{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:16:42Z","timestamp":1793107002569,"version":"4.5.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":37,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-026-09773-x","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T10:25:26Z","timestamp":1772533526000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["METTL3-mediated fibroblast-like synoviocytes senescence promotes temporomandibular joint osteoarthritis progression"],"prefix":"10.1038","volume":"9","author":[{"given":"Kun","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianrui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3599-1348","authenticated-orcid":false,"given":"Juan","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1829-6116","authenticated-orcid":false,"given":"Yandong","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2053-1074","authenticated-orcid":false,"given":"Li","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"key":"9773_CR1","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1111\/jopr.13203","volume":"29","author":"WE Roberts","year":"2020","unstructured":"Roberts, W. E. & Goodacre, C. J. The Temporomandibular joint: a critical review of life-support functions, development, articular surfaces, biomechanics and degeneration. J. Prosthodont. 29, 772\u2013779 (2020).","journal-title":"J. Prosthodont."},{"key":"9773_CR2","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1089\/ten.teb.2022.0065","volume":"29","author":"D Wang","year":"2023","unstructured":"Wang, D. et al. Recent advances in animal models, diagnosis, and treatment of temporomandibular joint Osteoarthritis. Tissue Eng. B Rev. 29, 62\u201377 (2023).","journal-title":"Tissue Eng. B Rev."},{"key":"9773_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115884","volume":"169","author":"G Liu","year":"2023","unstructured":"Liu, G. et al. Insights into the Notch signaling pathway in degenerative musculoskeletal disorders: Mechanisms and perspectives. Biomed. Pharmacother. 169, 115884 (2023).","journal-title":"Biomed. Pharmacother."},{"key":"9773_CR4","doi-asserted-by":"publisher","first-page":"300060521990530","DOI":"10.1177\/0300060521990530","volume":"49","author":"X Zhao","year":"2021","unstructured":"Zhao, X. et al. Symptoms, disc position, occluding pairs, and facial skeletal characteristics of older patients with temporomandibular disorders. J. Int. Med. Res. 49, 300060521990530 (2021).","journal-title":"J. Int. Med. Res."},{"key":"9773_CR5","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.1111\/odi.14266","volume":"29","author":"J Zhou","year":"2023","unstructured":"Zhou, J., Ren, R., Li, Z., Zhu, S. & Jiang, N. Temporomandibular joint osteoarthritis: A review of animal models induced by surgical interventions. Oral. Dis. 29, 2521\u20132528 (2023).","journal-title":"Oral. Dis."},{"key":"9773_CR6","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1038\/s41584-020-0413-5","volume":"16","author":"G Nygaard","year":"2020","unstructured":"Nygaard, G. & Firestein, G. S. Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes. Nat. Rev. Rheumatol. 16, 316\u2013333 (2020).","journal-title":"Nat. Rev. Rheumatol."},{"key":"9773_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2022.102304","volume":"67","author":"V Tsaltskan","year":"2022","unstructured":"Tsaltskan, V. & Firestein, G. S. Targeting fibroblast-like synoviocytes in rheumatoid arthritis. Curr. Opin. Pharm. 67, 102304 (2022).","journal-title":"Curr. Opin. Pharm."},{"key":"9773_CR8","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202304617","volume":"11","author":"J Yang","year":"2024","unstructured":"Yang, J. et al. Targeting YAP1-regulated glycolysis in fibroblast-like synoviocytes impairs macrophage infiltration to ameliorate diabetic osteoarthritis progression. Adv. Sci. 11, e2304617 (2024).","journal-title":"Adv. Sci."},{"key":"9773_CR9","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202307338","volume":"11","author":"B Liu","year":"2024","unstructured":"Liu, B. et al. Inflammatory fibroblast-like synoviocyte-derived exosomes aggravate osteoarthritis via enhancing macrophage glycolysis. Adv. Sci. 11, e2307338 (2024).","journal-title":"Adv. Sci."},{"key":"9773_CR10","doi-asserted-by":"publisher","first-page":"3308","DOI":"10.1111\/odi.14810","volume":"30","author":"F Yang","year":"2024","unstructured":"Yang, F. et al. Abnormal mechanical stress induced chondrocyte senescence by YAP loss-mediated METTL3 upregulation. Oral. Dis. 30, 3308\u20133320 (2024).","journal-title":"Oral. Dis."},{"key":"9773_CR11","doi-asserted-by":"crossref","unstructured":"Miwa, S., Kashyap, S., Chini, E. & von Zglinicki, T. Mitochondrial dysfunction in cell senescence and aging. J. Clin. Investig. 132 (2022).","DOI":"10.1172\/JCI158447"},{"key":"9773_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101315","volume":"67","author":"W Jiang","year":"2021","unstructured":"Jiang, W. et al. Mechanisms linking mitochondrial mechanotransduction and chondrocyte biology in the pathogenesis of osteoarthritis. Ageing Res. Rev. 67, 101315 (2021).","journal-title":"Ageing Res. Rev."},{"key":"9773_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115409","volume":"166","author":"Y Bai","year":"2023","unstructured":"Bai, Y. et al. RNA methylation, homologous recombination repair and therapeutic resistance. Biomed. Pharmacother. 166, 115409 (2023).","journal-title":"Biomed. Pharmacother."},{"key":"9773_CR14","doi-asserted-by":"publisher","first-page":"148","DOI":"10.31083\/j.fbl2807148","volume":"28","author":"X Zhao","year":"2023","unstructured":"Zhao, X. et al. Alterations of the m(6)A Methylation Induced by TGF-\u03b22 in ARPE-19 Cells. Front Biosci. 28, 148 (2023).","journal-title":"Front Biosci."},{"key":"9773_CR15","doi-asserted-by":"publisher","first-page":"120","DOI":"10.31083\/j.fbl2806120","volume":"28","author":"F Wei","year":"2023","unstructured":"Wei, F., Zhang, J. N., Zhao, Y. Q., Lyu, H. & Chen, F. Expression of m6A RNA Methylation Regulators and Their Clinical Predictive Value in Intrahepatic Cholangiocarcinoma. Front. Biosci. 28, 120 (2023).","journal-title":"Front. Biosci."},{"key":"9773_CR16","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1038\/s12276-023-01059-0","volume":"55","author":"G Ye","year":"2023","unstructured":"Ye, G. et al. ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression. Exp. Mol. Med. 55, 1743\u20131756 (2023).","journal-title":"Exp. Mol. Med."},{"key":"9773_CR17","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04173-9","volume":"21","author":"Y Lu","year":"2023","unstructured":"Lu, Y. et al. Expression pattern analysis of m6A regulators reveals IGF2BP3 as a key modulator in osteoarthritis synovial macrophages. J. Transl. Med. 21, 339 (2023).","journal-title":"J. Transl. Med."},{"key":"9773_CR18","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41392-020-00450-x","volume":"6","author":"X Jiang","year":"2021","unstructured":"Jiang, X. et al. The role of m6A modification in the biological functions and diseases. Signal Transduct. Target Ther. 6, 74 (2021).","journal-title":"Signal Transduct. Target Ther."},{"key":"9773_CR19","doi-asserted-by":"publisher","first-page":"9518","DOI":"10.1111\/jcmm.15669","volume":"24","author":"D Han","year":"2020","unstructured":"Han, D. et al. The emerging role of fibroblast-like synoviocytes-mediated synovitis in osteoarthritis: An update. J. Cell Mol. Med. 24, 9518\u20139532 (2020).","journal-title":"J. Cell Mol. Med."},{"key":"9773_CR20","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13394","volume":"20","author":"Y Zhou","year":"2021","unstructured":"Zhou, Y. et al. Senolytics alleviate the degenerative disorders of temporomandibular joint in old age. Aging Cell 20, e13394 (2021).","journal-title":"Aging Cell"},{"key":"9773_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32552-1","volume":"13","author":"D Saul","year":"2022","unstructured":"Saul, D. et al. A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues. Nat. Commun. 13, 4827 (2022).","journal-title":"Nat. Commun."},{"key":"9773_CR22","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41584-020-00533-7","volume":"17","author":"PR Coryell","year":"2021","unstructured":"Coryell, P. R., Diekman, B. O. & Loeser, R. F. Mechanisms and therapeutic implications of cellular senescence in osteoarthritis. Nat. Rev. Rheumatol. 17, 47\u201357 (2021).","journal-title":"Nat. Rev. Rheumatol."},{"key":"9773_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-34825-1","volume":"13","author":"M Yagi","year":"2023","unstructured":"Yagi, M., Endo, K., Komori, K. & Sekiya, I. Comparison of the effects of oxidative and inflammatory stresses on rat chondrocyte senescence. Sci. Rep. 13, 7697 (2023).","journal-title":"Sci. Rep."},{"key":"9773_CR24","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1038\/s41581-022-00601-z","volume":"18","author":"W Huang","year":"2022","unstructured":"Huang, W., Hickson, L. J., Eirin, A., Kirkland, J. L. & Lerman, L. O. Cellular senescence: the good, the bad and the unknown. Nat. Rev. Nephrol. 18, 611\u2013627 (2022).","journal-title":"Nat. Rev. Nephrol."},{"key":"9773_CR25","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/s41514-024-00168-y","volume":"10","author":"EA O\u2019Sullivan","year":"2024","unstructured":"O\u2019Sullivan, E. A., Wallis, R., Mossa, F. & Bishop, C. L. The paradox of senescent-marker positive cancer cells: challenges and opportunities. NPJ Aging 10, 41 (2024).","journal-title":"NPJ Aging"},{"key":"9773_CR26","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1159\/000502233","volume":"44","author":"J Chen","year":"2019","unstructured":"Chen, J. et al. DCR2, a cellular senescent molecule, is a novel marker for assessing tubulointerstitial fibrosis in patients with immunoglobulin A nephropathy. Kidney Blood Press Res 44, 1063\u20131074 (2019).","journal-title":"Kidney Blood Press Res"},{"key":"9773_CR27","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1136\/annrheumdis-2017-212658","volume":"77","author":"K Li","year":"2018","unstructured":"Li, K. et al. Tyrosine kinase Fyn promotes osteoarthritis by activating the \u03b2-catenin pathway. Ann. Rheum. Dis. 77, 935\u2013943 (2018).","journal-title":"Ann. Rheum. Dis."},{"key":"9773_CR28","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1080\/15548627.2020.1822097","volume":"17","author":"K Sun","year":"2021","unstructured":"Sun, K., Jing, X., Guo, J., Yao, X. & Guo, F. Mitophagy in degenerative joint diseases. Autophagy 17, 2082\u20132092 (2021).","journal-title":"Autophagy"},{"key":"9773_CR29","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/s41584-022-00875-4","volume":"19","author":"I Bernabei","year":"2023","unstructured":"Bernabei, I., So, A., Busso, N. & Nasi, S. Cartilage calcification in osteoarthritis: mechanisms and clinical relevance. Nat. Rev. Rheumatol. 19, 10\u201327 (2023).","journal-title":"Nat. Rev. Rheumatol."},{"key":"9773_CR30","doi-asserted-by":"publisher","first-page":"16211","DOI":"10.18632\/aging.103643","volume":"12","author":"Y Wang","year":"2020","unstructured":"Wang, Y. et al. Mst1 promotes mitochondrial dysfunction and apoptosis in oxidative stress-induced rheumatoid arthritis synoviocytes. Aging 12, 16211\u201316223 (2020).","journal-title":"Aging"},{"key":"9773_CR31","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-024-00487-0","volume":"57","author":"Y Luo","year":"2024","unstructured":"Luo, Y., Zhang, L., Su, N., Liu, L. & Zhao, T. YME1L-mediated mitophagy protects renal tubular cells against cellular senescence under diabetic conditions. Biol. Res. 57, 10 (2024).","journal-title":"Biol. Res."},{"key":"9773_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101817","volume":"84","author":"J Li","year":"2023","unstructured":"Li, J. et al. PINK1\/Parkin-mediated mitophagy in neurodegenerative diseases. Ageing Res. Rev. 84, 101817 (2023).","journal-title":"Ageing Res. Rev."},{"key":"9773_CR33","doi-asserted-by":"publisher","first-page":"4368","DOI":"10.1093\/brain\/awac313","volume":"145","author":"D Imberechts","year":"2022","unstructured":"Imberechts, D. et al. DJ-1 is an essential downstream mediator in PINK1\/parkin-dependent mitophagy. Brain 145, 4368\u20134384 (2022).","journal-title":"Brain"},{"key":"9773_CR34","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1080\/15548627.2019.1628520","volume":"16","author":"C Yan","year":"2020","unstructured":"Yan, C. et al. PHB2 (prohibitin 2) promotes PINK1-PRKN\/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis. Autophagy 16, 419\u2013434 (2020).","journal-title":"Autophagy"},{"key":"9773_CR35","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/832704","volume":"2014","author":"M Lippai","year":"2014","unstructured":"Lippai, M. & L\u0151w, P. The role of the selective adaptor p62 and ubiquitin-like proteins in autophagy. Biomed. Res. Int. 2014, 832704 (2014).","journal-title":"Biomed. Res. Int."},{"key":"9773_CR36","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.1080\/15548627.2021.2016231","volume":"18","author":"S Zhang","year":"2022","unstructured":"Zhang, S. et al. Negative pressure wound therapy improves bone regeneration by promoting osteogenic differentiation via the AMPK-ULK1-autophagy axis. Autophagy 18, 2229\u20132245 (2022).","journal-title":"Autophagy"},{"key":"9773_CR37","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39641-9","volume":"14","author":"V N\u00e4hse","year":"2023","unstructured":"N\u00e4hse, V. et al. ATPase activity of DFCP1 controls selective autophagy. Nat. Commun. 14, 4051 (2023).","journal-title":"Nat. Commun."},{"key":"9773_CR38","doi-asserted-by":"publisher","unstructured":"Sirko, A., Wawrzy\u0144ska, A., Brzywczy, J. & Sie\u0144ko, M. Control of ABA signaling and crosstalk with other hormones by the selective degradation of pathway components. Int. J. Mol. Sci. 22. https:\/\/doi.org\/10.3390\/ijms22094638 (2021).","DOI":"10.3390\/ijms22094638"},{"key":"9773_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112259","volume":"42","author":"S Luo","year":"2023","unstructured":"Luo, S. et al. METTL3-mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling. Cell Rep. 42, 112259 (2023).","journal-title":"Cell Rep."},{"key":"9773_CR40","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1093\/cvr\/cvab160","volume":"118","author":"R Kumari","year":"2022","unstructured":"Kumari, R. et al. mRNA modifications in cardiovascular biology and disease: with a focus on m6A modification. Cardiovasc. Res. 118, 1680\u20131692 (2022).","journal-title":"Cardiovasc. Res."},{"key":"9773_CR41","doi-asserted-by":"publisher","first-page":"11619","DOI":"10.1093\/nar\/gkac1027","volume":"50","author":"L Chen","year":"2022","unstructured":"Chen, L. et al. METTL3-mediated m6A modification stabilizes TERRA and maintains telomere stability. Nucleic Acids Res. 50, 11619\u201311634 (2022).","journal-title":"Nucleic Acids Res."},{"key":"9773_CR42","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1136\/annrheumdis-2021-221091","volume":"81","author":"X Chen","year":"2022","unstructured":"Chen, X. et al. METTL3-mediated m(6)A modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression. Ann. Rheum. Dis. 81, 87\u201399 (2022).","journal-title":"Ann. Rheum. Dis."},{"key":"9773_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.121092","volume":"312","author":"B Chen","year":"2023","unstructured":"Chen, B. et al. Metformin suppresses oxidative stress induced by high glucose via activation of the Nrf2\/HO-1 signaling pathway in Type 2 diabetic osteoporosis. Life Sci. 312, 121092 (2023).","journal-title":"Life Sci."},{"key":"9773_CR44","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1007\/s10571-020-01033-8","volume":"42","author":"H Jiang","year":"2022","unstructured":"Jiang, H. et al. Chronic pain causes peripheral and central responses in MIA-induced TMJOA Rats. Cell. Mol. Neurobiol. 42, 1441\u20131451 (2022).","journal-title":"Cell. Mol. Neurobiol."},{"key":"9773_CR45","doi-asserted-by":"publisher","unstructured":"Feng, S. Y. et al. Increased joint loading induces subchondral bone loss of the temporomandibular joint via the RANTES-CCRs-Akt2 axis. JCI Insight 7. https:\/\/doi.org\/10.1172\/jci.insight.158874 (2022).","DOI":"10.1172\/jci.insight.158874"},{"key":"9773_CR46","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1111\/joor.13300","volume":"49","author":"W Yuan","year":"2022","unstructured":"Yuan, W. et al. Comparison and applicability of three induction methods of temporomandibular joint osteoarthritis in murine models. J. Oral. Rehabil. 49, 430\u2013441 (2022).","journal-title":"J. Oral. Rehabil."},{"key":"9773_CR47","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1099\/jgv.0.001039","volume":"99","author":"A Sukkaew","year":"2018","unstructured":"Sukkaew, A. et al. Heterogeneity of clinical isolates of chikungunya virus and its impact on the responses of primary human fibroblast-like synoviocytes. J. Gen. Virol. 99, 525\u2013535 (2018).","journal-title":"J. Gen. Virol."}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-09773-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-09773-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-09773-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T14:04:56Z","timestamp":1775743496000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-09773-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,3]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["9773"],"URL":"https:\/\/doi.org\/10.1038\/s42003-026-09773-x","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,3]]},"assertion":[{"value":"9 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"510"}}