{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:44:02Z","timestamp":1793727842369,"version":"4.6.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-026-09798-2","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T10:01:54Z","timestamp":1773741714000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Single-cell insights into trophoblast heterogeneity and adaptive dysfunction in selective fetal growth restriction"],"prefix":"10.1038","volume":"9","author":[{"given":"Yan","family":"Bi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4556-7818","authenticated-orcid":false,"given":"Yuhong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucheng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0995-2393","authenticated-orcid":false,"given":"Yanlin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"9798_CR1","doi-asserted-by":"publisher","first-page":"20140066","DOI":"10.1098\/rstb.2014.0066","volume":"370","author":"GJ Burton","year":"2015","unstructured":"Burton, G. J. & Fowden, A. L. The placenta: a multifaceted, transient organ. Philos. Trans. R. Soc. Lond. B Biol. Sci. 370, 20140066 (2015).","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"9798_CR2","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.placenta.2014.02.012","volume":"35","author":"AE Guttmacher","year":"2014","unstructured":"Guttmacher, A. E., Maddox, Y. T. & Spong, C. Y. The Human Placenta Project: placental structure, development, and function in real time. Placenta 35, 303\u2013304 (2014).","journal-title":"Placenta"},{"key":"9798_CR3","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1097\/00001703-200304000-00013","volume":"15","author":"L Lewi","year":"2003","unstructured":"Lewi, L. et al. Monochorionic diamniotic twins: complications and management options. Curr. Opin. Obstet. Gynecol. 15, 177\u2013194 (2003).","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"9798_CR4","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/uog.15821","volume":"47","author":"A Khalil","year":"2016","unstructured":"Khalil, A. et al. ISUOG Practice Guidelines: role of ultrasound in twin pregnancy. Ultrasound Obstet. Gynecol. 47, 247\u2013263 (2016).","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"9798_CR5","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.siny.2010.07.002","volume":"15","author":"DV Valsky","year":"2010","unstructured":"Valsky, D. V., Eixarch, E., Martinez, J. M., Crispi, F. & Gratac\u00f3s, E. Selective intrauterine growth restriction in monochorionic twins: pathophysiology, diagnostic approach and management dilemmas. Semin Fetal Neonatal Med. 15, 342\u2013348 (2010).","journal-title":"Semin Fetal Neonatal Med"},{"key":"9798_CR6","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1002\/uog.15884","volume":"48","author":"SJ Gordijn","year":"2016","unstructured":"Gordijn, S. J. et al. Consensus definition of fetal growth restriction: a Delphi procedure. Ultrasound Obstet. Gynecol. 48, 333\u2013339 (2016).","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"9798_CR7","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1146\/annurev-virology-031413-085524","volume":"1","author":"E Delorme-Axford","year":"2014","unstructured":"Delorme-Axford, E., Sadovsky, Y. & Coyne, C. B. The Placenta as a Barrier to Viral Infections. Annu. Rev. Virol. 1, 133\u2013146 (2014).","journal-title":"Annu. Rev. Virol."},{"key":"9798_CR8","doi-asserted-by":"publisher","first-page":"E7786","DOI":"10.1073\/pnas.1710470114","volume":"114","author":"JCH Tsang","year":"2017","unstructured":"Tsang, J. C. H. et al. Integrative single-cell and cell-free plasma RNA transcriptomics elucidates placental cellular dynamics. Proc. Natl. Acad. Sci. USA 114, E7786\u2013e7795 (2017).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"9798_CR9","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1038\/s41422-018-0066-y","volume":"28","author":"Y Liu","year":"2018","unstructured":"Liu, Y. et al. Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta. Cell Res. 28, 819\u2013832 (2018).","journal-title":"Cell Res."},{"key":"9798_CR10","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/s41586-018-0698-6","volume":"563","author":"R Vento-Tormo","year":"2018","unstructured":"Vento-Tormo, R. et al. Single-cell reconstruction of the early maternal-fetal interface in humans. Nature 563, 347\u2013353 (2018).","journal-title":"Nature"},{"key":"9798_CR11","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aau4788","volume":"4","author":"H Suryawanshi","year":"2018","unstructured":"Suryawanshi, H. et al. A single-cell survey of the human first-trimester placenta and decidua. Sci. Adv. 4, eaau4788 (2018).","journal-title":"Sci. Adv."},{"key":"9798_CR12","doi-asserted-by":"crossref","unstructured":"Pique-Regi, R. et al. Single cell transcriptional signatures of the human placenta in term and preterm parturition. Elife 8, e52004 (2019).","DOI":"10.7554\/eLife.52004"},{"key":"9798_CR13","doi-asserted-by":"publisher","first-page":"13562","DOI":"10.1073\/pnas.2002630117","volume":"117","author":"G Meinhardt","year":"2020","unstructured":"Meinhardt, G. et al. Pivotal role of the transcriptional co-activator YAP in trophoblast stemness of the developing human placenta. Proc. Natl. Acad. Sci. USA 117, 13562\u201313570 (2020).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"9798_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-1190-9","volume":"9","author":"OJ Holland","year":"2018","unstructured":"Holland, O. J. et al. Placental mitochondrial adaptations in preeclampsia associated with progression to term delivery. Cell Death Dis. 9, 1150 (2018).","journal-title":"Cell Death Dis."},{"key":"9798_CR15","first-page":"15","volume":"17","author":"A Singh","year":"2023","unstructured":"Singh, A., Jaiswar, S. P., Priyadarshini, A. & Deo, S. Linking of oxidative stress and mitochondrial DNA damage to the pathophysiology of idiopathic intrauterine growth restriction. Int. J. Health Sci. 17, 15\u201322 (2023).","journal-title":"Int. J. Health Sci."},{"key":"9798_CR16","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/s00404-024-07453-x","volume":"310","author":"FB Firatligil","year":"2024","unstructured":"Firatligil, F. B. et al. Evaluation of systemic immune-inflammation index for predicting late-onset fetal growth restriction. Arch. Gynecol. Obstet. 310, 433\u2013439 (2024).","journal-title":"Arch. Gynecol. Obstet."},{"key":"9798_CR17","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.bpobgyn.2010.10.016","volume":"25","author":"GJ Burton","year":"2011","unstructured":"Burton, G. J. & Jauniaux, E. Oxidative stress. Best. Pr. Res Clin. Obstet. Gynaecol. 25, 287\u2013299 (2011).","journal-title":"Best. Pr. Res Clin. Obstet. Gynaecol."},{"key":"9798_CR18","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1146\/annurev-cellbio-100814-125620","volume":"31","author":"E Maltepe","year":"2015","unstructured":"Maltepe, E. & Fisher, S. J. Placenta: the forgotten organ. Annu. Rev. Cell Dev. Biol. 31, 523\u2013552 (2015).","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"9798_CR19","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.placenta.2024.09.005","volume":"156","author":"Y Hu","year":"2024","unstructured":"Hu, Y. et al. Mitochondrial dysfunction and oxidative stress in selective fetal growth restriction. Placenta 156, 46\u201354 (2024).","journal-title":"Placenta"},{"key":"9798_CR20","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1097\/GRF.0b013e3182993a2e","volume":"56","author":"T Jansson","year":"2013","unstructured":"Jansson, T. & Powell, T. L. Role of placental nutrient sensing in developmental programming. Clin. Obstet. Gynecol. 56, 591\u2013601 (2013).","journal-title":"Clin. Obstet. Gynecol."},{"key":"9798_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-07893-y","volume":"12","author":"R Kiyokoba","year":"2022","unstructured":"Kiyokoba, R. et al. Mitochondrial dysfunction-induced high hCG associated with development of fetal growth restriction and pre-eclampsia with fetal growth restriction. Sci. Rep. 12, 4056 (2022).","journal-title":"Sci. Rep."},{"key":"9798_CR22","doi-asserted-by":"crossref","unstructured":"Kajdy, A. et al. Evidence of placental aging in late SGA, fetal growth restriction and stillbirth-a systematic review. Biomedicines 11, 1785 (2023).","DOI":"10.3390\/biomedicines11071785"},{"key":"9798_CR23","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1002\/uog.20103","volume":"53","author":"C Paules","year":"2019","unstructured":"Paules, C. et al. Premature placental aging in term small-for-gestational-age and growth-restricted fetuses. Ultrasound Obstet. Gynecol. 53, 615\u2013622 (2019).","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"9798_CR24","doi-asserted-by":"publisher","unstructured":"Sultana, Z. et al. Oxidative stress, placental ageing-related pathologies and adverse pregnancy outcomes. Am. J. Reprod. Immunol. 77, https:\/\/doi.org\/10.1111\/aji.12653 (2017).","DOI":"10.1111\/aji.12653"},{"key":"9798_CR25","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1002\/path.4694","volume":"239","author":"FJ Tian","year":"2016","unstructured":"Tian, F. J. et al. The YY1\/MMP2 axis promotes trophoblast invasion at the maternal-fetal interface. J. Pathol. 239, 36\u201347 (2016).","journal-title":"J. Pathol."},{"key":"9798_CR26","doi-asserted-by":"crossref","unstructured":"Socha, M. W. et al. The role of NF-\u03baB in uterine spiral arteries remodeling, insight into the cornerstone of preeclampsia. Int. J. Mol. Sci. 22, 704 (2021).","DOI":"10.3390\/ijms22020704"},{"key":"9798_CR27","doi-asserted-by":"crossref","unstructured":"Armistead, B., Kadam, L., Drewlo, S. & Kohan-Ghadr, H. R. The role of NF\u03baB in healthy and preeclamptic placenta: trophoblasts in the spotlight. Int. J. Mol. Sci. 21, 1775 (2020).","DOI":"10.3390\/ijms21051775"},{"key":"9798_CR28","doi-asserted-by":"publisher","first-page":"3332","DOI":"10.1016\/j.ajpath.2014.08.006","volume":"184","author":"Y Li","year":"2014","unstructured":"Li, Y., Moretto-Zita, M., Leon-Garcia, S. & Parast, M. M. p63 inhibits extravillous trophoblast migration and maintains cells in a cytotrophoblast stem cell-like state. Am. J. Pathol. 184, 3332\u20133343 (2014).","journal-title":"Am. J. Pathol."},{"key":"9798_CR29","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29312-6","volume":"13","author":"LJ Wang","year":"2022","unstructured":"Wang, L. J. et al. Functional antagonism between \u0394Np63\u03b1 and GCM1 regulates human trophoblast stemness and differentiation. Nat. Commun. 13, 1626 (2022).","journal-title":"Nat. Commun."},{"key":"9798_CR30","doi-asserted-by":"publisher","first-page":"2628","DOI":"10.3389\/fimmu.2018.02628","volume":"9","author":"L Reyes","year":"2018","unstructured":"Reyes, L. & Golos, T. G. Hofbauer cells: their role in healthy and complicated pregnancy. Front. Immunol. 9, 2628 (2018).","journal-title":"Front. Immunol."},{"key":"9798_CR31","doi-asserted-by":"publisher","first-page":"1009867","DOI":"10.3389\/fimmu.2023.1009867","volume":"14","author":"X Wei","year":"2023","unstructured":"Wei, X. & Yang, X. The central role of natural killer cells in preeclampsia. Front. Immunol. 14, 1009867 (2023).","journal-title":"Front. Immunol."},{"key":"9798_CR32","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.cytogfr.2024.11.007","volume":"81","author":"J Zhou","year":"2025","unstructured":"Zhou, J., Yan, P., Ma, W. & Li, J. Cytokine modulation and immunoregulation of uterine NK cells in pregnancy disorders. Cytokine Growth Factor Rev. 81, 40\u201353 (2025).","journal-title":"Cytokine Growth Factor Rev."},{"key":"9798_CR33","doi-asserted-by":"publisher","first-page":"467","DOI":"10.3389\/fimmu.2017.00467","volume":"8","author":"LM Gaynor","year":"2017","unstructured":"Gaynor, L. M. & Colucci, F. Uterine natural killer cells: functional distinctions and influence on pregnancy in humans and mice. Front. Immunol. 8, 467 (2017).","journal-title":"Front. Immunol."},{"key":"9798_CR34","doi-asserted-by":"publisher","first-page":"4808072","DOI":"10.1155\/2020\/4808072","volume":"2020","author":"X Yang","year":"2020","unstructured":"Yang, X., Yang, Y., Yuan, Y., Liu, L. & Meng, T. The roles of uterine natural killer (NK) cells and KIR\/HLA-C combination in the development of preeclampsia: a systematic review. Biomed. Res. Int. 2020, 4808072 (2020).","journal-title":"Biomed. Res. Int."},{"key":"9798_CR35","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1038\/s41385-020-00374-3","volume":"14","author":"EV Shmeleva","year":"2021","unstructured":"Shmeleva, E. V. & Colucci, F. Maternal natural killer cells at the intersection between reproduction and mucosal immunity. Mucosal. Immunol. 14, 991\u20131005 (2021).","journal-title":"Mucosal. Immunol."}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-09798-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-09798-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-09798-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T19:03:11Z","timestamp":1773774191000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-09798-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,17]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["9798"],"URL":"https:\/\/doi.org\/10.1038\/s42003-026-09798-2","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,17]]},"assertion":[{"value":"7 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"387"}}