{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:47:44Z","timestamp":1792813664499,"version":"4.5.0"},"reference-count":98,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871181"],"award-info":[{"award-number":["81871181"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-025-07880-9","type":"journal-article","created":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T01:28:23Z","timestamp":1742606903000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["HIF1A facilitates hypoxia-induced changes in H3K27ac modification to promote myometrial contractility"],"prefix":"10.1038","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6293-6694","authenticated-orcid":false,"given":"Kaiyuan","family":"Ji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bolun","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunshan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lele","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guozheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1437-6749","authenticated-orcid":false,"given":"Yanmin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1197-5343","authenticated-orcid":false,"given":"Huishu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"7880_CR1","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/978-981-13-5895-1_10","volume":"1124","author":"S Wray","year":"2019","unstructured":"Wray, S. & Prendergast, C. The myometrium: from excitation to cntractions and labour. Adv. Exp. Med. Biol. 1124, 233\u2013263 (2019).","journal-title":"Adv. Exp. Med. Biol."},{"key":"7880_CR2","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.21873\/invivo.12392","volume":"35","author":"A Koutras","year":"2021","unstructured":"Koutras, A. et al. Physiology and pathology of contractility of the myometrium.  Vivo 35, 1401\u20131408 (2021).","journal-title":"Vivo"},{"key":"7880_CR3","doi-asserted-by":"publisher","first-page":"S1209","DOI":"10.1016\/j.ajog.2022.09.003","volume":"228","author":"H Rosen","year":"2023","unstructured":"Rosen, H. & Yogev, Y. Assessment of uterine contractions in labor and delivery. Am. J. Obstet. Gynecol. 228, S1209\u2013S1221 (2023).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"7880_CR4","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.addr.2021.04.021","volume":"174","author":"H. C Zierden","year":"2021","unstructured":"Zierden, H. C., Shapiro, R. L., DeLong, K., Carter, D. M. & Ensign, L. M. Next generation strategies for preventing preterm birth. Adv. Drug Deliv. Rev. 174, 190\u2013209 (2021).","journal-title":"Adv. Drug Deliv. Rev."},{"key":"7880_CR5","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1234","volume":"13","author":"K Ji","year":"2023","unstructured":"Ji, K. et al. Integrating single-cell RNA sequencing with spatial transcriptomics reveals an immune landscape of human myometrium during labour. Clin. Transl. Med. 13, e1234 (2023).","journal-title":"Clin. Transl. Med."},{"key":"7880_CR6","doi-asserted-by":"crossref","unstructured":"Deng, W. et al. Proteomic and miRNA profiles of exosomes derived from myometrial tissue in laboring women. Int. J. Mol. Sci. 23, 12343 (2022).","DOI":"10.3390\/ijms232012343"},{"key":"7880_CR7","doi-asserted-by":"publisher","first-page":"812105","DOI":"10.3389\/fgene.2022.812105","volume":"13","author":"L Chen","year":"2022","unstructured":"Chen, L. et al. Time course analysis of transcriptome in human myometrium depending on labor duration and correlating with postpartum blood loss. Front. Genet. 13, 812105 (2022).","journal-title":"Front. Genet."},{"key":"7880_CR8","doi-asserted-by":"publisher","first-page":"9763","DOI":"10.1073\/pnas.1503497112","volume":"112","author":"M Alotaibi","year":"2015","unstructured":"Alotaibi, M., Arrowsmith, S. & Wray, S. Hypoxia-induced force increase (HIFI) is a novel mechanism underlying the strengthening of labor contractions, produced by hypoxic stresses. Proc. Natl. Acad. Sci. USA 112, 9763\u20139768 (2015).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"7880_CR9","doi-asserted-by":"publisher","first-page":"F67","DOI":"10.1530\/REP-20-0327","volume":"161","author":"S Wray","year":"2021","unstructured":"Wray, S., Alruwaili, M. & Prendergast, C. HYPOXIA AND REPRODUCTIVE HEALTH: hypoxia and labour. Reproduction 161, F67\u2013F80 (2021).","journal-title":"Reproduction"},{"key":"7880_CR10","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1093\/biolre\/ioac174","volume":"107","author":"B Wen","year":"2022","unstructured":"Wen, B. et al. HIF-1alpha is essential for the augmentation of myometrial contractility during labordagger. Biol. Reprod. 107, 1540\u20131550 (2022).","journal-title":"Biol. Reprod."},{"key":"7880_CR11","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202301804R","volume":"38","author":"X Wang","year":"2024","unstructured":"Wang, X. et al. Serpin family E member 1 enhances myometrium contractility by increasing ATP production during labor. Faseb J. 38, e23368 (2024).","journal-title":"Faseb J."},{"key":"7880_CR12","first-page":"51","volume":"80","author":"J. E Ziello","year":"2007","unstructured":"Ziello, J. E., Jovin, I. S. & Huang, Y. Hypoxia-Inducible Factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia. Yale J. Biol. Med. 80, 51\u201360 (2007).","journal-title":"Yale J. Biol. Med."},{"key":"7880_CR13","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4577-1","volume":"18","author":"H Harrison","year":"2018","unstructured":"Harrison, H., Pegg, H. J., Thompson, J., Bates, C. & Shore, P. HIF1-alpha expressing cells induce a hypoxic-like response in neighbouring cancer cells. Bmc Cancer 18, 674 (2018).","journal-title":"Bmc Cancer"},{"key":"7880_CR14","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3390\/cells8050384","volume":"8","author":"M. J Strowitzki","year":"2019","unstructured":"Strowitzki, M. J., Cummins, E. P. & Taylor, C. T. Protein hydroxylation by hypoxia-inducible factor (HIF) hydroxylases: unique or ubiquitous? Cells 8, 5 (2019).","journal-title":"Cells"},{"key":"7880_CR15","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06893-9","volume":"9","author":"G Xiong","year":"2018","unstructured":"Xiong, G. et al. Collagen prolyl 4-hydroxylase 1 is essential for HIF-1alpha stabilization and TNBC chemoresistance. Nat. Commun. 9, 4456 (2018).","journal-title":"Nat. Commun."},{"key":"7880_CR16","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.ajog.2010.09.025","volume":"204","author":"P Mittal","year":"2011","unstructured":"Mittal, P. et al. A molecular signature of an arrest of descent in human parturition. Am. J. Obstet. Gynecol. 204, 115\u2013177 (2011).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"7880_CR17","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1515\/jpm-2013-0086","volume":"41","author":"P Chaemsaithong","year":"2013","unstructured":"Chaemsaithong, P. et al. Characterization of the myometrial transcriptome in women with an arrest of dilatation during labor. J. Perinat. Med. 41, 665\u2013681 (2013).","journal-title":"J. Perinat. Med."},{"key":"7880_CR18","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1093\/biolre\/ioac174","volume":"107","author":"B Wen","year":"2022","unstructured":"Wen, B. et al. HIF-1alpha is essential for the augmentation of myometrial contractility during labor. Biol. Reprod. 107, 6 (2022).","journal-title":"Biol. Reprod."},{"key":"7880_CR19","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1101\/gad.1529107","volume":"21","author":"J. J Lum","year":"2007","unstructured":"Lum, J. J. et al. The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev. 21, 1037\u20131049 (2007).","journal-title":"Genes Dev."},{"key":"7880_CR20","doi-asserted-by":"publisher","first-page":"722816","DOI":"10.3389\/fimmu.2021.722816","volume":"12","author":"L Chen","year":"2021","unstructured":"Chen, L. et al. Integrated proteotranscriptomics of human myometrium in labor landscape reveals the increased molecular asociated with inflammation under hypoxia stress. Front. Immunol. 12, 722816 (2021).","journal-title":"Front. Immunol."},{"key":"7880_CR21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000710","volume":"18","author":"V. M Shchuka","year":"2020","unstructured":"Shchuka, V. M. et al. The pregnant myometrium is epigenetically activated at contractility-driving gene loci prior to the onset of labor in mice. Plos. Biol. 18, e3000710 (2020).","journal-title":"Plos. Biol."},{"key":"7880_CR22","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1007\/s43032-022-01002-0","volume":"30","author":"A. J Dotts","year":"2023","unstructured":"Dotts, A. J. et al. In vivo genome-wide PGR binding in pregnant human myometrium identifies potential regulators of labor. Reprod. Sci. 30, 544\u2013559 (2023).","journal-title":"Reprod. Sci."},{"key":"7880_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/biom13010045","volume":"13","author":"W Wang","year":"2022","unstructured":"Wang, W. et al. Integrating transcriptomic and ChIP-seq reveals important regulatory regions modulating gene Expression in myometrium during implantation in pigs. Biomolecules 13, 1 (2022).","journal-title":"Biomolecules"},{"key":"7880_CR24","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s13238-020-00757-z","volume":"12","author":"R Xu","year":"2021","unstructured":"Xu, R., Li, C., Liu, X. & Gao, S. Insights into epigenetic patterns in mammalian early embryos. Protein Cell 12, 7\u201328 (2021).","journal-title":"Protein Cell"},{"key":"7880_CR25","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/nsmb.2470","volume":"20","author":"G. E Zentner","year":"2013","unstructured":"Zentner, G. E. & Henikoff, S. Regulation of nucleosome dynamics by histone modifications. Nat. Struct. Mol. Biol. 20, 259\u2013266 (2013).","journal-title":"Nat. Struct. Mol. Biol."},{"key":"7880_CR26","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1080\/21541264.2020.1713682","volume":"11","author":"J Yao","year":"2020","unstructured":"Yao, J., Chen, J., Li, L. Y. & Wu, M. Epigenetic plasticity of enhancers in cancer. Transcr. -Austin 11, 26\u201336 (2020).","journal-title":"Transcr. -Austin"},{"key":"7880_CR27","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1038\/s41588-022-01091-2","volume":"54","author":"A Sankar","year":"2022","unstructured":"Sankar, A. et al. Histone editing elucidates the functional roles of H3K27 methylation and acetylation in mammals. Nat. Genet 54, 754\u2013760 (2022).","journal-title":"Nat. Genet"},{"key":"7880_CR28","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1161\/CIRCRESAHA.118.312497","volume":"123","author":"W Zhang","year":"2018","unstructured":"Zhang, W., Song, M., Qu, J. & Liu, G. H. Epigenetic modifications in cardiovascular aging and diseases. Circ. Res. 123, 773\u2013786 (2018).","journal-title":"Circ. Res."},{"key":"7880_CR29","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/nrm3890","volume":"15","author":"P Tessarz","year":"2014","unstructured":"Tessarz, P. & Kouzarides, T. Histone core modifications regulating nucleosome structure and dynamics. Nat. Rev. Mol. Cell Biol. 15, 703\u2013708 (2014).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"7880_CR30","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1038\/nmeth.3999","volume":"13","author":"M. R Mumbach","year":"2016","unstructured":"Mumbach, M. R. et al. HiChIP: efficient and sensitive analysis of protein-directed genome architecture. Nat. Methods 13, 919\u2013922 (2016).","journal-title":"Nat. Methods"},{"key":"7880_CR31","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.devcel.2023.03.020","volume":"58","author":"P Zhou","year":"2023","unstructured":"Zhou, P. et al. Dynamic changes in P300 enhancers and enhancer-promoter contacts control mouse cardiomyocyte maturation. Dev. Cell. 58, 898\u2013914 (2023).","journal-title":"Dev. Cell."},{"key":"7880_CR32","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.cell.2017.02.007","volume":"169","author":"D Hnisz","year":"2017","unstructured":"Hnisz, D., Shrinivas, K., Young, R. A., Chakraborty, A. K. & Sharp, P. A. A phase separation model for transcriptional control. Cell 169, 13\u201323 (2017).","journal-title":"Cell"},{"key":"7880_CR33","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.cell.2013.03.035","volume":"153","author":"W. A Whyte","year":"2013","unstructured":"Whyte, W. A. et al. Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell 153, 307\u2013319 (2013).","journal-title":"Cell"},{"key":"7880_CR34","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/s42003-024-06201-w","volume":"7","author":"B Udayasuryan","year":"2024","unstructured":"Udayasuryan, B. et al. Fusobacterium nucleatum infection modulates the transcriptome and epigenome of HCT116 colorectal cancer cells in an oxygen-dependent manner. Commun. Biol. 7, 551 (2024).","journal-title":"Commun. Biol."},{"key":"7880_CR35","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1093\/nar\/gkx951","volume":"46","author":"M Tiana","year":"2018","unstructured":"Tiana, M. et al. The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia. Nucleic Acids Res. 46, 120\u2013133 (2018).","journal-title":"Nucleic Acids Res."},{"key":"7880_CR36","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","volume":"27","author":"A Liberzon","year":"2011","unstructured":"Liberzon, A. et al. Molecular signatures database (MSigDB) 3.0. Bioinformatics 27, 1739\u20131740 (2011).","journal-title":"Bioinformatics"},{"key":"7880_CR37","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1095\/biolreprod.105.045450","volume":"74","author":"W Massrieh","year":"2006","unstructured":"Massrieh, W. et al. Regulation of the MAFF transcription factor by proinflammatory cytokines in myometrial cells. Biol. Reprod. 74, 699\u2013705 (2006).","journal-title":"Biol. Reprod."},{"key":"7880_CR38","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1006\/bbrc.1999.1487","volume":"264","author":"T Kimura","year":"1999","unstructured":"Kimura, T. et al. Molecular cloning of a human MafF homologue, which specifically binds to the oxytocin receptor gene in term myometrium. Biochem. Biophys. Res. Commun. 264, 86\u201392 (1999).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"7880_CR39","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-024-00598-6","volume":"12","author":"K Ji","year":"2024","unstructured":"Ji, K. et al. Single-cell and spatial transcriptomics reveal alterations in trophoblasts at invasion sites and disturbed myometrial immune microenvironment in placenta accreta spectrum disorders. Biomark. Res. 12, 55 (2024).","journal-title":"Biomark. Res."},{"key":"7880_CR40","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1101\/gad.335794.119","volume":"34","author":"H Kang","year":"2020","unstructured":"Kang, H. et al. Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation. Genes Dev. 34, 913\u2013930 (2020).","journal-title":"Genes Dev."},{"key":"7880_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-981-15-8104-5_1","volume":"1283","author":"Y Zhang","year":"2021","unstructured":"Zhang, Y. et al. Overview of histone modification. Adv. Exp. Med. Biol. 1283, 1\u201316 (2021).","journal-title":"Adv. Exp. Med. Biol."},{"key":"7880_CR42","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.gde.2016.11.001","volume":"43","author":"E. T Wiles","year":"2017","unstructured":"Wiles, E. T. & Selker, E. U. H3K27 methylation: a promiscuous repressive chromatin mark. Curr. Opin. Genet. Dev. 43, 31\u201337 (2017).","journal-title":"Curr. Opin. Genet. Dev."},{"key":"7880_CR43","doi-asserted-by":"publisher","first-page":"2160551","DOI":"10.1080\/19491034.2022.2160551","volume":"14","author":"A Barral","year":"2023","unstructured":"Barral, A. & Dejardin, J. The chromatin signatures of enhancers and their dynamic regulation. Nucleus 14, 2160551 (2023).","journal-title":"Nucleus"},{"key":"7880_CR44","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.trecan.2021.10.004","volume":"8","author":"S. J Cowman","year":"2022","unstructured":"Cowman, S. J. & Koh, M. Y. Revisiting the HIF switch in the tumor and its immune microenvironment. Trends Cancer 8, 28\u201342 (2022).","journal-title":"Trends Cancer"},{"key":"7880_CR45","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3892\/mmr.2021.11991","volume":"23","author":"J Zheng","year":"2021","unstructured":"Zheng, J. et al. HIF\u20111alpha in myocardial ischemia\u2011reperfusion injury (Review). Mol. Med. Rep. 23, 5 (2021).","journal-title":"Mol. Med. Rep."},{"key":"7880_CR46","doi-asserted-by":"publisher","first-page":"145796","DOI":"10.1016\/j.gene.2021.145796","volume":"798","author":"M Rashid","year":"2021","unstructured":"Rashid, M. et al. Up-down regulation of HIF-1alpha in cancer progression. Gene 798, 145796 (2021).","journal-title":"Gene"},{"key":"7880_CR47","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-015-0054-z","volume":"3","author":"Anam","year":"2015","unstructured":"Anam et al. meta-analysis of hypoxia inducible factor 1-alpha (HIF1A) gene polymorphisms: association with cancers. Biomark. Res. 3, 29 (2015).","journal-title":"Biomark. Res."},{"key":"7880_CR48","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.mce.2018.01.003","volume":"473","author":"M Lappas","year":"2018","unstructured":"Lappas, M. Runt-related transcription factor 1 (RUNX1) deficiency attenuates inflammation-induced pro-inflammatory and pro-labour mediators in myometrium. Mol. Cell. Endocrinol. 473, 61\u201371 (2018).","journal-title":"Mol. Cell. Endocrinol."},{"key":"7880_CR49","doi-asserted-by":"publisher","first-page":"155707","DOI":"10.1016\/j.cyto.2021.155707","volume":"148","author":"Q Huang","year":"2021","unstructured":"Huang, Q. et al. Elevated inflammatory mediators from the maternal-fetal interface to fetal circulation during labor. Cytokine 148, 155707 (2021).","journal-title":"Cytokine"},{"key":"7880_CR50","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3390\/cells12050798","volume":"12","author":"A Yfantis","year":"2023","unstructured":"Yfantis, A. et al. Transcriptional response to hypoxia: the role of HIF-1-associated co-regulators. Cells 12, 5 (2023).","journal-title":"Cells"},{"key":"7880_CR51","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1093\/molehr\/gaad034","volume":"29","author":"J Bao","year":"2023","unstructured":"Bao, J. et al. Upregulated TIMP1 facilitates and coordinates myometrial contraction by decreasing collagens and cell adhesive capacity during human labor. Mol. Hum. Reprod. 29, 10 (2023).","journal-title":"Mol. Hum. Reprod."},{"key":"7880_CR52","doi-asserted-by":"publisher","first-page":"1115619","DOI":"10.3389\/fendo.2023.1115619","volume":"14","author":"T Li","year":"2023","unstructured":"Li, T. et al. High glucose induced HIF-1alpha\/TREK1 expression and myometrium relaxation during pregnancy. Front. Endocrinol. 14, 1115619 (2023).","journal-title":"Front. Endocrinol."},{"key":"7880_CR53","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1038\/s41580-020-0227-y","volume":"21","author":"P Lee","year":"2020","unstructured":"Lee, P., Chandel, N. S. & Simon, M. C. Cellular adaptation to hypoxia through hypoxia inducible factors and beyond. Nat. Rev. Mol. Cell Biol. 21, 268\u2013283 (2020).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"7880_CR54","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s13045-022-01292-6","volume":"15","author":"Q Wu","year":"2022","unstructured":"Wu, Q. et al. Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape. J. Hematol. Oncol. 15, 77 (2022).","journal-title":"J. Hematol. Oncol."},{"key":"7880_CR55","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-13-91","volume":"13","author":"K. M Reece","year":"2014","unstructured":"Reece, K. M. et al. Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1alpha\/p300 complex in a preclinical model of prostate cancer. Mol. Cancer 13, 91 (2014).","journal-title":"Mol. Cancer"},{"key":"7880_CR56","doi-asserted-by":"publisher","first-page":"3338","DOI":"10.1080\/15548627.2021.1872227","volume":"17","author":"R He","year":"2021","unstructured":"He, R. et al. HIF1A Alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy. Autophagy 17, 3338\u20133360 (2021).","journal-title":"Autophagy"},{"key":"7880_CR57","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.1447","volume":"12","author":"C Fan","year":"2023","unstructured":"Fan, C. et al. Hypoxia-inducible factor-1alpha regulates the interleukin-6 production by B cells in rheumatoid arthritis. Clin. Transl. Immunol. 12, e1447 (2023).","journal-title":"Clin. Transl. Immunol."},{"key":"7880_CR58","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3390\/ijms232314589","volume":"23","author":"K Eltarhoni","year":"2022","unstructured":"Eltarhoni, K., Kamel, F., Ihebunezie, K., Nisar, P. & Soloviev, M. Therapeutic antibodies in cancer treatment in the UK. Int. J. Mol. Sci. 23, 23 (2022).","journal-title":"Int. J. Mol. Sci."},{"key":"7880_CR59","doi-asserted-by":"publisher","first-page":"174178","DOI":"10.1016\/j.ejphar.2021.174178","volume":"905","author":"W Alshaer","year":"2021","unstructured":"Alshaer, W. et al. siRNA: Mechanism of action, challenges, and therapeutic approaches. Eur. J. Pharmacol. 905, 174178 (2021).","journal-title":"Eur. J. Pharmacol."},{"key":"7880_CR60","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1007\/s11864-023-01090-3","volume":"24","author":"J Wang","year":"2023","unstructured":"Wang, J., Tomlinson, B. & Lazarus, H. M. Update on small molecule targeted therapies for acute myeloid leukemia. Curr. Treat. Options Oncol. 24, 770\u2013801 (2023).","journal-title":"Curr. Treat. Options Oncol."},{"key":"7880_CR61","doi-asserted-by":"publisher","first-page":"6850","DOI":"10.1111\/febs.15776","volume":"288","author":"N. K Karamanos","year":"2021","unstructured":"Karamanos, N. K. et al. A guide to the composition and functions of the extracellular matrix. Febs J. 288, 6850\u20136912 (2021).","journal-title":"Febs J."},{"key":"7880_CR62","doi-asserted-by":"publisher","first-page":"021002","DOI":"10.1088\/1478-3975\/ac4390","volume":"19","author":"A. D Doyle","year":"2022","unstructured":"Doyle, A. D., Nazari, S. S. & Yamada, K. M. Cell-extracellular matrix dynamics. Phys. Biol. 19, 021002 (2022).","journal-title":"Phys. Biol."},{"key":"7880_CR63","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1177\/1933719117732158","volume":"25","author":"A Lombardi","year":"2018","unstructured":"Lombardi, A. et al. Expression of matrix metalloproteinases in the mouse uterus and human myometrium during pregnancy, labor, and preterm labor. Reprod. Sci. 25, 938\u2013949 (2018).","journal-title":"Reprod. Sci."},{"key":"7880_CR64","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1002\/jcb.29424","volume":"121","author":"Y Fan","year":"2020","unstructured":"Fan, Y. et al. Peptidomics analysis of myometrium tissues in term labor compared with term nonlabor. J. Cell. Biochem. 121, 1890\u20131900 (2020).","journal-title":"J. Cell. Biochem."},{"key":"7880_CR65","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1093\/biolre\/ioac102","volume":"107","author":"A Ouellette","year":"2022","unstructured":"Ouellette, A., Mahendroo, M. & Nallasamy, S. Collagen and elastic fiber remodeling in the pregnant mouse myometriumdagger. Biol. Reprod. 107, 741\u2013751 (2022).","journal-title":"Biol. Reprod."},{"key":"7880_CR66","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-48798-8","volume":"13","author":"K Islam","year":"2023","unstructured":"Islam, K. et al. Upregulated LAMA3 modulates proliferation, adhesion, migration and epithelial\u2011to\u2011mesenchymal transition of cholangiocarcinoma cells. Sci. Rep. 13, 22598 (2023).","journal-title":"Sci. Rep."},{"key":"7880_CR67","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/s41420-024-01886-8","volume":"10","author":"S Polo-Generelo","year":"2024","unstructured":"Polo-Generelo, S. et al. Serpine1 mRNA confers mesenchymal characteristics to the cell and promotes CD8+ T cells exclusion from colon adenocarcinomas. Cell Death Discov. 10, 116 (2024).","journal-title":"Cell Death Discov."},{"key":"7880_CR68","doi-asserted-by":"publisher","first-page":"1334931","DOI":"10.3389\/fmolb.2024.1334931","volume":"11","author":"S Wu","year":"2024","unstructured":"Wu, S. et al. Serpin peptidase inhibitor, clade E, member 2 in physiology and pathology: recent advancements. Front. Mol. Biosci. 11, 1334931 (2024).","journal-title":"Front. Mol. Biosci."},{"key":"7880_CR69","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3390\/cells12242851","volume":"12","author":"F Chellini","year":"2023","unstructured":"Chellini, F. et al. HIF-1alpha\/MMP-9 axis is required in the early phases of skeletal myoblast differentiation under normoxia condition in vitro. Cells 12, 24 (2023).","journal-title":"Cells"},{"key":"7880_CR70","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.molimm.2012.08.018","volume":"53","author":"G Li","year":"2013","unstructured":"Li, G. et al. Interleukin-17A promotes rheumatoid arthritis synoviocytes migration and invasion under hypoxia by increasing MMP2 and MMP9 expression through NF-kappaB\/HIF-1alpha pathway. Mol. Immunol. 53, 227\u2013236 (2013).","journal-title":"Mol. Immunol."},{"key":"7880_CR71","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1093\/jbcr\/iraa139","volume":"42","author":"W Jiang","year":"2021","unstructured":"Jiang, W. et al. HIF-1alpha enhances vascular endothelial cell permeability through degradation and translocation of vascular endothelial cadherin and claudin-5 in rats with burn injury. J. Burn Care Res. 42, 258\u2013268 (2021).","journal-title":"J. Burn Care Res."},{"key":"7880_CR72","doi-asserted-by":"publisher","first-page":"17894","DOI":"10.3748\/wjg.v20.i47.17894","volume":"20","author":"N. N Tang","year":"2014","unstructured":"Tang, N. N. et al. HIF-1alpha induces VE-cadherin expression and modulates vasculogenic mimicry in esophageal carcinoma cells. World J. Gastroenterol. 20, 17894\u201317904 (2014).","journal-title":"World J. Gastroenterol."},{"key":"7880_CR73","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.4049\/jimmunol.0903244","volume":"185","author":"S Winning","year":"2010","unstructured":"Winning, S., Splettstoesser, F., Fandrey, J. & Frede, S. Acute hypoxia induces HIF-independent monocyte adhesion to endothelial cells through increased intercellular adhesion molecule-1 expression: the role of hypoxic inhibition of prolyl hydroxylase activity for the induction of NF-kappa B. J. Immunol. 185, 1786\u20131793 (2010).","journal-title":"J. Immunol."},{"key":"7880_CR74","first-page":"47","volume":"2","author":"A. J Harris","year":"2014","unstructured":"Harris, A. J., Thompson, A. R., Whyte, M. K. & Walmsley, S. R. HIF-mediated innate immune responses: cell signaling and therapeutic implications. Hypoxia 2, 47\u201358 (2014).","journal-title":"Hypoxia"},{"key":"7880_CR75","doi-asserted-by":"publisher","first-page":"2368","DOI":"10.7150\/thno.83938","volume":"13","author":"X Han","year":"2023","unstructured":"Han, X. et al. Lactate-mediated Fascin protrusions promote cell adhesion and migration in cervical cancer. Theranostics 13, 2368\u20132383 (2023).","journal-title":"Theranostics"},{"key":"7880_CR76","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3390\/ijms20081933","volume":"20","author":"B Sousa","year":"2019","unstructured":"Sousa, B., Pereira, J. & Paredes, J. The crosstalk between cell adhesion and cancer metabolism. Int. J. Mol. Sci. 20, 8 (2019).","journal-title":"Int. J. Mol. Sci."},{"key":"7880_CR77","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062014","volume":"8","author":"D Wu","year":"2013","unstructured":"Wu, D. et al. A novel function of novobiocin: disrupting the interaction of HIF 1alpha and p300\/CBP through direct binding to the HIF1alpha C-terminal activation domain. Plos One 8, e62014 (2013).","journal-title":"Plos One"},{"key":"7880_CR78","doi-asserted-by":"publisher","first-page":"5367","DOI":"10.1073\/pnas.082117899","volume":"99","author":"S. J Freedman","year":"2002","unstructured":"Freedman, S. J. et al. Structural basis for recruitment of CBP\/p300 by hypoxia-inducible factor-1 alpha. Proc. Natl Acad. Sci. USA 99, 5367\u20135372 (2002).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"7880_CR79","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24641-4","volume":"12","author":"G Crispatzu","year":"2021","unstructured":"Crispatzu, G. et al. The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo. Nat. Commun. 12, 4344 (2021).","journal-title":"Nat. Commun."},{"key":"7880_CR80","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","volume":"42","author":"Y Hao","year":"2024","unstructured":"Hao, Y. et al. Dictionary learning for integrative, multimodal and scalable single-cell analysis. Nat. Biotechnol. 42, 293\u2013304 (2024).","journal-title":"Nat. Biotechnol."},{"key":"7880_CR81","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. USA 102, 15545\u201315550 (2005).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"7880_CR82","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"D. W Huang","year":"2009","unstructured":"Huang, D. W., Sherman, B. T. & Lempicki, R. A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 4, 44\u201357 (2009).","journal-title":"Nat. Protoc."},{"key":"7880_CR83","doi-asserted-by":"publisher","first-page":"D1144","DOI":"10.1093\/nar\/gkr1013","volume":"40","author":"X Wang","year":"2012","unstructured":"Wang, X., Spandidos, A., Wang, H. & Seed, B. PrimerBank: a PCR primer database for quantitative gene expression analysis, 2012 update. Nucleic Acids Res. 40, D1144\u2013D1149 (2012).","journal-title":"Nucleic Acids Res"},{"key":"7880_CR84","doi-asserted-by":"publisher","first-page":"D205","DOI":"10.1093\/nar\/gkae684","volume":"53","author":"X Li","year":"2024","unstructured":"Li, X. et al. qPrimerDB 2.0: an updated comprehensive gene-specific qPCR primer database for 1172 organisms. Nucleic Acids Res. 53, D205\u2013D210 (2024).","journal-title":"Nucleic Acids Res"},{"key":"7880_CR85","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1038\/nprot.2016.095","volume":"11","author":"M Pertea","year":"2016","unstructured":"Pertea, M., Kim, D., Pertea, G. M., Leek, J. T. & Salzberg, S. L. Transcript-level expression analysis of RNA-seq experiments with HISAT, stringTie and ballgown. Nat. Protoc. 11, 1650\u20131667 (2016).","journal-title":"Nat. Protoc."},{"key":"7880_CR86","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","volume":"30","author":"Y Liao","year":"2014","unstructured":"Liao, Y., Smyth, G. K. & Shi, W. featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics 30, 923\u2013930 (2014).","journal-title":"Bioinformatics"},{"key":"7880_CR87","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"M. I Love","year":"2014","unstructured":"Love, M. I., Huber, W. & Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15, 550 (2014).","journal-title":"Genome Biol."},{"key":"7880_CR88","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","volume":"30","author":"A. M Bolger","year":"2014","unstructured":"Bolger, A. M., Lohse, M. & Usadel, B. Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics 30, 2114\u20132120 (2014).","journal-title":"Bioinformatics"},{"key":"7880_CR89","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2008-9-9-r137","volume":"9","author":"Y Zhang","year":"2008","unstructured":"Zhang, Y. et al. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 9, R137 (2008).","journal-title":"Genome Biol."},{"key":"7880_CR90","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","volume":"26","author":"A. R Quinlan","year":"2010","unstructured":"Quinlan, A. R. & Hall, I. M. BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics 26, 841\u2013842 (2010).","journal-title":"Bioinformatics"},{"key":"7880_CR91","doi-asserted-by":"publisher","first-page":"2382","DOI":"10.1093\/bioinformatics\/btv145","volume":"31","author":"G Yu","year":"2015","unstructured":"Yu, G., Wang, L. G. & He, Q. Y. ChIPseeker: an R\/bioconductor package for ChIP peak annotation, comparison and visualization. Bioinformatics 31, 2382\u20132383 (2015).","journal-title":"Bioinformatics"},{"key":"7880_CR92","doi-asserted-by":"publisher","first-page":"W160","DOI":"10.1093\/nar\/gkw257","volume":"44","author":"F Ramirez","year":"2016","unstructured":"Ramirez, F. et al. deepTools2: a next generation web server for deep-sequencing data analysis. Nucleic Acids Res. 44, W160\u2013W165 (2016).","journal-title":"Nucleic Acids Res."},{"key":"7880_CR93","doi-asserted-by":"publisher","first-page":"W39","DOI":"10.1093\/nar\/gkv416","volume":"43","author":"T. L Bailey","year":"2015","unstructured":"Bailey, T. L., Johnson, J., Grant, C. E. & Noble, W. S. The MEME Suite. Nucleic Acids Res. 43, W39\u2013W49 (2015).","journal-title":"Nucleic Acids Res."},{"key":"7880_CR94","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3390\/ijms25010019","volume":"24","author":"M Liu","year":"2023","unstructured":"Liu, M. et al. Three-dimensional gene regulation network in glioblastoma ferroptosis. Int. J. Mol. Sci. 24, 19 (2023).","journal-title":"Int. J. Mol. Sci."},{"key":"7880_CR95","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-015-0831-x","volume":"16","author":"N Servant","year":"2015","unstructured":"Servant, N. et al. HiC-Pro: an optimized and flexible pipeline for Hi-C data processing. Genome Biol. 16, 259 (2015).","journal-title":"Genome Biol."},{"key":"7880_CR96","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.1923","volume":"9","author":"B Langmead","year":"2012","unstructured":"Langmead, B. & Salzberg, S. L. Fast gapped-read alignment with Bowtie 2. Nat. Methods 9, 357\u2013359 (2012).","journal-title":"Nat. Methods"},{"key":"7880_CR97","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.cels.2018.01.001","volume":"6","author":"J. T Robinson","year":"2018","unstructured":"Robinson, J. T. et al. Juicebox.js provides a cloud-based visualization system for Hi-C data. Cell Syst. 6, 256\u2013258 (2018).","journal-title":"Cell Syst."},{"key":"7880_CR98","doi-asserted-by":"publisher","first-page":"W774","DOI":"10.1093\/nar\/gkac238","volume":"50","author":"D Li","year":"2022","unstructured":"Li, D. et al. WashU epigenome browser update 2022. Nucleic Acids Res. 50, W774\u2013W781 (2022).","journal-title":"Nucleic Acids Res."}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-07880-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-07880-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-07880-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:35:37Z","timestamp":1742862937000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-07880-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,21]]},"references-count":98,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["7880"],"URL":"https:\/\/doi.org\/10.1038\/s42003-025-07880-9","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,21]]},"assertion":[{"value":"7 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Primary hMSMCs were isolated from pregnant women. This study has obtained approval from the Ethics Committee of the Guangzhou Women and Children Medical Center, with the Ethics Approval Number being 201915401. All ethical regulations relevant to human research participants were followed.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"475"}}