{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:53:31Z","timestamp":1780707211516,"version":"3.54.1"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM144399"],"award-info":[{"award-number":["R01GM144399"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA285515"],"award-info":[{"award-number":["R01CA285515"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-025-09084-7","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T14:17:57Z","timestamp":1764080277000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["TIPIN coordinates ATM-dependent checkpoint and NF-\u03baB signaling to counteract DNA replication damage from topoisomerase inhibition"],"prefix":"10.1038","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8810-2778","authenticated-orcid":false,"given":"Arafat","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin F.","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinal A.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Haley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1913-6373","authenticated-orcid":false,"given":"Hyungjin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"9084_CR1","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/s41573-022-00558-5","volume":"22","author":"A da Costa","year":"2023","unstructured":"da Costa, A., Chowdhury, D., Shapiro, G. I., D\u2019Andrea, A. D. & Konstantinopoulos, P. A. Targeting replication stress in cancer therapy. Nat. Rev. Drug Discov. 22, 38\u201358 (2023).","journal-title":"Nat. Rev. Drug Discov."},{"key":"9084_CR2","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/s41568-022-00535-5","volume":"23","author":"FJ Groelly","year":"2023","unstructured":"Groelly, F. J., Fawkes, M., Dagg, R. A., Blackford, A. N. & Tarsounas, M. Targeting DNA damage response pathways in cancer. Nat. Rev. Cancer 23, 78\u201394 (2023).","journal-title":"Nat. Rev. Cancer"},{"key":"9084_CR3","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1038\/s41568-022-00450-9","volume":"22","author":"L Wang","year":"2022","unstructured":"Wang, L., Lankhorst, L. & Bernards, R. Exploiting senescence for the treatment of cancer. Nat. Rev. Cancer 22, 340\u2013355 (2022).","journal-title":"Nat. Rev. Cancer"},{"key":"9084_CR4","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.molcel.2017.05.015","volume":"66","author":"AN Blackford","year":"2017","unstructured":"Blackford, A. N. & Jackson, S. P. ATM, ATR, and DNA-PK: the trinity at the heart of the DNA damage response. Mol. Cell 66, 801\u2013817 (2017).","journal-title":"Mol. Cell"},{"key":"9084_CR5","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/cr.2010.179","volume":"21","author":"S Miyamoto","year":"2011","unstructured":"Miyamoto, S. Nuclear initiated NF-kappaB signaling: NEMO and ATM take center stage. Cell Res. 21, 116\u2013130 (2011).","journal-title":"Cell Res."},{"key":"9084_CR6","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/S0092-8674(03)00895-X","volume":"115","author":"TT Huang","year":"2003","unstructured":"Huang, T. T., Wuerzberger-Davis, S. M., Wu, Z. H. & Miyamoto, S. Sequential modification of NEMO\/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress. Cell 115, 565\u2013576 (2003).","journal-title":"Cell"},{"key":"9084_CR7","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/sj.cdd.4401843","volume":"13","author":"S Janssens","year":"2006","unstructured":"Janssens, S. & Tschopp, J. Signals from within: the DNA-damage-induced NF-kappaB response. Cell Death Differ. 13, 773\u2013784 (2006).","journal-title":"Cell Death Differ."},{"key":"9084_CR8","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1007\/s00018-023-04738-3","volume":"80","author":"JA Patel","year":"2023","unstructured":"Patel, J. A. & Kim, H. The TIMELESS effort for timely DNA replication and protection. Cell Mol. Life Sci. 80, 84 (2023).","journal-title":"Cell Mol. Life Sci."},{"key":"9084_CR9","doi-asserted-by":"publisher","unstructured":"Patel J. A. et al. Replisome dysfunction upon inducible TIMELESS degradation synergizes with ATR inhibition to trigger replication catastrophe. Nucleic Acids Res. https:\/\/doi.org\/10.1093\/nar\/gkad363 (2023).","DOI":"10.1093\/nar\/gkad363"},{"key":"9084_CR10","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19162-5","volume":"11","author":"J Rageul","year":"2020","unstructured":"Rageul, J. et al. SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks. Nat. Commun. 11, 5495 (2020).","journal-title":"Nat. Commun."},{"key":"9084_CR11","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/s41586-024-07217-2","volume":"628","author":"M Petropoulos","year":"2024","unstructured":"Petropoulos, M. et al. Transcription-replication conflicts underlie sensitivity to PARP inhibitors. Nature 628, 433\u2013441 (2024).","journal-title":"Nature"},{"key":"9084_CR12","doi-asserted-by":"publisher","first-page":"6424","DOI":"10.1093\/nar\/gkae445","volume":"52","author":"J Saldanha","year":"2024","unstructured":"Saldanha, J. et al. The TIMELESS and PARP1 interaction suppresses replication-associated DNA gap accumulation. Nucleic Acids Res. 52, 6424\u20136440 (2024).","journal-title":"Nucleic Acids Res."},{"key":"9084_CR13","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1101\/gad.331868.119","volume":"34","author":"M Shyian","year":"2020","unstructured":"Shyian, M. et al. Fork pausing complex engages topoisomerases at the replisome. Genes Dev. 34, 87\u201398 (2020).","journal-title":"Genes Dev."},{"key":"9084_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.113845","volume":"43","author":"J Rageul","year":"2024","unstructured":"Rageul, J. et al. Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection. Cell Rep. 43, 113845 (2024).","journal-title":"Cell Rep."},{"key":"9084_CR15","doi-asserted-by":"publisher","first-page":"16562","DOI":"10.1074\/jbc.M110.110304","volume":"285","author":"MG Kemp","year":"2010","unstructured":"Kemp, M. G. et al. Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress. J. Biol. Chem. 285, 16562\u201316571 (2010).","journal-title":"J. Biol. Chem."},{"key":"9084_CR16","doi-asserted-by":"publisher","first-page":"3131","DOI":"10.1128\/MCB.02190-06","volume":"27","author":"K Unsal-Kacmaz","year":"2007","unstructured":"Unsal-Kacmaz, K. et al. The human Tim\/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement. Mol. Cell Biol. 27, 3131\u20133142 (2007).","journal-title":"Mol. Cell Biol."},{"key":"9084_CR17","doi-asserted-by":"publisher","first-page":"2729","DOI":"10.1074\/jbc.M605596200","volume":"282","author":"N Yoshizawa-Sugata","year":"2007","unstructured":"Yoshizawa-Sugata, N. & Masai, H. Human Tim\/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint. J. Biol. Chem. 282, 2729\u20132740 (2007).","journal-title":"J. Biol. Chem."},{"key":"9084_CR18","doi-asserted-by":"publisher","first-page":"18143","DOI":"10.1073\/pnas.0609251103","volume":"103","author":"DM Chou","year":"2006","unstructured":"Chou, D. M. & Elledge, S. J. Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function. Proc. Natl. Acad. Sci. USA 103, 18143\u201318147 (2006).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"9084_CR19","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2021108819","volume":"40","author":"ML Jones","year":"2021","unstructured":"Jones, M. L., Baris, Y., Taylor, M. R. G. & Yeeles, J. T. P. Structure of a human replisome shows the organisation and interactions of a DNA replication machine. EMBO J. 40, e108819 (2021).","journal-title":"EMBO J."},{"key":"9084_CR20","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1038\/nrc1977","volume":"6","author":"Y Pommier","year":"2006","unstructured":"Pommier, Y. Topoisomerase I inhibitors: camptothecins and beyond. Nat. Rev. Cancer 6, 789\u2013802 (2006).","journal-title":"Nat. Rev. Cancer"},{"key":"9084_CR21","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.chembiol.2010.04.012","volume":"17","author":"Y Pommier","year":"2010","unstructured":"Pommier, Y., Leo, E., Zhang, H. & Marchand, C. DNA topoisomerases and their poisoning by anticancer and antibacterial drugs. Chem. Biol. 17, 421\u2013433 (2010).","journal-title":"Chem. Biol."},{"key":"9084_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2020.102926","volume":"94","author":"Y Sun","year":"2020","unstructured":"Sun, Y., Saha, L. K., Saha, S., Jo, U. & Pommier, Y. Debulking of topoisomerase DNA-protein crosslinks (TOP-DPC) by the proteasome, non-proteasomal and non-proteolytic pathways. DNA Repair 94, 102926 (2020).","journal-title":"DNA Repair"},{"key":"9084_CR23","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.dnarep.2015.04.016","volume":"32","author":"N Makharashvili","year":"2015","unstructured":"Makharashvili, N. & Paull, T. T. CtIP: A DNA damage response protein at the intersection of DNA metabolism. DNA Repair 32, 75\u201381 (2015).","journal-title":"DNA Repair"},{"key":"9084_CR24","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/j.molcel.2016.10.017","volume":"64","author":"R Anand","year":"2016","unstructured":"Anand, R., Ranjha, L., Cannavo, E. & Cejka, P. Phosphorylated CtIP functions as a co-factor of the MRE11-RAD50-NBS1 endonuclease in DNA end resection. Mol. Cell 64, 940\u2013950 (2016).","journal-title":"Mol. Cell"},{"key":"9084_CR25","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1006\/jmbi.2001.4564","volume":"307","author":"C Arnaudeau","year":"2001","unstructured":"Arnaudeau, C., Lundin, C. & Helleday, T. DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells. J. Mol. Biol. 307, 1235\u20131245 (2001).","journal-title":"J. Mol. Biol."},{"key":"9084_CR26","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1126\/science.1140321","volume":"316","author":"S Matsuoka","year":"2007","unstructured":"Matsuoka, S. et al. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316, 1160\u20131166 (2007).","journal-title":"Science"},{"key":"9084_CR27","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1089\/hum.2010.099","volume":"22","author":"N Heinz","year":"2011","unstructured":"Heinz, N. et al. Retroviral and transposon-based tet-regulated all-in-one vectors with reduced background expression and improved dynamic range. Hum. Gene Ther. 22, 166\u2013176 (2011).","journal-title":"Hum. Gene Ther."},{"key":"9084_CR28","doi-asserted-by":"publisher","first-page":"9501","DOI":"10.1074\/jbc.275.13.9501","volume":"275","author":"TT Huang","year":"2000","unstructured":"Huang, T. T. et al. NF-kappaB activation by camptothecin. A linkage between nuclear DNA damage and cytoplasmic signaling events. J. Biol. Chem. 275, 9501\u20139509 (2000).","journal-title":"J. Biol. Chem."},{"key":"9084_CR29","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1126\/science.1121513","volume":"311","author":"ZH Wu","year":"2006","unstructured":"Wu, Z. H., Shi, Y., Tibbetts, R. S. & Miyamoto, S. Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli. Science 311, 1141\u20131146 (2006).","journal-title":"Science"},{"key":"9084_CR30","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/j.dnarep.2009.04.004","volume":"8","author":"DH Mohammad","year":"2009","unstructured":"Mohammad, D. H. & Yaffe, M. B. 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response. DNA Repair 8, 1009\u20131017 (2009).","journal-title":"DNA Repair"},{"key":"9084_CR31","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1038\/nature01447","volume":"421","author":"Z Lou","year":"2003","unstructured":"Lou, Z., Minter-Dykhouse, K., Wu, X. & Chen, J. MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature 421, 957\u2013961 (2003).","journal-title":"Nature"},{"key":"9084_CR32","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1038\/nature01446","volume":"421","author":"GS Stewart","year":"2003","unstructured":"Stewart, G. S., Wang, B., Bignell, C. R., Taylor, A. M. & Elledge, S. J. MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature 421, 961\u2013966 (2003).","journal-title":"Nature"},{"key":"9084_CR33","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1038\/nature01445","volume":"421","author":"M Goldberg","year":"2003","unstructured":"Goldberg, M. et al. MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature 421, 952\u2013956 (2003).","journal-title":"Nature"},{"key":"9084_CR34","doi-asserted-by":"crossref","unstructured":"Liptay M. et al. MDC1 counteracts restrained replication fork restart and its loss causes chemoresistance in BRCA1\/2-deficient mammary tumors. bioRxiv, 2022.2008.2018.504391 (2022).","DOI":"10.1101\/2022.08.18.504391"},{"key":"9084_CR35","doi-asserted-by":"publisher","first-page":"3097","DOI":"10.1038\/s41418-020-0564-6","volume":"27","author":"A Shahbandi","year":"2020","unstructured":"Shahbandi, A. et al. BH3 mimetics selectively eliminate chemotherapy-induced senescent cells and improve response in TP53 wild-type breast cancer. Cell Death Differ. 27, 3097\u20133116 (2020).","journal-title":"Cell Death Differ."},{"key":"9084_CR36","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.trecan.2021.12.002","volume":"8","author":"NV Ivanisenko","year":"2022","unstructured":"Ivanisenko, N. V. et al. Regulation of extrinsic apoptotic signaling by c-FLIP: towards targeting cancer networks. Trends Cancer 8, 190\u2013209 (2022).","journal-title":"Trends Cancer"},{"key":"9084_CR37","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.ctrv.2006.07.001","volume":"32","author":"C Fuchs","year":"2006","unstructured":"Fuchs, C., Mitchell, E. P. & Hoff, P. M. Irinotecan in the treatment of colorectal cancer. Cancer Treat. Rev. 32, 491\u2013503 (2006).","journal-title":"Cancer Treat. Rev."},{"key":"9084_CR38","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1002\/humu.10175","volume":"21","author":"B Iacopetta","year":"2003","unstructured":"Iacopetta, B. TP53 mutation in colorectal cancer. Hum. Mutat. 21, 271\u2013276 (2003).","journal-title":"Hum. Mutat."},{"key":"9084_CR39","doi-asserted-by":"crossref","unstructured":"Saldanha J., Rageul J., Patel J. A. & Kim H. The adaptive mechanisms and checkpoint responses to a stressed DNA replication fork. Int. J. Mol. Sci. 24, 10488 (2023).","DOI":"10.3390\/ijms241310488"},{"key":"9084_CR40","doi-asserted-by":"publisher","first-page":"597","DOI":"10.3892\/ijo.2014.2751","volume":"46","author":"N Elgohary","year":"2015","unstructured":"Elgohary, N. et al. Protumorigenic role of timeless in hepatocellular carcinoma. Int. J. Oncol. 46, 597\u2013606 (2015).","journal-title":"Int. J. Oncol."},{"key":"9084_CR41","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1111\/cas.12068","volume":"104","author":"K Yoshida","year":"2013","unstructured":"Yoshida, K. et al. TIMELESS is overexpressed in lung cancer and its expression correlates with poor patient survival. Cancer Sci. 104, 171\u2013177 (2013).","journal-title":"Cancer Sci."},{"key":"9084_CR42","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08886-8","volume":"10","author":"JN Bianco","year":"2019","unstructured":"Bianco, J. N. et al. Overexpression of claspin and timeless protects cancer cells from replication stress in a checkpoint-independent manner. Nat. Commun. 10, 910 (2019).","journal-title":"Nat. Commun."},{"key":"9084_CR43","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.molcel.2005.11.025","volume":"21","author":"Z Lou","year":"2006","unstructured":"Lou, Z. et al. MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol. Cell 21, 187\u2013200 (2006).","journal-title":"Mol. Cell"},{"key":"9084_CR44","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/j.1600-065X.2012.01101.x","volume":"246","author":"KW McCool","year":"2012","unstructured":"McCool, K. W. & Miyamoto, S. DNA damage-dependent NF-kappaB activation: NEMO turns nuclear signaling inside out. Immunol. Rev. 246, 311\u2013326 (2012).","journal-title":"Immunol. Rev."},{"key":"9084_CR45","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/s41392-024-01757-9","volume":"9","author":"Q Guo","year":"2024","unstructured":"Guo, Q. et al. NF-kappaB in biology and targeted therapy: new insights and translational implications. Signal. Transduct. Target Ther. 9, 53 (2024).","journal-title":"Signal. Transduct. Target Ther."},{"key":"9084_CR46","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/s41571-022-00668-4","volume":"19","author":"CA Schmitt","year":"2022","unstructured":"Schmitt, C. A., Wang, B. & Demaria, M. Senescence and cancer\u2014role and therapeutic opportunities. Nat. Rev. Clin. Oncol. 19, 619\u2013636 (2022).","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"9084_CR47","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1038\/cdd.2015.137","volume":"23","author":"K Schleich","year":"2016","unstructured":"Schleich, K. et al. Molecular architecture of the DED chains at the DISC: regulation of procaspase-8 activation by short DED proteins c-FLIP and procaspase-8 prodomain. Cell Death Differ. 23, 681\u2013694 (2016).","journal-title":"Cell Death Differ."},{"key":"9084_CR48","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.molcel.2011.06.006","volume":"43","author":"T Tenev","year":"2011","unstructured":"Tenev, T. et al. The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol. Cell 43, 432\u2013448 (2011).","journal-title":"Mol. Cell"},{"key":"9084_CR49","doi-asserted-by":"publisher","first-page":"2432","DOI":"10.1158\/1535-7163.MCT-16-0211","volume":"15","author":"KA McLaughlin","year":"2016","unstructured":"McLaughlin, K. A. et al. FLIP: a targetable mediator of resistance to radiation in non-small cell lung cancer. Mol. Cancer Ther. 15, 2432\u20132441 (2016).","journal-title":"Mol. Cancer Ther."},{"key":"9084_CR50","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1038\/sj.onc.1209122","volume":"25","author":"DB Longley","year":"2006","unstructured":"Longley, D. B. et al. c-FLIP inhibits chemotherapy-induced colorectal cancer cell death. Oncogene 25, 838\u2013848 (2006).","journal-title":"Oncogene"},{"key":"9084_CR51","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1016\/j.molcel.2019.12.023","volume":"77","author":"I Muller","year":"2020","unstructured":"Muller, I. et al. Cancer cells employ nuclear caspase-8 to overcome the p53-dependent G2\/M checkpoint through cleavage of USP28. Mol. Cell 77, 970\u2013984.e977 (2020).","journal-title":"Mol. Cell"},{"key":"9084_CR52","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/s41422-022-00673-3","volume":"32","author":"W Li","year":"2022","unstructured":"Li, W. et al. Nuclear RIPK1 promotes chromatin remodeling to mediate inflammatory response. Cell Res. 32, 621\u2013637 (2022).","journal-title":"Cell Res."},{"key":"9084_CR53","doi-asserted-by":"crossref","unstructured":"Patel J. A. et al. The DNA-PKcs\/JNK\/p53 pathway underlies changes in cell fate decision toward death during DNA replication catastrophe. Nucleic Acids Res. 53, gkaf573 (2025).","DOI":"10.1093\/nar\/gkaf573"},{"key":"9084_CR54","doi-asserted-by":"crossref","unstructured":"Sun Y. Quantitative Detection of DNA-protein crosslinks and their post-translational modifications. J. Vis. Exp. 194, e65315 (2023).","DOI":"10.3791\/65315"},{"key":"9084_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.102268","volume":"298","author":"AS Weinheimer","year":"2022","unstructured":"Weinheimer, A. S. et al. Extended DNA-binding interfaces beyond the canonical SAP domain contribute to the function of replication stress regulator SDE2 at DNA replication forks. J. Biol. Chem. 298, 102268 (2022).","journal-title":"J. Biol. Chem."}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-09084-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-09084-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-09084-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T15:05:06Z","timestamp":1764083106000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-09084-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["9084"],"URL":"https:\/\/doi.org\/10.1038\/s42003-025-09084-7","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]},"assertion":[{"value":"26 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1683"}}