{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:27:39Z","timestamp":1789676859863,"version":"4.0.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T00:00:00Z","timestamp":1763856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-025-09213-2","type":"journal-article","created":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T08:25:07Z","timestamp":1763886307000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dcaf15-mediated EphA2 degradation triggers disruption of the blood-brain barrier during Streptococcus suis meningitis"],"prefix":"10.1038","volume":"8","author":[{"given":"Hang","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqi","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuying","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqiao","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0191-1378","authenticated-orcid":false,"given":"Xiangru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9005-3186","authenticated-orcid":false,"given":"Lianci","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3094-5059","authenticated-orcid":false,"given":"Rendong","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,23]]},"reference":[{"key":"9213_CR1","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1007\/s10571-018-0609-2","volume":"38","author":"MMJ Al-Obaidi","year":"2018","unstructured":"Al-Obaidi, M. M. J. & Desa, M. N. M. Mechanisms of blood brain barrier disruption by different types of bacteria, and bacterial-host interactions facilitate the bacterial pathogen invading the brain. Cell Mol. Neurobiol. 38, 1349\u20131368 (2018).","journal-title":"Cell Mol. Neurobiol."},{"key":"9213_CR2","doi-asserted-by":"publisher","first-page":"e13132","DOI":"10.1111\/cmi.13132","volume":"22","author":"L Le Guennec","year":"2020","unstructured":"Le Guennec, L., Coureuil, M., Nassif, X. & Bourdoulous, S. Strategies used by bacterial pathogens to cross the blood-brain barrier. Cell Microbiol. 22, e13132 (2020).","journal-title":"Cell Microbiol."},{"key":"9213_CR3","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.3201\/eid2512.181709","volume":"25","author":"NM Susilawathi","year":"2019","unstructured":"Susilawathi, N. M. et al. Streptococcus suis-associated Meningitis, Bali, Indonesia, 2014-2017. Emerg. Infect. Dis. 25, 2235\u20132242 (2019).","journal-title":"Emerg. Infect. Dis."},{"key":"9213_CR4","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.vetmic.2016.12.034","volume":"199","author":"G Xiao","year":"2017","unstructured":"Xiao, G. et al. Streptococcus suis small RNA rss04 contributes to the induction of meningitis by regulating capsule synthesis and by inducing biofilm formation in a mouse infection model. Vet. Microbiol. 199, 111\u2013119 (2017).","journal-title":"Vet. Microbiol."},{"key":"9213_CR5","doi-asserted-by":"publisher","first-page":"e12862","DOI":"10.1111\/cmi.12862","volume":"20","author":"L Rui","year":"2018","unstructured":"Rui, L. et al. The serine\/threonine protein kinase of Streptococcus suis serotype 2 affects the ability of the pathogen to penetrate the blood-brain barrier. Cell Microbiol. 20, e12862 (2018).","journal-title":"Cell Microbiol."},{"key":"9213_CR6","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s13567-020-00887-6","volume":"52","author":"H Liu","year":"2021","unstructured":"Liu, H. et al. Streptococcus suis serotype 2 enolase interaction with host brain microvascular endothelial cells and RPSA-induced apoptosis lead to loss of BBB integrity. Vet. Res. 52, 30 (2021).","journal-title":"Vet. Res."},{"key":"9213_CR7","doi-asserted-by":"publisher","first-page":"e1010710","DOI":"10.1371\/journal.ppat.1010710","volume":"18","author":"Z Pan","year":"2022","unstructured":"Pan, Z. et al. SssP1, a Fimbria-like component of Streptococcus suis, binds to the vimentin of host cells and contributes to bacterial meningitis. PLoS Pathog. 18, e1010710 (2022).","journal-title":"PLoS Pathog."},{"key":"9213_CR8","doi-asserted-by":"publisher","first-page":"131839","DOI":"10.1016\/j.ijbiomac.2024.131839","volume":"268","author":"C Jiang","year":"2024","unstructured":"Jiang, C. et al. ARF6 promotes Streptococcus suis suilysin induced apoptosis in HBMECs. Int. J. Biol. Macromol. 268, 131839 (2024).","journal-title":"Int. J. Biol. Macromol."},{"key":"9213_CR9","doi-asserted-by":"publisher","first-page":"110161","DOI":"10.1016\/j.vetmic.2024.110161","volume":"295","author":"X Cao","year":"2024","unstructured":"Cao, X. et al. The critical role of NLRP3 inflammasome activation in Streptococcus suis-induced blood-brain barrier disruption. Vet. Microbiol. 295, 110161 (2024).","journal-title":"Vet. Microbiol."},{"key":"9213_CR10","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/nrm.2015.16","volume":"17","author":"A Kania","year":"2016","unstructured":"Kania, A. & Klein, R. Mechanisms of ephrin-Eph signalling in development, physiology and disease. Nat. Rev. Mol. Cell Biol. 17, 240\u2013256 (2016).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"9213_CR11","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.celrep.2019.06.020","volume":"28","author":"M Swidergall","year":"2019","unstructured":"Swidergall, M. et al. EphA2 is a neutrophil receptor for candida albicans that stimulates antifungal activity during oropharyngeal infection. Cell Rep. 28, 423\u2013433.e425 (2019).","journal-title":"Cell Rep."},{"key":"9213_CR12","doi-asserted-by":"publisher","first-page":"e1004846","DOI":"10.1371\/journal.ppat.1004846","volume":"11","author":"P Subbarayal","year":"2015","unstructured":"Subbarayal, P. et al. EphrinA2 receptor (EphA2) is an invasion and intracellular signaling receptor for Chlamydia trachomatis. PLoS Pathog. 11, e1004846 (2015).","journal-title":"PLoS Pathog."},{"key":"9213_CR13","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/nm.2341","volume":"17","author":"J Lupberger","year":"2011","unstructured":"Lupberger, J. et al. EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. Nat. Med. 17, 589\u2013595 (2011).","journal-title":"Nat. Med."},{"key":"9213_CR14","doi-asserted-by":"publisher","unstructured":"Aaron, P. A., Jamklang, M., Uhrig, J. P. & Gelli, A. The blood-brain barrier internalises Cryptococcus neoformans via the EphA2-tyrosine kinase receptor. Cell Microbiol. 20, https:\/\/doi.org\/10.1111\/cmi.12811 (2018).","DOI":"10.1111\/cmi.12811"},{"key":"9213_CR15","doi-asserted-by":"publisher","first-page":"e1008261","DOI":"10.1371\/journal.ppat.1008261","volume":"16","author":"TK Darling","year":"2020","unstructured":"Darling, T. K. et al. EphA2 contributes to disruption of the blood-brain barrier in cerebral malaria. PLoS Pathog. 16, e1008261 (2020).","journal-title":"PLoS Pathog."},{"key":"9213_CR16","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.mvr.2011.06.005","volume":"82","author":"N Zhou","year":"2011","unstructured":"Zhou, N. et al. Inactivation of EphA2 promotes tight junction formation and impairs angiogenesis in brain endothelial cells. Microvasc. Res. 82, 113\u2013121 (2011).","journal-title":"Microvasc. Res."},{"key":"9213_CR17","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1128\/IAI.69.2.845-852.2001","volume":"69","author":"G Zysk","year":"2001","unstructured":"Zysk, G. et al. Pneumolysin is the main inducer of cytotoxicity to brain microvascular endothelial cells caused by Streptococcus pneumoniae. Infect. Immun. 69, 845\u2013852 (2001).","journal-title":"Infect. Immun."},{"key":"9213_CR18","doi-asserted-by":"publisher","first-page":"109024","DOI":"10.1016\/j.abb.2021.109024","volume":"711","author":"J Han","year":"2021","unstructured":"Han, J. et al. EphA2 inhibits SRA01\/04 cells apoptosis by suppressing autophagy via activating PI3K\/Akt\/mTOR pathway. Arch. Biochem. Biophys. 711, 109024 (2021).","journal-title":"Arch. Biochem. Biophys."},{"key":"9213_CR19","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.jtos.2021.06.006","volume":"21","author":"N Kaplan","year":"2021","unstructured":"Kaplan, N. et al. Ciliogenesis and autophagy are coordinately regulated by EphA2 in the cornea to maintain proper epithelial architecture. Ocul. Surf. 21, 193\u2013205 (2021).","journal-title":"Ocul. Surf."},{"key":"9213_CR20","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1007\/s11033-024-09875-x","volume":"51","author":"PP Mubthasima","year":"2024","unstructured":"Mubthasima, P. P., Singh, S. A. & Kannan, A. Sesamol-mediated targeting of EPHA2 sensitises cervical cancer for cisplatin treatment by regulating mitochondrial dynamics, autophagy, and mitophagy. Mol. Biol. Rep. 51, 949 (2024).","journal-title":"Mol. Biol. Rep."},{"key":"9213_CR21","doi-asserted-by":"publisher","unstructured":"Harly, C. et al. Human \u03b3\u03b4 T cell sensing of AMPK-dependent metabolic tumor reprogramming through TCR recognition of EphA2. Sci. Immunol. 6, https:\/\/doi.org\/10.1126\/sciimmunol.aba9010 (2021).","DOI":"10.1126\/sciimmunol.aba9010"},{"key":"9213_CR22","doi-asserted-by":"publisher","first-page":"2440","DOI":"10.1002\/ijc.32313","volume":"145","author":"Z Chen","year":"2019","unstructured":"Chen, Z. et al. EPHA2 blockade reverses acquired resistance to afatinib induced by EPHA2-mediated MAPK pathway activation in gastric cancer cells and avatar mice. Int. J. Cancer 145, 2440\u20132449 (2019).","journal-title":"Int. J. Cancer"},{"key":"9213_CR23","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-024-01689-5","volume":"22","author":"CB Trelford","year":"2024","unstructured":"Trelford, C. B. & Shepherd, T. G. LKB1 biology: assessing the therapeutic relevancy of LKB1 inhibitors. Cell Commun. Signal 22, 310 (2024).","journal-title":"Cell Commun. Signal"},{"key":"9213_CR24","doi-asserted-by":"publisher","first-page":"103025","DOI":"10.1016\/j.jbc.2023.103025","volume":"299","author":"J Lu","year":"2023","unstructured":"Lu, J. et al. The aryl sulfonamide indisulam inhibits gastric cancer cell migration by promoting the ubiquitination and degradation of the transcription factor ZEB1. J. Biol. Chem. 299, 103025 (2023).","journal-title":"J. Biol. Chem."},{"key":"9213_CR25","doi-asserted-by":"publisher","unstructured":"Han, T. et al. Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15. Science 356, https:\/\/doi.org\/10.1126\/science.aal3755 (2017).","DOI":"10.1126\/science.aal3755"},{"key":"9213_CR26","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1016\/j.celrep.2019.09.079","volume":"29","author":"TC Ting","year":"2019","unstructured":"Ting, T. C. et al. Aryl sulfonamides degrade RBM39 and RBM23 by recruitment to CRL4-DCAF15. Cell Rep. 29, 1499\u20131510.e1496 (2019).","journal-title":"Cell Rep."},{"key":"9213_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15398","volume":"8","author":"J An","year":"2017","unstructured":"An, J. et al. pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4(CRBN) ubiquitin ligase. Nat. Commun. 8, 15398 (2017).","journal-title":"Nat. Commun."},{"key":"9213_CR28","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/s41580-018-0081-3","volume":"20","author":"T Narita","year":"2019","unstructured":"Narita, T., Weinert, B. T. & Choudhary, C. Functions and mechanisms of non-histone protein acetylation. Nat. Rev. Mol. Cell Biol. 20, 156\u2013174 (2019).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"9213_CR29","doi-asserted-by":"publisher","first-page":"135234","DOI":"10.1016\/j.neulet.2020.135234","volume":"736","author":"Y Zhao","year":"2020","unstructured":"Zhao, Y. et al. High expression of EphA2 led to secondary injury by destruction of BBB integrity though the ROCK pathway after diffuse axonal injury. Neurosci. Lett. 736, 135234 (2020).","journal-title":"Neurosci. Lett."},{"key":"9213_CR30","doi-asserted-by":"publisher","first-page":"e53528","DOI":"10.1371\/journal.pone.0053528","volume":"8","author":"J Thundyil","year":"2013","unstructured":"Thundyil, J. et al. Evidence that the EphA2 receptor exacerbates ischemic brain injury. PLoS One 8, e53528 (2013).","journal-title":"PLoS One"},{"key":"9213_CR31","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/s41564-017-0059-5","volume":"3","author":"M Swidergall","year":"2018","unstructured":"Swidergall, M., Solis, N. V., Lionakis, M. S. & Filler, S. G. EphA2 is an epithelial cell pattern recognition receptor for fungal \u03b2-glucans. Nat. Microbiol. 3, 53\u201361 (2018).","journal-title":"Nat. Microbiol."},{"key":"9213_CR32","doi-asserted-by":"publisher","first-page":"e0081123","DOI":"10.1128\/aac.00811-23","volume":"68","author":"TJ Kottom","year":"2024","unstructured":"Kottom, T. J., Carmona, E. M. & Limper, A. H. Targeting host tyrosine kinase receptor EphA2 signaling via small-molecule ALW-II-41-27 inhibits macrophage pro-inflammatory signaling responses to Pneumocystis carinii \u03b2-glucans. Antimicrob. Agents Chemother. 68, e0081123 (2024).","journal-title":"Antimicrob. Agents Chemother."},{"key":"9213_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41564-017-0080-8","volume":"3","author":"H Zhang","year":"2018","unstructured":"Zhang, H. et al. Ephrin receptor A2 is an epithelial cell receptor for Epstein-Barr virus entry. Nat. Microbiol. 3, 1\u20138 (2018).","journal-title":"Nat. Microbiol."},{"key":"9213_CR34","doi-asserted-by":"publisher","first-page":"5670","DOI":"10.2174\/0109298673256638231003111234","volume":"31","author":"M Vincenzi","year":"2024","unstructured":"Vincenzi, M., Mercurio, F. A. & Leone, M. EPHA2 Receptor as a Possible Therapeutic Target in Viral Infections. Curr. Med. Chem. 31, 5670\u20135701 (2024).","journal-title":"Curr. Med. Chem."},{"key":"9213_CR35","doi-asserted-by":"publisher","first-page":"e49666","DOI":"10.15252\/embr.201949666","volume":"21","author":"A Zhang","year":"2020","unstructured":"Zhang, A. et al. EphA2 phosphorylates NLRP3 and inhibits inflammasomes in airway epithelial cells. EMBO Rep. 21, e49666 (2020).","journal-title":"EMBO Rep."},{"key":"9213_CR36","doi-asserted-by":"publisher","first-page":"3048","DOI":"10.1080\/15548627.2020.1851897","volume":"17","author":"Z Yang","year":"2021","unstructured":"Yang, Z. et al. Autophagy alleviates hypoxia-induced blood-brain barrier injury via regulation of CLDN5 (claudin 5). Autophagy 17, 3048\u20133067 (2021).","journal-title":"Autophagy"},{"key":"9213_CR37","doi-asserted-by":"publisher","first-page":"136743","DOI":"10.1016\/j.neulet.2022.136743","volume":"783","author":"G Wang","year":"2022","unstructured":"Wang, G. et al. NOD2-RIP2 signaling alleviates microglial ROS damage and pyroptosis via ULK1-mediated autophagy during Streptococcus pneumonia infection. Neurosci. Lett. 783, 136743 (2022).","journal-title":"Neurosci. Lett."},{"key":"9213_CR38","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1016\/j.ymthe.2021.11.004","volume":"30","author":"Z Yang","year":"2022","unstructured":"Yang, Z. et al. Circular RNA circ-FoxO3 attenuates blood-brain barrier damage by inducing autophagy during ischemia\/reperfusion. Mol. Ther. 30, 1275\u20131287 (2022).","journal-title":"Mol. Ther."},{"key":"9213_CR39","doi-asserted-by":"publisher","first-page":"3813","DOI":"10.1080\/15548627.2021.1872187","volume":"17","author":"A Wani","year":"2021","unstructured":"Wani, A. et al. Crocetin promotes clearance of amyloid-\u03b2 by inducing autophagy via the STK11\/LKB1-mediated AMPK pathway. Autophagy 17, 3813\u20133832 (2021).","journal-title":"Autophagy"},{"key":"9213_CR40","doi-asserted-by":"publisher","first-page":"e2219435120","DOI":"10.1073\/pnas.2219435120","volume":"120","author":"F Pan","year":"2023","unstructured":"Pan, F. et al. Membrane vesicle delivery of a streptococcal M protein disrupts the blood-brain barrier by inducing autophagic endothelial cell death. Proc. Natl. Acad. Sci. USA 120, e2219435120 (2023).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"9213_CR41","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-06624-7","volume":"15","author":"A Li","year":"2024","unstructured":"Li, A. et al. USP3 promotes osteosarcoma progression via deubiquitinating EPHA2 and activating the PI3K\/AKT signaling pathway. Cell Death Dis. 15, 235 (2024).","journal-title":"Cell Death Dis."},{"key":"9213_CR42","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06188-y","volume":"14","author":"X Li","year":"2023","unstructured":"Li, X., Wang, F., Huang, L., Yang, M. & Kuang, E. Downregulation of EphA2 stability by RNF5 limits its tumor-suppressive function in HER2-negative breast cancers. Cell Death Dis. 14, 662 (2023).","journal-title":"Cell Death Dis."},{"key":"9213_CR43","doi-asserted-by":"publisher","first-page":"10603","DOI":"10.18632\/aging.202823","volume":"13","author":"X Dong","year":"2021","unstructured":"Dong, X. et al. Tumor suppressor DCAF15 inhibits epithelial-mesenchymal transition by targeting ZEB1 for proteasomal degradation in hepatocellular carcinoma. Aging 13, 10603\u201310618 (2021).","journal-title":"Aging"},{"key":"9213_CR44","doi-asserted-by":"publisher","unstructured":"Waltho, A. et al. K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors. Life Sci. Alliance 7, https:\/\/doi.org\/10.26508\/lsa.202402740 (2024).","DOI":"10.26508\/lsa.202402740"},{"key":"9213_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s11658-020-00245-6","volume":"26","author":"M Tracz","year":"2021","unstructured":"Tracz, M. & Bialek, W. Beyond K48 and K63: non-canonical protein ubiquitination. Cell Mol. Biol. Lett. 26, 1 (2021).","journal-title":"Cell Mol. Biol. Lett."},{"key":"9213_CR46","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49882-x","volume":"15","author":"GP Grothusen","year":"2024","unstructured":"Grothusen, G. P. et al. DCAF15 control of cohesin dynamics sustains acute myeloid leukemia. Nat. Commun. 15, 5604 (2024).","journal-title":"Nat. Commun."},{"key":"9213_CR47","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1080\/15548627.2024.2330043","volume":"20","author":"L Cui","year":"2024","unstructured":"Cui, L. et al. Streptococcus pneumoniae extracellular vesicles aggravate alveolar epithelial barrier disruption via autophagic degradation of OCLN (occludin). Autophagy 20, 1577\u20131596 (2024).","journal-title":"Autophagy"}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-09213-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-09213-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-09213-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T23:03:39Z","timestamp":1767049419000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-09213-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,23]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["9213"],"URL":"https:\/\/doi.org\/10.1038\/s42003-025-09213-2","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,23]]},"assertion":[{"value":"30 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1838"}}