{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T03:54:02Z","timestamp":1784346842093,"version":"3.55.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170507"],"award-info":[{"award-number":["82170507"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970402"],"award-info":[{"award-number":["81970402"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2022JH2\/101300037"],"award-info":[{"award-number":["2022JH2\/101300037"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"name":"None"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-025-08604-9","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T10:14:38Z","timestamp":1755252878000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Targeting VCAM-1 with chimeric antigen receptor and regulatory T cell for abdominal aortic aneurysm treatment"],"prefix":"10.1038","volume":"8","author":[{"given":"Qingwei","family":"Gang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Lun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamol","family":"Uzokov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikai","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Erhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dittmar","family":"B\u00f6ckler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuemeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4897-2998","authenticated-orcid":false,"given":"Yanshuo","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4448-0774","authenticated-orcid":false,"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"key":"8604_CR1","doi-asserted-by":"publisher","first-page":"2682","DOI":"10.1093\/eurheartj\/ehad386","volume":"44","author":"J Golledge","year":"2023","unstructured":"Golledge, J., Thanigaimani, S., Powell, J. T. & Tsao, P. S. Pathogenesis and management of abdominal aortic aneurysm. Eur. Heart J. 44, 2682\u20132697 (2023).","journal-title":"Eur. Heart J."},{"key":"8604_CR2","doi-asserted-by":"publisher","first-page":"E351","DOI":"10.1532\/hsf.3571","volume":"24","author":"K Song","year":"2021","unstructured":"Song, K., Guo, C., Yang, K., Li, C. & Ding, N. Clinical characteristics of aortic aneurysm in MIMIC-III. Heart Surg. Forum 24, E351\u2013E358 (2021).","journal-title":"Heart Surg. Forum"},{"key":"8604_CR3","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1042\/CS20220795","volume":"137","author":"L Puertas-Umbert","year":"2023","unstructured":"Puertas-Umbert, L. et al. Novel pharmacological approaches in abdominal aortic aneurysm. Clin. Sci.137, 1167\u20131194 (2023).","journal-title":"Clin. Sci."},{"key":"8604_CR4","doi-asserted-by":"publisher","first-page":"6650","DOI":"10.1021\/acsnano.4c00120","volume":"18","author":"K Hu","year":"2024","unstructured":"Hu, K. et al. Pathogenesis-guided rational engineering of nanotherapies for the targeted treatment of abdominal aortic aneurysm by inhibiting neutrophilic inflammation. ACS Nano. 18, 6650\u20136672 (2024).","journal-title":"ACS Nano."},{"key":"8604_CR5","doi-asserted-by":"publisher","unstructured":"Tian, K., Thanigaimani, S., Gibson, K. & Golledge, J. Systematic review examining the association of angiotensin converting enzyme inhibitor and angiotensin receptor blocker prescription with abdominal aortic aneurysm growth and events. Eur. J. Vasc. Endovasc. Surg. https:\/\/doi.org\/10.1016\/j.ejvs.2024.03.034 (2024).","DOI":"10.1016\/j.ejvs.2024.03.034"},{"key":"8604_CR6","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1016\/j.jvs.2019.08.285","volume":"72","author":"MK Suh","year":"2020","unstructured":"Suh, M. K. et al. Ex vivo expansion of regulatory T cells from abdominal aortic aneurysm patients inhibits aneurysm in humanized murine model. J. Vasc. Surg. 72, 1087\u20131096 e1081 (2020).","journal-title":"J. Vasc. Surg."},{"key":"8604_CR7","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/j.jvs.2019.09.045","volume":"72","author":"FM Davis","year":"2020","unstructured":"Davis, F. M. & Obi, A. T. Recognizing the evolving and beneficial role of regulatory T cells in aneurysm growth. J. Vasc. Surg. 72, 1097 (2020).","journal-title":"J. Vasc. Surg."},{"key":"8604_CR8","doi-asserted-by":"publisher","first-page":"2374","DOI":"10.1161\/ATVBAHA.113.301280","volume":"33","author":"H Ait-Oufella","year":"2013","unstructured":"Ait-Oufella, H. et al. Natural regulatory T cells limit angiotensin II-induced aneurysm formation and rupture in mice. Arterioscler. Thrombosis Vasc. Biol. 33, 2374\u20132379 (2013).","journal-title":"Arterioscler. Thrombosis Vasc. Biol."},{"key":"8604_CR9","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1161\/HYPERTENSIONAHA.114.03950","volume":"64","author":"X Meng","year":"2014","unstructured":"Meng, X. et al. Regulatory T cells prevent angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E knockout mice. Hypertension 64, 875\u2013882 (2014).","journal-title":"Hypertension"},{"key":"8604_CR10","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.jacbts.2022.05.001","volume":"7","author":"F Yang","year":"2022","unstructured":"Yang, F. et al. Propionate alleviates abdominal aortic aneurysm by modulating colonic regulatory T-cell expansion and recirculation. JACC Basic Transl. Sci. 7, 934\u2013947 (2022).","journal-title":"JACC Basic Transl. Sci."},{"key":"8604_CR11","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.3389\/fimmu.2018.02359","volume":"9","author":"Q Zhang","year":"2018","unstructured":"Zhang, Q. et al. Chimeric antigen receptor (CAR) Treg: a promising approach to inducing immunological tolerance. Front. Immunol. 9, 2359 (2018).","journal-title":"Front. Immunol."},{"key":"8604_CR12","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1172\/JCI86827","volume":"126","author":"M Edinger","year":"2016","unstructured":"Edinger, M. Driving allotolerance: CAR-expressing Tregs for tolerance induction in organ and stem cell transplantation.  J. Clin. Investig. 126, 1248\u20131250 (2016).","journal-title":"J. Clin. Investig."},{"key":"8604_CR13","doi-asserted-by":"publisher","first-page":"927153","DOI":"10.3389\/fimmu.2022.927153","volume":"13","author":"X Zhang","year":"2022","unstructured":"Zhang, X., Zhu, L., Zhang, H., Chen, S. & Xiao, Y. CAR-T cell therapy in hematological malignancies: current opportunities and challenges. Front. Immunol. 13, 927153 (2022).","journal-title":"Front. Immunol."},{"key":"8604_CR14","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/S0140-6736(20)31366-0","volume":"396","author":"JS Abramson","year":"2020","unstructured":"Abramson, J. S. et al. Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study. Lancet 396, 839\u2013852 (2020).","journal-title":"Lancet"},{"key":"8604_CR15","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-022-00694-6","volume":"12","author":"J Yang","year":"2022","unstructured":"Yang, J. et al. Next-day manufacture of a novel anti-CD19 CAR-T therapy for B-cell acute lymphoblastic leukemia: first-in-human clinical study. Blood Cancer J. 12, 104 (2022).","journal-title":"Blood Cancer J."},{"key":"8604_CR16","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1056\/NEJMoa1817226","volume":"380","author":"N Raje","year":"2019","unstructured":"Raje, N. et al. Anti-BCMA CAR T-cell therapy bb2121 in relapsed or refractory multiple myeloma.  N. Engl. J. Med. 380, 1726\u20131737 (2019).","journal-title":"N. Engl. J. Med."},{"key":"8604_CR17","doi-asserted-by":"publisher","first-page":"166170","DOI":"10.1016\/j.bbadis.2021.166170","volume":"1867","author":"MF Troncoso","year":"2021","unstructured":"Troncoso, M. F. et al. VCAM-1 as a predictor biomarker in cardiovascular disease. Biochim. Biophys. Acta Mol. Basis Dis. 1867, 166170 (2021).","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"8604_CR18","doi-asserted-by":"publisher","unstructured":"Zhao, G. et al. KLF11 protects against abdominal aortic aneurysm through inhibition of endothelial cell dysfunction. JCI Insight 6, https:\/\/doi.org\/10.1172\/jci.insight.141673 (2021).","DOI":"10.1172\/jci.insight.141673"},{"key":"8604_CR19","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1016\/j.ymthe.2018.02.010","volume":"26","author":"X Wang","year":"2018","unstructured":"Wang, X. et al. Dual-targeted theranostic delivery of miRs arrests abdominal aortic aneurysm development. Mol. Ther. 26, 1056\u20131065 (2018).","journal-title":"Mol. Ther."},{"key":"8604_CR20","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1002\/bjs.9593","volume":"101","author":"PW Stather","year":"2014","unstructured":"Stather, P. W. et al. Meta-analysis and meta-regression analysis of biomarkers for abdominal aortic aneurysm.  Br. J. Surg. 101, 1358\u20131372 (2014).","journal-title":"Br. J. Surg."},{"key":"8604_CR21","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/joim.12958","volume":"288","author":"J Golledge","year":"2020","unstructured":"Golledge, J. et al. Lack of an effective drug therapy for abdominal aortic aneurysm. J. Intern Med. 288, 6\u201322 (2020).","journal-title":"J. Intern Med."},{"key":"8604_CR22","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1161\/ATVBAHA.109.200303","volume":"30","author":"M Yin","year":"2010","unstructured":"Yin, M. et al. Deficient CD4\u2009+\u2009CD25\u2009+\u2009T regulatory cell function in patients with abdominal aortic aneurysms. Arterioscler. Thrombosis Vasc. Biol. 30, 1825\u20131831 (2010).","journal-title":"Arterioscler. Thrombosis Vasc. Biol."},{"key":"8604_CR23","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.atherosclerosis.2018.02.001","volume":"271","author":"H Jiang","year":"2018","unstructured":"Jiang, H. et al. Abnormal acetylation of FOXP3 regulated by SIRT-1 induces Treg functional deficiency in patients with abdominal aortic aneurysms. Atherosclerosis 271, 182\u2013192 (2018).","journal-title":"Atherosclerosis"},{"key":"8604_CR24","doi-asserted-by":"publisher","first-page":"609161","DOI":"10.3389\/fimmu.2020.609161","volume":"11","author":"Z Yuan","year":"2020","unstructured":"Yuan, Z. et al. Abdominal aortic aneurysm: roles of inflammatory cells. Front. Immunol. 11, 609161 (2020).","journal-title":"Front. Immunol."},{"key":"8604_CR25","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1161\/ATVBAHA.115.305269","volume":"35","author":"MA Dale","year":"2015","unstructured":"Dale, M. A., Ruhlman, M. K. & Baxter, B. T. Inflammatory cell phenotypes in AAAs: their role and potential as targets for therapy. Arterioscler. Thrombosis Vasc. Biol. 35, 1746\u20131755 (2015).","journal-title":"Arterioscler. Thrombosis Vasc. Biol."},{"key":"8604_CR26","doi-asserted-by":"publisher","first-page":"2035117","DOI":"10.1080\/21645515.2022.2035117","volume":"18","author":"TK Goswami","year":"2022","unstructured":"Goswami, T. K. et al. Regulatory T cells (Tregs) and their therapeutic potential against autoimmune disorders - advances and challenges. Hum. Vaccin Immunother. 18, 2035117 (2022).","journal-title":"Hum. Vaccin Immunother."},{"key":"8604_CR27","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1093\/cei\/uxac105","volume":"211","author":"F Harris","year":"2023","unstructured":"Harris, F., Berdugo, Y. A. & Tree, T. IL-2-based approaches to Treg enhancement. Clin. Exp. Immunol. 211, 149\u2013163 (2023).","journal-title":"Clin. Exp. Immunol."},{"key":"8604_CR28","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-022-02778-6","volume":"22","author":"M Al-Haideri","year":"2022","unstructured":"Al-Haideri, M. et al. CAR-T cell combination therapy: the next revolution in cancer treatment. Cancer Cell Int. 22, 365 (2022).","journal-title":"Cancer Cell Int."},{"key":"8604_CR29","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-018-0759-3","volume":"17","author":"E Zhang","year":"2018","unstructured":"Zhang, E., Gu, J. & Xu, H. Prospects for chimeric antigen receptor-modified T cell therapy for solid tumors. Mol. Cancer 17, 7 (2018).","journal-title":"Mol. Cancer"},{"key":"8604_CR30","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1080\/14728222.2023.2187778","volume":"27","author":"MF Troncoso","year":"2023","unstructured":"Troncoso, M. F. et al. Targeting VCAM-1: a therapeutic opportunity for vascular damage. Expert Opin. Therapeutic Targets 27, 207\u2013223 (2023).","journal-title":"Expert Opin. Therapeutic Targets"},{"key":"8604_CR31","first-page":"1551","volume":"143","author":"H Li","year":"1993","unstructured":"Li, H., Cybulsky, M. I., Gimbrone, M. A. Jr. & Libby, P. Inducible expression of vascular cell adhesion molecule-1 by vascular smooth muscle cells in vitro and within rabbit atheroma.  Am. J. Pathol. 143, 1551\u20131559 (1993).","journal-title":"Am. J. Pathol."},{"key":"8604_CR32","doi-asserted-by":"publisher","first-page":"456","DOI":"10.2353\/ajpath.2010.090381","volume":"177","author":"S Schulte","year":"2010","unstructured":"Schulte, S. et al. Cystatin C deficiency promotes inflammation in angiotensin II-induced abdominal aortic aneurisms in atherosclerotic mice.  Am. J. Pathol. 177, 456\u2013463 (2010).","journal-title":"Am. J. Pathol."},{"key":"8604_CR33","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1002\/eji.202048992","volume":"51","author":"S Dees","year":"2021","unstructured":"Dees, S., Ganesan, R., Singh, S. & Grewal, I. S. Regulatory T cell targeting in cancer: emerging strategies in immunotherapy. Eur. J. Immunol. 51, 280\u2013291 (2021).","journal-title":"Eur. J. Immunol."},{"key":"8604_CR34","doi-asserted-by":"publisher","first-page":"2783519","DOI":"10.1155\/2019\/2783519","volume":"2019","author":"C Liu","year":"2019","unstructured":"Liu, C. et al. Single-chain variable fragment antibody of vascular cell adhesion molecule 1 as a molecular imaging probe for colitis model rabbit investigation. Contrast Media Mol. Imaging 2019, 2783519 (2019).","journal-title":"Contrast Media Mol. Imaging"},{"key":"8604_CR35","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.jconrel.2016.02.006","volume":"226","author":"CF Greineder","year":"2016","unstructured":"Greineder, C. F. et al. Molecular engineering of high affinity single-chain antibody fragment for endothelial targeting of proteins and nanocarriers in rodents and humans. J. Control Rel. 226, 229\u2013237 (2016).","journal-title":"J. Control Rel."},{"key":"8604_CR36","doi-asserted-by":"publisher","first-page":"2003119","DOI":"10.1002\/advs.202003119","volume":"8","author":"G Marsico","year":"2021","unstructured":"Marsico, G., Martin-Saldana, S. & Pandit, A. Therapeutic biomaterial approaches to alleviate chronic limb threatening ischemia. Adv. Sci.8, 2003119 (2021).","journal-title":"Adv. Sci."},{"key":"8604_CR37","doi-asserted-by":"publisher","first-page":"1305049","DOI":"10.1155\/2019\/1305049","volume":"2019","author":"X Huang","year":"2019","unstructured":"Huang, X. et al. Adipose-derived mesenchymal stem cells isolated from patients with abdominal aortic aneurysm exhibit senescence phenomena. Oxid. Med. Cell Longev. 2019, 1305049 (2019).","journal-title":"Oxid. Med. Cell Longev."},{"key":"8604_CR38","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1038\/nri2889","volume":"10","author":"JH Buckner","year":"2010","unstructured":"Buckner, J. H. Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases. Nat. Rev. Immunol. 10, 849\u2013859 (2010).","journal-title":"Nat. Rev. Immunol."},{"key":"8604_CR39","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/cr.2007.46","volume":"17","author":"Q Cao","year":"2007","unstructured":"Cao, Q. et al. Downregulation of CD4+CD25+ regulatory T cells may underlie enhanced Th1 immunity caused by immunization with activated autologous T cells. Cell Res. 17, 627\u2013637 (2007).","journal-title":"Cell Res."},{"key":"8604_CR40","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1093\/cei\/uxac118","volume":"211","author":"R Steiner","year":"2023","unstructured":"Steiner, R. & Pilat, N. The potential for Treg-enhancing therapies in transplantation. Clin. Exp. Immunol. 211, 122\u2013137 (2023).","journal-title":"Clin. Exp. Immunol."},{"key":"8604_CR41","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1111\/ajt.14175","volume":"17","author":"F Noyan","year":"2017","unstructured":"Noyan, F. et al. Prevention of allograft rejection by use of regulatory T cells with an MHC-specific chimeric antigen receptor. Am. J. Transplant. 17, 917\u2013930 (2017).","journal-title":"Am. J. Transplant."},{"key":"8604_CR42","doi-asserted-by":"publisher","unstructured":"Arjomandnejad M., Kopec A. L., Keeler A. M. CAR-T regulatory (CAR-Treg) cells: engineering and applications. Biomedicines 10, https:\/\/doi.org\/10.3390\/biomedicines10020287 (2022).","DOI":"10.3390\/biomedicines10020287"},{"key":"8604_CR43","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.2147\/CIA.S202188","volume":"14","author":"D Tang","year":"2019","unstructured":"Tang, D. et al. Y chromosome loss is associated with age-related male patients with abdominal aortic aneurysms. Clin. Inter. Aging 14, 1227\u20131241 (2019).","journal-title":"Clin. Inter. Aging"},{"key":"8604_CR44","doi-asserted-by":"publisher","first-page":"117","DOI":"10.15212\/CVIA.2022.0001","volume":"6","author":"G Feng","year":"2022","unstructured":"Feng, G., Qin, G., Zhang, T., Chen, Z. & Zhao, Y. Common Statistical Methods and Reporting of Results in Medical Research. CVIA 6, 117\u2013125 (2022).","journal-title":"CVIA"}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-08604-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-08604-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-08604-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T04:44:10Z","timestamp":1757393050000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-08604-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,15]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["8604"],"URL":"https:\/\/doi.org\/10.1038\/s42003-025-08604-9","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,15]]},"assertion":[{"value":"25 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1230"}}