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The serotonergic psychedelic N,N-dimethyltryptamine (DMT) induces a profoundly immersive altered state of consciousness lasting under 20\u2009min, allowing the entire experience to be captured during a single functional magnetic resonance imaging (fMRI) scan. Using network control theory, we map energy trajectories of 14 individuals undergoing fMRI during DMT and placebo. We find that global control energy is reduced after DMT injection compared to placebo. Longitudinal trajectories of global control energy correlate with longitudinal trajectories of electroencephalography (EEG) signal diversity (a measure of entropy) and subjective drug intensity ratings. At the regional level, spatial patterns of DMT\u2019s effects on these metrics correlate with serotonin 2a receptor density from positron emission tomography (PET) data. Using receptor distribution and pharmacokinetic information, we recapitulate DMT\u2019s effects on global control energy trajectories, demonstrating control models can predict pharmacological effects on brain dynamics.<\/jats:p>","DOI":"10.1038\/s42003-025-08078-9","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T09:19:16Z","timestamp":1744967956000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Network control energy reductions under DMT relate to serotonin receptors, signal diversity, and subjective experience"],"prefix":"10.1038","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7102-7820","authenticated-orcid":false,"given":"S. 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