{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:50:10Z","timestamp":1792180210134,"version":"4.4.0"},"reference-count":86,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-025-08261-y","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T06:12:14Z","timestamp":1748585534000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Human placenta mesenchymal stromal cells alleviate intestinal inflammation and repair intestinal barrier function by activating AMPK-FXR pathway"],"prefix":"10.1038","volume":"8","author":[{"given":"Ruo","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qigu","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoling","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoxu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6945-0593","authenticated-orcid":false,"given":"Lanjuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6604-6867","authenticated-orcid":false,"given":"Hongcui","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4270-671X","authenticated-orcid":false,"given":"Jue","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"8261_CR1","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41572-020-0156-2","volume":"6","author":"G Roda","year":"2020","unstructured":"Roda, G. et al. Crohn\u2019s disease. Nat. Rev. Dis. Prim. 6, 22 (2020).","journal-title":"Nat. Rev. Dis. Prim."},{"key":"8261_CR2","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1016\/S0140-6736(16)31711-1","volume":"389","author":"J Torres","year":"2017","unstructured":"Torres, J., Mehandru, S., Colombel, J.-F. & Peyrin-Biroulet, L. Crohn\u2019s disease. Lancet Lond. Engl. 389, 1741\u20131755 (2017).","journal-title":"Lancet Lond. Engl."},{"key":"8261_CR3","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S2468-1253(19)30333-4","volume":"5","author":"G. B. D. 2017 Inflammatory Bowel Disease Collaborators","year":"2020","unstructured":"G. B. D. 2017 Inflammatory Bowel Disease Collaborators The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol. Hepatol. 5, 17\u201330 (2020).","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"8261_CR4","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3748\/wjg.v24.i1.15","volume":"24","author":"N Li","year":"2018","unstructured":"Li, N. & Shi, R.-H. Updated review on immune factors in pathogenesis of Crohn\u2019s disease. World J. Gastroenterol. 24, 15\u201322 (2018).","journal-title":"World J. Gastroenterol."},{"key":"8261_CR5","doi-asserted-by":"publisher","first-page":"5267","DOI":"10.3390\/jcm11185267","volume":"11","author":"L Bertani","year":"2022","unstructured":"Bertani, L. Treatment and management of chronic inflammatory bowel diseases: optimizing present and future therapeutic choices. J. Clin. Med. 11, 5267 (2022).","journal-title":"J. Clin. Med."},{"key":"8261_CR6","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1093\/ecco-jcc\/jjac013","volume":"16","author":"FP N\u00fa\u00f1ez","year":"2022","unstructured":"N\u00fa\u00f1ez, F. P., Quera, R., Bay, C., Castro, F. & Mezzano, G. Drug-induced liver injury used in the treatment of inflammatory bowel disease. J. Crohns Colitis 16, 1168\u20131176 (2022).","journal-title":"J. Crohns Colitis"},{"key":"8261_CR7","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.autrev.2019.03.002","volume":"18","author":"DY Jeong","year":"2019","unstructured":"Jeong, D.Y. Induction and maintenance treatment of inflammatory bowel disease: a comprehensive review. Autoimmun. Rev. 18, 439\u2013454 (2019).","journal-title":"Autoimmun. Rev."},{"key":"8261_CR8","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s13287-020-1552-y","volume":"11","author":"S-N Li","year":"2020","unstructured":"Li, S.-N. & Wu, J.-F. TGF-\u03b2\/SMAD signaling regulation of mesenchymal stem cells in adipocyte commitment. Stem Cell Res. Ther. 11, 41 (2020).","journal-title":"Stem Cell Res. Ther."},{"key":"8261_CR9","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1007\/s12015-021-10170-6","volume":"17","author":"TZ Brose","year":"2021","unstructured":"Brose, T. Z., Kubosch, E. J., Schmal, H., Stoddart, M. J. & Armiento, A. R. Crosstalk between mesenchymal stromal cells and chondrocytes: the hidden therapeutic potential for cartilage regeneration. Stem Cell Rev. Rep. 17, 1647\u20131665 (2021).","journal-title":"Stem Cell Rev. Rep."},{"key":"8261_CR10","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/978-1-0716-1425-9_3","volume":"2308","author":"Z Abou Nader","year":"2021","unstructured":"Abou Nader, Z., Esp\u00e9li, M., Balabanian, K. & Lemos, P. J. Culture, expansion and differentiation of mouse bone-derived mesenchymal stromal cells. Methods Mol. Biol. Clifton NJ 2308, 35\u201346 (2021).","journal-title":"Methods Mol. Biol. Clifton NJ"},{"key":"8261_CR11","volume":"35","author":"Z Yao","year":"2021","unstructured":"Yao, Z. et al. CCL2 is a critical mechano-responsive mediator in crosstalk between osteoblasts and bone mesenchymal stromal cells. FASEB J. Publ. Fed. Am. Soc. Exp. Biol. 35, e21851 (2021).","journal-title":"FASEB J. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"8261_CR12","doi-asserted-by":"crossref","unstructured":"Feng, X. et al. Mesenchymal stem cells alleviate mouse liver fibrosis by inhibiting pathogenic function of intrahepatic B cells. Hepatol. Baltim. 81, 1221\u20131227 (2024).","DOI":"10.1097\/HEP.0000000000000831"},{"key":"8261_CR13","first-page":"100889","volume":"19","author":"W Chen","year":"2024","unstructured":"Chen, W. et al. MSC-derived exosomes attenuate hepatic fibrosis in primary sclerosing cholangitis through inhibition of Th17 differentiation. Asian J. Pharm. Sci. 19, 100889 (2024).","journal-title":"Asian J. Pharm. Sci."},{"key":"8261_CR14","doi-asserted-by":"publisher","first-page":"106229","DOI":"10.1016\/j.phrs.2022.106229","volume":"179","author":"J Zhou","year":"2022","unstructured":"Zhou, J. et al. Mesenchymal stem cell treatment restores liver macrophages homeostasis to alleviate mouse acute liver injury revealed by single-cell analysis. Pharmacol. Res. 179, 106229 (2022).","journal-title":"Pharmacol. Res."},{"key":"8261_CR15","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1186\/s13287-023-03543-w","volume":"14","author":"H Yang","year":"2023","unstructured":"Yang, H., Cheong, S., He, Y. & Lu, F. Mesenchymal stem cell-based therapy for autoimmune-related fibrotic skin diseases-systemic sclerosis and sclerodermatous graft-versus-host disease. Stem Cell Res. Ther. 14, 372 (2023).","journal-title":"Stem Cell Res. Ther."},{"key":"8261_CR16","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1186\/s13287-021-02533-0","volume":"12","author":"R Wang","year":"2021","unstructured":"Wang, R. et al. Stem cell therapy for Crohn\u2019s disease: systematic review and meta-analysis of preclinical and clinical studies. Stem Cell Res. Ther. 12, 463 (2021).","journal-title":"Stem Cell Res. Ther."},{"key":"8261_CR17","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1093\/ecco-jcc\/jjab154","volume":"16","author":"S Vieujean","year":"2022","unstructured":"Vieujean, S. et al. Mesenchymal stem cell injection in Crohn\u2019s disease strictures: a phase I-II clinical study. J. Crohns Colitis 16, 506\u2013510 (2022).","journal-title":"J. Crohns Colitis"},{"key":"8261_CR18","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s12929-023-00935-1","volume":"30","author":"H Wade","year":"2023","unstructured":"Wade, H. et al. Akkermansia muciniphila and its membrane protein ameliorates intestinal inflammatory stress and promotes epithelial wound healing via CREBH and miR-143\/145. J. Biomed. Sci. 30, 38 (2023).","journal-title":"J. Biomed. Sci."},{"key":"8261_CR19","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1210\/er.2001-0033","volume":"23","author":"SM Firth","year":"2002","unstructured":"Firth, S. M. & Baxter, R. C. Cellular actions of the insulin-like growth factor binding proteins. Endocr. Rev. 23, 824\u2013854 (2002).","journal-title":"Endocr. Rev."},{"key":"8261_CR20","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1161\/CIRCULATIONAHA.123.064719","volume":"150","author":"M Katoh","year":"2024","unstructured":"Katoh, M. et al. Vaccine therapy for heart failure targeting the inflammatory cytokine Igfbp7. Circulation 150, 374\u2013389 (2024).","journal-title":"Circulation"},{"key":"8261_CR21","doi-asserted-by":"publisher","first-page":"29890","DOI":"10.1074\/jbc.M113.510826","volume":"288","author":"P Fu","year":"2013","unstructured":"Fu, P., Yang, Z. & Bach, L. A. Prohibitin-2 binding modulates insulin-like growth factor-binding protein-6 (IGFBP-6)-induced rhabdomyosarcoma cell migration. J. Biol. Chem. 288, 29890\u201329900 (2013).","journal-title":"J. Biol. Chem."},{"key":"8261_CR22","doi-asserted-by":"publisher","first-page":"3456","DOI":"10.1210\/endo.139.8.6150","volume":"139","author":"SE Damon","year":"1998","unstructured":"Damon, S. E., Maddison, L., Ware, J. L. & Plymate, S. R. Overexpression of an inhibitory insulin-like growth factor binding protein (IGFBP), IGFBP-4, delays onset of prostate tumor formation. Endocrinology 139, 3456\u20133464 (1998).","journal-title":"Endocrinology"},{"key":"8261_CR23","doi-asserted-by":"publisher","first-page":"2278","DOI":"10.1210\/en.2011-0047","volume":"152","author":"DO Daza","year":"2011","unstructured":"Daza, D. O., Sundstr\u00f6m, G., Bergqvist, C. A., Duan, C. & Larhammar, D. Evolution of the insulin-like growth factor binding protein (IGFBP) family. Endocrinology 152, 2278\u20132289 (2011).","journal-title":"Endocrinology"},{"key":"8261_CR24","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1210\/en.2007-1068","volume":"149","author":"VE DeMambro","year":"2008","unstructured":"DeMambro, V. E. et al. Gender-specific changes in bone turnover and skeletal architecture in IGFBP-2-null mice. Endocrinology 149, 2051\u20132061 (2008).","journal-title":"Endocrinology"},{"key":"8261_CR25","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1002\/jcb.24804","volume":"115","author":"Y Xue","year":"2014","unstructured":"Xue, Y. et al. Insulin-like growth factor binding protein 4 enhances cardiomyocytes induction in murine-induced pluripotent stem cells. J. Cell. Biochem. 115, 1495\u20131504 (2014).","journal-title":"J. Cell. Biochem."},{"key":"8261_CR26","doi-asserted-by":"publisher","first-page":"5268","DOI":"10.1210\/en.2005-1568","volume":"147","author":"X Yan","year":"2006","unstructured":"Yan, X., Baxter, R. C., Perbal, B. & Firth, S. M. The aminoterminal insulin-like growth factor (IGF) binding domain of IGF binding protein-3 cannot be functionally substituted by the structurally homologous domain of CCN3. Endocrinology 147, 5268\u20135274 (2006).","journal-title":"Endocrinology"},{"key":"8261_CR27","first-page":"1008","volume":"1","author":"B Chen","year":"2016","unstructured":"Chen, B. et al. AMPK: a bridge between inflammation and metabolism. JSM Atherosclerosis 1, 1008\u20131016 (2016).","journal-title":"JSM Atherosclerosis"},{"key":"8261_CR28","doi-asserted-by":"publisher","first-page":"260","DOI":"10.3389\/fphar.2017.00260","volume":"9","author":"J Yang","year":"2017","unstructured":"Yang, J. et al. Activation of sirt1\/FXR signaling pathway attenuates triptolide-induced hepatotoxicity in rats. Front. Pharm. 9, 260 (2017).","journal-title":"Front. Pharm."},{"key":"8261_CR29","doi-asserted-by":"publisher","first-page":"115248","DOI":"10.1016\/j.taap.2020.115248","volume":"408","author":"T Li","year":"2020","unstructured":"Li, T. et al. Picroside II alleviates liver injury induced by alpha-naphthylisothiocyanate through AMPK-FXR pathway. Toxicol. Appl. Pharmacol. 408, 115248 (2020).","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"8261_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.phrs.2013.08.008","volume":"77","author":"B Renga","year":"2013","unstructured":"Renga, B. et al. FXR mediates a chromatin looping in the GR promoter thus promoting the resolution of colitis in rodents. Pharmacol. Res. 77, 1\u201310 (2013).","journal-title":"Pharmacol. Res."},{"key":"8261_CR31","doi-asserted-by":"publisher","first-page":"6251","DOI":"10.4049\/jimmunol.0803978","volume":"183","author":"P Vavassori","year":"2009","unstructured":"Vavassori, P., Mencarelli, A., Renga, B., Distrutti, E. & Fiorucci, S. The bile acid receptor FXR is a modulator of intestinal innate immunity. J. Immunol. Baltim.183, 6251\u20136261 (2009).","journal-title":"J. Immunol. Baltim."},{"key":"8261_CR32","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1172\/JCI12559","volume":"107","author":"W Strober","year":"2001","unstructured":"Strober, W., Nakamura, K. & Kitani, A. The SAMP1\/Yit mouse: another step closer to modeling human inflammatory bowel disease. J. Clin. Invest. 107, 667\u2013670 (2001).","journal-title":"J. Clin. Invest."},{"key":"8261_CR33","doi-asserted-by":"publisher","first-page":"197","DOI":"10.26599\/JNR.2020.9040021","volume":"8","author":"S Xiang","year":"2020","unstructured":"Xiang, S. et al. Standards of clinical-grade mesenchymal stromal cell preparation and quality control (2020 China Version). J. Neurorestoratol.8, 197\u2013216 (2020).","journal-title":"J. Neurorestoratol."},{"key":"8261_CR34","doi-asserted-by":"publisher","first-page":"2821","DOI":"10.1182\/blood-2004-09-3696","volume":"105","author":"S Glennie","year":"2005","unstructured":"Glennie, S. et al. Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells. Blood 105, 2821\u20132827 (2005).","journal-title":"Blood"},{"key":"8261_CR35","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1007\/BF02256058","volume":"10","author":"MK Majumdar","year":"2003","unstructured":"Majumdar, M. K. et al. Characterization and functionality of cell surface molecules on human mesenchymal stem cells. J. Biomed. Sci. 10, 228\u2013241 (2003).","journal-title":"J. Biomed. Sci."},{"key":"8261_CR36","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.stem.2007.11.014","volume":"2","author":"G Ren","year":"2008","unstructured":"Ren, G. et al. Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell 2, 141\u2013150 (2008).","journal-title":"Cell Stem Cell"},{"key":"8261_CR37","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.4049\/jimmunol.0902023","volume":"184","author":"G Ren","year":"2010","unstructured":"Ren, G. et al. Inflammatory cytokine-induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in mesenchymal stem cells are critical for immunosuppression. J. Immunol. 184, 2321\u20132328 (2010).","journal-title":"J. Immunol."},{"key":"8261_CR38","doi-asserted-by":"publisher","first-page":"2741","DOI":"10.1002\/eji.201343335","volume":"43","author":"F Gieseke","year":"2013","unstructured":"Gieseke, F. et al. Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation. Eur. J. Immunol. 43, 2741\u20132749 (2013).","journal-title":"Eur. J. Immunol."},{"key":"8261_CR39","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1002\/stem.2254","volume":"34","author":"P Luz-Crawford","year":"2016","unstructured":"Luz-Crawford, P. et al. Mesenchymal stem cell-derived interleukin 1 receptor antagonist promotes macrophage polarization and inhibits B cell differentiation. Stem Cells 34, 483\u2013492 (2016).","journal-title":"Stem Cells"},{"key":"8261_CR40","doi-asserted-by":"publisher","first-page":"4991","DOI":"10.1182\/blood-2008-07-166892","volume":"112","author":"M Rafei","year":"2008","unstructured":"Rafei, M. et al. Mesenchymal stromal cell\u2013derived CCL2 suppresses plasma cell immunoglobulin production via STAT3 inactivation and PAX5 induction. Blood 112, 4991\u20134998 (2008).","journal-title":"Blood"},{"key":"8261_CR41","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1111\/j.1582-4934.2011.01391.x","volume":"16","author":"F Saldanha-Araujo","year":"2012","unstructured":"Saldanha-Araujo, F. et al. Mesenchymal stem cells promote the sustained expression of CD69 on activated T lymphocytes: roles of canonical and non-canonical NF-\u03baB signalling. J. Cell Mol. Med. 16, 1232\u20131244 (2012).","journal-title":"J. Cell Mol. Med."},{"key":"8261_CR42","doi-asserted-by":"publisher","first-page":"728190","DOI":"10.3389\/fimmu.2021.728190","volume":"12","author":"A Li","year":"2021","unstructured":"Li, A. et al. Mesenchymal stem cell therapy: hope for patients with systemic lupus erythematosus. Front. Immunol. 12, 728190 (2021).","journal-title":"Front. Immunol."},{"key":"8261_CR43","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/s41577-019-0240-6","volume":"20","author":"AC Doran","year":"2020","unstructured":"Doran, A. C. et al. Efferocytosis in health and disease. Nat. Rev. Immunol. 20, 254\u2013267 (2020).","journal-title":"Nat. Rev. Immunol."},{"key":"8261_CR44","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.2147\/IJN.S355366","volume":"17","author":"S Wang","year":"2022","unstructured":"Wang, S. et al. Targeted therapy for inflammatory diseases with mesenchymal stem cells and their derived exosomes: from basic to clinics. Int. J. Nanomed. 17, 1757\u20131781 (2022).","journal-title":"Int. J. Nanomed."},{"key":"8261_CR45","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.3390\/ijms22041790","volume":"22","author":"B Usunier","year":"2021","unstructured":"Usunier, B. et al. HGF and TSG-6 released by mesenchymal stem cells attenuate colon radiation-induced fibrosis. Int. J. Mol. Sci. 22, 1790 (2021).","journal-title":"Int. J. Mol. Sci."},{"key":"8261_CR46","doi-asserted-by":"publisher","first-page":"835005","DOI":"10.3389\/fimmu.2022.835005","volume":"13","author":"Y Wang","year":"2022","unstructured":"Wang, Y. et al. Intestinal fibrosis in inflammatory bowel disease and the prospects of mesenchymal stem cell therapy. Front. Immunol. 13, 835005 (2022).","journal-title":"Front. Immunol."},{"key":"8261_CR47","doi-asserted-by":"publisher","first-page":"660614","DOI":"10.3389\/fmed.2021.660614","volume":"8","author":"L Gu","year":"2021","unstructured":"Gu, L. et al. Exosomal microRNA-181a derived from mesenchymal stem cells improves gut microbiota composition, barrier function, and inflammatory status in an experimental colitis model. Front. Med. 8, 660614 (2021).","journal-title":"Front. Med."},{"key":"8261_CR48","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.addr.2015.05.001","volume":"87","author":"SM Hammond","year":"2015","unstructured":"Hammond, S. M. An overview of microRNAs. Adv. Drug Deliv. Rev. 87, 3\u201314 (2015).","journal-title":"Adv. Drug Deliv. Rev."},{"key":"8261_CR49","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1038\/s41580-020-0232-1","volume":"21","author":"E Boada-Romero","year":"2020","unstructured":"Boada-Romero, E. et al. The clearance of dead cells by efferocytosis. Nat. Rev. Mol. Cell Biol. 21, 398\u2013414 (2020).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"8261_CR50","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1016\/j.immuni.2019.04.018","volume":"50","author":"S Morioka","year":"2019","unstructured":"Morioka, S. et al. Living on the edge: efferocytosis at the interface of homeostasis and pathology. Immunity 50, 1149\u20131162 (2019).","journal-title":"Immunity"},{"key":"8261_CR51","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1038\/s41556-019-0431-1","volume":"21","author":"JSA Perry","year":"2019","unstructured":"Perry, J. S. A. et al. Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway. Nat. Cell Biol. 21, 1532\u20131543 (2019).","journal-title":"Nat. Cell Biol."},{"key":"8261_CR52","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.cmet.2018.12.004","volume":"29","author":"S Zhang","year":"2019","unstructured":"Zhang, S. et al. Efferocytosis fuels requirements of fatty acid oxidation and the electron transport chain to polarize macrophages for tissue repair. Cell Metab. 29, 443\u2013456.e5 (2019).","journal-title":"Cell Metab."},{"key":"8261_CR53","first-page":"267","volume":"4","author":"AJ Friedenstein","year":"1976","unstructured":"Friedenstein, A. J. et al. Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Exp. Hematol. 4, 267\u2013274 (1976).","journal-title":"Exp. Hematol."},{"key":"8261_CR54","first-page":"55","volume":"123","author":"JW Kuhbier","year":"2010","unstructured":"Kuhbier, J. W. et al. Isolation, characterization, differentiation, and application of adipose-derived stem cells. Adv. Biochem Eng. Biotechnol. 123, 55\u2013105 (2010).","journal-title":"Adv. Biochem Eng. Biotechnol."},{"key":"8261_CR55","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1046\/j.1365-2141.2000.01986.x","volume":"109","author":"A Erices","year":"2000","unstructured":"Erices, A. et al. Mesenchymal progenitor cells in human umbilical cord blood. Br. J. Haematol. 109, 235\u2013242 (2000).","journal-title":"Br. J. Haematol."},{"key":"8261_CR56","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/174328","volume":"2012","author":"V Sabapathy","year":"2012","unstructured":"Sabapathy, V. et al. Long-Term cultured human term placenta-derived mesenchymal stem cells of maternal origin displays plasticity. Stem Cells Int 2012, 174328 (2012).","journal-title":"Stem Cells Int"},{"key":"8261_CR57","doi-asserted-by":"publisher","first-page":"13625","DOI":"10.1073\/pnas.240309797","volume":"97","author":"S Gronthos","year":"2000","unstructured":"Gronthos, S. et al. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc. Natl. Acad. Sci. USA 97, 13625\u201313630 (2000).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"8261_CR58","doi-asserted-by":"publisher","first-page":"100508","DOI":"10.1016\/j.repbio.2021.100508","volume":"21","author":"P Pethe","year":"2021","unstructured":"Pethe, P. & Kale, V. Placenta: a gold mine for translational research and regenerative medicine. Reprod. Biol. 21, 100508 (2021).","journal-title":"Reprod. Biol."},{"key":"8261_CR59","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1089\/scd.2007.0154","volume":"17","author":"S Barlow","year":"2008","unstructured":"Barlow, S. et al. Comparison of human placenta- and bone marrow-derived multipotent mesenchymal stem cells. Stem Cells Dev. 17, 1095\u20131107 (2008).","journal-title":"Stem Cells Dev."},{"key":"8261_CR60","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.610544","volume":"17","author":"AR Silini","year":"2020","unstructured":"Silini, A. R. et al. Perinatal derivatives: where do we stand? A roadmap of the human placenta and consensus for tissue and cell nomenclature. Front. Bioeng. Biotechnol. 17, 610544 (2020).","journal-title":"Front. Bioeng. Biotechnol."},{"key":"8261_CR61","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1111\/apt.13717","volume":"44","author":"T Dhere","year":"2016","unstructured":"Dhere, T. et al. The safety of autologous and metabolically fit bone marrow mesenchymal stromal cells in medically refractory Crohn\u2019s disease - a phase 1 trial with three doses. Aliment. Pharmacol. Ther. 44, 471\u2013481 (2016).","journal-title":"Aliment. Pharmacol. Ther."},{"key":"8261_CR62","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1136\/gut.2010.215152","volume":"59","author":"M Duijvestein","year":"2010","unstructured":"Duijvestein, M. et al. Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn\u2019s disease: results of a phase I study. Gut 59, 1662\u20131669 (2010).","journal-title":"Gut"},{"key":"8261_CR63","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1093\/qjmed\/hcu095","volume":"107","author":"JA Snowden","year":"2014","unstructured":"Snowden, J. A. et al. Autologous stem cell transplantation in severe treatment-resistant Crohn\u2019s disease: long-term follow-up of UK patients treated on compassionate basis. QJM Mon. J. Assoc. Physicians 107, 871\u2013877 (2014).","journal-title":"QJM Mon. J. Assoc. Physicians"},{"key":"8261_CR64","first-page":"1251","volume":"50","author":"C Gregoire","year":"2018","unstructured":"Gregoire, C. et al. Allogeneic mesenchymal stromal cells for refractory luminal Crohn\u2019s disease: A phase I-II study. Dig. Liver Dis. J. Ital. Soc. Gastroenterol. Ital. Assoc. Study Liver 50, 1251\u20131255 (2018).","journal-title":"Dig. Liver Dis. J. Ital. Soc. Gastroenterol. Ital. Assoc. Study Liver"},{"key":"8261_CR65","doi-asserted-by":"publisher","first-page":"151","DOI":"10.5217\/ir.2019.09154","volume":"18","author":"E Mizoguchi","year":"2020","unstructured":"Mizoguchi, E. et al. Recent updates on the basic mechanisms and pathogenesis of inflammatory bowel diseases in experimental animal models. Intest. Res. 18, 151\u2013167 (2020).","journal-title":"Intest. Res."},{"key":"8261_CR66","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1136\/gut.43.1.71","volume":"43","author":"S Matsumoto","year":"1998","unstructured":"Matsumoto, S. et al. Inflammatory bowel disease-like enteritis and caecitis in a senescence accelerated mouse P1\/Yit strain. Gut 43, 71\u201378 (1998).","journal-title":"Gut"},{"key":"8261_CR67","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1159\/000068143","volume":"70","author":"JC Hoffmann","year":"2002","unstructured":"Hoffmann, J. C., Pawlowski, N. N., K\u00fchl, A. A., H\u00f6hne, W. & Zeitz, M. Animal models of inflammatory bowel disease: an overview. Pathobiol. J. Immunopathol. Mol. Cell. Biol. 70, 121\u2013130 (2002).","journal-title":"Pathobiol. J. Immunopathol. Mol. Cell. Biol."},{"key":"8261_CR68","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1172\/JCI10956","volume":"107","author":"MM Kosiewicz","year":"2001","unstructured":"Kosiewicz, M. M. et al. Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn\u2019s disease. J. Clin. Invest. 107, 695\u2013702 (2001).","journal-title":"J. Clin. Invest."},{"key":"8261_CR69","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s13287-018-0816-2","volume":"9","author":"L Zhao","year":"2018","unstructured":"Zhao, L., Chen, S., Shi, X., Cao, H. & Li, L. A pooled analysis of mesenchymal stem cell-based therapy for liver disease. Stem Cell Res. Ther. 9, 72 (2018).","journal-title":"Stem Cell Res. Ther."},{"key":"8261_CR70","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1002\/hep.28693","volume":"64","author":"KT Suk","year":"2016","unstructured":"Suk, K. T. et al. Transplantation with autologous bone marrow-derived mesenchymal stem cells for alcoholic cirrhosis: phase 2 trial. Hepatol. Baltim.64, 2185\u20132197 (2016).","journal-title":"Hepatol. Baltim."},{"key":"8261_CR71","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.livres.2019.01.001","volume":"3","author":"AL Ticho","year":"2019","unstructured":"Ticho, A. L., Malhotra, P., Dudeja, P. K., Gill, R. K. & Alrefai, W. A. Bile acid receptors and gastrointestinal functions. Liver Res. 3, 31\u201339 (2019).","journal-title":"Liver Res."},{"key":"8261_CR72","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1136\/gut.2010.212159","volume":"60","author":"RM Gadaleta","year":"2011","unstructured":"Gadaleta, R. M. et al. Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease. Gut 60, 463\u2013472 (2011).","journal-title":"Gut"},{"key":"8261_CR73","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1007\/s10620-020-06715-3","volume":"66","author":"S Fiorucci","year":"2021","unstructured":"Fiorucci, S. et al. Bile acid signaling in inflammatory bowel diseases. Dig. Dis. Sci. 66, 674\u2013693 (2021).","journal-title":"Dig. Dis. Sci."},{"key":"8261_CR74","doi-asserted-by":"publisher","first-page":"3488","DOI":"10.1210\/en.2017-00248","volume":"158","author":"DE Maridas","year":"2017","unstructured":"Maridas, D. E., DeMambro, V. E., Le, P. T., Mohan, S. & Rosen, C. J. IGFBP4 is required for adipogenesis and influences the distribution of adipose depots. Endocrinology 158, 3488\u20133500 (2017).","journal-title":"Endocrinology"},{"key":"8261_CR75","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1530\/JOE-16-0673","volume":"233","author":"DE Maridas","year":"2017","unstructured":"Maridas, D. E. et al. IGFBP-4 regulates adult skeletal growth in a sex-specific manner. J. Endocrinol. 233, 131\u2013144 (2017).","journal-title":"J. Endocrinol."},{"key":"8261_CR76","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-017-0722-8","volume":"16","author":"B Yang","year":"2017","unstructured":"Yang, B. et al. Overexpression of lncRNA IGFBP4-1 reprograms energy metabolism to promote lung cancer progression. Mol. Cancer 16, 154 (2017).","journal-title":"Mol. Cancer"},{"key":"8261_CR77","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-13163-8","volume":"12","author":"Y Xi","year":"2022","unstructured":"Xi, Y., Liu, J. & Shen, G. Low expression of IGFBP4 and TAGLN accelerate the poor overall survival of osteosarcoma. Sci. Rep. 12, 9298 (2022).","journal-title":"Sci. Rep."},{"key":"8261_CR78","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s12072-023-10552-7","volume":"18","author":"L Tao","year":"2024","unstructured":"Tao, L. et al. Activation of IGFBP4 via unconventional mechanism of miRNA attenuates metastasis of intrahepatic cholangiocarcinoma. Hepatol. Int. 18, 91\u2013107 (2024).","journal-title":"Hepatol. Int."},{"key":"8261_CR79","doi-asserted-by":"publisher","first-page":"8832","DOI":"10.1093\/nar\/gky589","volume":"46","author":"Y-Y Lee","year":"2018","unstructured":"Lee, Y.-Y. et al. Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis. Nucleic Acids Res. 46, 8832\u20138847 (2018).","journal-title":"Nucleic Acids Res."},{"key":"8261_CR80","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-10-56","volume":"10","author":"H Cao","year":"2012","unstructured":"Cao, H. et al. Therapeutic potential of transplanted placental mesenchymal stem cells in treating Chinese miniature pigs with acute liver failure. BMC Med. 10, 56 (2012).","journal-title":"BMC Med."},{"key":"8261_CR81","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/14653240600855905","volume":"8","author":"M Dominici","year":"2006","unstructured":"Dominici, M. et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement. Cytotherapy 8, 315\u2013317 (2006).","journal-title":"Cytotherapy"},{"key":"8261_CR82","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/nature07935","volume":"459","author":"T Sato","year":"2009","unstructured":"Sato, T. et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459, 262\u2013265 (2009).","journal-title":"Nature"},{"key":"8261_CR83","doi-asserted-by":"publisher","first-page":"1762","DOI":"10.1053\/j.gastro.2011.07.050","volume":"141","author":"T Sato","year":"2011","unstructured":"Sato, T. et al. Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett\u2019s epithelium. Gastroenterology 141, 1762\u20131772 (2011).","journal-title":"Gastroenterology"},{"key":"8261_CR84","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1957-7","volume":"10","author":"H Yang","year":"2019","unstructured":"Yang, H. et al. Human induced pluripotent stem cell-derived mesenchymal stem cells promote healing via TNF-\u03b1-stimulated gene-6 in inflammatory bowel disease models. Cell Death Dis. 10, 718 (2019).","journal-title":"Cell Death Dis."},{"key":"8261_CR85","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1002\/ibd.20753","volume":"15","author":"P Alex","year":"2009","unstructured":"Alex, P. et al. Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis. Inflamm. Bowel Dis. 15, 341\u2013352 (2009).","journal-title":"Inflamm. Bowel Dis."},{"key":"8261_CR86","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1038\/s41390-019-0284-0","volume":"85","author":"P Singh","year":"2019","unstructured":"Singh, P. et al. Effect of polyunsaturated fatty acids on postnatal ileum development using the fat-1 transgenic mouse model. Pediatr. Res. 85, 556\u2013565 (2019).","journal-title":"Pediatr. Res."}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-08261-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-08261-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-08261-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T07:03:09Z","timestamp":1748588589000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-08261-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,30]]},"references-count":86,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["8261"],"URL":"https:\/\/doi.org\/10.1038\/s42003-025-08261-y","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,30]]},"assertion":[{"value":"7 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was approved by the Animal Experimental Ethical Inspection of The First Affiliated Hospital of Zhejiang University School of Medicine (Reference number: 2020-1088) and the Clinical Research Ethics Committee of The First Affiliated Hospital of Zhejiang University School of Medicine (Reference number: 2021-158).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"830"}}