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In this study, we employed the western clawed frog (<jats:italic>Xenopus tropicalis<\/jats:italic>) as a model and conducted a long-tern experiment from zygotes to adult stage. We find that even within the previously considered normal temperature range, a 5\u2009\u00b0C increase in ambient temperature can establish a new metabolic state, resulting in elevated oxidative stress and a shift in energy allocation towards immune defense at the expense of sexual development. This conceptual framework of temperature-dependent trade-off strategy suggests that, while some studies observed that warm temperature reduces the risk of infection, it is important to note that this change may present challenges in the form of accelerated aging and reduced fertility, especially in ectotherms. 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