{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T06:07:08Z","timestamp":1767679628425,"version":"3.48.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":37,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-025-09243-w","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T10:43:47Z","timestamp":1764413027000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SNX16 aggravates AngII-induced cardiac hypertrophy in mice via EGFR transactivation"],"prefix":"10.1038","volume":"9","author":[{"given":"Lin","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guan-Hui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Ye","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu-Hui","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing-Qian","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Jiong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Yong","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi-Kun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu-Lu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2650-5747","authenticated-orcid":false,"given":"Yong","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4257-207X","authenticated-orcid":false,"given":"Hong-Bo","family":"Xin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3519-6846","authenticated-orcid":false,"given":"Ke-Yu","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,29]]},"reference":[{"key":"9243_CR1","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1038\/s41419-021-04222-5","volume":"12","author":"BB Zhang","year":"2021","unstructured":"Zhang, B. B. et al. Role of GALNT4 in protecting against cardiac hypertrophy through ASK1 signaling pathway. Cell Death Dis. 12, 980 (2021).","journal-title":"Cell Death Dis."},{"key":"9243_CR2","doi-asserted-by":"crossref","unstructured":"Greene, S. J., Failure Society of America Quality of Care et al. Building a Heart Failure Clinic: A Practical Guide from the Heart Failure Society of America. J. Card Fail. 27, 2\u201319 (2021).","DOI":"10.1016\/j.cardfail.2020.10.008"},{"key":"9243_CR3","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/nrm1983","volume":"7","author":"J Heineke","year":"2006","unstructured":"Heineke, J. & Molkentin, J. D. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat. Rev. Mol. Cell Biol. 7, 589\u2013600 (2006).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"9243_CR4","doi-asserted-by":"publisher","first-page":"2695","DOI":"10.1007\/s00018-004-4244-3","volume":"61","author":"NJ Smith","year":"2004","unstructured":"Smith, N. J., Chan, H. W., Osborne, J. E., Thomas, W. G. & Hannan, R. D. Hijacking epidermal growth factor receptors by angiotensin II: new possibilities for understanding and treating cardiac hypertrophy. Cell Mol. Life Sci. 61, 2695\u20132703 (2004).","journal-title":"Cell Mol. Life Sci."},{"key":"9243_CR5","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.advenzreg.2009.10.002","volume":"50","author":"N Attar","year":"2010","unstructured":"Attar, N. & Cullen, P. J. The retromer complex. Adv. Enzym. Regul. 50, 216\u2013236 (2010).","journal-title":"Adv. Enzym. Regul."},{"key":"9243_CR6","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1042\/BJ20111226","volume":"441","author":"RD Teasdale","year":"2012","unstructured":"Teasdale, R. D. & Collins, B. M. Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease. Biochem. J. 441, 39\u201359 (2012).","journal-title":"Biochem. J."},{"key":"9243_CR7","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1042\/CS20190034","volume":"133","author":"J Yang","year":"2019","unstructured":"Yang, J., Villar, V. A. M., Rozyyev, S., Jose, P. A. & Zeng, C. The emerging role of sorting nexins in cardiovascular diseases. Clin. Sci. 133, 723\u2013737 (2019).","journal-title":"Clin. Sci."},{"key":"9243_CR8","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1038\/s41440-021-00661-x","volume":"44","author":"C Liu","year":"2021","unstructured":"Liu, C. et al. Increased AT1 receptor expression mediates vasoconstriction leading to hypertension in Snx1-\/- mice. Hypertens. Res. 44, 906\u2013917 (2021).","journal-title":"Hypertens. Res."},{"key":"9243_CR9","doi-asserted-by":"publisher","first-page":"34617","DOI":"10.1074\/jbc.M300143200","volume":"278","author":"BJ Hanson","year":"2003","unstructured":"Hanson, B. J. & Hong, W. Evidence for a role of SNX16 in regulating traffic between the early and later endosomal compartments. J. Biol. Chem. 278, 34617\u201334630 (2003).","journal-title":"J. Biol. Chem."},{"key":"9243_CR10","doi-asserted-by":"publisher","first-page":"2600","DOI":"10.1083\/jcb.201811074","volume":"218","author":"S Wang","year":"2019","unstructured":"Wang, S., Zhao, Z. & Rodal, A. A. Higher-order assembly of Sorting Nexin 16 controls tubulation and distribution of neuronal endosomes. J. Cell Biol. 218, 2600\u20132618 (2019).","journal-title":"J. Cell Biol."},{"key":"9243_CR11","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1016\/j.str.2017.06.015","volume":"25","author":"J Xu","year":"2017","unstructured":"Xu, J. et al. SNX16 regulates the recycling of E-cadherin through a unique mechanism of coordinated membrane and cargo binding. Structure 25, 1251\u20131263 e1255 (2017).","journal-title":"Structure"},{"key":"9243_CR12","doi-asserted-by":"publisher","first-page":"4209","DOI":"10.1242\/jcs.01233","volume":"117","author":"JH Choi","year":"2004","unstructured":"Choi, J. H. et al. Sorting nexin 16 regulates EGF receptor trafficking by phosphatidylinositol-3-phosphate interaction with the Phox domain. J. Cell Sci. 117, 4209\u20134218 (2004).","journal-title":"J. Cell Sci."},{"key":"9243_CR13","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/ncb1269","volume":"7","author":"IL Blanc","year":"2005","unstructured":"Blanc, I. L. et al. Endosome-to-cytosol transport of viral nucleocapsids. Nat. Cell Biol. 7, 653\u2013664 (2005).","journal-title":"Nat. Cell Biol."},{"key":"9243_CR14","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/2045-9769-2-3","volume":"2","author":"L Zhang","year":"2013","unstructured":"Zhang, L., Qin, D., Hao, C., Shu, X. & Pei, D. SNX16 negatively regulates the migration and tumorigenesis of MCF-7 cells. Cell Regen. 2, 3 (2013).","journal-title":"Cell Regen."},{"key":"9243_CR15","doi-asserted-by":"publisher","first-page":"e21771","DOI":"10.1371\/journal.pone.0021771","volume":"6","author":"B Brankatschk","year":"2011","unstructured":"Brankatschk, B., Pons, V., Parton, R. G. & Gruenberg, J. Role of SNX16 in the dynamics of tubulo-cisternal membrane domains of late endosomes. PLoS One 6, e21771 (2011).","journal-title":"PLoS One"},{"key":"9243_CR16","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1002\/1878-0261.12626","volume":"14","author":"Z Shen","year":"2020","unstructured":"Shen, Z. et al. SNX16 activates c-Myc signaling by inhibiting ubiquitin-mediated proteasomal degradation of eEF1A2 in colorectal cancer development. Mol. Oncol. 14, 387\u2013406 (2020).","journal-title":"Mol. Oncol."},{"key":"9243_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6177","volume":"5","author":"J Li","year":"2014","unstructured":"Li, J. et al. SNX13 reduction mediates heart failure through degradative sorting of apoptosis repressor with caspase recruitment domain. Nat. Commun. 5, 5177 (2014).","journal-title":"Nat. Commun."},{"key":"9243_CR18","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1161\/CIRCGENETICS.109.895763","volume":"3","author":"NL Smith","year":"2010","unstructured":"Smith, N. L. et al. Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium. Circ. Cardiovasc. Genet. 3, 256\u2013266 (2010).","journal-title":"Circ. Cardiovasc. Genet."},{"key":"9243_CR19","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1590\/1414-431X20132809","volume":"47","author":"WG Sui","year":"2014","unstructured":"Sui, W. G. et al. ChIP-seq analysis of histone H3K9 trimethylation in peripheral blood mononuclear cells of membranous nephropathy patients. Braz. J. Med. Biol. Res. 47, 42\u201349 (2014).","journal-title":"Braz. J. Med. Biol. Res."},{"key":"9243_CR20","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1146\/annurev-pharmtox-070115-095427","volume":"56","author":"SJ Forrester","year":"2016","unstructured":"Forrester, S. J. et al. Epidermal growth factor receptor transactivation: mechanisms, pathophysiology, and potential therapies in the cardiovascular system. Annu. Rev. Pharm. Toxicol. 56, 627\u2013653 (2016).","journal-title":"Annu. Rev. Pharm. Toxicol."},{"key":"9243_CR21","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1111\/jcmm.12763","volume":"20","author":"K Peng","year":"2016","unstructured":"Peng, K. et al. Novel EGFR inhibitors attenuate cardiac hypertrophy induced by angiotensin II. J. Cell Mol. Med. 20, 482\u2013494 (2016).","journal-title":"J. Cell Mol. Med."},{"key":"9243_CR22","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1146\/annurev-biochem-081820-092427","volume":"90","author":"M von Zastrow","year":"2021","unstructured":"von Zastrow, M. & Sorkin, A. Mechanisms for regulating and organizing receptor signaling by endocytosis. Annu. Rev. Biochem. 90, 709\u2013737 (2021).","journal-title":"Annu. Rev. Biochem."},{"key":"9243_CR23","doi-asserted-by":"publisher","first-page":"10761","DOI":"10.3390\/ijms140610761","volume":"14","author":"K Sato","year":"2013","unstructured":"Sato, K. Cellular functions regulated by phosphorylation of EGFR on Tyr845. Int. J. Mol. Sci. 14, 10761\u201310790 (2013).","journal-title":"Int. J. Mol. Sci."},{"key":"9243_CR24","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1161\/CIRCULATIONAHA.120.051094","volume":"144","author":"Y Zhang","year":"2021","unstructured":"Zhang, Y. et al. HINT1 (Histidine Triad Nucleotide-Binding Protein 1) attenuates cardiac hypertrophy via suppressing HOXA5 (Homeobox A5) expression. Circulation 144, 638\u2013654 (2021).","journal-title":"Circulation"},{"key":"9243_CR25","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1042\/CS20060342","volume":"112","author":"S Higuchi","year":"2007","unstructured":"Higuchi, S. et al. Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology. Clin. Sci. 112, 417\u2013428 (2007).","journal-title":"Clin. Sci."},{"key":"9243_CR26","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/35052055","volume":"2","author":"M Zerial","year":"2001","unstructured":"Zerial, M. & McBride, H. Rab proteins as membrane organizers. Nat. Rev. Mol. Cell Biol. 2, 107\u2013117 (2001).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"9243_CR27","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1083\/jcb.131.6.1435","volume":"131","author":"Y Feng","year":"1995","unstructured":"Feng, Y., Press, B. & Wandinger-Ness, A. Rab 7: an important regulator of late endocytic membrane traffic. J. Cell Biol. 131, 1435\u20131452 (1995).","journal-title":"J. Cell Biol."},{"key":"9243_CR28","doi-asserted-by":"publisher","first-page":"3349","DOI":"10.1242\/jcs.108.11.3349","volume":"108","author":"S Meresse","year":"1995","unstructured":"Meresse, S., Gorvel, J. P. & Chavrier, P. The rab7 GTPase resides on a vesicular compartment connected to lysosomes. J. Cell Sci. 108, 3349\u20133358 (1995).","journal-title":"J. Cell Sci."},{"key":"9243_CR29","doi-asserted-by":"publisher","first-page":"3241","DOI":"10.1091\/mbc.9.11.3241","volume":"9","author":"W Chen","year":"1998","unstructured":"Chen, W., Feng, Y., Chen, D. & Wandinger-Ness, A. Rab11 is required for trans-golgi network-to-plasma membrane transport and a preferential target for GDP dissociation inhibitor. Mol. Biol. Cell 9, 3241\u20133257 (1998).","journal-title":"Mol. Biol. Cell"},{"key":"9243_CR30","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/S0092-8674(00)80578-4","volume":"96","author":"A Wilde","year":"1999","unstructured":"Wilde, A. et al. EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake. Cell 96, 677\u2013687 (1999).","journal-title":"Cell"},{"key":"9243_CR31","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.2174\/138161211796390976","volume":"17","author":"T Aoyagi","year":"2011","unstructured":"Aoyagi, T. & Matsui, T. Phosphoinositide-3 kinase signaling in cardiac hypertrophy and heart failure. Curr. Pharm. Des. 17, 1818\u20131824 (2011).","journal-title":"Curr. Pharm. Des."},{"key":"9243_CR32","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1016\/j.biocel.2009.08.002","volume":"41","author":"K Lorenz","year":"2009","unstructured":"Lorenz, K., Schmitt, J. P., Vidal, M. & Lohse, M. J. Cardiac hypertrophy: targeting Raf\/MEK\/ERK1\/2-signaling. Int. J. Biochem. Cell Biol. 41, 2351\u20132355 (2009).","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"9243_CR33","doi-asserted-by":"publisher","first-page":"e133","DOI":"10.1161\/atvb.26.9.1976","volume":"26","author":"H Ohtsu","year":"2006","unstructured":"Ohtsu, H. et al. ADAM17 mediates epidermal growth factor receptor transactivation and vascular smooth muscle cell hypertrophy induced by angiotensin II. Arterioscler Thromb. Vasc. Biol. 26, e133\u2013e137 (2006).","journal-title":"Arterioscler Thromb. Vasc. Biol."},{"key":"9243_CR34","doi-asserted-by":"publisher","first-page":"C1-10","DOI":"10.1152\/ajpcell.00620.2005","volume":"291","author":"H Ohtsu","year":"2006","unstructured":"Ohtsu, H., Dempsey, P. J. & Eguchi, S. ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors. Am. J. Physiol. Cell Physiol. 291, C1-10 (2006).","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"9243_CR35","doi-asserted-by":"publisher","first-page":"20597","DOI":"10.3390\/ijms141020597","volume":"14","author":"N Makki","year":"2013","unstructured":"Makki, N., Thiel, K. W. & Miller, F. J. Jr The epidermal growth factor receptor and its ligands in cardiovascular disease. Int. J. Mol. Sci. 14, 20597\u201320613 (2013).","journal-title":"Int. J. Mol. Sci."},{"key":"9243_CR36","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/bs.pmbts.2016.03.002","volume":"141","author":"A Conte","year":"2016","unstructured":"Conte, A. & Sigismund, S. Chapter six - the ubiquitin network in the control of EGFR endocytosis and signaling. Prog. Mol. Biol. Transl. Sci. 141, 225\u2013276 (2016).","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"9243_CR37","first-page":"55293","volume":"14","author":"W","year":"2017","unstructured":"W, C, Zaw, A. M., Law, H. K. & Chow, B. K. Minimally invasive transverse aortic constriction in mice. J. Vis. Exp. 14, 55293 (2017).","journal-title":"J. Vis. Exp."},{"key":"9243_CR38","first-page":"1265","volume":"42","author":"Z Li","year":"2018","unstructured":"Li, Z. et al. Long noncoding RNA myocardial infarctionassociated transcript is associated with the microRNA1505p\/P300 pathway in cardiac hypertrophy. Int. J. Mol. Med. 42, 1265\u20131272 (2018).","journal-title":"Int. J. Mol. Med."},{"key":"9243_CR39","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1042\/bj3500891","volume":"350","author":"SP Hauselmann","year":"2000","unstructured":"Hauselmann, S. P. et al. Sustained activation of p42\/p44 mitogen-activated protein kinase during recovery from simulated ischaemia mediates adaptive cytoprotection in cardiomyocytes. Biochem. J. 350, 891\u2013899 (2000).","journal-title":"Biochem. J."}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-09243-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-09243-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-09243-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T06:02:43Z","timestamp":1767679363000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-025-09243-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,29]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["9243"],"URL":"https:\/\/doi.org\/10.1038\/s42003-025-09243-w","relation":{},"ISSN":["2399-3642"],"issn-type":[{"type":"electronic","value":"2399-3642"}],"subject":[],"published":{"date-parts":[[2025,11,29]]},"assertion":[{"value":"2 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"14"}}