{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T16:43:35Z","timestamp":1781196215326,"version":"3.54.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,10]],"date-time":"2025-08-10T00:00:00Z","timestamp":1754784000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,10]],"date-time":"2025-08-10T00:00:00Z","timestamp":1754784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000628"],"award-info":[{"award-number":["82000628"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-025-08642-3","type":"journal-article","created":{"date-parts":[[2025,8,10]],"date-time":"2025-08-10T01:33:58Z","timestamp":1754789638000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multi-omics insights of immune cells in the risk and prognosis of idiopathic membranous nephropathy"],"prefix":"10.1038","volume":"8","author":[{"given":"Xiaoyi","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanwei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieyu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanping","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyue","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3839-0281","authenticated-orcid":false,"given":"Man","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,10]]},"reference":[{"key":"8642_CR1","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41572-021-00303-z","volume":"7","author":"P Ronco","year":"2021","unstructured":"Ronco, P. et al. Membranous nephropathy. Nat. Rev. Dis. Prim. 7, 69 (2021).","journal-title":"Nat. Rev. Dis. Prim."},{"key":"8642_CR2","doi-asserted-by":"publisher","first-page":"983","DOI":"10.2215\/CJN.11761116","volume":"12","author":"WG Couser","year":"2017","unstructured":"Couser, W. G. Primary membranous nephropathy. Clin. J. Am. Soc. Nephrol. 12, 983\u2013997 (2017).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"8642_CR3","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1093\/ndt\/gfq665","volume":"26","author":"A Mcgrogan","year":"2011","unstructured":"Mcgrogan, A., Franssen, C. F. & De Vries, C. S. The incidence of primary glomerulonephritis worldwide: a systematic review of the literature. Nephrol. Dial. Transpl. 26, 414\u2013430 (2011).","journal-title":"Nephrol. Dial. Transpl."},{"key":"8642_CR4","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.kint.2016.09.048","volume":"91","author":"DC Cattran","year":"2017","unstructured":"Cattran, D. C. & Brenchley, P. E. Membranous nephropathy: integrating basic science into improved clinical management. Kidney Int 91, 566\u2013574 (2017).","journal-title":"Kidney Int"},{"key":"8642_CR5","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1016\/S0140-6736(15)60731-0","volume":"385","author":"P Ronco","year":"2015","unstructured":"Ronco, P. & Debiec, H. Pathophysiological advances in membranous nephropathy: time for a shift in patient\u2019s care. Lancet 385, 1983\u20131992 (2015).","journal-title":"Lancet"},{"key":"8642_CR6","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S0272-6386(00)70316-7","volume":"35","author":"P Maisonneuve","year":"2000","unstructured":"Maisonneuve, P. et al. Distribution of primary renal diseases leading to end-stage renal failure in the United States, Europe, and Australia\/New Zealand: results from an international comparative study. Am. J. Kidney Dis. 35, 157\u2013165 (2000).","journal-title":"Am. J. Kidney Dis."},{"key":"8642_CR7","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1146\/annurev-med-050522-034537","volume":"75","author":"R Avasare","year":"2024","unstructured":"Avasare, R., Andeen, N. & Beck, L. Novel antigens and clinical updates in membranous nephropathy. Annu. Rev. Med. 75, 219\u2013332 (2024).","journal-title":"Annu. Rev. Med."},{"key":"8642_CR8","doi-asserted-by":"publisher","first-page":"108976","DOI":"10.1016\/j.clim.2022.108976","volume":"237","author":"I Nieto-Ga\u00f1\u00e1n","year":"2022","unstructured":"Nieto-Ga\u00f1\u00e1n, I. et al. Revisiting immunological and clinical aspects of membranous nephropathy. Clin. Immunol. 237, 108976 (2022).","journal-title":"Clin. Immunol."},{"key":"8642_CR9","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/j.kint.2021.05.021","volume":"100","author":"Kidney Disease","year":"2021","unstructured":"Kidney Disease Improving Global Outcomes (KDIGO) Glomerular Diseases Work Group. KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases. Kidney Int 100, S1\u2013S276 (2021).","journal-title":"Kidney Int"},{"key":"8642_CR10","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/j.ekir.2020.12.035","volume":"6","author":"P Gauckler","year":"2021","unstructured":"Gauckler, P. et al. Rituximab in membranous nephropathy. Kidney Int. Rep. 6, 881\u2013893 (2021).","journal-title":"Kidney Int. Rep."},{"key":"8642_CR11","doi-asserted-by":"publisher","first-page":"683330","DOI":"10.3389\/fimmu.2021.683330","volume":"12","author":"J Xu","year":"2021","unstructured":"Xu, J. et al. Single-Cell Profiling Reveals Transcriptional Signatures and Cell-Cell Crosstalk in Anti-PLA2R Positive Idiopathic Membranous Nephropathy Patients. Front. Immunol. 12, 683330 (2021).","journal-title":"Front. Immunol."},{"key":"8642_CR12","doi-asserted-by":"publisher","first-page":"1203062","DOI":"10.3389\/fimmu.2023.1203062","volume":"14","author":"M Shi","year":"2023","unstructured":"Shi, M. et al. Single-cell RNA sequencing shows the immune cell landscape in the kidneys of patients with idiopathic membranous nephropathy. Front Immunol. 14, 1203062 (2023).","journal-title":"Front Immunol."},{"key":"8642_CR13","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1001\/jama.2021.18236","volume":"326","author":"VW Skrivankova","year":"2021","unstructured":"Skrivankova, V. W. et al. Strengthening the reporting of observational studies in epidemiology using mendelian randomization: The STROBE-MR Statement. JAMA 326, 1614\u20131621 (2021).","journal-title":"JAMA"},{"key":"8642_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15383-w","volume":"11","author":"J Xie","year":"2020","unstructured":"Xie, J. et al. The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis. Nat. Commun. 11, 1600 (2020).","journal-title":"Nat. Commun."},{"key":"8642_CR15","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1038\/s41588-020-0684-4","volume":"52","author":"V Orr\u00f9","year":"2020","unstructured":"Orr\u00f9, V. et al. Complex genetic signatures in immune cells underlie autoimmunity and inform therapy. Nat. Genet 52, 1036\u20131045 (2020).","journal-title":"Nat. Genet"},{"key":"8642_CR16","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s10157-006-0421-z","volume":"10","author":"Y Yasuda","year":"2006","unstructured":"Yasuda, Y. et al. European Renal cDNA Bank (ERCB) Consortium. Gene expression profiling analysis in nephrology: towards molecular definition of renal disease. Clin. Exp. Nephrol. 10, 91\u201398 (2006).","journal-title":"Clin. Exp. Nephrol."},{"key":"8642_CR17","doi-asserted-by":"publisher","first-page":"2993","DOI":"10.2337\/db06-0477","volume":"55","author":"H Schmid","year":"2006","unstructured":"Schmid, H. et al. Modular activation of nuclear factor-kappaB transcriptional programs in human diabetic nephropathy. Diabetes 55, 2993\u20133003 (2006).","journal-title":"Diabetes"},{"key":"8642_CR18","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/ki.2012.428","volume":"83","author":"CA Gadegbeku","year":"2013","unstructured":"Gadegbeku, C. A. et al. Design of the Nephrotic Syndrome Study Network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach. Kidney Int. 83, 749\u2013756 (2013).","journal-title":"Kidney Int."},{"key":"8642_CR19","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.2215\/CJN.08370812","volume":"8","author":"L Barisoni","year":"2013","unstructured":"Barisoni, L. et al. Digital pathology evaluation in the multicenter Nephrotic Syndrome Study Network (NEPTUNE). Clin. J. Am. Soc. Nephrol. 8, 1449\u20131459 (2013).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"8642_CR20","doi-asserted-by":"publisher","first-page":"1364841","DOI":"10.3389\/fnut.2024.1364841","volume":"11","author":"F Shao","year":"2024","unstructured":"Shao, F. et al. Causal association of plasma circulating metabolites with nephritis: a Mendelian randomization study. Front Nutr. 11, 1364841 (2024).","journal-title":"Front Nutr."},{"key":"8642_CR21","doi-asserted-by":"publisher","first-page":"e34408","DOI":"10.7554\/eLife.34408","volume":"7","author":"G Hemani","year":"2018","unstructured":"Hemani, G. et al. The MR-Base platform supports systematic causal inference across the human phenome. Elife 7, e34408 (2018).","journal-title":"Elife"},{"key":"8642_CR22","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1093\/ije\/dyt179","volume":"42","author":"MJ Brion","year":"2013","unstructured":"Brion, M. J., Shakhbazov, K. & Visscher, P. M. Calculating statistical power in Mendelian randomization studies. Int. J. Epidemiol. 42, 1497\u20131501 (2013).","journal-title":"Int. J. Epidemiol."},{"key":"8642_CR23","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1093\/ije\/dyx034","volume":"46","author":"OO Yavorska","year":"2017","unstructured":"Yavorska, O. O. & Burgess, S. MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data. Int. J. Epidemiol. 46, 1734\u20131739 (2017).","journal-title":"Int. J. Epidemiol."},{"key":"8642_CR24","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1093\/ije\/dyv080","volume":"44","author":"J Bowden","year":"2015","unstructured":"Bowden, J., Davey, S. G. & Burgess, S. Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int. J. Epidemiol. 44, 512\u2013525 (2015).","journal-title":"Int. J. Epidemiol."},{"key":"8642_CR25","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","volume":"50","author":"M Verbanck","year":"2018","unstructured":"Verbanck, M. et al. Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat. Genet 50, 693\u2013698 (2018).","journal-title":"Nat. Genet"},{"key":"8642_CR26","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1038\/ki.2014.49","volume":"86","author":"WG Couser","year":"2014","unstructured":"Couser, W. G. & Johnson, R. J. The etiology of glomerulonephritis: roles of infection and autoimmunity. Kidney Int. 86, 905\u2013914 (2014).","journal-title":"Kidney Int."},{"key":"8642_CR27","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1159\/000364782","volume":"40","author":"N Leeaphorn","year":"2014","unstructured":"Leeaphorn, N. et al. Prevalence of cancer in membranous nephropathy: a systematic review and meta-analysis of observational studies. Am. J. Nephrol. 40, 29\u201335 (2014).","journal-title":"Am. J. Nephrol."},{"key":"8642_CR28","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.kint.2018.10.018","volume":"95","author":"J Floege","year":"2019","unstructured":"Floege, J. et al. Management and treatment of glomerular diseases (part 1): conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int 95, 268\u2013280 (2019).","journal-title":"Kidney Int"},{"key":"8642_CR29","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.2215\/CJN.01910215","volume":"10","author":"JJ Hogan","year":"2015","unstructured":"Hogan, J. J., Markowitz, G. S. & Radhakrishnan, J. Drug-induced glomerular disease: immune-mediated injury. Clin. J. Am. Soc. Nephrol. 10, 1300\u20131310 (2015).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"8642_CR30","doi-asserted-by":"publisher","first-page":"609","DOI":"10.2215\/CJN.04160413","volume":"9","author":"C Ponticelli","year":"2014","unstructured":"Ponticelli, C. & Glassock, R. J. Glomerular diseases: membranous nephropathy\u2013a modern view. Clin. J. Am. Soc. Nephrol. 9, 609\u2013616 (2014).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"8642_CR31","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s10654-021-00757-1","volume":"36","author":"AR Carter","year":"2021","unstructured":"Carter, A. R. et al. Mendelian randomisation for mediation analysis: current methods and challenges for implementation. Eur. J. Epidemiol. 36, 465\u2013478 (2021).","journal-title":"Eur. J. Epidemiol."},{"key":"8642_CR32","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-019-0351-8","volume":"7","author":"J Liao","year":"2020","unstructured":"Liao, J. et al. Single-cell RNA sequencing of human kidney. Sci. Data 7, 4 (2020).","journal-title":"Sci. Data"},{"key":"8642_CR33","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-020-02116-x","volume":"21","author":"C Wang","year":"2020","unstructured":"Wang, C. et al. Integrative analyses of single-cell transcriptome and regulome using MAESTRO. Genome Biol. 21, 198 (2020).","journal-title":"Genome Biol."},{"key":"8642_CR34","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.cels.2020.05.010","volume":"11","author":"NJ Bernstein","year":"2020","unstructured":"Bernstein, N. J. et al. Solo: doublet identification in single-cell RNA-Seq via semi-supervised deep learning. Cell Syst. 11, 95\u2013101.e5 (2020).","journal-title":"Cell Syst."},{"key":"8642_CR35","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1038\/s41586-019-0969-x","volume":"566","author":"J Cao","year":"2019","unstructured":"Cao, J. et al. The single-cell transcriptional landscape of mammalian organogenesis. Nature 566, 496\u2013502 (2019).","journal-title":"Nature"},{"key":"8642_CR36","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21246-9","volume":"12","author":"S Jin","year":"2021","unstructured":"Jin, S. et al. Inference and analysis of cell-cell communication using CellChat. Nat. Commun. 12, 1088 (2021).","journal-title":"Nat. Commun."},{"key":"8642_CR37","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-7","volume":"14","author":"S H\u00e4nzelmann","year":"2013","unstructured":"H\u00e4nzelmann, S., Castelo, R. & Guinney, J. GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinform. 14, 7 (2013).","journal-title":"BMC Bioinform."},{"key":"8642_CR38","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-021-02337-8","volume":"22","author":"M Chung","year":"2021","unstructured":"Chung, M. et al. Best practices on the differential expression analysis of multi-species RNA-seq. Genome Biol. 22, 121 (2021).","journal-title":"Genome Biol."},{"key":"8642_CR39","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1182\/blood.2023021149","volume":"143","author":"H Zelaya","year":"2024","unstructured":"Zelaya, H. et al. Nucleic acid sensing promotes inflammatory monocyte migration through biased coagulation factor VIIa signaling. Blood 143, 845\u2013857 (2024).","journal-title":"Blood"},{"key":"8642_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1335936","volume":"14","author":"H Jiang","year":"2024","unstructured":"Jiang, H. et al. Understanding the podocyte immune responses in proteinuric kidney diseases: from pathogenesis to therapy. Front. Immunol. 14, 1335936 (2024).","journal-title":"Front. Immunol."},{"key":"8642_CR41","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1038\/s41588-024-01802-x","volume":"56","author":"A Abedini","year":"2024","unstructured":"Abedini, A. et al. Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression. Nat. Genet 56, 1712\u20131724 (2024).","journal-title":"Nat. Genet"},{"key":"8642_CR42","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1053\/j.ajkd.2021.07.019","volume":"79","author":"S Kant","year":"2022","unstructured":"Kant, S. et al. Advances in understanding of pathogenesis and treatment of immune-mediated kidney disease: a review. Am. J. Kidney Dis. 79, 582\u2013600 (2022).","journal-title":"Am. J. Kidney Dis."},{"key":"8642_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116923","volume":"238","author":"R Motavalli","year":"2019","unstructured":"Motavalli, R. et al. Immune system-mediated cellular and molecular mechanisms in idiopathic membranous nephropathy pathogenesis and possible therapeutic targets. Life Sci. 238, 116923 (2019).","journal-title":"Life Sci."},{"key":"8642_CR44","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.665629","volume":"12","author":"Q Zhao","year":"2021","unstructured":"Zhao, Q. et al. Helper T cells in idiopathic membranous nephropathy. Front Immunol. 12, 665629 (2021).","journal-title":"Front Immunol."},{"key":"8642_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/biom14010001","volume":"14","author":"MA Ortiz","year":"2023","unstructured":"Ortiz, M. A. et al. Altered CD39 and CD73 expression in rheumatoid arthritis: implications for disease activity and treatment response. Biomolecules 14, 1 (2023).","journal-title":"Biomolecules"},{"key":"8642_CR46","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1007\/s00018-022-04315-0","volume":"79","author":"PM do Sacramento","year":"2022","unstructured":"do Sacramento, P. M. et al. Major depression favors the expansion of Th17-like cells and decrease the proportion of CD39+Treg cell subsets in response to myelin antigen in multiple sclerosis patients. Cell Mol. Life Sci. 79, 298 (2022).","journal-title":"Cell Mol. Life Sci."},{"key":"8642_CR47","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1184167","volume":"14","author":"Q Zhang","year":"2023","unstructured":"Zhang, Q. et al. Integration of single-cell RNA sequencing and bulk RNA transcriptome sequencing reveals a heterogeneous immune landscape and pivotal cell subpopulations associated with colorectal cancer prognosis. Front. Immunol. 14, 1184167 (2023).","journal-title":"Front. Immunol."},{"key":"8642_CR48","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/j.kint.2023.01.021","volume":"103","author":"L Li","year":"2023","unstructured":"Li, L. et al. Proteomic landscape of the extracellular matrix in the fibrotic kidney. Kidney Int 103, 1063\u20131076 (2023).","journal-title":"Kidney Int"},{"key":"8642_CR49","doi-asserted-by":"publisher","first-page":"e20231244050320","DOI":"10.1084\/jem.2023124405032024c","volume":"221","author":"LF Loffredo","year":"2024","unstructured":"Loffredo, L. F., Savage, T. M., Ringham, O. R. & Arpaia, N. Treg-tissue cell interactions in repair and regeneration. J. Exp. Med. 221, e2023124405032024c (2024).","journal-title":"J. Exp. Med."},{"key":"8642_CR50","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-60928-4","volume":"14","author":"S Kurawaki","year":"2024","unstructured":"Kurawaki, S. et al. Mesenchymal stem cells pretreated with interferon-gamma attenuate renal fibrosis by enhancing regulatory T cell induction. Sci. Rep. 14, 10251 (2024).","journal-title":"Sci. Rep."},{"key":"8642_CR51","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1631","volume":"14","author":"JY Jang","year":"2024","unstructured":"Jang, J. Y. et al. Interleukin-2\/anti-interleukin-2 immune complex attenuates cold ischemia-reperfusion injury after kidney transplantation by increasing renal regulatory T cells. Clin. Transl. Med. 14, e1631 (2024).","journal-title":"Clin. Transl. Med."},{"key":"8642_CR52","doi-asserted-by":"publisher","first-page":"S117","DOI":"10.1016\/j.kint.2023.10.018","volume":"105","author":"Kidney Disease","year":"2024","unstructured":"Kidney Disease Improving global outcomes (KDIGO) CKD Work Group. KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int. 105, S117\u2013S314 (2024).","journal-title":"Kidney Int."}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-08642-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-08642-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-08642-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T15:57:36Z","timestamp":1757347056000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-08642-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,10]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["8642"],"URL":"https:\/\/doi.org\/10.1038\/s42003-025-08642-3","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,10]]},"assertion":[{"value":"23 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1192"}}