{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:17:00Z","timestamp":1794003420646,"version":"4.8.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-026-09561-7","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T18:54:50Z","timestamp":1769194490000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Gut metabolite indole-3-acetic acid aggravates neuropsychiatric lupus via the AHR\/STAT3 pathway in microglia"],"prefix":"10.1038","volume":"9","author":[{"given":"Yi","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxia","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5017-6272","authenticated-orcid":false,"given":"Ligang","family":"Jie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6485-8781","authenticated-orcid":false,"given":"Guangchuang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0094-5026","authenticated-orcid":false,"given":"Hao","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9566-4147","authenticated-orcid":false,"given":"Qin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"9561_CR1","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1136\/ard-2022-223741","volume":"82","author":"MK Crow","year":"2023","unstructured":"Crow, M. K. Pathogenesis of systemic lupus erythematosus: risks, mechanisms and therapeutic targets. Ann. Rheum. Dis. 82, 999\u20131014 (2023).","journal-title":"Ann. Rheum. Dis."},{"key":"9561_CR2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41584-018-0156-8","volume":"15","author":"N Schwartz","year":"2019","unstructured":"Schwartz, N., Stock, A. D. & Putterman, C. Neuropsychiatric lupus: new mechanistic insights and future treatment directions. Nat. Rev. Rheumatol. 15, 137\u2013152 (2019).","journal-title":"Nat. Rev. Rheumatol."},{"key":"9561_CR3","first-page":"414","volume":"19","author":"M Feng","year":"2014","unstructured":"Feng, M. et al. Clinical features and mortality in Chinese with lupus nephritis and neuropsychiatric lupus: A 124-patient study. J. Res. Med. Sci. 19, 414\u2013419 (2014).","journal-title":"J. Res. Med. Sci."},{"key":"9561_CR4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1749-6632.2011.06076.x","volume":"1228","author":"R Curiel","year":"2011","unstructured":"Curiel, R., Akin, E. A., Beaulieu, G., DePalma, L. & Hashefi, M. PET\/CT imaging in systemic lupus erythematosus. Ann. N. Y. Acad. Sci. 1228, 71\u201380 (2011).","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"9561_CR5","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1080\/1744666X.2018.1538789","volume":"14","author":"V Ocampo-Piraquive","year":"2018","unstructured":"Ocampo-Piraquive, V., Nieto-Aristiz\u00e1bal, I., Ca\u00f1as, C. A. & Tob\u00f3n, G. J. Mortality in systemic lupus erythematosus: causes, predictors and interventions. Expert Rev. Clin. Immunol. 14, 1043\u20131053 (2018).","journal-title":"Expert Rev. Clin. Immunol."},{"key":"9561_CR6","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41579-020-0433-9","volume":"19","author":"Y Fan","year":"2021","unstructured":"Fan, Y. & Pedersen, O. Gut microbiota in human metabolic health and disease. Nat. Rev. Microbiol. 19, 55\u201371 (2021).","journal-title":"Nat. Rev. Microbiol."},{"key":"9561_CR7","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.molmed.2020.04.001","volume":"26","author":"X Zhang","year":"2020","unstructured":"Zhang, X., Chen, B. D., Zhao, L. D. & Li, H. The gut microbiota: emerging evidence in autoimmune diseases. Trends Mol. Med. 26, 862\u2013873 (2020).","journal-title":"Trends Mol. Med."},{"key":"9561_CR8","volume":"132","author":"Y Chen","year":"2022","unstructured":"Chen, Y. et al. Gut microbiota in systemic lupus erythematosus: a fuse and a solution. J. Autoimmun. 132, 102867 (2022).","journal-title":"J. Autoimmun."},{"key":"9561_CR9","volume":"233","author":"Y Ma","year":"2021","unstructured":"Ma, Y. et al. Lupus gut microbiota transplants cause autoimmunity and inflammation. Clin. Immunol. 233, 108892 (2021).","journal-title":"Clin. Immunol."},{"key":"9561_CR10","doi-asserted-by":"crossref","first-page":"e01548","DOI":"10.1128\/mBio.01548-14","volume":"5","author":"A Hevia","year":"2014","unstructured":"Hevia, A. et al. Intestinal dysbiosis associated with systemic lupus erythematosus. mBio 5, e01548\u201301514 (2014).","journal-title":"mBio"},{"key":"9561_CR11","volume":"57","author":"R Lu","year":"2024","unstructured":"Lu, R. & Luo, X. M. The role of gut microbiota in different murine models of systemic lupus erythematosus. Autoimmunity 57, 2378876 (2024).","journal-title":"Autoimmunity"},{"key":"9561_CR12","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.chom.2024.07.019","volume":"32","author":"A Castells-Nobau","year":"2024","unstructured":"Castells-Nobau, A., Mayneris-Perxachs, J. & Fern\u00e1ndez-Real, J. M. Unlocking the mind-gut connection: impact of human microbiome on cognition. Cell Host Microbe 32, 1248\u20131263 (2024).","journal-title":"Cell Host Microbe"},{"key":"9561_CR13","doi-asserted-by":"crossref","unstructured":"Li, R. et al. The brain-gut-bone axis in neurodegenerative diseases: insights, challenges, and future prospects. Adv. Sci. 11, e2307971 (2024).","DOI":"10.1002\/advs.202307971"},{"key":"9561_CR14","doi-asserted-by":"crossref","unstructured":"Xiong, R. G. et al. The role of gut microbiota in anxiety, depression, and other mental disorders as well as the protective effects of dietary components. Nutrients 15, 3258 (2023).","DOI":"10.3390\/nu15143258"},{"key":"9561_CR15","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jad.2024.08.164","volume":"366","author":"H Zhang","year":"2024","unstructured":"Zhang, H. et al. Is anxiety and depression transmissible? Depressed mother rats transmit anxiety- and depression-like phenotypes to cohabited rat pups through gut microbiota assimilation. J. Affect. Disord. 366, 124\u2013135 (2024).","journal-title":"J. Affect. Disord."},{"key":"9561_CR16","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1002\/art.40930","volume":"71","author":"M Aringer","year":"2019","unstructured":"Aringer, M. et al. 2019 European League Against Rheumatism\/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus. Arthritis Rheumatol. 71, 1400\u20131412 (2019).","journal-title":"Arthritis Rheumatol."},{"key":"9561_CR17","doi-asserted-by":"crossref","unstructured":"The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes. Arthritis Rheum. 42, 599\u2013608 (1999).","DOI":"10.1002\/1529-0131(199904)42:4<599::AID-ANR2>3.0.CO;2-F"},{"key":"9561_CR18","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.4049\/jimmunol.129.6.2612","volume":"129","author":"HC Morse","year":"1982","unstructured":"Morse, H. C. et al. Abnormalities induced by the mutant gene Ipr: expansion of a unique lymphocyte subset. J. Immunol. 129, 2612\u20132615 (1982).","journal-title":"J. Immunol."},{"key":"9561_CR19","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0065-2776(08)60342-9","volume":"37","author":"AN Theofilopoulos","year":"1985","unstructured":"Theofilopoulos, A. N. & Dixon, F. J. Murine models of systemic lupus erythematosus. Adv. Immunol. 37, 269\u2013390 (1985).","journal-title":"Adv. Immunol."},{"key":"9561_CR20","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/s43587-022-00311-y","volume":"2","author":"RY Pan","year":"2022","unstructured":"Pan, R. Y. et al. Intermittent fasting protects against Alzheimer\u2019s disease in mice by altering metabolism through remodeling of the gut microbiota. Nat. Aging 2, 1024\u20131039 (2022).","journal-title":"Nat. Aging"},{"key":"9561_CR21","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1038\/s43587-023-00516-9","volume":"3","author":"X Guo","year":"2023","unstructured":"Guo, X. et al. Chiral nanoparticle-remodeled gut microbiota alleviates neurodegeneration via the gut-brain axis. Nat. Aging 3, 1415\u20131429 (2023).","journal-title":"Nat. Aging"},{"key":"9561_CR22","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41392-021-00867-y","volume":"7","author":"X Han","year":"2022","unstructured":"Han, X. et al. Neuronal NR4A1 deficiency drives complement-coordinated synaptic stripping by microglia in a mouse model of lupus. Signal. Transduct. Target Ther. 7, 50 (2022).","journal-title":"Signal. Transduct. Target Ther."},{"key":"9561_CR23","volume":"14","author":"Z Luo","year":"2023","unstructured":"Luo, Z. et al. Limosilactobacillus reuteri in immunomodulation: molecular mechanisms and potential applications. Front. Immunol. 14, 1228754 (2023).","journal-title":"Front. Immunol."},{"key":"9561_CR24","volume":"16","author":"M Li","year":"2024","unstructured":"Li, M. et al. Gut microbiota metabolite indole-3-acetic acid maintains intestinal epithelial homeostasis through mucin sulfation. Gut Microbes 16, 2377576 (2024).","journal-title":"Gut Microbes"},{"key":"9561_CR25","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s10571-022-01226-3","volume":"43","author":"D Dilimulati","year":"2023","unstructured":"Dilimulati, D. et al. Ketogenic diet modulates neuroinflammation via metabolites from Lactobacillus reuteri after repetitive mild traumatic brain injury in adolescent mice. Cell Mol. Neurobiol. 43, 907\u2013923 (2023).","journal-title":"Cell Mol. Neurobiol."},{"key":"9561_CR26","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41421-024-00709-5","volume":"10","author":"H Li","year":"2024","unstructured":"Li, H. et al. Gut microbiota-derived indole-3-acetic acid suppresses high myopia progression by promoting type I collagen synthesis. Cell Discov. 10, 89 (2024).","journal-title":"Cell Discov."},{"key":"9561_CR27","doi-asserted-by":"crossref","unstructured":"Li, M. et al. Aged gut microbiota contributes to cognitive impairment and hippocampal synapse loss in mice. Aging Cell 24, e70064 (2025).","DOI":"10.1111\/acel.70064"},{"key":"9561_CR28","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1421346","volume":"15","author":"F Bahman","year":"2024","unstructured":"Bahman, F. et al. Aryl hydrocarbon receptor: current perspectives on key signaling partners and immunoregulatory role in inflammatory diseases. Front. Immunol. 15, 1421346 (2024).","journal-title":"Front. Immunol."},{"key":"9561_CR29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2023.103049","volume":"138","author":"W Huang","year":"2023","unstructured":"Huang, W. et al. The aryl hydrocarbon receptor in immune regulation and autoimmune pathogenesis. J. Autoimmun. 138, 103049 (2023).","journal-title":"J. Autoimmun."},{"key":"9561_CR30","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2023.109690","volume":"239","author":"Y Zhou","year":"2023","unstructured":"Zhou, Y. et al. The role of the indoles in microbiota-gut-brain axis and potential therapeutic targets: a focus on human neurological and neuropsychiatric diseases. Neuropharmacology 239, 109690 (2023).","journal-title":"Neuropharmacology"},{"key":"9561_CR31","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2024.1433747","volume":"18","author":"L Coretti","year":"2024","unstructured":"Coretti, L., Buommino, E. & Lembo, F. The aryl hydrocarbon receptor pathway: a linking bridge between the gut microbiome and neurodegenerative diseases. Front. Cell Neurosci. 18, 1433747 (2024).","journal-title":"Front. Cell Neurosci."},{"key":"9561_CR32","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41423-020-00585-5","volume":"18","author":"A Barroso","year":"2021","unstructured":"Barroso, A., Mahler, J. V., Fonseca-Castro, P. H. & Quintana, F. J. The aryl hydrocarbon receptor and the gut-brain axis. Cell Mol. Immunol. 18, 259\u2013268 (2021).","journal-title":"Cell Mol. Immunol."},{"key":"9561_CR33","volume":"11","author":"Y Zhang","year":"2023","unstructured":"Zhang, Y. et al. AhR agonist tapinarof ameliorates lupus autoimmunity by suppressing Tfh cell differentiation via regulation of the JAK2-STAT3 signaling pathway. Immun. Inflamm. Dis. 11, e903 (2023).","journal-title":"Immun. Inflamm. Dis."},{"key":"9561_CR34","volume":"119","author":"B Yan","year":"2023","unstructured":"Yan, B. et al. Spermidine protects intestinal mucosal barrier function in mice colitis via the AhR\/Nrf2 and AhR\/STAT3 signaling pathways. Int. Immunopharmacol. 119, 110166 (2023).","journal-title":"Int. Immunopharmacol."},{"key":"9561_CR35","doi-asserted-by":"crossref","first-page":"263ra158","DOI":"10.1126\/scitranslmed.3009759","volume":"6","author":"V Braniste","year":"2014","unstructured":"Braniste, V. et al. The gut microbiota influences blood-brain barrier permeability in mice. Sci. Transl. Med. 6, 263ra158 (2014).","journal-title":"Sci. Transl. Med."},{"key":"9561_CR36","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.bbi.2016.02.020","volume":"56","author":"EE Fr\u00f6hlich","year":"2016","unstructured":"Fr\u00f6hlich, E. E. et al. Cognitive impairment by antibiotic-induced gut dysbiosis: Analysis of gut microbiota-brain communication. Brain Behav. Immun. 56, 140\u2013155 (2016).","journal-title":"Brain Behav. Immun."},{"key":"9561_CR37","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3390\/nu3010104","volume":"3","author":"S Ahrne","year":"2011","unstructured":"Ahrne, S. & Hagslatt, M. L. Effect of lactobacilli on paracellular permeability in the gut. Nutrients 3, 104\u2013117 (2011).","journal-title":"Nutrients"},{"key":"9561_CR38","doi-asserted-by":"crossref","unstructured":"Wang, L. et al. Current research progress, opportunities, and challenges of Limosillactobacillus reuteri-based probiotic dietary strategies. Crit. Rev. Food Sci. Nutr. 65, 3607\u20133627 (2024).","DOI":"10.1080\/10408398.2024.2369946"},{"key":"9561_CR39","volume":"5","author":"Q Mu","year":"2017","unstructured":"Mu, Q. et al. Control of lupus nephritis by changes of gut microbiota. Microbiome 5, 73 (2017).","journal-title":"Microbiome"},{"key":"9561_CR40","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.chom.2018.11.009","volume":"25","author":"DF Zegarra-Ruiz","year":"2019","unstructured":"Zegarra-Ruiz, D. F. et al. A Diet-sensitive commensal lactobacillus strain mediates TLR7-dependent systemic autoimmunity. Cell Host Microbe 25, 113\u2013127.e116 (2019).","journal-title":"Cell Host Microbe"},{"key":"9561_CR41","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41392-024-01743-1","volume":"9","author":"JS Loh","year":"2024","unstructured":"Loh, J. S. et al. Microbiota-gut-brain axis and its therapeutic applications in neurodegenerative diseases. Signal. Transduct. Target Ther. 9, 37 (2024).","journal-title":"Signal. Transduct. Target Ther."},{"key":"9561_CR42","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2022.2102878","volume":"14","author":"H Ahmed","year":"2022","unstructured":"Ahmed, H. et al. Microbiota-derived metabolites as drivers of gut-brain communication. Gut Microbes 14, 2102878 (2022).","journal-title":"Gut Microbes"},{"key":"9561_CR43","volume":"16","author":"S Li","year":"2024","unstructured":"Li, S. et al. Quinic acid alleviates high-fat diet-induced neuroinflammation by inhibiting DR3\/IKK\/NF-\u03baB signaling via gut microbial tryptophan metabolites. Gut Microbes 16, 2374608 (2024).","journal-title":"Gut Microbes"},{"key":"9561_CR44","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.neuro.2019.02.019","volume":"73","author":"YT Lin","year":"2019","unstructured":"Lin, Y. T. et al. Indole-3 acetic acid increased risk of impaired cognitive function in patients receiving hemodialysis. Neurotoxicology 73, 85\u201391 (2019).","journal-title":"Neurotoxicology"},{"key":"9561_CR45","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1136\/ard-2022-223506","volume":"82","author":"D Nikolopoulos","year":"2023","unstructured":"Nikolopoulos, D. et al. Microglia activation in the presence of intact blood-brain barrier and disruption of hippocampal neurogenesis via IL-6 and IL-18 mediate early diffuse neuropsychiatric lupus. Ann. Rheum. Dis. 82, 646\u2013657 (2023).","journal-title":"Ann. Rheum. Dis."},{"key":"9561_CR46","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.569881","volume":"11","author":"M Burek","year":"2020","unstructured":"Burek, M. et al. Kidney ischemia\/reperfusion injury induces changes in the drug transporter expression at the blood-brain barrier in vivo and in vitro. Front. Physiol. 11, 569881 (2020).","journal-title":"Front. Physiol."},{"key":"9561_CR47","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1080\/19490976.2020.1758008","volume":"11","author":"N Ma","year":"2020","unstructured":"Ma, N., He, T., Johnston, L. J. & Ma, X. Host-microbiome interactions: the aryl hydrocarbon receptor as a critical node in tryptophan metabolites to brain signaling. Gut Microbes 11, 1203\u20131219 (2020).","journal-title":"Gut Microbes"},{"key":"9561_CR48","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.bbi.2024.08.051","volume":"122","author":"H Kim","year":"2024","unstructured":"Kim, H. et al. Microbiome-derived indole-3-lactic acid reduces amyloidopathy through aryl-hydrocarbon receptor activation. Brain Behav. Immun. 122, 568\u2013582 (2024).","journal-title":"Brain Behav. Immun."},{"key":"9561_CR49","volume":"20","author":"Y Wang","year":"2023","unstructured":"Wang, Y. et al. Microglial aryl hydrocarbon receptor enhances phagocytic function via SYK and promotes remyelination in the cuprizone mouse model of demyelination. J. Neuroinflammation 20, 83 (2023).","journal-title":"J. Neuroinflammation"},{"key":"9561_CR50","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.brainresbull.2021.08.013","volume":"176","author":"Y Zhou","year":"2021","unstructured":"Zhou, Y. et al. Dynamic changes of activated AHR in microglia and astrocytes in the substantia nigra-striatum system in an MPTP-induced Parkinson\u2019s disease mouse model. Brain Res. Bull. 176, 174\u2013183 (2021).","journal-title":"Brain Res. Bull."},{"key":"9561_CR51","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00204-018-2328-3","volume":"93","author":"T Addi","year":"2019","unstructured":"Addi, T. et al. Mechanisms of tissue factor induction by the uremic toxin indole-3 acetic acid through aryl hydrocarbon receptor\/nuclear factor-kappa B signaling pathway in human endothelial cells. Arch. Toxicol. 93, 121\u2013136 (2019).","journal-title":"Arch. Toxicol."},{"key":"9561_CR52","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1161\/ATVBAHA.110.220202","volume":"31","author":"D Wu","year":"2011","unstructured":"Wu, D. et al. Activation of aryl hydrocarbon receptor induces vascular inflammation and promotes atherosclerosis in apolipoprotein E-\/- mice. Arter. Thromb. Vasc. Biol. 31, 1260\u20131267 (2011).","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"9561_CR53","volume":"101","author":"H Liu","year":"2021","unstructured":"Liu, H., Zhou, Y. C. & Song, W. Involvement of IL-10R\/STAT3 pathway in amyloid \u03b2 clearance by microlgia in Alzheimer\u2019s disease. Int. Immunopharmacol. 101, 108263 (2021).","journal-title":"Int. Immunopharmacol."},{"key":"9561_CR54","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jare.2023.06.003","volume":"59","author":"K Xu","year":"2024","unstructured":"Xu, K. et al. HMGB1\/STAT3\/p65 axis drives microglial activation and autophagy exert a crucial role in chronic Stress-Induced major depressive disorder. J. Adv. Res. 59, 79\u201396 (2024).","journal-title":"J. Adv. Res."},{"key":"9561_CR55","volume":"38","author":"X Li","year":"2024","unstructured":"Li, X. et al. The binding of PKC\u03b5 and MEG2 to STAT3 regulates IL-6-mediated microglial hyperalgesia during inflammatory pain. FASEB J. 38, e23590 (2024).","journal-title":"FASEB J."},{"key":"9561_CR56","volume":"239","author":"C Han","year":"2024","unstructured":"Han, C. et al. HIPK2 mediates M1 polarization of microglial cells via STAT3: a new mechanism of depression-related neuroinflammation. J. Cell Physiol. 239, e30994 (2024).","journal-title":"J. Cell Physiol."},{"key":"9561_CR57","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1136\/svn-2021-001028","volume":"7","author":"ZV Zheng","year":"2022","unstructured":"Zheng, Z. V. et al. Novel role of STAT3 in microglia-dependent neuroinflammation after experimental subarachnoid haemorrhage. Stroke Vasc. Neurol. 7, 62\u201370 (2022).","journal-title":"Stroke Vasc. Neurol."}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-09561-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-09561-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-09561-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T01:07:52Z","timestamp":1771549672000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-09561-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,23]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["9561"],"URL":"https:\/\/doi.org\/10.1038\/s42003-026-09561-7","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,23]]},"assertion":[{"value":"22 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"281"}}