{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:59:16Z","timestamp":1790351956620,"version":"4.1.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":62,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Commun Biol"],"DOI":"10.1038\/s42003-026-10078-2","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T16:53:09Z","timestamp":1776444789000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Chinese cobra (Naja atra) SVPLA2 promotes muscle inflammation via RPL35A-mediated translational reprogramming"],"prefix":"10.1038","volume":"9","author":[{"given":"Jiahao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zejing","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunkun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1097-7842","authenticated-orcid":false,"given":"Chunhong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"10078_CR1","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S0140-6736(09)61754-2","volume":"375","author":"DA Warrell","year":"2010","unstructured":"Warrell, D. A. Snake bite. Lancet 375, 77\u201388 (2010).","journal-title":"Lancet"},{"key":"10078_CR2","doi-asserted-by":"publisher","first-page":"239","DOI":"10.4103\/aam.aam_9_23","volume":"22","author":"SB Naik","year":"2023","unstructured":"Naik, S. B. Intravenous snake bite: a catastrophic snake envenomation. Ann. Afr. Med. 22, 239\u2013245 (2023).","journal-title":"Ann. Afr. Med."},{"key":"10078_CR3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.4997\/jrcpe.2021.102","volume":"51","author":"HS Bawaskar","year":"2021","unstructured":"Bawaskar, H. S., Bawaskar, P. H. & Bawaskar, P. H. The global burden of snake bite envenoming. J. R. Coll. Physicians Edinb. 51, 7\u20138 (2021).","journal-title":"J. R. Coll. Physicians Edinb."},{"key":"10078_CR4","doi-asserted-by":"publisher","first-page":"114135","DOI":"10.1016\/j.bcp.2020.114135","volume":"181","author":"A Alangode","year":"2020","unstructured":"Alangode, A., Rajan, K. & Nair, B. G. Snake antivenom: challenges and alternate approaches. Biochem. Pharmacol. 181, 114135 (2020).","journal-title":"Biochem. Pharmacol."},{"key":"10078_CR5","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1080\/15563650.2017.1366502","volume":"56","author":"YC Mao","year":"2018","unstructured":"Mao, Y. C. et al. Naja atra snakebite in Taiwan. Clin. Toxicol. 56, 273\u2013280 (2018).","journal-title":"Clin. Toxicol."},{"key":"10078_CR6","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-024-02044-3","volume":"22","author":"L Jones","year":"2024","unstructured":"Jones, L. et al. Breaking muscle: neurotoxic and myotoxic effects of Central American snake venoms and the relative efficacies of antivenom and varespladib. BMC Biol. 22, 243 (2024).","journal-title":"BMC Biol."},{"key":"10078_CR7","doi-asserted-by":"publisher","DOI":"10.1590\/1678-9199-jvatitd-2021-0040","volume":"28","author":"G Xiao","year":"2022","unstructured":"Xiao, G., Liu, J., Peng, L., Yang, Y. & Sun, Z. Compositional and toxicological investigation of pooled venom from farm-raised Naja atra. J. Venom. Anim. Toxins Incl. Trop. Dis. 28, e20210040 (2022).","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10078_CR8","doi-asserted-by":"publisher","first-page":"gigabyte99","DOI":"10.46471\/gigabyte.99","volume":"2023","author":"J Wang","year":"2023","unstructured":"Wang, J. et al. The genome assembly and annotation of the Chinese cobra, Naja atra. GigaByte 2023, gigabyte99 (2023).","journal-title":"GigaByte"},{"key":"10078_CR9","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.jprot.2016.02.028","volume":"138","author":"LL Shan","year":"2016","unstructured":"Shan, L. L. et al. Proteomic characterization and comparison of venoms from two elapid snakes (Bungarus multicinctus and Naja atra) from China. J. Proteom. 138, 83\u201394 (2016).","journal-title":"J. Proteom."},{"key":"10078_CR10","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s00204-022-03420-0","volume":"97","author":"T Tasoulis","year":"2023","unstructured":"Tasoulis, T. & Isbister, G. K. A current perspective on snake venom composition and constituent protein families. Arch. Toxicol. 97, 133\u2013153 (2023).","journal-title":"Arch. Toxicol."},{"key":"10078_CR11","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1007\/s43440-023-00543-8","volume":"75","author":"GH Sampat","year":"2023","unstructured":"Sampat, G. H. et al. Unraveling snake venom phospholipase A(2): an overview of its structure, pharmacology, and inhibitors. Pharmacol. Rep. 75, 1454\u20131473 (2023).","journal-title":"Pharmacol. Rep."},{"key":"10078_CR12","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1111\/j.1471-4159.2006.03965.x","volume":"97","author":"O Rossetto","year":"2006","unstructured":"Rossetto, O., Morbiato, L., Caccin, P., Rigoni, M. & Montecucco, C. Presynaptic enzymatic neurotoxins. J. Neurochem. 97, 1534\u20131545 (2006).","journal-title":"J. Neurochem."},{"key":"10078_CR13","doi-asserted-by":"publisher","first-page":"116","DOI":"10.3390\/toxins11020116","volume":"11","author":"CA-OX Tan","year":"2019","unstructured":"Tan, C. A.-O. X., Wong, K. Y., Tan, N. H., Ng, T. S. & Tan, K. A.-O. Distinctive distribution of secretory phospholipases A\u2082 in the venoms of afro-asian cobras (Subgenus: Naja, Afronaja, Boulengerina and Uraeus). Toxins 11, 116 (2019).","journal-title":"Toxins"},{"key":"10078_CR14","doi-asserted-by":"publisher","first-page":"107288","DOI":"10.1016\/j.toxicon.2023.107288","volume":"234","author":"P Luo","year":"2023","unstructured":"Luo, P. et al. Affected inflammation-related signaling pathways in snake envenomation: a recent insight. Toxicon 234, 107288 (2023).","journal-title":"Toxicon"},{"key":"10078_CR15","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1042\/BST20200110","volume":"48","author":"JJ Hiu","year":"2020","unstructured":"Hiu, J. J. & Yap, M. K. K. Cytotoxicity of snake venom enzymatic toxins: phospholipase A2 and L-amino acid oxidase. Biochem. Soc. Trans. 48, 719\u2013731 (2020).","journal-title":"Biochem. Soc. Trans."},{"key":"10078_CR16","doi-asserted-by":"crossref","unstructured":"Khan S. A., Ilies M. A. The Phospholipase A2 superfamily: structure, isozymes, catalysis, physiologic and pathologic roles. Int. J. Mol. Sci. 24, 1353 (2023).","DOI":"10.3390\/ijms24021353"},{"key":"10078_CR17","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.toxlet.2009.08.016","volume":"191","author":"WH Liu","year":"2009","unstructured":"Liu, W. H. & Chang, L. S. Arachidonic acid induces Fas and FasL upregulation in human leukemia U937 cells via Ca2+\/ROS-mediated suppression of ERK\/c-Fos pathway and activation of p38 MAPK\/ATF-2 pathway. Toxicol. Lett. 191, 140\u2013148 (2009).","journal-title":"Toxicol. Lett."},{"key":"10078_CR18","doi-asserted-by":"publisher","first-page":"114598","DOI":"10.1016\/j.ecoenv.2023.114598","volume":"252","author":"Y Hu","year":"2023","unstructured":"Hu, Y. et al. Arachidonic acid impairs the function of the blood-testis barrier via triggering mitochondrial complex-ROS-P38 MAPK axis in hyperthermal Sertoli cells. Ecotoxicol. Environ. Saf. 252, 114598 (2023).","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10078_CR19","doi-asserted-by":"publisher","first-page":"2507557","DOI":"10.1080\/13510002.2025.2507557","volume":"30","author":"J Liu","year":"2025","unstructured":"Liu, J. et al. Varespladib attenuates Naja atra-induced acute liver injury via reversing Nrf2 signaling-mediated ferroptosis and mitochondrial dysfunction. Redox. Rep. 30, 2507557 (2025).","journal-title":"Redox. Rep."},{"key":"10078_CR20","doi-asserted-by":"crossref","unstructured":"Boeno, C. N. et al. Inflammasome activation induced by a snake venom Lys49-phospholipase A(2) homologue. Toxins. 12, 22 (2019).","DOI":"10.3390\/toxins12010022"},{"key":"10078_CR21","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1042\/CS20201419","volume":"135","author":"ESPA Ran\u00e9ia","year":"2021","unstructured":"Ran\u00e9ia, E. S. P. A. et al. Inflammatory effect of Bothropstoxin-I from Bothrops jararacussu venom mediated by NLRP3 inflammasome involves ATP and P2X7 receptor. Clin. Sci. 135, 687\u2013701 (2021).","journal-title":"Clin. Sci."},{"key":"10078_CR22","doi-asserted-by":"publisher","DOI":"10.1186\/s13062-024-00453-6","volume":"19","author":"C Zhang","year":"2024","unstructured":"Zhang, C. et al. RPL35A promotes the progression of cholangiocarcinoma by mediating HSPA8 ubiquitination. Biol. Direct. 19, 16 (2024).","journal-title":"Biol. Direct."},{"key":"10078_CR23","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.18115","volume":"28","author":"H Wu","year":"2024","unstructured":"Wu, H. et al. RPL35A drives ovarian cancer progression by promoting the binding of YY1 to the CTCF promoter. J. Cell Mol. Med. 28, e18115 (2024).","journal-title":"J. Cell Mol. Med."},{"key":"10078_CR24","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.70394","volume":"29","author":"S Wei","year":"2025","unstructured":"Wei, S. et al. Smurf2 suppresses proliferation and cell cycle of triple-negative breast cancer cells by promoting the polyubiquitination and degradation of RPL35A. J. Cell Mol. Med. 29, e70394 (2025).","journal-title":"J. Cell Mol. Med."},{"key":"10078_CR25","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-02199-x","volume":"21","author":"F Wu","year":"2021","unstructured":"Wu, F., Sun, D., Liao, Y., Shang, K. & Lu, C. A.-O. RPL35A is a key promotor involved in the development and progression of gastric cancer. Cancer Cell Int. 21, 497 (2021).","journal-title":"Cancer Cell Int."},{"key":"10078_CR26","doi-asserted-by":"publisher","DOI":"10.1111\/ped.15275","volume":"64","author":"KA-O Tamefusa","year":"2022","unstructured":"Tamefusa, K. A.-O., Muraoka, M., Washio, K., Wakamatsu, M. & Shimada, A. Late-onset familial diamond-blackfan anemia with neutropenia caused by RPL35A variant. Pediatr. Int. 64, e15275 (2022).","journal-title":"Pediatr. Int."},{"key":"10078_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19981-6","volume":"11","author":"LO Albulescu","year":"2020","unstructured":"Albulescu, L. O. et al. A therapeutic combination of two small-molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite. Nat. Commun. 11, 6094 (2020).","journal-title":"Nat. Commun."},{"key":"10078_CR28","doi-asserted-by":"crossref","unstructured":"Lewin, M. R. et al. Varespladib in the treatment of snakebite envenoming: development history and preclinical evidence supporting advancement to clinical trials in patients bitten by venomous snakes. Toxins. 14, 783 (2022).","DOI":"10.3390\/toxins14110783"},{"key":"10078_CR29","doi-asserted-by":"publisher","first-page":"129913","DOI":"10.1016\/j.bbagen.2021.129913","volume":"1865","author":"GHM Salvador","year":"2021","unstructured":"Salvador, G. H. M., Borges, R. J., Lomonte, B., Lewin, M. R. & Fontes, M. R. M. The synthetic varespladib molecule is a multi-functional inhibitor for PLA(2) and PLA(2)-like ophidic toxins. Biochim. Biophys. Acta Gen. Subj. 1865, 129913 (2021).","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10078_CR30","doi-asserted-by":"crossref","unstructured":"Gerardo, C. J. et al. Oral varespladib for the treatment of snakebite envenoming in India and the USA (BRAVO): a phase II randomised clinical trial. BMJ Glob. Health. 9, e015985 (2024).","DOI":"10.1136\/bmjgh-2024-015985"},{"key":"10078_CR31","doi-asserted-by":"publisher","first-page":"3117","DOI":"10.1016\/j.cell.2025.03.050","volume":"188","author":"J Glanville","year":"2025","unstructured":"Glanville, J. et al. Snake venom protection by a cocktail of varespladib and broadly neutralizing human antibodies. Cell 188, 3117\u20133134.e3111 (2025).","journal-title":"Cell"},{"key":"10078_CR32","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/978-1-0716-3441-7_5","volume":"2714","author":"A Singh","year":"2024","unstructured":"Singh, A., Copeland, M. M., Kundrotas, P. J. & Vakser, I. A. GRAMM Web server for protein docking. Methods Mol. Biol. 2714, 101\u2013112 (2024).","journal-title":"Methods Mol. Biol."},{"key":"10078_CR33","doi-asserted-by":"crossref","unstructured":"Park, M. Y. et al. Scutellarein inhibits LPS-induced inflammation through NF-\u03baB\/MAPKs signaling pathway in RAW264.7 cells. Molecules. 27, 3782 (2022).","DOI":"10.3390\/molecules27123782"},{"key":"10078_CR34","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1093\/nar\/gkad057","volume":"51","author":"X Zhu","year":"2023","unstructured":"Zhu, X. et al. p38-mediated FOXN3 phosphorylation modulates lung inflammation and injury through the NF-\u03baB signaling pathway. Nucleic Acids Res. 51, 2195\u20132214 (2023).","journal-title":"Nucleic Acids Res."},{"key":"10078_CR35","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/nrm.2017.103","volume":"19","author":"K Leppek","year":"2018","unstructured":"Leppek, K., Das, R. & Barna, M. Functional 5\u2019 UTR mRNA structures in eukaryotic translation regulation and how to find them. Nat. Rev. Mol. Cell Biol. 19, 158\u2013174 (2018).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10078_CR36","doi-asserted-by":"publisher","first-page":"7813","DOI":"10.1073\/pnas.1901310116","volume":"116","author":"J Zhou","year":"2019","unstructured":"Zhou, J., Lancaster, L., Donohue, J. P. & Noller, H. F. Spontaneous ribosomal translocation of mRNA and tRNAs into a chimeric hybrid state. Proc. Natl. Acad. Sci. USA 116, 7813\u20137818 (2019).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10078_CR37","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.molcel.2022.12.030","volume":"83","author":"AM Bourke","year":"2023","unstructured":"Bourke, A. M., Schwarz, A. & Schuman, E. M. De-centralizing the Central Dogma: mRNA translation in space and time. Mol. Cell 83, 452\u2013468 (2023).","journal-title":"Mol. Cell"},{"key":"10078_CR38","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/nature14010","volume":"517","author":"S Xue","year":"2015","unstructured":"Xue, S. et al. RNA regulons in Hox 5\u2019 UTRs confer ribosome specificity to gene regulation. Nature 517, 33\u201338 (2015).","journal-title":"Nature"},{"key":"10078_CR39","doi-asserted-by":"crossref","unstructured":"Godet, A. C. et al. IRES trans-acting factors, key actors of the stress response. Int. J. Mol. Sci. 20, 924 (2019).","DOI":"10.3390\/ijms20040924"},{"key":"10078_CR40","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1093\/jmcb\/mjz091","volume":"11","author":"Y Yang","year":"2019","unstructured":"Yang, Y. & Wang, Z. IRES-mediated cap-independent translation, a path leading to hidden proteome. J. Mol. Cell Biol. 11, 911\u2013919 (2019).","journal-title":"J. Mol. Cell Biol."},{"key":"10078_CR41","doi-asserted-by":"publisher","first-page":"4383","DOI":"10.1007\/s00018-015-1938-7","volume":"72","author":"B Yang","year":"2015","unstructured":"Yang, B. et al. PTBP1 induces ADAR1 p110 isoform expression through IRES-like dependent translation control and influences cell proliferation in gliomas. Cell Mol. Life Sci. 72, 4383\u20134397 (2015).","journal-title":"Cell Mol. Life Sci."},{"key":"10078_CR42","doi-asserted-by":"publisher","first-page":"696","DOI":"10.3724\/abbs.2022046","volume":"54","author":"X Fan","year":"2022","unstructured":"Fan, X. et al. PTBP1 promotes IRES-mediated translation of cyclin B1 in cancer. Acta. Biochim. Biophys. Sin. 54, 696\u2013707 (2022).","journal-title":"Acta. Biochim. Biophys. Sin."},{"key":"10078_CR43","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42012-z","volume":"14","author":"G Dorn","year":"2023","unstructured":"Dorn, G. et al. Integrative solution structure of PTBP1-IRES complex reveals strong compaction and ordering with residual conformational flexibility. Nat. Commun. 14, 6429 (2023).","journal-title":"Nat. Commun."},{"key":"10078_CR44","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1186\/s12876-023-02962-6","volume":"23","author":"F Zhang","year":"2023","unstructured":"Zhang, F. & Xu, D. Zerumbone ameliorates the inflammatory response and organ damage in severe acute pancreatitis via the ROS\/NF-\u03baB pathway. BMC Gastroenterol. 23, 333 (2023).","journal-title":"BMC Gastroenterol."},{"key":"10078_CR45","doi-asserted-by":"publisher","first-page":"111264","DOI":"10.1016\/j.intimp.2023.111264","volume":"126","author":"S \u00c7omakl\u0131","year":"2024","unstructured":"\u00c7omakl\u0131, S., K\u00fc\u00e7\u00fckler, S., De\u011firmen\u00e7ay, \u015e, Bolat, \u0130 & \u00d6zdemir, S. Quinacrine, a PLA2 inhibitor, alleviates LPS-induced acute kidney injury in rats: Involvement of TLR4\/NF-\u03baB\/TNF \u03b1-mediated signaling. Int. Immunopharmacol. 126, 111264 (2024).","journal-title":"Int. Immunopharmacol."},{"key":"10078_CR46","doi-asserted-by":"publisher","first-page":"105879","DOI":"10.1155\/2014\/105879","volume":"2014","author":"V Moreira","year":"2014","unstructured":"Moreira, V. et al. An Asp49 phospholipase A2 from snake venom induces cyclooxygenase-2 expression and prostaglandin E2 production via activation of NF-\u03baB, p38MAPK, and PKC in macrophages. Mediators Inflamm. 2014, 105879 (2014).","journal-title":"Mediators Inflamm."},{"key":"10078_CR47","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.mam.2011.10.006","volume":"32","author":"BM Hybertson","year":"2011","unstructured":"Hybertson, B. M., Gao, B., Bose, S. K. & McCord, J. M. Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. Mol. Asp. Med. 32, 234\u2013246 (2011).","journal-title":"Mol. Asp. Med."},{"key":"10078_CR48","doi-asserted-by":"crossref","unstructured":"Resiere D., Mehdaoui H., Neviere R. Inflammation and oxidative stress in snakebite envenomation: a brief descriptive review and clinical implications. Toxins. 14, 802 (2022).","DOI":"10.3390\/toxins14110802"},{"key":"10078_CR49","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1089\/dna.2022.0353","volume":"41","author":"Y Tang","year":"2022","unstructured":"Tang, Y. et al. Endoplasmic reticulum stress and oxidative stress in inflammatory diseases. DNA Cell Biol. 41, 924\u2013934 (2022).","journal-title":"DNA Cell Biol."},{"key":"10078_CR50","doi-asserted-by":"publisher","first-page":"102452","DOI":"10.1016\/j.redox.2022.102452","volume":"56","author":"J Liu","year":"2022","unstructured":"Liu, J. et al. Chenodeoxycholic acid suppresses AML progression through promoting lipid peroxidation via ROS\/p38 MAPK\/DGAT1 pathway and inhibiting M2 macrophage polarization. Redox Biol. 56, 102452 (2022).","journal-title":"Redox Biol."},{"key":"10078_CR51","first-page":"2140","volume":"11","author":"L Gong","year":"2019","unstructured":"Gong, L. et al. Vaccarin prevents ox-LDL-induced HUVEC EndMT, inflammation and apoptosis by suppressing ROS\/p38 MAPK signaling. Am. J. Transl. Res. 11, 2140\u20132154 (2019).","journal-title":"Am. J. Transl. Res."},{"key":"10078_CR52","doi-asserted-by":"publisher","first-page":"12515","DOI":"10.1096\/fj.201802805RR","volume":"33","author":"Y An","year":"2019","unstructured":"An, Y. et al. Activation of ROS\/MAPKs\/NF-\u03baB\/NLRP3 and inhibition of efferocytosis in osteoclast-mediated diabetic osteoporosis. FASEB J. 33, 12515\u201312527 (2019).","journal-title":"FASEB J."},{"key":"10078_CR53","doi-asserted-by":"publisher","first-page":"658","DOI":"10.4062\/biomolther.2021.143","volume":"29","author":"SO Lee","year":"2021","unstructured":"Lee, S. O. et al. Podophyllotoxin induces ROS-mediated apoptosis and cell cycle arrest in human colorectal cancer cells via p38 MAPK signaling. Biomol. Ther. 29, 658\u2013666 (2021).","journal-title":"Biomol. Ther."},{"key":"10078_CR54","doi-asserted-by":"publisher","DOI":"10.1186\/s12989-022-00512-8","volume":"20","author":"JH Woo","year":"2023","unstructured":"Woo, J. H. et al. Polypropylene nanoplastic exposure leads to lung inflammation through p38-mediated NF-\u03baB pathway due to mitochondrial damage. Part Fibre Toxicol. 20, 2 (2023).","journal-title":"Part Fibre Toxicol."},{"key":"10078_CR55","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.toxicon.2017.07.019","volume":"137","author":"S Xiong","year":"2017","unstructured":"Xiong, S. et al. Investigation of the inhibitory potential of phospholipase A(2) inhibitor gamma from Sinonatrix annularis to snake envenomation. Toxicon 137, 83\u201391 (2017).","journal-title":"Toxicon"},{"key":"10078_CR56","doi-asserted-by":"publisher","first-page":"107694","DOI":"10.1016\/j.toxicon.2024.107694","volume":"242","author":"W Zhao","year":"2024","unstructured":"Zhao, W. et al. Varespladib mitigates acute liver injury via suppression of excessive mitophagy on Naja atra envenomed mice by inhibiting PLA(2). Toxicon 242, 107694 (2024).","journal-title":"Toxicon"},{"key":"10078_CR57","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1038\/s41573-019-0012-9","volume":"18","author":"D Wang","year":"2019","unstructured":"Wang, D., Tai, P. W. L. & Gao, G. Adeno-associated virus vector as a platform for gene therapy delivery. Nat. Rev. Drug Discov. 18, 358\u2013378 (2019).","journal-title":"Nat. Rev. Drug Discov."},{"key":"10078_CR58","doi-asserted-by":"crossref","unstructured":"Wang C., Yue F., Kuang S. Muscle histology characterization using h&e staining and muscle fiber type classification using immunofluorescence staining. Bio. Protoc. 7, e2279 (2017).","DOI":"10.21769\/BioProtoc.2279"},{"key":"10078_CR59","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/978-1-4939-7163-3_14","volume":"1639","author":"DA Fu","year":"2017","unstructured":"Fu, D. A. & Campbell-Thompson, M. Periodic acid-schiff staining with diastase. Methods Mol. Biol. 1639, 145\u2013149 (2017).","journal-title":"Methods Mol. Biol."}],"container-title":["Communications Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10078-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10078-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10078-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:19:34Z","timestamp":1781741974000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s42003-026-10078-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,17]]},"references-count":59,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["10078"],"URL":"https:\/\/doi.org\/10.1038\/s42003-026-10078-2","relation":{},"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,17]]},"assertion":[{"value":"4 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"833"}}