ferulic acid in Vanilla planifolia is catalysed by a single enzyme. Nat. Commun. 5, 4037 (2014).","journal-title":"Nat. Commun."},{"key":"7770_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s13596-020-00531-w","volume":"21","author":"S. S Arya","year":"2021","unstructured":"Arya, S. S., Rookes, J. E., Cahill, D. M. & Lenka, S. K. Vanillin: a review on the therapeutic prospects of a popular flavouring molecule. Adv. Tradit. Med. 21, 1\u201317 (2021).","journal-title":"Adv. Tradit. Med."},{"key":"7770_CR19","doi-asserted-by":"publisher","unstructured":"Moreno-Hernandez, Y., Olivo-Vidal, Z. E., S\u00e1nchez-Chino, X. M., Betanzos-Reyes, A. & Salvatierra-Izaba, B. Cecropia obtusifolia: phytopharmacology and its potential use in the treatment of diseases. Adv. Tradit. Med. https:\/\/doi.org\/10.1007\/s13596-024-00756-z (2024).","DOI":"10.1007\/s13596-024-00756-z"},{"key":"7770_CR20","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1021\/acs.jnatprod.5b00246","volume":"78","author":"C Calixto-Campos","year":"2015","unstructured":"Calixto-Campos, C. et al. Vanillic acid inhibits inflammatory pain by inhibiting neutrophil recruitment, oxidative stress, cytokine production, and NF\u03baB activation in mice. J. Nat. Prod. 78, 1799\u20131808 (2015).","journal-title":"J. Nat. Prod."},{"key":"7770_CR21","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1096\/fj.201700231RR","volume":"32","author":"Y Jung","year":"2018","unstructured":"Jung, Y. et al. Vanillic acid attenuates obesity via activation of the AMPK pathway and thermogenic factors in vivo and in vitro. FASEB J. 32, 1388\u20131402 (2018).","journal-title":"FASEB J."},{"key":"7770_CR22","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1172\/JCI200420174","volume":"114","author":"S Acharyya","year":"2004","unstructured":"Acharyya, S. et al. Cancer cachexia is regulated by selective targeting of skeletal muscle gene products. J. Clin. Invest. 114, 370\u2013378 (2004).","journal-title":"J. Clin. Invest."},{"key":"7770_CR23","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1200\/JCO.20.00611","volume":"38","author":"E. J Roeland","year":"2020","unstructured":"Roeland, E. J. et al. Management of cancer cachexia: ASCO guideline. J. Clin. Oncol. 38, 2438\u20132453 (2020).","journal-title":"J. Clin. Oncol."},{"key":"7770_CR24","doi-asserted-by":"publisher","unstructured":"Rohm, M., Zeigerer, A., Machado, J. & Herzig, S. Energy metabolism in cachexia. EMBO Rep. https:\/\/doi.org\/10.15252\/embr.201847258 (2019).","DOI":"10.15252\/embr.201847258"},{"key":"7770_CR25","doi-asserted-by":"publisher","first-page":"4821","DOI":"10.1172\/JCI68523","volume":"123","author":"W. A He","year":"2013","unstructured":"He, W. A. et al. NF-\u03baB-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia. J. Clin. Invest. 123, 4821\u20134835 (2013).","journal-title":"J. Clin. Invest."},{"key":"7770_CR26","doi-asserted-by":"publisher","first-page":"4178","DOI":"10.1200\/JCO.23.01280","volume":"41","author":"E. J Roeland","year":"2023","unstructured":"Roeland, E. J., Bohlke, K., Baracos, V. E., Smith, T. J. & Loprinzi, C. L. Cancer Cachexia: ASCO Guideline Rapid Recommendation Update. J. Clin. Oncol. 41, 4178\u20134179 (2023).","journal-title":"J. Clin. Oncol."},{"key":"7770_CR27","doi-asserted-by":"publisher","unstructured":"Vainshtein, A. & Sandri, M. Signaling pathways that control muscle mass. Int. J. Mol. Sci. https:\/\/doi.org\/10.3390\/ijms21134759 (2020).","DOI":"10.3390\/ijms21134759"},{"key":"7770_CR28","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/1743-7075-10-63","volume":"10","author":"J McInnes","year":"2013","unstructured":"McInnes, J. Mitochondrial-associated metabolic disorders: foundations, pathologies and recent progress. Nutr. Metab. (Lond.) 10, 63 (2013).","journal-title":"Nutr. Metab. (Lond.)"},{"key":"7770_CR29","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1126\/science.1219855","volume":"337","author":"R. J Youle","year":"2012","unstructured":"Youle, R. J. & van der Bliek, A. M. Mitochondrial fission, fusion, and stress. Science 337, 1062\u20131065 (2012).","journal-title":"Science"},{"key":"7770_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25727-8","volume":"8","author":"C Scholtes","year":"2018","unstructured":"Scholtes, C. et al. DRP-1-mediated apoptosis induces muscle degeneration in dystrophin mutants. Sci. Rep. 8, 7354 (2018).","journal-title":"Sci. Rep."},{"key":"7770_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.595","volume":"6","author":"T Touvier","year":"2015","unstructured":"Touvier, T. et al. Muscle-specific Drp1 overexpression impairs skeletal muscle growth via translational attenuation. Cell Death Dis. 6, e1663 (2015).","journal-title":"Cell Death Dis."},{"key":"7770_CR32","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1111\/brv.12378","volume":"93","author":"G Chandhok","year":"2018","unstructured":"Chandhok, G., Lazarou, M. & Neumann, B. Structure, function, and regulation of mitofusin-2 in health and disease. Biol. Rev. Camb. Philos. Soc. 93, 933\u2013949 (2018).","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"7770_CR33","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1016\/j.cmet.2017.04.021","volume":"25","author":"C Tezze","year":"2017","unstructured":"Tezze, C. et al. Age-associated loss of OPA1 in muscle impacts muscle mass, metabolic homeostasis, systemic inflammation, and epithelial senescence. Cell Metab. 25, 1374\u20131389.e1376 (2017).","journal-title":"Cell Metab."},{"key":"7770_CR34","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.bbcan.2018.07.008","volume":"1870","author":"M van der Ende","year":"2018","unstructured":"van der Ende, M. et al. Mitochondrial dynamics in cancer-induced cachexia. Biochim. Biophys. Acta Rev. Cancer 1870, 137\u2013150 (2018).","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"7770_CR35","doi-asserted-by":"publisher","first-page":"14447","DOI":"10.1073\/pnas.0803790105","volume":"105","author":"B. H Ahn","year":"2008","unstructured":"Ahn, B. H. et al. A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc. Natl. Acad. Sci. USA 105, 14447\u201314452 (2008).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"7770_CR36","doi-asserted-by":"publisher","unstructured":"Tang, J. X., Thompson, K., Taylor, R. W. & Ol\u00e1hov\u00e1, M. Mitochondrial OXPHOS Biogenesis: co-regulation of protein synthesis, import, and assembly pathways. Int. J. Mol. Sci. https:\/\/doi.org\/10.3390\/ijms21113820 (2020).","DOI":"10.3390\/ijms21113820"},{"key":"7770_CR37","doi-asserted-by":"publisher","first-page":"R68","DOI":"10.1152\/ajpregu.00028.2019","volume":"317","author":"J. L Halle","year":"2019","unstructured":"Halle, J. L. et al. Tissue-specific dysregulation of mitochondrial respiratory capacity and coupling control in colon-26 tumor-induced cachexia. Am. J. Physiol. Regul. Integr. Comp. Physiol. 317, R68\u2013r82 (2019).","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"7770_CR38","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.826981","volume":"10","author":"M. M Chen","year":"2022","unstructured":"Chen, M. M. et al. Mitochondrial function and reactive oxygen\/nitrogen species in skeletal muscle. Front Cell Dev. Biol. 10, 826981 (2022).","journal-title":"Front Cell Dev. Biol."},{"key":"7770_CR39","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3164\/jcbn.23-1","volume":"73","author":"Z Zhang","year":"2023","unstructured":"Zhang, Z. et al. Mitophagy-mediated inflammation and oxidative stress contribute to muscle wasting in cancer cachexia. J. Clin. Biochem. Nutr. 73, 34\u201342 (2023).","journal-title":"J. Clin. Biochem. Nutr."},{"key":"7770_CR40","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1007\/s11914-020-00628-w","volume":"18","author":"X Zhong","year":"2020","unstructured":"Zhong, X. & Zimmers, T. A. Sex differences in cancer cachexia. Curr. Osteoporos. Rep. 18, 646\u2013654 (2020).","journal-title":"Curr. Osteoporos. Rep."},{"key":"7770_CR41","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1152\/japplphysiol.00196.2023","volume":"135","author":"A. R Cabrera","year":"2023","unstructured":"Cabrera, A. R. et al. Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia. J. Appl. Physiol. (1985) 135, 655\u2013672 (2023).","journal-title":"J. Appl. Physiol. (1985)"},{"key":"7770_CR42","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1097\/SPC.0000000000000380","volume":"12","author":"R. N Montalvo","year":"2018","unstructured":"Montalvo, R. N., Counts, B. R. & Carson, J. A. Understanding sex differences in the regulation of cancer-induced muscle wasting. Curr. Opin. Support Palliat. Care 12, 394\u2013403 (2018).","journal-title":"Curr. Opin. Support Palliat. Care"},{"key":"7770_CR43","doi-asserted-by":"publisher","first-page":"432","DOI":"10.4274\/tjps.galenos.2019.92678","volume":"17","author":"A. C Mirza","year":"2020","unstructured":"Mirza, A. C. & Panchal, S. S. Safety assessment of vanillic acid: subacute oral toxicity studies in Wistar rats. Turk. J. Pharm. Sci. 17, 432\u2013439 (2020).","journal-title":"Turk. J. Pharm. Sci."},{"key":"7770_CR44","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1530\/RAF-22-0045","volume":"3","author":"B Ogunlade","year":"2022","unstructured":"Ogunlade, B., Gbotolorun, S. C., Adedotun, O. A., Iteire, K. & Adejayi, J. Vanillic acid and vitamin C attenuated di-2-ethylhexyl phthalate-induced testicular toxicity in adult male rats. Reprod. Fertil. 3, 220\u2013230 (2022).","journal-title":"Reprod. Fertil."},{"key":"7770_CR45","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.toxrep.2024.03.013","volume":"12","author":"A Salimi","year":"2024","unstructured":"Salimi, A., Haddadi, S., Khezri, S., Asgari, B. & Pourgholi, M. Vanillic acid protects mortality and toxicity induced by N-ethyl-N-nitrosourea in mice; in vivo model of chronic lymphocytic leukemia. Toxicol. Rep. 12, 389\u2013396 (2024).","journal-title":"Toxicol. Rep."},{"key":"7770_CR46","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s13539-014-0141-2","volume":"5","author":"E. E Talbert","year":"2014","unstructured":"Talbert, E. E., Metzger, G. A., He, W. A. & Guttridge, D. C. Modeling human cancer cachexia in colon 26 tumor-bearing adult mice. J. Cachexia Sarcopenia Muscle 5, 321\u2013328 (2014).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"7770_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153858","volume":"95","author":"Q Shen","year":"2022","unstructured":"Shen, Q. et al. Alantolactone ameliorates cancer cachexia-associated muscle atrophy mainly by inhibiting the STAT3 signaling pathway. Phytomedicine 95, 153858 (2022).","journal-title":"Phytomedicine"},{"key":"7770_CR48","doi-asserted-by":"publisher","first-page":"2674","DOI":"10.1016\/j.jmb.2019.05.032","volume":"431","author":"F Penna","year":"2019","unstructured":"Penna, F. et al. Autophagy exacerbates muscle wasting in cancer cachexia and impairs mitochondrial function. J. Mol. Biol. 431, 2674\u20132686 (2019).","journal-title":"J. Mol. Biol."}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-07770-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-07770-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-07770-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T23:03:42Z","timestamp":1744239822000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-07770-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,9]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["7770"],"URL":"https:\/\/doi.org\/10.1038\/s42003-025-07770-0","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,9]]},"assertion":[{"value":"6 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"585"}}