{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T03:45:56Z","timestamp":1790480756086,"version":"4.1.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":68,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"This work was supported by ShanghaiTech University start-up fund and Shanghai Frontiers Science Center for Biomacromolecules and Precision Medicine (ShanghaiTech University, China)."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-026-09974-4","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T16:55:55Z","timestamp":1777049755000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Deciphering the multi-site phos-code of IRBIT underlying its binding to IP3R"],"prefix":"10.1038","volume":"9","author":[{"given":"Qing","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0040-276X","authenticated-orcid":false,"given":"Hao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9981-8886","authenticated-orcid":false,"given":"Qi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohide","family":"Sumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2795-802X","authenticated-orcid":false,"given":"Kozo","family":"Hamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6376-0240","authenticated-orcid":false,"given":"Yi","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1468-5568","authenticated-orcid":false,"given":"Fang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4155-802X","authenticated-orcid":false,"given":"Akihiro","family":"Mizutani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3487-6970","authenticated-orcid":false,"given":"Katsuhiko","family":"Mikoshiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"9974_CR1","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/361315a0","volume":"361","author":"MJ Berridge","year":"1993","unstructured":"Berridge, M. J. Inositol trisphosphate and calcium signalling. Nature 361, 315\u2013325 (1993).","journal-title":"Nature"},{"key":"9974_CR2","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.ceca.2005.06.030","volume":"38","author":"I Bezprozvanny","year":"2005","unstructured":"Bezprozvanny, I. The inositol 1,4,5-trisphosphate receptors. Cell Calcium 38, 261\u2013272 (2005).","journal-title":"Cell Calcium"},{"key":"9974_CR3","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1111\/j.1471-4159.2006.03985.x","volume":"97","author":"K Mikoshiba","year":"2006","unstructured":"Mikoshiba, K. Inositol 1,4,5-trisphosphate IP(3) receptors and their role in neuronal cell function. J. Neurochem. 97, 1627\u20131633 (2006).","journal-title":"J. Neurochem."},{"key":"9974_CR4","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1152\/physrev.00035.2006","volume":"87","author":"JK Foskett","year":"2007","unstructured":"Foskett, J. K. et al. Inositol trisphosphate receptor Ca2+ release channels. Physiol. Rev. 87, 593\u2013658 (2007).","journal-title":"Physiol. Rev."},{"key":"9974_CR5","doi-asserted-by":"publisher","first-page":"1940","DOI":"10.1126\/science.278.5345.1940","volume":"278","author":"S Kume","year":"1997","unstructured":"Kume, S. et al. Role of inositol 1,4,5-trisphosphate receptor in ventral signaling in Xenopus embryos. Science 278, 1940\u20131943 (1997).","journal-title":"Science"},{"key":"9974_CR6","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/417295a","volume":"417","author":"T Saneyoshi","year":"2002","unstructured":"Saneyoshi, T. et al. The Wnt\/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos. Nature 417, 295\u2013299 (2002).","journal-title":"Nature"},{"key":"9974_CR7","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1126\/science.1321497","volume":"257","author":"S Miyazaki","year":"1992","unstructured":"Miyazaki, S. et al. Block of Ca2+ wave and Ca2+ oscillation by antibody to the inositol 1,4,5-trisphosphate receptor in fertilized hamster eggs. Science 257, 251\u2013255 (1992).","journal-title":"Science"},{"key":"9974_CR8","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1126\/science.1059042","volume":"292","author":"K Fukami","year":"2001","unstructured":"Fukami, K. et al. Requirement of phospholipase Cdelta4 for the zona pellucida-induced acrosome reaction. Science 292, 920\u2013923 (2001).","journal-title":"Science"},{"key":"9974_CR9","doi-asserted-by":"publisher","first-page":"2232","DOI":"10.1126\/science.1114110","volume":"309","author":"A Futatsugi","year":"2005","unstructured":"Futatsugi, A. et al. IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism. Science 309, 2232\u20132234 (2005).","journal-title":"Science"},{"key":"9974_CR10","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1126\/science.282.5394.1705","volume":"282","author":"K Takei","year":"1998","unstructured":"Takei, K. et al. Regulation of nerve growth mediated by inositol 1,4,5-trisphosphate receptors in growth cones. Science 282, 1705\u20131708 (1998).","journal-title":"Science"},{"key":"9974_CR11","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/379168a0","volume":"379","author":"M Matsumoto","year":"1996","unstructured":"Matsumoto, M. et al. Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor. Nature 379, 168\u2013171 (1996).","journal-title":"Nature"},{"key":"9974_CR12","doi-asserted-by":"publisher","first-page":"5366","DOI":"10.1523\/JNEUROSCI.18-14-05366.1998","volume":"18","author":"T Inoue","year":"1998","unstructured":"Inoue, T. et al. Type 1 inositol 1,4,5-trisphosphate receptor is required for induction of long-term depression in cerebellar Purkinje neurons. J. Neurosci. 18, 5366\u20135373 (1998).","journal-title":"J. Neurosci."},{"key":"9974_CR13","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1101\/lm.34100","volume":"7","author":"S Fujii","year":"2000","unstructured":"Fujii, S. et al. Synaptic plasticity in hippocampal CA1 neurons of mice lacking type 1 inositol-1,4,5-trisphosphate receptors. Learn Mem. 7, 312\u2013320 (2000).","journal-title":"Learn Mem."},{"key":"9974_CR14","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/35046067","volume":"408","author":"M Nishiyama","year":"2000","unstructured":"Nishiyama, M. et al. Calcium stores regulate the polarity and input specificity of synaptic modification. Nature 408, 584\u2013588 (2000).","journal-title":"Nature"},{"key":"9974_CR15","doi-asserted-by":"publisher","first-page":"6349","DOI":"10.1093\/emboj\/18.22.6349","volume":"18","author":"G Szalai","year":"1999","unstructured":"Szalai, G., Krishnamurthy, R. & Hajnoczky, G. Apoptosis driven by IP(3)-linked mitochondrial calcium signals. EMBO J. 18, 6349\u20136361 (1999).","journal-title":"EMBO J."},{"key":"9974_CR16","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1038\/sj.cdd.4402099","volume":"14","author":"A Criollo","year":"2007","unstructured":"Criollo, A. et al. Regulation of autophagy by the inositol trisphosphate receptor. Cell Death Differ. 14, 1029\u20131039 (2007).","journal-title":"Cell Death Differ."},{"key":"9974_CR17","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/s41420-021-00404-4","volume":"7","author":"G Mo","year":"2021","unstructured":"Mo, G. et al. IP3R1 regulates Ca(2+) transport and pyroptosis through the NLRP3\/Caspase-1 pathway in myocardial ischemia\/reperfusion injury. Cell Death Discov. 7, 31 (2021).","journal-title":"Cell Death Discov."},{"key":"9974_CR18","doi-asserted-by":"publisher","first-page":"re15","DOI":"10.1126\/stke.3632006re15","volume":"2006","author":"CU Choe","year":"2006","unstructured":"Choe, C. U. & Ehrlich, B. E. The inositol 1,4,5-trisphosphate receptor (IP3R) and its regulators: sometimes good and sometimes bad teamwork. Sci. STKE 2006, re15 (2006).","journal-title":"Sci. STKE"},{"key":"9974_CR19","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1146\/annurev-physiol-021119-034433","volume":"82","author":"K Hamada","year":"2020","unstructured":"Hamada, K. & Mikoshiba, K. IP(3) Receptor plasticity underlying diverse functions. Annu. Rev. Physiol. 82, 151\u2013176 (2020).","journal-title":"Annu. Rev. Physiol."},{"key":"9974_CR20","doi-asserted-by":"publisher","first-page":"10602","DOI":"10.1074\/jbc.M210119200","volume":"278","author":"H Ando","year":"2003","unstructured":"Ando, H. et al. IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor. J. Biol. Chem. 278, 10602\u201310612 (2003).","journal-title":"J. Biol. Chem."},{"key":"9974_CR21","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1016\/j.bbamcr.2014.01.031","volume":"1843","author":"H Ando","year":"2014","unstructured":"Ando, H., Kawaai, K. & Mikoshiba, K. IRBIT: a regulator of ion channels and ion transporters. Biochim. Biophys. Acta 1843, 2195\u20132204 (2014).","journal-title":"Biochim. Biophys. Acta"},{"key":"9974_CR22","doi-asserted-by":"publisher","first-page":"10694","DOI":"10.1074\/jbc.M807136200","volume":"284","author":"H Kiefer","year":"2009","unstructured":"Kiefer, H. et al. Inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) associates with components of the mRNA 3\u2019 processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation. J. Biol. Chem. 284, 10694\u201310705 (2009).","journal-title":"J. Biol. Chem."},{"key":"9974_CR23","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1126\/science.1251550","volume":"345","author":"A Arnaoutov","year":"2014","unstructured":"Arnaoutov, A. & Dasso, M. Enzyme regulation. IRBIT is a novel regulator of ribonucleotide reductase in higher eukaryotes. Science 345, 1512\u20131515 (2014).","journal-title":"Science"},{"key":"9974_CR24","doi-asserted-by":"crossref","unstructured":"Bonneau, B. et al., IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact. Elife 5, e19896 (2016).","DOI":"10.7554\/eLife.19896"},{"key":"9974_CR25","doi-asserted-by":"publisher","first-page":"5515","DOI":"10.1073\/pnas.1503310112","volume":"112","author":"K Kawaai","year":"2015","unstructured":"Kawaai, K. et al. IRBIT regulates CaMKIIalpha activity and contributes to catecholamine homeostasis through tyrosine hydroxylase phosphorylation. Proc. Natl. Acad. Sci. USA 112, 5515\u20135520 (2015).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"9974_CR26","doi-asserted-by":"publisher","first-page":"9542","DOI":"10.1073\/pnas.0602250103","volume":"103","author":"K Shirakabe","year":"2006","unstructured":"Shirakabe, K. et al. IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein, specifically binds to and activates pancreas-type Na+\/HCO3- cotransporter 1 (pNBC1). Proc. Natl. Acad. Sci. USA 103, 9542\u20139547 (2006).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"9974_CR27","first-page":"193","volume":"119","author":"D Yang","year":"2009","unstructured":"Yang, D. et al. IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct. J. Clin. Investig. 119, 193\u2013202 (2009).","journal-title":"J. Clin. Investig."},{"key":"9974_CR28","doi-asserted-by":"publisher","first-page":"e0141569","DOI":"10.1371\/journal.pone.0141569","volume":"10","author":"H Ando","year":"2015","unstructured":"Ando, H. et al. IRBIT interacts with the catalytic core of phosphatidylinositol phosphate kinase type I alpha and II alpha through conserved catalytic aspartate residues. PLoS One 10, e0141569 (2015).","journal-title":"PLoS One"},{"key":"9974_CR29","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.molcel.2006.05.017","volume":"22","author":"H Ando","year":"2006","unstructured":"Ando, H. et al. IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor. Mol. Cell 22, 795\u2013806 (2006).","journal-title":"Mol. Cell"},{"key":"9974_CR30","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1042\/BJ20070361","volume":"407","author":"B Devogelaere","year":"2007","unstructured":"Devogelaere, B. et al. Protein phosphatase-1 is a novel regulator of the interaction between IRBIT and the inositol 1,4,5-trisphosphate receptor. Biochem. J. 407, 303\u2013311 (2007).","journal-title":"Biochem. J."},{"key":"9974_CR31","doi-asserted-by":"publisher","first-page":"5972","DOI":"10.1074\/jbc.M411220200","volume":"280","author":"MO Collins","year":"2005","unstructured":"Collins, M. O. et al. Proteomic analysis of in vivo phosphorylated synaptic proteins. J. Biol. Chem. 280, 5972\u20135982 (2005).","journal-title":"J. Biol. Chem."},{"key":"9974_CR32","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nrm2822","volume":"11","author":"LR Pearce","year":"2010","unstructured":"Pearce, L. R., Komander, D. & Alessi, D. R. The nuts and bolts of AGC protein kinases. Nat. Rev. Mol. Cell Biol. 11, 9\u201322 (2010).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"9974_CR33","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1038\/s41586-022-05575-3","volume":"613","author":"JL Johnson","year":"2023","unstructured":"Johnson, J. L. et al. An atlas of substrate specificities for the human serine\/threonine kinome. Nature 613, 759\u2013766 (2023).","journal-title":"Nature"},{"key":"9974_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.semcancer.2017.05.011","volume":"48","author":"AE Leroux","year":"2018","unstructured":"Leroux, A. E., Schulze, J. O. & Biondi, R. M. AGC kinases, mechanisms of regulation and innovative drug development. Semin. Cancer Biol. 48, 1\u201317 (2018).","journal-title":"Semin. Cancer Biol."},{"key":"9974_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/bj20021469","volume":"369","author":"DW Litchfield","year":"2003","unstructured":"Litchfield, D. W. Protein kinase CK2: structure, regulation and role in cellular decisions of life and death. Biochem. J. 369, 1\u201315 (2003).","journal-title":"Biochem. J."},{"key":"9974_CR36","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.cels.2024.05.005","volume":"15","author":"D Bradley","year":"2024","unstructured":"Bradley, D. et al. The substrate quality of CK2 target sites has a determinant role on their function and evolution. Cell Syst. 15, 544\u2013562.e8 (2024).","journal-title":"Cell Syst."},{"key":"9974_CR37","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1038\/nature01268","volume":"420","author":"I Bosanac","year":"2002","unstructured":"Bosanac, I. et al. Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand. Nature 420, 696\u2013700 (2002).","journal-title":"Nature"},{"key":"9974_CR38","doi-asserted-by":"publisher","first-page":"18277","DOI":"10.1074\/jbc.271.30.18277","volume":"271","author":"F Yoshikawa","year":"1996","unstructured":"Yoshikawa, F. et al. Mutational analysis of the ligand binding site of the inositol 1,4,5-trisphosphate receptor. J. Biol. Chem. 271, 18277\u201318284 (1996).","journal-title":"J. Biol. Chem."},{"key":"9974_CR39","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/0143-4160(91)90018-A","volume":"12","author":"R Sauve","year":"1991","unstructured":"Sauve, R. et al. Ca2+ oscillations induced by histamine H1 receptor stimulation in HeLa cells: Fura-2 and patch clamp analysis. Cell Calcium 12, 165\u2013176 (1991).","journal-title":"Cell Calcium"},{"key":"9974_CR40","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/S0898-6568(03)00012-3","volume":"15","author":"B Aguilar-Maldonado","year":"2003","unstructured":"Aguilar-Maldonado, B. et al. Histamine potentiates IP(3)-mediated Ca(2+) release via thapsigargin-sensitive Ca(2+) pumps. Cell Signal 15, 689\u2013697 (2003).","journal-title":"Cell Signal"},{"key":"9974_CR41","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1042\/BJ20140178","volume":"460","author":"A Venerando","year":"2014","unstructured":"Venerando, A., Ruzzene, M. & Pinna, L. A. Casein kinase: the triple meaning of a misnomer. Biochem. J. 460, 141\u2013156 (2014).","journal-title":"Biochem. J."},{"key":"9974_CR42","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1021\/ar020164f","volume":"36","author":"LA Pinna","year":"2003","unstructured":"Pinna, L. A. The raison d\u2019etre of constitutively active protein kinases: the lesson of CK2. Acc. Chem. Res. 36, 378\u2013384 (2003).","journal-title":"Acc. Chem. Res."},{"key":"9974_CR43","doi-asserted-by":"crossref","unstructured":"Roffey, S. E. and Litchfield. D. W., CK2 regulation: perspectives in 2021. Biomedicines, 9, 1361 (2021).","DOI":"10.3390\/biomedicines9101361"},{"key":"9974_CR44","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.celrep.2013.02.011","volume":"3","author":"A Sanz-Clemente","year":"2013","unstructured":"Sanz-Clemente, A. et al. Activated CaMKII couples GluN2B and casein kinase 2 to control synaptic NMDA receptors. Cell Rep. 3, 607\u2013614 (2013).","journal-title":"Cell Rep."},{"key":"9974_CR45","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1113\/JP280578","volume":"599","author":"P Su","year":"2021","unstructured":"Su, P. et al. IRBIT activates NBCe1-B by releasing the auto-inhibition module from the transmembrane domain. J. Physiol. 599, 1151\u20131172 (2021).","journal-title":"J. Physiol."},{"key":"9974_CR46","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34574-1","volume":"13","author":"G Fan","year":"2022","unstructured":"Fan, G. et al. Conformational motions and ligand-binding underlying gating and regulation in IP(3)R channel. Nat. Commun. 13, 6942 (2022).","journal-title":"Nat. Commun."},{"key":"9974_CR47","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1002\/pmic.201000472","volume":"11","author":"E Kinoshita","year":"2011","unstructured":"Kinoshita, E. & Kinoshita-Kikuta, E. Improved Phos-tag SDS-PAGE under neutral pH conditions for advanced protein phosphorylation profiling. Proteomics 11, 319\u2013323 (2011).","journal-title":"Proteomics"},{"key":"9974_CR48","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1021\/jm0306430","volume":"47","author":"RA Friesner","year":"2004","unstructured":"Friesner, R. A. et al. Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy. J. Med. Chem. 47, 1739\u20131749 (2004).","journal-title":"J. Med. Chem."},{"key":"9974_CR49","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1007\/s10822-010-9349-1","volume":"24","author":"JR Greenwood","year":"2010","unstructured":"Greenwood, J. R. et al. Towards the comprehensive, rapid, and accurate prediction of the favorable tautomeric states of drug-like molecules in aqueous solution. J. Comput. Aided Mol. Des. 24, 591\u2013604 (2010).","journal-title":"J. Comput. Aided Mol. Des."},{"key":"9974_CR50","doi-asserted-by":"publisher","first-page":"e82849","DOI":"10.1371\/journal.pone.0082849","volume":"8","author":"H Beard","year":"2013","unstructured":"Beard, H. et al. Applying physics-based scoring to calculate free energies of binding for single amino acid mutations in protein-protein complexes. PLoS One 8, e82849 (2013).","journal-title":"PLoS One"},{"key":"9974_CR51","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.ccell.2021.01.006","volume":"39","author":"LB Wang","year":"2021","unstructured":"Wang, L. B. et al. Proteogenomic and metabolomic characterization of human glioblastoma. Cancer Cell 39, 509\u2013528.e20 (2021).","journal-title":"Cancer Cell"},{"key":"9974_CR52","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1089\/omi.2019.0191","volume":"24","author":"G Sathe","year":"2020","unstructured":"Sathe, G. et al. Multiplexed phosphoproteomic study of brain in patients with Alzheimer\u2019s disease and age-matched cognitively healthy controls. OMICS 24, 216\u2013227 (2020).","journal-title":"OMICS"},{"key":"9974_CR53","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/j.cell.2020.01.026","volume":"180","author":"Y Dou","year":"2020","unstructured":"Dou, Y. et al. Proteogenomic Characterization of Endometrial Carcinoma. Cell 180, 729\u2013748.e26 (2020).","journal-title":"Cell"},{"key":"9974_CR54","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.cell.2020.06.013","volume":"182","author":"MA Gillette","year":"2020","unstructured":"Gillette, M. A. et al. Proteogenomic characterization reveals therapeutic vulnerabilities in lung adenocarcinoma. Cell 182, 200\u2013225 e35 (2020).","journal-title":"Cell"},{"key":"9974_CR55","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14381-2","volume":"11","author":"S Satpathy","year":"2020","unstructured":"Satpathy, S. et al. Microscaled proteogenomic methods for precision oncology. Nat. Commun. 11, 532 (2020).","journal-title":"Nat. Commun."},{"key":"9974_CR56","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-14175-1","volume":"11","author":"ND Udeshi","year":"2020","unstructured":"Udeshi, N. D. et al. Rapid and deep-scale ubiquitylation profiling for biology and translational research. Nat. Commun. 11, 359 (2020).","journal-title":"Nat. Commun."},{"key":"9974_CR57","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nature18003","volume":"534","author":"P Mertins","year":"2016","unstructured":"Mertins, P. et al. Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55\u201362 (2016).","journal-title":"Nature"},{"key":"9974_CR58","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1016\/j.cell.2020.10.036","volume":"183","author":"K Krug","year":"2020","unstructured":"Krug, K. et al. Proteogenomic landscape of breast cancer tumorigenesis and targeted therapy. Cell 183, 1436\u20131456.e31 (2020).","journal-title":"Cell"},{"key":"9974_CR59","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1021\/acs.jproteome.8b00165","volume":"17","author":"DJ Clark","year":"2018","unstructured":"Clark, D. J. et al. Evaluation of NCI-7 Cell Line Panel as a Reference Material for Clinical Proteomics. J. Proteome Res. 17, 2205\u20132215 (2018).","journal-title":"J. Proteome Res."}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-09974-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-09974-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-09974-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:09:02Z","timestamp":1782864542000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-09974-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,24]]},"references-count":59,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["9974"],"URL":"https:\/\/doi.org\/10.1038\/s42003-026-09974-4","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,24]]},"assertion":[{"value":"7 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"877"}}