{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:53:58Z","timestamp":1793195638249,"version":"4.5.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373120, 81871876"],"award-info":[{"award-number":["82373120, 81871876"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515013256"],"award-info":[{"award-number":["2024A1515013256"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-025-08776-4","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T13:35:22Z","timestamp":1756820122000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A-to-I edited SNHG3 promotes non-small cell lung cancer metastasis by promoting fatty acid oxidation and resisting ferroptosis"],"prefix":"10.1038","volume":"8","author":[{"given":"Shizhen","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amei","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renyu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siming","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wujun","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjiang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boqi","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9999-7220","authenticated-orcid":false,"given":"Jiachun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8544-2339","authenticated-orcid":false,"given":"Zhili","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1315-7651","authenticated-orcid":false,"given":"Lei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"8776_CR1","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","volume":"12","author":"D Hanahan","year":"2022","unstructured":"Hanahan, D. Hallmarks of cancer: new dimensions. Cancer Discov. 12, 31\u201346 (2022).","journal-title":"Cancer Discov."},{"key":"8776_CR2","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.ccell.2018.03.026","volume":"33","author":"X Peng","year":"2018","unstructured":"Peng, X. et al. A-to-I RNA editing contributes to proteomic diversity in cancer. Cancer cell 33, 817\u2013828 e817 (2018).","journal-title":"Cancer cell"},{"key":"8776_CR3","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.celrep.2015.08.080","volume":"13","author":"N Paz-Yaacov","year":"2015","unstructured":"Paz-Yaacov, N. et al. Elevated RNA editing activity is a major contributor to transcriptomic diversity in tumors. Cell Rep. 13, 267\u2013276 (2015).","journal-title":"Cell Rep."},{"key":"8776_CR4","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1038\/s41392-022-01175-9","volume":"7","author":"L Cui","year":"2022","unstructured":"Cui, L. et al. RNA modifications: importance in immune cell biology and related diseases. Signal Transduct. Target. Ther. 7, 334 (2022).","journal-title":"Signal Transduct. Target. Ther."},{"key":"8776_CR5","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1158\/0008-5472.CAN-13-3485","volume":"74","author":"L Qi","year":"2014","unstructured":"Qi, L., Chan, T. H., Tenen, D. G. & Chen, L. RNA editome imbalance in hepatocellular carcinoma. Cancer Res. 74, 1301\u20131306 (2014).","journal-title":"Cancer Res."},{"key":"8776_CR6","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1158\/0008-5472.CAN-13-2545","volume":"74","author":"YR Qin","year":"2014","unstructured":"Qin, Y. R. et al. Adenosine-to-inosine RNA editing mediated by ADARs in esophageal squamous cell carcinoma. Cancer Res. 74, 840\u2013851 (2014).","journal-title":"Cancer Res."},{"key":"8776_CR7","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-018-1740-z","volume":"16","author":"Y Okugawa","year":"2018","unstructured":"Okugawa, Y. et al. Enhanced AZIN1 RNA editing and overexpression of its regulatory enzyme ADAR1 are important prognostic biomarkers in gastric cancer. J. Transl. Med. 16, 366 (2018).","journal-title":"J. Transl. Med."},{"key":"8776_CR8","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.canlet.2018.12.009","volume":"444","author":"S Takeda","year":"2019","unstructured":"Takeda, S. et al. Activation of AZIN1 RNA editing is a novel mechanism that promotes invasive potential of cancer-associated fibroblasts in colorectal cancer. Cancer Lett. 444, 127\u2013135 (2019).","journal-title":"Cancer Lett."},{"key":"8776_CR9","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.ygyno.2022.05.026","volume":"166","author":"K Nakamura","year":"2022","unstructured":"Nakamura, K., Shigeyasu, K., Okamoto, K., Matsuoka, H. & Masuyama, H. ADAR1 and AZIN1 RNA editing function as an oncogene and contributes to immortalization in endometrial cancer. Gynecol. Oncol. 166, 326\u2013333 (2022).","journal-title":"Gynecol. Oncol."},{"key":"8776_CR10","doi-asserted-by":"publisher","first-page":"3258","DOI":"10.1016\/j.ymthe.2021.05.008","volume":"29","author":"DJT Tay","year":"2021","unstructured":"Tay, D. J. T. et al. Targeting RNA editing of antizyme inhibitor 1: A potential oligonucleotide-based antisense therapy for cancer. Mol. Ther.: J. Am. Soc. Gene Ther. 29, 3258\u20133273 (2021).","journal-title":"Mol. Ther.: J. Am. Soc. Gene Ther."},{"key":"8776_CR11","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1101\/gr.219741.116","volume":"27","author":"Y Wang","year":"2017","unstructured":"Wang, Y. et al. Systematic characterization of A-to-I RNA editing hotspots in microRNAs across human cancers. Genome Res. 27, 1112\u20131125 (2017).","journal-title":"Genome Res."},{"key":"8776_CR12","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.ccell.2015.08.013","volume":"28","author":"L Han","year":"2015","unstructured":"Han, L. et al. The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers. Cancer Cell 28, 515\u2013528 (2015).","journal-title":"Cancer Cell"},{"key":"8776_CR13","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-09773-0","volume":"22","author":"L Liu","year":"2022","unstructured":"Liu, L. et al. A nomogram based on A-to-I RNA editing predicting overall survival of patients with lung squamous carcinoma. BMC Cancer 22, 715 (2022).","journal-title":"BMC Cancer"},{"key":"8776_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.861439","volume":"12","author":"J Wan","year":"2022","unstructured":"Wan, J. et al. Development and validation of a Four Adenosine-to-Inosine RNA editing site-relevant prognostic signature for assessing survival in breast cancer patients. Front. Oncol. 12, 861439 (2022).","journal-title":"Front. Oncol."},{"key":"8776_CR15","doi-asserted-by":"publisher","first-page":"389","DOI":"10.3389\/fonc.2020.00389","volume":"10","author":"AA Zimta","year":"2020","unstructured":"Zimta, A. A. et al. An emerging class of long non-coding rna with oncogenic role arises from the snoRNA host genes. Front. Oncol. 10, 389 (2020).","journal-title":"Front. Oncol."},{"key":"8776_CR16","doi-asserted-by":"publisher","first-page":"D79","DOI":"10.1093\/nar\/gkw835","volume":"45","author":"J Gong","year":"2017","unstructured":"Gong, J. et al. LNCediting: a database for functional effects of RNA editing in lncRNAs. Nucleic acids Res. 45, D79\u2013D84 (2017).","journal-title":"Nucleic acids Res."},{"key":"8776_CR17","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-0995-1","volume":"18","author":"Y Guo","year":"2019","unstructured":"Guo, Y. et al. Effects of exosomes on pre-metastatic niche formation in tumors. Mol. Cancer 18, 39 (2019).","journal-title":"Mol. Cancer"},{"key":"8776_CR18","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/s41392-020-00216-5","volume":"5","author":"D Li","year":"2020","unstructured":"Li, D. & Li, Y. The interaction between ferroptosis and lipid metabolism in cancer. Signal Transduct. Target. Ther. 5, 108 (2020).","journal-title":"Signal Transduct. Target. Ther."},{"key":"8776_CR19","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1158\/0008-5472.CAN-16-1978","volume":"77","author":"LE Stevens","year":"2017","unstructured":"Stevens, L. E. et al. Extracellular Matrix Receptor expression in subtypes of lung adenocarcinoma potentiates outgrowth of micrometastases. Cancer Res. 77, 1905\u20131917 (2017).","journal-title":"Cancer Res."},{"key":"8776_CR20","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/s43018-023-00513-2","volume":"4","author":"P Altea-Manzano","year":"2023","unstructured":"Altea-Manzano, P. et al. A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-kappaB signaling. Nat. Cancer 4, 344\u2013364 (2023).","journal-title":"Nat. Cancer"},{"key":"8776_CR21","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/22350","volume":"400","author":"G Orphanides","year":"1999","unstructured":"Orphanides, G., Wu, W. H., Lane, W. S., Hampsey, M. & Reinberg, D. The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins. Nature 400, 284\u2013288 (1999).","journal-title":"Nature"},{"key":"8776_CR22","doi-asserted-by":"publisher","first-page":"2725","DOI":"10.7150\/ijbs.78588","volume":"19","author":"L Lu","year":"2023","unstructured":"Lu, L. et al. EIF4a3-regulated circRABL2B regulates cell stemness and drug sensitivity of lung cancer via YBX1-dependent downregulation of MUC5AC expression. Int. J. Biol. Sci. 19, 2725\u20132739 (2023).","journal-title":"Int. J. Biol. Sci."},{"key":"8776_CR23","doi-asserted-by":"publisher","first-page":"11517","DOI":"10.18632\/oncotarget.14076","volume":"8","author":"L Peng","year":"2017","unstructured":"Peng, L. et al. Characterization of RNA editome in primary and metastatic lung adenocarcinomas. Oncotarget 8, 11517\u201311529 (2017).","journal-title":"Oncotarget"},{"key":"8776_CR24","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s11427-020-1928-0","volume":"65","author":"C Wang","year":"2022","unstructured":"Wang, C. et al. Identification of A-to-I RNA editing profiles and their clinical relevance in lung adenocarcinoma. Sci. China Life Sci. 65, 19\u201332 (2022).","journal-title":"Sci. China Life Sci."},{"key":"8776_CR25","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1002\/mc.23490","volume":"62","author":"KJ Chen","year":"2023","unstructured":"Chen, K. J. et al. Somatic A-to-I RNA-edited RHOA isoform 2 specific-R176G mutation promotes tumor progression in lung adenocarcinoma. Mol. Carcinog. 62, 348\u2013359 (2023).","journal-title":"Mol. Carcinog."},{"key":"8776_CR26","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1038\/s41388-023-02673-y","volume":"42","author":"G Romano","year":"2023","unstructured":"Romano, G. et al. A-to-I edited miR-411-5p targets MET and promotes TKI response in NSCLC-resistant cells. Oncogene 42, 1597\u20131606 (2023).","journal-title":"Oncogene"},{"key":"8776_CR27","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-020-01608-x","volume":"20","author":"B Xu","year":"2020","unstructured":"Xu, B. et al. LncRNA SNHG3, a potential oncogene in human cancers. Cancer Cell Int. 20, 536 (2020).","journal-title":"Cancer Cell Int."},{"key":"8776_CR28","doi-asserted-by":"publisher","first-page":"153303382110193","DOI":"10.1177\/15330338211019376","volume":"20","author":"Y Li","year":"2021","unstructured":"Li, Y., Gao, L., Zhang, C. & Meng, J. LncRNA SNHG3 Promotes Proliferation and Metastasis of Non-Small-Cell Lung Cancer Cells Through miR-515-5p\/SUMO2 Axis. Technol. Cancer Res. Treat. 20, 15330338211019376 (2021).","journal-title":"Technol. Cancer Res. Treat."},{"key":"8776_CR29","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5736716","volume":"2018","author":"L Liu","year":"2018","unstructured":"Liu, L., Ni, J. & He, X. Upregulation of the long noncoding RNA SNHG3 promotes lung Adenocarcinoma proliferation. Dis. markers 2018, 5736716 (2018).","journal-title":"Dis. markers"},{"key":"8776_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15180-5","volume":"11","author":"L Falbo","year":"2020","unstructured":"Falbo, L. et al. SSRP1-mediated histone H1 eviction promotes replication origin assembly and accelerated development. Nat. Commun. 11, 1345 (2020).","journal-title":"Nat. Commun."},{"key":"8776_CR31","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1136\/gutjnl-2019-318668","volume":"69","author":"J Shen","year":"2020","unstructured":"Shen, J. et al. Histone chaperone FACT complex mediates oxidative stress response to promote liver cancer progression. Gut 69, 329\u2013342 (2020).","journal-title":"Gut"},{"key":"8776_CR32","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1016\/j.celrep.2016.07.009","volume":"16","author":"MS Padanad","year":"2016","unstructured":"Padanad, M. S. et al. Fatty acid oxidation mediated by Acyl-CoA Synthetase long chain 3 is required for mutant KRAS Lung Tumorigenesis. Cell Rep. 16, 1614\u20131628 (2016).","journal-title":"Cell Rep."},{"key":"8776_CR33","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/nature11066","volume":"485","author":"SM Jeon","year":"2012","unstructured":"Jeon, S. M., Chandel, N. S. & Hay, N. AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress. Nature 485, 661\u2013665 (2012).","journal-title":"Nature"},{"key":"8776_CR34","doi-asserted-by":"publisher","first-page":"e21724","DOI":"10.1200\/JCO.2020.38.15_suppl.e21724","volume":"38","author":"S Li","year":"2020","unstructured":"Li, S., Zhu, X., Wang, L. & Zheng, Z. The role of radiation dose-dependent enhancement of fatty acid oxidation in radiation surviving\/resistant lung cancer cells. J. Clin. Oncol. 38, e21724 (2020).","journal-title":"J. Clin. Oncol."},{"key":"8776_CR35","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-02057-w","volume":"21","author":"M Li","year":"2021","unstructured":"Li, M., Xian, H. C., Tang, Y. J., Liang, X. H. & Tang, Y. L. Fatty acid oxidation: driver of lymph node metastasis. Cancer Cell Int. 21, 339 (2021).","journal-title":"Cancer Cell Int."},{"key":"8776_CR36","doi-asserted-by":"crossref","unstructured":"Li, L. et al. Transcription factor KLF16 activates MAGT1 to regulate the tumorigenesis and progression of breast cancer. Int. J. Mol. Med. 50, 115 (2022).","DOI":"10.3892\/ijmm.2022.5171"},{"key":"8776_CR37","doi-asserted-by":"publisher","first-page":"5435","DOI":"10.1038\/s41388-018-0315-z","volume":"37","author":"H Miess","year":"2018","unstructured":"Miess, H. et al. The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma. Oncogene 37, 5435\u20135450 (2018).","journal-title":"Oncogene"},{"key":"8776_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103118","volume":"71","author":"J Liu","year":"2024","unstructured":"Liu, J. et al. ATF3-CBS signaling axis coordinates ferroptosis and tumorigenesis in colorectal cancer. Redox Biol. 71, 103118 (2024).","journal-title":"Redox Biol."},{"key":"8776_CR39","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1038\/s41419-023-06359-x","volume":"14","author":"H Zhu","year":"2023","unstructured":"Zhu, H. et al. Gss deficiency causes age-related fertility impairment via ROS-triggered ferroptosis in the testes of mice. Cell Death Dis. 14, 845 (2023).","journal-title":"Cell Death Dis."},{"key":"8776_CR40","doi-asserted-by":"publisher","DOI":"10.1186\/s13062-021-00294-7","volume":"16","author":"Y Zhang","year":"2021","unstructured":"Zhang, Y., Li, S., Li, F., Lv, C. & Yang, Q. K. High-fat diet impairs ferroptosis and promotes cancer invasiveness via downregulating tumor suppressor ACSL4 in lung adenocarcinoma. Biol. Direct 16, 10 (2021).","journal-title":"Biol. Direct"},{"key":"8776_CR41","doi-asserted-by":"crossref","unstructured":"Zhang, X. et al. Palmitic acid promotes lung metastasis of melanomas via the TLR4\/TRIF-Peli1-pNF-kappaB Pathway. Metabolites 12, 1132 (2022).","DOI":"10.3390\/metabo12111132"},{"key":"8776_CR42","doi-asserted-by":"publisher","first-page":"3023","DOI":"10.1039\/C9CC09993J","volume":"56","author":"S Uchinomiya","year":"2020","unstructured":"Uchinomiya, S. et al. Fluorescence detection of metabolic activity of the fatty acid beta oxidation pathway in living cells. Chem. Commun. 56, 3023\u20133026 (2020).","journal-title":"Chem. Commun."},{"key":"8776_CR43","doi-asserted-by":"crossref","unstructured":"Wang Y. et al. Ligand- and voltage-gated Ca(2+) channels differentially regulate the mode of vesicular neuropeptide release in mammalian sensory neurons. Sci. Signal.10, (2022).","DOI":"10.1126\/scisignal.aal1683"},{"key":"8776_CR44","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1016\/j.jmoldx.2020.05.011","volume":"22","author":"J Xian","year":"2020","unstructured":"Xian, J. et al. Identification of three circular RNA Cargoes in serum exosomes as diagnostic biomarkers of non-small-cell lung cancer in the Chinese population. J. Mol. Diagn. 22, 1096\u20131108 (2020).","journal-title":"J. Mol. Diagn."},{"key":"8776_CR45","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/nprot.2015.035","volume":"10","author":"G Fuchs","year":"2015","unstructured":"Fuchs, G. et al. Simultaneous measurement of genome-wide transcription elongation speeds and rates of RNA polymerase II transition into active elongation with 4sUDRB-seq. Nat. Protoc. 10, 605\u2013618 (2015).","journal-title":"Nat. Protoc."},{"key":"8776_CR46","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3612","volume":"4","author":"K Yoshihara","year":"2013","unstructured":"Yoshihara, K. et al. Inferring tumour purity and stromal and immune cell admixture from expression data. Nat. Commun. 4, 2612 (2013).","journal-title":"Nat. Commun."}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-08776-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-08776-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-08776-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T12:26:05Z","timestamp":1756902365000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-08776-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,2]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["8776"],"URL":"https:\/\/doi.org\/10.1038\/s42003-025-08776-4","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,2]]},"assertion":[{"value":"7 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1333"}}